메뉴 건너뛰기




Volumn 386, Issue 4, 2001, Pages 293-301

Overexpression of phosphatidylinositol 3-kinase in human lung cancer

Author keywords

AKT2; Human lung cancer; Immunohistochemistry; Northern blot assay; PI3K expression pattern

Indexed keywords

ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B BETA; PROTEIN P85; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

EID: 0034939761     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004230100203     Document Type: Article
Times cited : (77)

References (59)
  • 2
    • 0030175487 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase related kinases
    • Abraham RT (1996) Phosphatidylinositol 3-kinase related kinases. Curr Opin Immunol 8:412-418
    • (1996) Curr Opin Immunol , vol.8 , pp. 412-418
    • Abraham, R.T.1
  • 3
    • 0030575539 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and the regulation of cell growth
    • Carpenter CL, Cantley LC (1996) Phosphoinositide 3-kinase and the regulation of cell growth. Biochem Biophys Acta 1288:M11-M16
    • (1996) Biochem Biophys Acta , vol.1288
    • Carpenter, C.L.1    Cantley, L.C.2
  • 4
    • 0030911052 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
    • Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J (1997) Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89:457-467
    • (1997) Cell , vol.89 , pp. 457-467
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 5
    • 0030695034 scopus 로고    scopus 로고
    • Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells
    • Khwaja A, Downward J (1997) Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells. J Cell Biol 139:1017-1023
    • (1997) J Cell Biol , vol.139 , pp. 1017-1023
    • Khwaja, A.1    Downward, J.2
  • 7
    • 0027523229 scopus 로고
    • Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation
    • Glenn GM, Eckhart W (1993) Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation. J Virol 67:1945-1952
    • (1993) J Virol , vol.67 , pp. 1945-1952
    • Glenn, G.M.1    Eckhart, W.2
  • 8
    • 0031961980 scopus 로고    scopus 로고
    • Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor
    • Moscatello DK, Holgado-Madruga M, Emlet DR, Montgomery RB, Wong AJ (1998) Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor. J Biol Chem 273:200-206
    • (1998) J Biol Chem , vol.273 , pp. 200-206
    • Moscatello, D.K.1    Holgado-Madruga, M.2    Emlet, D.R.3    Montgomery, R.B.4    Wong, A.J.5
  • 9
    • 0029843344 scopus 로고    scopus 로고
    • Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells
    • Huang C, Ma WY, Dong Z (1996) Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells. Mol Cell Biol 16:6427-6435
    • (1996) Mol Cell Biol , vol.16 , pp. 6427-6435
    • Huang, C.1    Ma, W.Y.2    Dong, Z.3
  • 10
    • 0030666921 scopus 로고    scopus 로고
    • Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase
    • Dufourny B, Alblas J, van Teeffelen HA, van Schaik FM, van der Burg B, Steenbergh PH, Sussenbach JS (1997) Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J Biol Chem 272:31163-31171
    • (1997) J Biol Chem , vol.272 , pp. 31163-31171
    • Dufourny, B.1    Alblas, J.2    Van Teeffelen, H.A.3    Van Schaik, F.M.4    Van Der Burg, B.5    Steenbergh, P.H.6    Sussenbach, J.S.7
  • 11
    • 0032510109 scopus 로고    scopus 로고
    • Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes
    • Amundadottir LT, Leder P (1998) Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes. Oncogene 16:737-746
    • (1998) Oncogene , vol.16 , pp. 737-746
    • Amundadottir, L.T.1    Leder, P.2
  • 13
    • 0030684122 scopus 로고    scopus 로고
    • Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors
    • Carver RS, Mathew PM, Russell WE (1997) Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors. Endocrinology 138:5195-5201
    • (1997) Endocrinology , vol.138 , pp. 5195-5201
    • Carver, R.S.1    Mathew, P.M.2    Russell, W.E.3
  • 15
    • 0031033308 scopus 로고    scopus 로고
    • Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase
    • Anderson SM, Burton EA, Koch BL (1997) Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase. J Biol Chem 272:739-745
    • (1997) J Biol Chem , vol.272 , pp. 739-745
    • Anderson, S.M.1    Burton, E.A.2    Koch, B.L.3
  • 16
    • 0029118910 scopus 로고
    • Heregulin-stimulated signaling in rat pheochromocytoma cells. Evidence for ErbB3 interactions with Neu/ErbB2 and p85
