Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde

QJM: An International Journal of Medicine

Volumn 94, Issue 9, 2001, Pages 485-490

  McGrath, L T ^a   McGleenon, B M ^a   Brennan, S ^a   McColl, D ^a   McIlroy, S ^a   Passmore, A P ^a,b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Whitla Medical Building   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; ASCORBIC ACID; MALONALDEHYDE; SCAVENGER; THIOL DERIVATIVE;

ADULT; AGE; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAIN; CLINICAL ARTICLE; COGNITIVE DEFECT; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE MARKER; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; MALE; MEDICAL ASSESSMENT; MEDICAL EXAMINATION; MENTAL HEALTH; OXIDATIVE STRESS; PATHOGENESIS; PERIPHERAL CIRCULATION; PRIORITY JOURNAL;

EID: 0034834620     PISSN: 14602725     EISSN: None     Source Type: Journal    
DOI: 10.1093/qjmed/94.9.485     Document Type: Article

References (37)

1. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
2. Advanced glycation endproducts in ageing and Alzheimer's disease
3. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease
4. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
5. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro
6. Increased oxidative damage in lymphocytes of Alzheimer's disease patients
7. Free radicals and superoxide dismutase in blood of patients with Alzheimer's disease and vascular dementia
8. Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease
9. Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease
10. Altered plasma antioxidant status in subjects with Alzheimer's disease and vascular dementia
11. Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease
12. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
13. 'Mini-mental state': A practical method for grading the cognitive state of patients for the clinician
14. Assessing the nutritional status of the elderly: The Mini Nutritional Assessment as part of the geriatric evaluation
15. Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal
16. Evidence for increased oxidative damage in patients with cystic fibrosis
17. The determination of carbonyl content in oxidatively modified proteins
18. Simultaneous determination of uric acid and ascorbic acid in human serum by reversed-phase high-performance liquid chromatography with electrochemical detection
19. A high performance liquid chromatographic method for the determination of tocopherol in plasma and cellular elements of the blood
20. Platelet membrane abnormality in Alzheimer's Disease
21. Platelet activation in Alzheimer disease
22. No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease
23. Lipid peroxidation and free radical scavengers in Alzheimer's disease
24. Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
25. Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease
26. Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid
27. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes
28. Blood-brain barrier integrity in Alzheimer's disease patients and elderly control subjects
29. Quantitative evaluation of blood-brain-barrier integrity in Alzheimer type dementia: Positron emission tomographic studies with rubidium-82
30. Brain microvascular changes in Alzheimer's disease and other dementias
31. Morphological changes of blood vessels in the brain with Alzheimer's disease
32. Cytotoxic and genotoxic effects of 4-hydroxynonenal in cerebral endothelial cells
33. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: Role of the lipid peroxidation product 4-hydroxynonenal
34. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
35. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide
36. 4-Hydroxynonenal prevents NF-κB activation and tumour necrosis factor expression by inhibiting lκB phosphorylation and subsequent proteolysis
37. Biochemical evaluation of oxidative stress in propylthiouracil treated hyperthyroid patients. Effects of vitamin C supplementation