RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)

Leukemia

Volumn 13, Issue 1, 1999, Pages 32-37

  Flotho, C ^c   Valcamonica, S ^a   Mach Pascual, S ^b   Schmahl, G ^d   Corral, L ^a   Ritterbach, J ^d   Hasle, H ^d   Arico M ^d   Biondi, A ^a   Niemeyer, C M ^d  

^a UNIVERSITY OF MILAN   (Italy)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d NONE

Author keywords

Childhood; Clonality; Juvenile chronic myelogenous leukemia; Juvenile myelomonocytic leukemia; RAS mutations

Indexed keywords

RAS PROTEIN;

ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CHILD; CHILDHOOD LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CODON; GENE MUTATION; HUMAN; HUMAN CELL; INFANT; KARYOTYPE; ONCOGENE RAS; POINT MUTATION; PRIORITY JOURNAL; PROTO ONCOGENE; SIGNAL TRANSDUCTION; SINGLE STRAND CONFORMATION POLYMORPHISM; T LYMPHOCYTE;

EID: 0032896457     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401240     Document Type: Article

References (37)

1. Niemeyer CM, Aricó M, Basso G, Biondi A, Cantú Rajnoldi A, Creutzig U, Haas O, Harbott J, Hasle H, Kerndrup G, Locatelli G, Mann G, Stollmann-Gibbels B, van't Veer-Korthof ET, van Wering E, Zimmermann M, Members of the European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS). Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. Blood 1997; 89: 3534-3543.
2. Niemeyer CM, Fenu S, Hasle H, Mann G, Stary J, van Wering E. Differentiating juvenile myelomonocytic leukemia from infectious disease. Blood 1998; 91: 365-367.
3. Hasle H, Kerndrup G, Jacobsen BB. Childhood myelodysplastic syndrome in Denmark - incidence and predisposing conditions. Leukemia 1995; 9: 1569-1572.
4. Busque L, Gilliland DG, Prchal JT, Sieff CA, Weinstein HJ, Sokol JM, Belickova M, Wayne AS, Zuckerman KS, Sokol L, Castleberry RP, Emanuel PD. Clonality in juvenile chronic myelogenous leukemia. Blood 1995; 85: 21-30.
5. Emanuel PD, Bates LJ, Castleberry RP, Gualtieri RJ, Zuckerman KS. Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood 1991; 77: 925-929.
6. Satoh T, Nakafuku M, Miyajima A, Kaziro Y. Involvement of ras p21 protein in signal transduction pathways from interleukin 2, interleukin 3, and granulocyte-macrophage colony-stimulating factor, but not from interleukin 4. Proc Nat Acad Sci USA 1991; 88: 3314-3318.
7. Seger R, Krebs EG. The MAPK signaling cascade. FASEB J 1995; 9: 726-735.
8. Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: conserved structure and molecular mechanism. Nature 1991; 349: 117-127.
9. Hall A. Signal transduction through small GTPases - a tale of two GAPs. Cell 1992; 69: 389-391.
10. Side LE, Emanuel PD, Taylor B, Franklin J, Thompson P, Castleberry RP, Shannon KM. Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. Blood 1998; 92: 267-272.
11. Bollag G, Clapp DW, Shih S, Adler F, Zhang YY, Thompson P, Lange BJ, Freedman MH, McCormick F, Jacks T, Shannon K. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet 1996; 12: 144-148.
12. Largaespada DA, Brannan CI, Jenkins NA, Copeland NG. Nf1 deficiency causes Ras-mediated granulocyte-macrophage colony-stimulating factor hypersensitivity and chronic myeloid leukaemia. Nat Genet 1996; 12: 137-143.
13. Barbacid M. Ras genes. Ann Rev Biochem 1987; 56: 779-827.
14. Sieff CA, Ekern SC, Nathan DG, Anderson JW. Combinations of recombinant colony-stimulating factors are required for optimal hematopoietic differentiation in serum-deprived culture. Blood 1989; 73: 688-693.
15. Ventura M, Gibaud A, Le Pendu J, Hillaire D, Gerard G, Vitrac D, Oriol R. Use of a simple method for the Epstein-Barr virus transformation of lymphocytes from members of large families of Reunion Island. Hum Hered 1988; 38: 36-43.
16. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
17. Todd AV, Iland HJ. Rapid screening of mutant N-ras alleles by analysis of PCR-induced restriction sites: allele-specific restriction analysis. Leuk Lymphoma 1991; 3: 293-300.