    • Gamett DC, Greene T, Wagreich AR, Kim HH, Koland JG, Cerione RA (1995) Heregulin-stimulated signaling in rat pheochromocytoma cells. Evidence for ErbB3 interactions with Neu/ErbB2 and p85. J Biol Chem 270:19022-19027
    • (1995) J Biol Chem , vol.270 , pp. 19022-19027
    • Gamett, D.C.1    Greene, T.2    Wagreich, A.R.3    Kim, H.H.4    Koland, J.G.5    Cerione, R.A.6
  • 17
    • 0030582693 scopus 로고    scopus 로고
    • Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells
    • Izuhara K, Harada N (1996) Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells. Biochem Biophys Res Commun 229:624-629
    • (1996) Biochem Biophys Res Commun , vol.229 , pp. 624-629
    • Izuhara, K.1    Harada, N.2
  • 18
    • 0026234461 scopus 로고
    • Phosphatidylinositol-3 kinase, a candidate for a second messenger producer
    • Fukui Y (1991) Phosphatidylinositol-3 kinase, a candidate for a second messenger producer. Tanpakushitsu Kakusan Koso 36:1901-1910
    • (1991) Tanpakushitsu Kakusan Koso , vol.36 , pp. 1901-1910
    • Fukui, Y.1
  • 19
    • 0028077047 scopus 로고
    • Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product
    • Kim HH, Sierke SL, Koland JG (1994) Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product. J Biol Chem 269:24747-24755
    • (1994) J Biol Chem , vol.269 , pp. 24747-24755
    • Kim, H.H.1    Sierke, S.L.2    Koland, J.G.3
  • 20
    • 0029849027 scopus 로고    scopus 로고
    • Interleukin-4 induces association of the c-fos proto-oncogene product with phosphatidylinositol-3 kinase
    • Izuhara K, Feldman RA, Greer P, Harada N (1996) Interleukin-4 induces association of the c-fos proto-oncogene product with phosphatidylinositol-3 kinase. Blood 88:3910-3918
    • (1996) Blood , vol.88 , pp. 3910-3918
    • Izuhara, K.1    Feldman, R.A.2    Greer, P.3    Harada, N.4
  • 21
    • 0030580319 scopus 로고    scopus 로고
    • Association of phosphatidylinositol 3-kinase with the proto-oncogene product Cbl upon CD38 ligation by a specific monoclonal antibody in THP-1 cells
    • Matsuo T, Hazeki K, Tsujimoto N, Inoue S, Kurosu H, Kontani K, Hazeki O, Ui M, Katada T (1996) Association of phosphatidylinositol 3-kinase with the proto-oncogene product Cbl upon CD38 ligation by a specific monoclonal antibody in THP-1 cells. FEBS Lett 397:113-116
    • (1996) FEBS Lett , vol.397 , pp. 113-116
    • Matsuo, T.1    Hazeki, K.2    Tsujimoto, N.3    Inoue, S.4    Kurosu, H.5    Kontani, K.6    Hazeki, O.7    Ui, M.8    Katada, T.9
  • 22
    • 0030860466 scopus 로고    scopus 로고
    • Transforming activity and mitosis-related expression of the AKT2 oncogene: Evidence suggesting a link between cell cycle regulation and oncogenesis
    • Cheng JQ, Altomare DA, Klein MA, Lee WC, Kruh GD, Lissy NA, Testa JR (1997) Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis. Oncogene 14:2793-2801
    • (1997) Oncogene , vol.14 , pp. 2793-2801
    • Cheng, J.Q.1    Altomare, D.A.2    Klein, M.A.3    Lee, W.C.4    Kruh, G.D.5    Lissy, N.A.6    Testa, J.R.7
  • 23
    • 0029807471 scopus 로고    scopus 로고
    • Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells
    • Datta K, Bellacosa A, Chan TO, Tsichlis PN (1996) Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. J Biol Chem 271:30835-30839
    • (1996) J Biol Chem , vol.271 , pp. 30835-30839
    • Datta, K.1    Bellacosa, A.2    Chan, T.O.3    Tsichlis, P.N.4
  • 26
    • 0032431032 scopus 로고    scopus 로고
    • The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
    • Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL (1998) The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 95:15587-15591
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15587-15591
    • Wu, X.1    Senechal, K.2    Neshat, M.S.3    Whang, Y.E.4    Sawyers, C.L.5
  • 27
    • 0032558822 scopus 로고    scopus 로고
    • Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
    • Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D (1998) Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr Biol 8:1195-1198
    • (1998) Curr Biol , vol.8 , pp. 1195-1198
    • Haas-Kogan, D.1    Shalev, N.2    Wong, M.3    Mills, G.4    Yount, G.5    Stokoe, D.6
  • 28
    • 0028339242 scopus 로고
    • Functional insulin and insulin-like growth factor-1 receptors are preferentially expressed in multiple myeloma cell lines as compared to B-lymphoblastoid cell lines
