Effect of the activated Raf protein kinase on the human multidrug resistance 1 (MDR1) gene promoter

Cancer Letters

Volumn 98, Issue 2, 1996, Pages 199-205

  Kim, Sun Hee ^a   Lee, Sang Hoon ^a   Kwak, Nam Hee ^a   Kang, Chi Dug ^a   Chung, Byung Seon ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

Heat shock; Heat shock element; MDR1 promoter; Protein kinase A; Raf

Indexed keywords

ARSENITE SODIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; HEAT SHOCK PROTEIN; PROTEIN KINASE INHIBITOR; RAF PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; DNA SEQUENCE; DNA TRANSFECTION; ENZYME ACTIVATION; HEAT SHOCK; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION;

EID: 0030048861     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(06)80032-7     Document Type: Article

References (29)

1. Chen, C., Clark, D., Ueda, K., Pastan, I., Gottesman, M.M. and Roninson, I.B. (1990) Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J. Biol. Chem., 265, 506-514.
2. Pastan, I. and Gottesman, M.M. (1991) Multidrug resistance. Annu. Rev. Med., 42, 277-286.
3. Takatori, T., Ogura, M. and Tsuruo, T. (1993) Purification and characterization of NF-R2 that regulates the expression of the human. Jpn. J. Cancer Res., 84, 293-303.
4. Combates, N.J., Rzepka, R.W., Chen, Y.N.P. and Cohen, D (1994) NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter. J. Biol. Chem., 47, 29715-29719.
5. Miyazaki, M., Kohno, K., Uchiumi, I., Tanimura, H., Matsuo, K.-I., Nasu, M. and Kuwano, M. (1992) Activation of human multidrug resistance-1 gene promoter in response to heat shock stress. Biochem. Biophys. Res. Commun., 187, 677-684.
6. Chin, K.V., Tanaka, S., Darlington, G., Pastan, I. and Gottesman, M.M. (1990) Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. J. Biol. Chem., 265, 221-226.
7. Morimoto, R.I., Sarge, K.D. and Abravaya, K. (1992) Transcriptional regulation of heat shock genes: a paradigm for inducible genemic responses. J. Biol. Chem., 267, 21987-21990.
8. Mosser, D.D., Duchaine, J. and Massie, B. (1993) The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70. Mol. Cell. Biol., 13, 5427-5438.
9. Sistonen, L., Sarge, K.D. and Morimoto, R.I. (1994) Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Mol. Cell. Biol., 14, 2087-2099.
10. Shibahara, S., Muller, R.M. and Taguchi, H. (1987) Transcriptional control of rat heme oxygenase by heat shock. J. Biol. Chem., 262, 12889-12892.
11. Colotta, F., Polentarutti, N., Staffico, M., Fincato, G. and Mantovani, A. (1990) Heat shock induces the transcriptional activation of the c-fos protooncogene. Biochem. Biophys. Res. Commun., 168, 1013-1019.
12. Sorger, P.K. (1990) Yeast heat shock factor contains separable transient and sustained response transcriptional activators. Cell, 62, 793-805.
13. Howe, L.R., Leevers, S.J., Gomez, N., Nakielny, S., Cohen, P. and Marshall, C.J. (1992) Activation of the MAP kinase pathway by the protein kinase raf. Cell, 71, 335-342.
14. Kim, S.H., Park, Y.H., Kim, D.W., Kang, C.D. and Chung, B.S. (1993) Oncogenes and tumor suppressor genes regulate the human multidrug resistance gene (MDR1) expression. Mol. Cell, 3, 13-19.
15. Kim, S.H., Park, J.H., Chung, B.S., Kang, C.D. and Hidaka, H. (1993) Inhibition of MDR1 gene expression by H-87, a selective inhibitor of cAMP-dependent protein kinase. Cancer Lett., 74, 37-41.
16. Cornwell, M.M. and Smith, D.E. (1993) SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity. J. Biol. Chem., 268, 19505-19511.
17. Goldsmith, M.E., Madden, M.J., Morrow, C.S. and Cowan, K.H. (1993) A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene. J. Biol. Chem., 268, 5856-5860.
18. Ueda, K., Pastan, I. and Gottesman, M.M. (1987) Isolation and sequence of promoter region of the human multidrug-resistance (P-glycoprotein) gene. J. Biol. Chem., 262, 17432-14736.
19. Stanton, V.P., Nichols, D.W., Laudano, A.P. and Copper, G.M. (1989) Definition of the human raf amino terminal regulatory region by deletion mutagenesis. Mol. Cell. Biol., p(2), 639-647.
20. Sarge, K.D., Murphy, S.P. and Morimoto, R.I. (1993) Activation of heat shock transcription by HSF1 involves oligomerization, acquisition of DNA binding activity, and nuclear localization and can occur in the absence of stress. Mol. Cell. Biol., 13, 1392-1407.
21. Hensold, J.O., Hunt, C.R., Calderwood, S.K., Housman, D.E. and Kingston, R.E. (1990) DNA binding of the heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells. Mol. Cell. Biol., 10, 1660-1608.
22. 2+ is essential for multistep activation of the heat shock factor in permeabilised cells. Mol. Cell. Biol., 11, 3365-3368.
23. Rapp, U.R. (1991) Role of raf-1 serine/threonine protein kinase in growth factor signal transduction. Oncogene, 6, 495-500.
24. Kharbands, S., Saleem, A., Emoto, Y., Stone, R., Rapp, U. and Kufe, D. (1994) Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. J. Biol. Chem., 269, 872-878.
25. Uchiumi, T., Kohno, K., Tanimura, H., Hidaka, K., Asakuno, K., Abe, H., Uchida, Y. and Kuwano, M. (1993) Involvement of protein kinase in environmental stress-induced activation of human multidrug resistance 1 (MDR1) gene promoter. FEBS Lett., 326, 11-16.
26. Morimoto, R.T., Tissières, A. and Georgopoulos, C. (1994) The Biology of Heat Shock Proteins and Molecular Chaperones, 438 pp. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
27. Lindquist, S. and Craig, E.A. (1988) The heat-shock proteins. Annu. Rev. Genet., 22, 631-677.
28. Nieto-Sotelo, J., Wiederrecht, G., Okuda, A. and Parker, C.S. (1990) The yeast heat shock transcription factor contains a transcriptional activation domain whose activity is repressed under nonshock condition. Cell, 62, 807-817.
29. Hunter, T. and Karin, M. (1992) The regulation of transcription by phosphorylation. Cell, 70, 375-387.