-
1
-
-
0032579226
-
Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemias
-
Martínez-Lorenzo M.J., Gamen S., Etxeberria J., Lasierra P., Larrad L., Piñeiro A., Anel A., Naval J., Alava M.A. Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemias. Int. J. Cancer. 75:1998;473-481.
-
(1998)
Int. J. Cancer
, vol.75
, pp. 473-481
-
-
Martínez-Lorenzo, M.J.1
Gamen, S.2
Etxeberria, J.3
Lasierra, P.4
Larrad, L.5
Piñeiro, A.6
Anel, A.7
Naval, J.8
Alava, M.A.9
-
2
-
-
0026069474
-
Oncogenes and signal transduction
-
Cantley L.C., Auger K.R., Carpenter C., Duckworth B., Graziani A., Kapeller R., Soltoff S. Oncogenes and signal transduction. Cell. 64:1991;281-302.
-
(1991)
Cell
, vol.64
, pp. 281-302
-
-
Cantley, L.C.1
Auger, K.R.2
Carpenter, C.3
Duckworth, B.4
Graziani, A.5
Kapeller, R.6
Soltoff, S.7
-
3
-
-
0029814079
-
CD28: A signalling perspective
-
Ward S.G. CD28: A signalling perspective. Biochem. J. 318:1996;361-377.
-
(1996)
Biochem. J.
, vol.318
, pp. 361-377
-
-
Ward, S.G.1
-
4
-
-
0033605718
-
The role of phosphoinositide 3-kinase lipid products in cell function
-
Rameh L.E., Cantley L.C. The role of phosphoinositide 3-kinase lipid products in cell function. J. Biol. Chem. 274:1999;8347-8350.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8347-8350
-
-
Rameh, L.E.1
Cantley, L.C.2
-
5
-
-
0025201426
-
Purification and characterization of phosphoinositide 3-kinase from rat liver
-
Carpenter C.L., Duckworth B.C., Auger K.R., Cohen B., Schaffhausen B.S., Cantley L.C. Purification and characterization of phosphoinositide 3-kinase from rat liver. J. Biol. Chem. 265:1990;19704-19711.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 19704-19711
-
-
Carpenter, C.L.1
Duckworth, B.C.2
Auger, K.R.3
Cohen, B.4
Schaffhausen, B.S.5
Cantley, L.C.6
-
6
-
-
0023665027
-
c-src: A possible phosphatidylinositol kinase
-
c-src: A possible phosphatidylinositol kinase. Cell. 50:1987;1031-1037.
-
(1987)
Cell
, vol.50
, pp. 1031-1037
-
-
Courtneidge, S.A.1
Heber, A.2
-
7
-
-
0023665111
-
Common events in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
-
Kaplan D.R., Whitman M., Schaffhausen B., Pallas D.C., White M., Cantley L., Roberts T.M. Common events in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell. 50:1987;1021-1030.
-
(1987)
Cell
, vol.50
, pp. 1021-1030
-
-
Kaplan, D.R.1
Whitman, M.2
Schaffhausen, B.3
Pallas, D.C.4
White, M.5
Cantley, L.6
Roberts, T.M.7
-
8
-
-
0027193980
-
Divergent regulation of phosphatidylinositol 3-kinase p85α and p85β isoforms upon T cell activation
-
Reif K., Gout I., Waterfield M.D., Cantrell D.A. Divergent regulation of phosphatidylinositol 3-kinase p85α and p85β isoforms upon T cell activation. J. Biol. Chem. 268:1993;10780-10788.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 10780-10788
-
-
Reif, K.1
Gout, I.2
Waterfield, M.D.3
Cantrell, D.A.4
-
9
-
-
0026538621
-
Increased intracelular cyclic AMP inhibits inositol phospholipid hydrolysis induced by perturbation of the T cell receptor/CD3 complex but not by G-protein stimulation.
-
Alava M.A., DeBell K.E., Conti A., Hoffman T., Bonvini E. Increased intracelular cyclic AMP inhibits inositol phospholipid hydrolysis induced by perturbation of the T cell receptor/CD3 complex but not by G-protein stimulation. Biochem. J. 284:1992;189-199.
-
(1992)
Biochem. J.