    • Freund GG, Kulas DT, Way BA, Mooney RA (1994) Functional insulin and insulin-like growth factor-1 receptors are preferentially expressed in multiple myeloma cell lines as compared to B-lymphoblastoid cell lines. Cancer Res 54:3179-3185
    • (1994) Cancer Res , vol.54 , pp. 3179-3185
    • Freund, G.G.1    Kulas, D.T.2    Way, B.A.3    Mooney, R.A.4
  • 29
    • 0029760745 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells
    • Rahimi N, Tremblay E, Elliott B (1996) Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells. J Biol Chem 271:24850-24855
    • (1996) J Biol Chem , vol.271 , pp. 24850-24855
    • Rahimi, N.1    Tremblay, E.2    Elliott, B.3
  • 30
    • 0029824114 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification
    • Ram TG, Ethier SP (1996) Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification. Cell Growth Differ 7:551-561
    • (1996) Cell Growth Differ , vol.7 , pp. 551-561
    • Ram, T.G.1    Ethier, S.P.2
  • 32
    • 0031023661 scopus 로고    scopus 로고
    • Inhibition of MG-63 cell proliferation and PDGF-stimulated cellular processes by inhibitors of phosphatidylinositol 3-kinase
    • Thomas JE, Venugopalan M, Calvin R, Wang Y, Bokoch CM, Vlahos CJ (1997) Inhibition of MG-63 cell proliferation and PDGF-stimulated cellular processes by inhibitors of phosphatidylinositol 3-kinase. J Cell Biochem 64:182-195
    • (1997) J Cell Biochem , vol.64 , pp. 182-195
    • Thomas, J.E.1    Venugopalan, M.2    Calvin, R.3    Wang, Y.4    Bokoch, C.M.5    Vlahos, C.J.6
  • 34
    • 0032125580 scopus 로고    scopus 로고
    • Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors
    • Phillips WA, St Munday AD, Thomas RJ, Mitchell CA (1998) Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors. Cancer 83:41-47
    • (1998) Cancer , vol.83 , pp. 41-47
    • Phillips, W.A.1    St Munday, A.D.2    Thomas, R.J.3    Mitchell, C.A.4
  • 37
    • 0030980781 scopus 로고    scopus 로고
    • Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression
    • Rusch V, Klimstra D, Venkatraman E, Pisters PW, Langenfeld J, Dmitrovsky E (1997) Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin Cancer Res 3:515-522
    • (1997) Clin Cancer Res , vol.3 , pp. 515-522
    • Rusch, V.1    Klimstra, D.2    Venkatraman, E.3    Pisters, P.W.4    Langenfeld, J.5    Dmitrovsky, E.6
  • 40
    • 0030849377 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor and transforming growth factor-alpha in human non-small cell lung cancers
    • Chong IW, Lin SR, Lin MS, Huang MS, Tsai MS, Hwang JJ (1997) Heparin-binding epidermal growth factor-like growth factor and transforming growth factor-alpha in human non-small cell lung cancers. J Formes Med Assoc 96:579-585
    • (1997) J Formes Med Assoc , vol.96 , pp. 579-585
    • Chong, I.W.1    Lin, S.R.2    Lin, M.S.3    Huang, M.S.4    Tsai, M.S.5    Hwang, J.J.6
  • 41
    • 0028046042 scopus 로고
    • The role of platelet-derived growth factor production by tumor-associated macrophages in tumor stroma formation in lung cancer
    • Vignaud JM, Marie B, Klein N, Plenat F, Pech M, Borrelly J, Martinet N, Duprez A, Martinet Y (1994) The role of platelet-derived growth factor production by tumor-associated macrophages in tumor stroma formation in lung cancer. Cancer Res 54:5455-5463
    • (1994) Cancer Res , vol.54 , pp. 5455-5463
    • Vignaud, J.M.1    Marie, B.2    Klein, N.3    Plenat, F.4    Pech, M.5    Borrelly, J.6    Martinet, N.7    Duprez, A.8    Martinet, Y.9
  • 42
    • 0026909770 scopus 로고
    • Ras and human tumors
    • Rodenhuis S (1992) ras and human tumors. Semin Cancer Biol 3:241-247
    • (1992) Semin Cancer Biol , vol.3 , pp. 241-247
    • Rodenhuis, S.1
  • 44
    • 0027787814 scopus 로고
    • Correlation between successful heterotransplantation of lung tumors in nude mice, poor prognosis of patients and expression of Fos, Jun, ErbB1, and Ras
    • Volm M, Mattern J (1993) Correlation between successful heterotransplantation of lung tumors in nude mice, poor prognosis of patients and expression of Fos, Jun, ErbB1, and Ras. Anticancer Res 13:2021-2025
    • (1993) Anticancer Res , vol.13 , pp. 2021-2025
    • Volm, M.1    Mattern, J.2
  • 46
    • 0028948872 scopus 로고
    • Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of phosphatidylinositol 3-kinase: Use of the antibodies in recognition of mutant p85
