Chromosome and oxidative damage biomarkers in lymphocytes of Parkinson's disease patients

International Journal of Hygiene and Environmental Health

Volumn 204, Issue 1, 2001, Pages 61-66

  Migliore, Lucia ^a   Scarpato, Roberto ^a   Coppede, Fabio ^a   Petrozzi, Lucia ^a   Bonuccelli, Ubaldo ^a   Rodilla, Vicente ^b  

^a UNIVERSITY OF PISA   (Italy)

^b ROBERT GORDON UNIVERSITY   (United Kingdom)

Author keywords

Comet assay; Glutathione S Transferases; Micronuclei; Oxidative damage biomarkers; Parkinson's disease

Indexed keywords

BIOLOGICAL MARKER; GLUTATHIONE TRANSFERASE; PURINE; PYRIMIDINE;

ADULT; AGED; CENTROMERE; CHROMOSOME DAMAGE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; MICRONUCLEUS; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; RISK FACTOR;

EID: 0034761844     PISSN: 14384639     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4639-00074     Document Type: Article

References (23)

1. Identification of cDNAs encoding two human Alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. Comet assay in human biomonitoring studies: Reliability, validation and applications
4. DNA damage in diabetes: Correlation with a clinical marker
5. Case-control study of interactions between genetic and environmental factors in Parkinson's disease
6. The genetics of Parkinson's disease
7. Activation of endogenous antioxidant defenses in neuronal cells prevents free radical-mediated damage
8. The pathogenesis of neurodegenerative disease: Neurotoxic mechanisms of action and genetics
9. The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations
10. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease
11. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
12. The Glutathione S-transferase supergene family: Regulation of GST* and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
13. Human glutathione transferase A4-4: An alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation
14. Parkinson's disease, pesticides and glutathione transferase polymorphisms
15. Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients
16. Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients
17. Subunit diversity and tissue distribution of human glutathione S-transferase: Interpretations based on electrospray ionization-MS and peptide sequence-specific antisera
18. Alterations in glutathione levels in Parkinso's disease and other neurodegenerative disorders affecting basal ganglia
19. A simple technique for quantitation of low levels of DNA damage in individual cells
20. Determination of glutathione S-transferase mu and theta polymorphisms in neurological disease
21. Drug metabolism polymorphisms as modulators of cancer susceptibility
22. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease
23. The role of human glutathione S-transferases hGSTA1-1 and hGSTA2-2 in protection against oxidative stress