, vol.284
, pp. 189-199
-
-
Alava, M.A.1
DeBell, K.E.2
Conti, A.3
Hoffman, T.4
Bonvini, E.5
-
10
-
-
0027274632
-
Tyrosine phosphorylation of a 100 kDa protein is correlated with cytotoxic T-lymphocyte function. Evidence from fatty acid and phenylarsineoxide inhibition
-
Anel A., Kleinfeld A.M. Tyrosine phosphorylation of a 100 kDa protein is correlated with cytotoxic T-lymphocyte function. Evidence from fatty acid and phenylarsineoxide inhibition. J. Biol. Chem. 268:1993;17578-17587.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 17578-17587
-
-
Anel, A.1
Kleinfeld, A.M.2
-
11
-
-
0023664272
-
Genistein, a specific inhibitor of tyrosine-specific protein kinases
-
Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S.I., Itoh N., Shibuya M., Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262:1987;5592-5595.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 5592-5595
-
-
Akiyama, T.1
Ishida, J.2
Nakagawa, S.3
Ogawara, H.4
Watanabe, S.I.5
Itoh, N.6
Shibuya, M.7
Fukami, Y.8
-
12
-
-
0025094356
-
Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction
-
June C.H., Fletcher M.C., Ledbetter J.A., Schieven G.L., Siegel J.N., Phillips A.F., Samelson L.E. Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc. Natl. Acad. Sci. USA. 87:1990;7722-7726.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 7722-7726
-
-
June, C.H.1
Fletcher, M.C.2
Ledbetter, J.A.3
Schieven, G.L.4
Siegel, J.N.5
Phillips, A.F.6
Samelson, L.E.7
-
13
-
-
0029134065
-
JAK3 protein tyrosine kinase mediates Interleukin-7-induced activation of phosphatidylinositol-3′ kinase
-
Sharfe N., Dadi H.K., Roifman C.M. JAK3 protein tyrosine kinase mediates Interleukin-7-induced activation of phosphatidylinositol-3′ kinase. Blood. 86:1995;2077-2085.
-
(1995)
Blood
, vol.86
, pp. 2077-2085
-
-
Sharfe, N.1
Dadi, H.K.2
Roifman, C.M.3
-
14
-
-
0030029143
-
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
-
Hanke J.H., Gardner J.P., Dow R.L., Changelian P.S., Brissette W.H., Weringer E.J., Pollok B.A., Conelly P.A. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271:1996;695-701.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 695-701
-
-
Hanke, J.H.1
Gardner, J.P.2
Dow, R.L.3
Changelian, P.S.4
Brissette, W.H.5
Weringer, E.J.6
Pollok, B.A.7
Conelly, P.A.8
-
15
-
-
0029118603
-
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
-
Ui M., Okada T., Hazeki K., Hazeki O. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem. Sci. 20:1995;303-307.
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 303-307
-
-
Ui, M.1
Okada, T.2
Hazeki, K.3
Hazeki, O.4
-
16
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos C.J., Matter W.F., Hui K.Y., Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269:1994;5241-5248.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
17
-
-
0029915031
-
P70 S6 kinase: An enigma with variations
-
Proud C.G. p70 S6 kinase: An enigma with variations. Trends Biochem. Sci. 21:1996;181-185.
-
(1996)
Trends Biochem. Sci.
, vol.21
, pp. 181-185
-
-
Proud, C.G.1
-
18
-
-
0028884033
-
PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
-
Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:1995;27489-27494.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27489-27494
-
-
Alessi, D.R.1
Cuenda, A.2
Cohen, P.3
Dudley, D.T.4
Saltiel, A.R.5
-
19
-
-
84965822602
-
Sensibility of drug screening with panels of human tumor cell lines using microculture tetrazolium assay
-
Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D., Abbot B.J., Mayo J.G., Shoemaker R.H., Boyd M.R. Sensibility of drug screening with panels of human tumor cell lines using microculture tetrazolium assay. Cancer Res. 46:1988;589-601.
-
(1988)
Cancer Res.
, vol.46
, pp. 589-601
-
-
Alley, M.C.1
Scudiero, D.A.2
Monks, A.3
Hursey, M.L.4
Czerwinski, M.J.5
Fine, D.6
Abbot, B.J.7
Mayo, J.G.8
Shoemaker, R.H.9
Boyd, M.R.10
-
20
-
-
0025285280
-
Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation
-
June C.H., Fletcher M.C., Ledbetter J.A., Samelson L.E. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J. Immunol. 144:1990;1591-1599.
