Phosphoinositide 3-kinase signalling in breast cancer: How big a role might it play?

Breast Cancer Research

Volumn 3, Issue 5, 2001, Pages 304-312

  Fry, M J ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Akt; Ataxia telangiectasia mutated; BRCA1; Phosphoinositide 3 kinase; PTEN

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ATM PROTEIN; BRCA1 PROTEIN; CYCLIN D1; LIPID KINASE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RAPAMYCIN; UNCLASSIFIED DRUG; WORTMANNIN;

BREAST CANCER; CARCINOGENESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STRUCTURE; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION; VIRUS ONCOGENE;

1-PHOSPHATIDYLINOSITOL 4-KINASE; BRCA1 PROTEIN; BREAST NEOPLASMS; FEMALE; HUMANS; SIGNAL TRANSDUCTION;

EID: 0034841661     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr312     Document Type: Review

References (56)

1. Structure, regulation and function of phosphoinositide 3-kinases
2. Phosphatidylinositol 3-kinases in tumor progression
3. Signalling through phosphoinositide 3-kinase: The lipids take centre stage
4. PI3-kinase inhibition: A target for drug development?
5. Signaling by distinct classes of phosphoinositide 3-kinases
6. The many substrates and functions of ATM
7. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
8. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
9. Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K
10. Identification of four novel human phosphoinositide 3-kinase defines a multi-isoform subfamily
11. cDNA cloning of a third human C2 domain-containing Class II phosphoinositide 3-kinase, PI3K-C2γ, and chromosomal assignment of this gene (PIK3C2G) to 12p12
12. Phosphoinositide signalling and regulation of membrane trafficking in yeast
13. Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis
14. Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
15. In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin
16. The phosphatidylinositol 3-kinase inhibitor wortmannin sensitises murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage
17. Wortmannin, a phosphoinositide 3-kinase inhibitor, selectively enhances cytotoxicity of receptor-directed-toxin chimeras in vitro and in vivo
18. Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase
19. The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signalling
20. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
21. PIK3CA as an oncogene in cervical cancer
22. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3K and Akt
23. Rapamycin and CCI-779
24. Phosphatidylinositol 3-kinase expression in human breast
25. Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes
26. Requirement for both Shc and phosphatidylinositol 3′ kinase signalling pathways in polyomavirus middle T-mediated mammary tumorigenesis
27. Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product
28. Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent c-erbB-2 gene amplification
29. Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism
30. ERBB-2 overexpression confers PI 3′ kinase dependent invasion capacity on human mammary epithelial cells
31. Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor and c-Src interactions in breast cancer
32. BRK tyrosine kinase expression in a high proportion of human breast carcinomas
33. Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitises mammary epithelial cells to epidermal growth factor
34. Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation
35. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
36. Deficiency of pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
37. PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways
38. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
39. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
40. Stabilisation of cyclin D1 mRNA via the phosphatidylinositol 3-kinase pathway in MCF-7 human breast cancer cells
41. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
42. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-kinase/AKT in breast cancer cells
43. Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer
44. Heterozygous ATM mutations do not contribute to early onset breast cancer
45. Cancer risk in ATM heterozygotes: A model of phenotypic and mechanistic differences between missense and truncating mutations
46. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double strand breaks
47. Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage
48. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phosphospecific antibodies
49. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
50. Estrogen receptor is associated with protein and phospholipid kinase activities
51. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
52. Role of AKT1 in 17beta-estradiol-and insulin-like growth factor I (IGF-1)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells
53. Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis
54. Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer
55. A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I
56. PI3 kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance