β-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients

Neurobiology of Disease

Volumn 19, Issue 1-2, 2005, Pages 340-347

  Calingasan, Noel Y ^a   Chen, Junyu ^a   Kiaei, Mahmoud ^a   Beal, M Flint ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Amyotrophic lateral sclerosis; Immunohistochemistry; Motor neurons; Neurodegeneration; Oxidative stress; Spinal cord; amyloid 42

Indexed keywords

3 NITROTYROSINE; 8 HYDROXYDEOXYGUANOSINE; AMYLOID BETA PROTEIN; HEME OXYGENASE 1; MALONALDEHYDE; THIOFLAVINE;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CADAVER; CELL DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUMBAR SPINAL CORD; MALE; MOTONEURON; NERVE DEGENERATION; NERVE FIBER; OXIDATIVE STRESS; PATHOGENESIS; PERIKARYON; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SPINAL CORD VENTRAL HORN;

EID: 17444419749     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.01.012     Document Type: Article

References (44)

1. N.Y. Barnes, L. Li, K. Yoshikawa, L.M. Schwartz, R.W. Oppenheim, and C.E. Milligan Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons J. Neurosci. 18 1998 5869 5880
2. C. Behl, J.B. Davis, F.G. Klier, and D. Schubert Amyloid beta peptide induces necrosis rather than apoptosis Brain Res. 645 1994 253 264
3. C. Behl, J.B. Davis, R. Lesley, and D. Schubert Hydrogen peroxide mediates amyloid beta protein toxicity Cell 77 1994 817 827
4. D.A. Butterfield, and A.I. Bush Alzheimer's amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide Neurobiol. Aging 25 2004 563 568
5. M.T. Carri, A. Ferri, M. Cozzolino, L. Calabrese, and G. Rotilio Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals Brain Res. Bull. 61 2003 365 374
6. C. Casas, N. Sergeant, J.M. Itier, V. Blanchard, O. Wirths, N. van der Kolk, V. Vingtdeux, E. van de Steeg, G. Ret, T. Canton, H. Drobecq, A. Clark, B. Bonici, A. Delacourte, J. Benavides, C. Schmitz, G. Tremp, T.A. Bayer, P. Benoit, and L. Pradier Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Aβ42 accumulation in a novel Alzheimer transgenic model Am. J. Pathol. 165 2004 1289 1300
7. M.P. Cuajungco, L.E. Goldstein, A. Nunomura, M.A. Smith, J.T. Lim, C.S. Atwood, X. Huang, Y.W. Farrag, G. Perry, and A.I. Bush Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc J. Biol. Chem. 275 2000 19439 19442
8. M.R. D'Andrea, R.G. Nagele, H.Y. Wang, P.A. Peterson, and D.H. Lee Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease Histopathology 38 2001 120 134
9. L. Dominguez, V. Garza, A.M. Lacosta, V. Sorribas, and M. Sarasa Developmental spatiotemporal expression of Alzheimer APP isoforms in the chick embryo Int. J. Dev. Biol. 45 2001 S73 S74
10. N. Embacher, W.A. Kaufmann, R. Beer, H. Maier, K.A. Jellinger, W. Poewe, and G. Ransmayr Apoptosis signals in sporadic amyotrophic lateral sclerosis: an immunocytochemical study Acta Neuropathol. (Berlin) 102 2001 426 434
11. R.J. Ferrante, S.E. Browne, L.A. Shinobu, A.C. Bowling, M.J. Baik, U. MacGarvey, N.W. Kowall, R.H. Brown Jr., and M.F. Beal Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis J. Neurochem. 9 1997 2064 2074
12. F.G. Gervais, D. Xu, G.S. Robertson, J.P. Vaillancourt, Y. Zhu, J. Huang, A. LeBlanc, D. Smith, M. Rigby, M.S. Shearman, E.E. Clarke, H. Zheng, L.H. Van Der Ploeg, S.C. Ruffolo, N.A. Thornberry, S. Xanthoudakis, R.J. Zamboni, S. Roy, and D.W. Nicholson Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A β peptide formation Cell 97 1999 395 406
13. G.K. Gouras, J. Tsai, J. Naslund, B. Vincent, M. Edgar, F. Checler, J.P. Greenfield, V. Haroutunian, J.D. Buxbaum, H. Xu, P. Greengard, and N. Relkin Intraneuronal Abeta42 accumulation in human brain Am. J. Pathol. 156 2000 15 20
14. R. Guntern, C. Bouras, P.R. Hof, and P.G. Valet An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease Experientia 48 1992 8 10
15. E.D. Hall, J.A. Oostveen, P.K. Andrus, D.K. Anderson, and C.E. Thomas Immunocytochemical method for investigating in vivo neuronal oxygen radical-induced lipid peroxidation J. Neurosci. Methods 76 1997 115 122
16. C.Z. He, and A.P. Hays Expression of peripherin in ubiquitinated inclusions of amyotrophic lateral sclerosis J. Neurol. Sci. 217 2004 47 54
17. K. Hensley, J.M. Carney, M.P. Mattson, M. Aksenova, M. Harris, J.F. Wu, R.A. Floyd, and D.A. Butterfield A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease Proc. Natl. Acad. Sci. U. S. A. 91 1994 3270 3274
18. S. Hsu, L. Raine, and H. Fanger Use of avidin-biotin-peroxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures J. Histochem. Cytochem. 29 1981 577 580
19. X. Huang, R.D. Moir, R.E. Tanzi, A.I. Bush, and J.T. Rogers Redox-active metals, oxidative stress, and Alzheimer's disease pathology Ann. N. Y. Acad. Sci. 1012 2004 153 163