18. Janssen JW, Steenvoorden AC, Lyons J, Anger B, Bohlke JU, Bos JL. Seliger H, Bartram CR. RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes. Proc Natl Acad Sci USA 1987; 84: 9228-9232.
19. Janssen JW, Lyons J, Steenvoorden ACM, Seliger H, Bartram CR. Concurrent mutations in two different ras genes in acute myelocytic leukemias. Nucleic Acids Res 1987; 15: 5669-5680.
20. Orita M, Suzuki Y, Sekiya T, Hayashi K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 1989; 5: 874-879.
21. Mach-Pascual S, Legare RD, Lu D, Kroon M, Neuberg D, Tantravahi R, Stone RM, Freedman AS, Nadler LU, Gribben JG, Gilliland DG. Predictive value of clonality assays in patients with non-Hodgkin's lymphoma undergoing autologous transplant. Blood 1998; 91: 4496-4503.
22. Willard HF, Waye JS. Hierarchical order in chromosome-specific human alpha satellite DNA. Trends Genet 1987; 3: 192-198.
23. Pinkel D, Straume T, Gray JW. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc Nat Acad Sci USA 1986; 83: 2934-2938.
24. Hopman AH, Ramaekers FC, Raap AK, Beck JL, Devilee P, van der Ploeg M, Vooijs GP. In situ hybridization as a tool to study numerical chromosome aberrations in solid bladder tumors. Histochemistry 1988; 89: 307-316.
25. Kalra R, Paderanga DC, Olson K, Shannon KM. Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras. Blood 1994; 84: 3435-3439.
26. Sheng XM, Kawamura M, Ohnishi H, Ida K, Hanada R, Kojima S, Kobayashi M, Bessho F, Yanagisawa M, Hayashi Y. Mutations of the ras genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia. Leukemia Res 1997; 21: 697-701.
27. Miyauchi J, Asada M, Sasaki M, Tsunematsu Y, Kojima S, Mizutani S. Mutations of the N-ras gene in juvenile chronic myelogenous leukemia. Blood 1994; 83: 2248-2254.
28. Gow J, Hughes D, Farr C, Hamblin T, Oscier D, Brown R, Padua RA. Activation of Ha-ras in human chronic granulocytic and chronic myelomonocytic leukaemia. Leukemia Res 1988; 12: 805-810.
29. Horiike S, Misawa S, Nakai H, Kaneko H, Yokota S, Taniwaki M, Yamane Y, Inazawa J, Abe T, Kashima K. N-ras mutation and karyotypic evolution are closely associated with leukemic transformation in myelodysplastic syndrome. Leukemia 1994; 8: 1331-1336.
30. van Kamp H, de Pijper C, Verlaan-de Vries M, Bos JL, Leeksma CH, Kerkhofs H, Willemze R, Fibbe WE, Landegent JE. Longitudinal analysis of point mutations of the N-ras proto-oncogene in patients with myelodysplasia using archived blood smears. Blood 1992; 79: 1266-1270.
31. Nakagawa T, Saitoh S, Imoto S, Itoh M, Tsutsumi M, Hikiji K, Nakamura H, Matozaki S, Ogawa R, Nakao Y, Fujita T. Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia. Oncology 1992; 49: 114-122.
32. Inoue S, Shibata T, Ravindranath Y, Gohle N. Clonal origin of erythroid cells in juvenile chronic myelogenous leukemia. Blood 1987; 69: 975-976.
33. Miles DK, Freedman MK, Stephens K, Pallavicini M, Sievers EL, Weaver M, Grunberger T, Thompson P, Shannon KM. Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders. Blood 1996; 88: 4314-4320.
34. Neubauer A, Shannon K, Liu E. Mutations of the ras proto-oncogenes in childhood monosomy 7. Blood 1991; 77: 594-598.
35. Lau RC, Squire J, Brisson L, Kamel-Reid S, Grunberger T, Dube I, Letarte M, Shannon K, Freedman MH. Lymphoid blast crisis of B-lineage phenotype with monosomy 7 in a patient with juvenile chronic myelogenous leukemia (JCML). Leukemia 1994; 8: 903-908.
36. Yamamoto M, Nakagawa M, Ichimura N, Ohtsuki F, Ohtsuka Y, Tsujino Y, Tanaka A, Kamiya T, Wada H. Lymphoblastic transformation of chronic myelornonocytic leukemia in an infant. Am J Hematol 1996; 52: 212-214.
37. Mark Z, Toren A, Amariglio N, Vonsover A, Rechavi G, Brok-Simoni F. Rearrangement of the immunoglobulin heavy chain gene in juvenile chronic myeloid leukaemia. Br J Haematol 1995; 90: 353-357.