-
(1990)
J. Immunol.
, vol.144
, pp. 1591-1599
-
-
June, C.H.1
Fletcher, M.C.2
Ledbetter, J.A.3
Samelson, L.E.4
-
21
-
-
0027165150
-
The mitogen-activated protein kinase signal transduction pathway
-
Davis R.J. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268:1993;14553.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14553
-
-
Davis, R.J.1
-
24
-
-
0032512637
-
Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688
-
von Willebrand M., Williams S., Saxena M., Gilman J., Tailor P., Jascur T., Amarante-Mendes G.P., Green D.R., Mustelin T. Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688. J. Biol. Chem. 273:1998;3994-4000.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3994-4000
-
-
Von Willebrand, M.1
Williams, S.2
Saxena, M.3
Gilman, J.4
Tailor, P.5
Jascur, T.6
Amarante-Mendes, G.P.7
Green, D.R.8
Mustelin, T.9
-
25
-
-
0028304998
-
Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor ζ chain is dependent on T cell activation
-
Exley M., Varticovski L., Peter M., Sancho J., Terhorst C. Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor ζ chain is dependent on T cell activation. J. Biol. Chem. 269:1994;15140-15146.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 15140-15146
-
-
Exley, M.1
Varticovski, L.2
Peter, M.3
Sancho, J.4
Terhorst, C.5
-
26
-
-
0030820813
-
Tyrosine phosphorylation of the CD3-ε subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells
-
de Aos I., Metzger M.H., Exley M., Dahl C.E., Misra S., Zheng D., Varticovski L., Terhost C., Sancho J. Tyrosine phosphorylation of the CD3-ε subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells. J. Biol. Chem. 272:1997;25310-25318.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 25310-25318
-
-
De Aos, I.1
Metzger, M.H.2
Exley, M.3
Dahl, C.E.4
Misra, S.5
Zheng, D.6
Varticovski, L.7
Terhost, C.8
Sancho, J.9
-
27
-
-
0032514801
-
Regulation of the p85/p110α phosphatidylinositol 3′-kinase. Distinct roles for the N-terminal and C-terminal SH2 domains
-
Yu J., Wjasow C., Backer J.M. Regulation of the p85/p110α phosphatidylinositol 3′-kinase. Distinct roles for the N-terminal and C-terminal SH2 domains. J. Biol. Chem. 273:1998;30199-30203.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30199-30203
-
-
Yu, J.1
Wjasow, C.2
Backer, J.M.3
-
28
-
-
0028308191
-
The Src-family kinase Fyn regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line
-
Karnitz L.M., Sutor S.L., Abraham R.T. The Src-family kinase Fyn regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line. J. Exp. Med. 179:1994;1799-1808.
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1799-1808
-
-
Karnitz, L.M.1
Sutor, S.L.2
Abraham, R.T.3
-
29
-
-
0027117408
-
A signal chain of events
-
Roberts T.A. A signal chain of events. Nature. 360:1992;534.
-
(1992)
Nature
, vol.360
, pp. 534
-
-
Roberts, T.A.1
-
30
-
-
0028918408
-
Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
-
Hu Q., Klippel A., Muslin A.J., Fantl W.J., Williams L.T. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science. 268:1995;100-102.
-
(1995)
Science
, vol.268
, pp. 100-102
-
-
Hu, Q.1
Klippel, A.2
Muslin, A.J.3
Fantl, W.J.4
Williams, L.T.5
-
31
-
-
0031037296
-
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ
-
Lopez-Ilasaca M., Crespo P., Pellici P.G., Gutkind J.S., Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ Science. 275:1997;394-397.
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
Gutkind, J.S.4
Wetzker, R.5
-
33
-
-
0030921302
-
Involvement of phosphatidylinositol 3-kinase in NFAT activation in T cells
-
Jascur T., Gilman J., Mustelin T. Involvement of phosphatidylinositol 3-kinase in NFAT activation in T cells. J. Biol. Chem. 272:1997;14483-14488.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14483-14488
-
-
Jascur, T.1
Gilman, J.2
Mustelin, T.3
-
34
-
-
0033616930
-
Intermolecular interactions of the p85α regulatory subunit of phosphatidylinositol 3-kinase
-
Harpur A.G., Layton M.J., Das P., Bottomley M.J., Panayotou G., Driscoll P.C., Waterfield M.D. Intermolecular interactions of the p85α regulatory subunit of phosphatidylinositol 3-kinase. J. Biol. Chem. 274:1999;12323-12332.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12323-12332
-
-
Harpur, A.G.1
Layton, M.J.2
Das, P.3
Bottomley, M.J.4
Panayotou, G.5
Driscoll, P.C.6
Waterfield, M.D.7
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