20. J.P. Julien Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded Cell 104 2001 581 591
21. A. Kamal, A. Almenar-Queralt, J.F. LeBlanc, E.A. Roberts, and L.S. Goldstein Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP Nature 414 2001 643 648
22. H.G. Lee, G. Casadesus, X. Zhu, A. Takeda, G. Perry, and M.A. Smith Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease Ann. N. Y. Acad. Sci. 1019 2004 1 4
23. M. Li, V.O. Ona, C. Guegan, M. Chen, V. Jackson-Lewis, L.J. Andrews, A.J. Olszewski, P.E. Stieg, J.P. Lee, S. Przedborski, and R.M. Friedlander Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model Science 288 2000 335 339
24. J.W. Lustbader, M. Cirilli, C. Lin, H.W. Xu, K. Takuma, N. Wang, C. Caspersen, X. Chen, S. Pollak, M. Chaney, F. Trinchese, S. Liu, F. Gunn-Moore, L.F. Lue, D.G. Walker, P. Kuppusamy, Z.L. Zewier, O. Arancio, D. Stern, S.S. Yan, and H. Wu ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease Science 304 2004 448 452
25. L.J. Martin Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism J. Neuropathol. Exp. Neurol. 58 1999 459 471
26. B. Mazur-Kolecka, D. Kowal, T. Sukontasup, D. Dickson, and J. Frackowiak The effect of oxidative stress on amyloid precursor protein processing in cells engaged in beta-amyloidosis is related to apolipoprotein E genotype Acta Neuropathol. 108 2004 287 294
27. H. Misonou, M. Morishima-Kawashima, and Y. Ihara Oxidative stress induces intracellular accumulation of amyloid beta-protein (Aβ) in human neuroblastoma cells Biochemistry 39 2000 6951 6959
28. A. Nunomura, G. Perry, G. Aliev, K. Hirai, A. Takeda, E.K. Balraj, P.K. Jones, H. Ghanbari, T. Wataya, S. Shimohama, S. Chiba, C.S. Atwood, R.B. Petersen, and M.A. Smith Oxidative damage is the earliest event in Alzheimer disease J. Neuropathol. Exp. Neurol. 60 2001 759 767
29. Y. Ohyagi, T. Yamada, K. Nishioka, N.J. Clarke, A.J. Tomlinson, S. Naylor, Y. Nakabeppu, J. Kira, and S.G. Younkin Selective increase in cellular Aβ42 is related to apoptosis but not necrosis NeuroReport 11 2000 167 171
30. P. Pasinelli, M.K. Houseweart, R.H. Brown Jr., and D.W. Cleveland Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U. S. A. 97 2000 13901 13906
31. D. Perrelet, F.E. Perrin, P. Liston, R.G. Korneluk, A. MacKenzie, M. Ferrer-Alcon, and A.C. Kato Motoneuron resistance to apoptotic cell death in vivo correlates with the ratio between X-linked inhibitor of apoptosis proteins (XIAPs) and its inhibitor, XIAP-associated factor 1 J. Neurosci. 24 2004 3777 3785
32. S. Przedborski Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance Neurologist 10 2004 1 7
33. G.S. Salvesen, and V.M. Dixit Caspases: intracellular signaling by proteolysis Cell 91 1997 443 446
34. S. Sasaki, and M. Iwata Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis Neurology 47 1996 535 540
35. S. Sasaki, and M. Iwata Immunoreactivity of beta-amyloid precursor protein in amyotrophic lateral sclerosis Acta Neuropathol. (Berlin) 97 1999 463 468
36. S. Sasaki, N. Shibata, T. Komori, and M. Iwata iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis Neurosci. Lett. 291 2000 44 48
37. J.H. Su, M. Zhao, A.J. Anderson, A. Srinivasan, and C.W. Cotman Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology Brain Res. 898 2001 350 357
38. R.H. Takahashi, T.A. Milner, F. Li, E.E. Nam, M.A. Edgar, H. Yamaguchi, M.F. Beal, H. Xu, P. Greengard, and G.K. Gouras Intraneuronal Alzheimer Aβ42 accumulates in multivesicular bodies and is associated with synaptic pathology Am. J. Pathol. 161 2002 1869 1879
39. A. Tamaoka, S. Matsuno, S. Ono, N. Shimizu, and S. Shoji Increased amyloid beta protein in the skin of patients with amyotrophic lateral sclerosis J. Neurol. 247 2000 633 635
40. Y.M. Tsang, F. Chiong, D. Kuznetsov, E. Kasarskis, and C. Geula Motor neurons are rich in non-phosphorylated neurofilaments: cross-species comparison and alterations in ALS Brain Res. 861 2000 45 58
41. S. Vukosavic, L. Stefanis, V. Jackson-Lewis, C. Guegan, N. Romero, C. Chen, G.S. Salvesen, and V.M. Dixit Caspases: intracellular signaling by proteolysis Cell 91 1997 443 446
42. D.C. Wilcockson, S.J. Campbell, D.C. Anthony, and V.H. Perry The systemic and local acute phase response following acute brain injury J. Cereb. Blood Flow Metab. 22 2002 318 326
43. O. Wirths, G. Multhaup, and T.A. Bayer A modified β-amyloid hypothesis: intraneuronal accumulation of the β-amyloid peptide-the first step of a fatal cascade J. Neurochem. 91 2004 513 520
44. Y. Zhang, R. McLaughlin, C. Goodyer, and A. LeBlanc Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons J. Cell Biol. 156 2002 519 529