Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

Human Molecular Genetics

Volumn 15, Issue 3, 2006, Pages 467-479

  Gakh, Oleksandr ^a   Park, Sungjo ^a   Liu, Gang ^a   Macomber, Lee ^b   Imlay, James A ^b   Ferreira, Gloria C ^c   Isaya, Grazia ^a  

^a Mayo Clinic   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CHAPERONE; FRATAXIN; HEME; IRON; IRON SULFUR PROTEIN; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL DIVISION; CELL METABOLISM; CELL SURVIVAL; CHRONOLOGY; CONTROLLED STUDY; GENE MUTATION; HEART MUSCLE CELL; HEME SYNTHESIS; IRON METABOLISM; LIFESPAN; LONGEVITY; MICROENVIRONMENT; MINERALIZATION; MITOCHONDRIAL RESPIRATION; NERVE CELL; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; YEAST CELL;

AMINO ACIDS; CERULOPLASMIN; IRON; IRON-BINDING PROTEINS; METABOLIC DETOXICATION, DRUG; MINERALS; MITOCHONDRIA; MOLECULAR CHAPERONES; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; SUPEROXIDE DISMUTASE;

ATAXIA;

EID: 31544445770     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddi461     Document Type: Article

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