    • Daduang S, Nagata S, Matsuda M, Yamori T, Onodera K, Fukui Y (1995) Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of phosphatidylinositol 3-kinase: use of the antibodies in recognition of mutant p85. Immunol Cell Biol 73:134-139
    • (1995) Immunol Cell Biol , vol.73 , pp. 134-139
    • Daduang, S.1    Nagata, S.2    Matsuda, M.3    Yamori, T.4    Onodera, K.5    Fukui, Y.6
  • 48
    • 0031906278 scopus 로고    scopus 로고
    • Disruption of dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis
    • Zhou K, Pandol S, Bokoch G, Traynor-Kaplan AE (1998) Disruption of dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis. J Cell Sci 111:283-294
    • (1998) J Cell Sci , vol.111 , pp. 283-294
    • Zhou, K.1    Pandol, S.2    Bokoch, G.3    Traynor-Kaplan, A.E.4
  • 51
    • 0031936947 scopus 로고    scopus 로고
    • Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
    • Ruggeri BA, Huang L, Wood M, Cheng JQ, Testa JR (1998) Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog 21:81-86
    • (1998) Mol Carcinog , vol.21 , pp. 81-86
    • Ruggeri, B.A.1    Huang, L.2    Wood, M.3    Cheng, J.Q.4    Testa, J.R.5
  • 52
    • 0032527913 scopus 로고    scopus 로고
    • AKT2, a member of the protein kinase B family, is activated by growth factors v-Ha-ras and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells
    • Liu AX, Testa JR, Hamilton TC, Jove R, Nicosia SV, Cheng JQ (1998) AKT2, a member of the protein kinase B family, is activated by growth factors v-Ha-ras and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer Res 58:2973-2977
    • (1998) Cancer Res , vol.58 , pp. 2973-2977
    • Liu, A.X.1    Testa, J.R.2    Hamilton, T.C.3    Jove, R.4    Nicosia, S.V.5    Cheng, J.Q.6
  • 53
    • 0029858116 scopus 로고    scopus 로고
    • Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma-sensitive and multidrug-resistant Saos-2 cells
    • Zini N, Ognibene A, Bavelloni A, Santi S, Sabatelli P, Baldini N, Scotlandi K, Serra M, Maraldi NM (1996) Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma-sensitive and multidrug-resistant Saos-2 cells. Histochem Cell Biol 106:457-464
    • (1996) Histochem Cell Biol , vol.106 , pp. 457-464
    • Zini, N.1    Ognibene, A.2    Bavelloni, A.3    Santi, S.4    Sabatelli, P.5    Baldini, N.6    Scotlandi, K.7    Serra, M.8    Maraldi, N.M.9
  • 55
    • 0029818708 scopus 로고    scopus 로고
    • Evidence of the involvement of phosphatidylinositol 3-kinase in the migration, actin stress fiber formation, and alpha v beta 3-integrin-mediated adherence of human melanoma cells
    • Metzner B, Barbisch M, Bachmann F, Czech W, Norgauer J (1996) Evidence of the involvement of phosphatidylinositol 3-kinase in the migration, actin stress fiber formation, and alpha v beta 3-integrin-mediated adherence of human melanoma cells. J Invest Dermatol 107:597-602
    • (1996) J Invest Dermatol , vol.107 , pp. 597-602
    • Metzner, B.1    Barbisch, M.2    Bachmann, F.3    Czech, W.4    Norgauer, J.5
  • 56
    • 0031459917 scopus 로고    scopus 로고
    • Cdc42 and Racl induce integrin-mediated cell motility and invasiveness through PI(3)K
    • Keely PJ, Westwick JK, Whitehead IP, Der CI, Parise LV (1997) Cdc42 and Racl induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390:632-636
    • (1997) Nature , vol.390 , pp. 632-636
    • Keely, P.J.1    Westwick, J.K.2    Whitehead, I.P.3    Der, C.I.4    Parise, L.V.5
  • 57
    • 7344258310 scopus 로고    scopus 로고
    • Inhibition by platelet-activating factor of Src- And hepatocyte growth-factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3′-kinase is a critical mediator of tumor invasion
    • Kotelevets L, Noe V, Bruyneel E, Myssiakine E, Chastre E, Mareel M, Gespach C (1998) Inhibition by platelet-activating factor of Src- and hepatocyte growth-factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3′-kinase is a critical mediator of tumor invasion. J Biol Chem 273:14138-14145
    • (1998) J Biol Chem , vol.273 , pp. 14138-14145
    • Kotelevets, L.1    Noe, V.2    Bruyneel, E.3    Myssiakine, E.4    Chastre, E.5    Mareel, M.6    Gespach, C.7
  • 58
    • 0031456065 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
    • Shaw LM, Rabinovitz I, Wang HH, Toker A, Mercurio AM (1997) Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 91:949-960
    • (1997) Cell , vol.91 , pp. 949-960
    • Shaw, L.M.1    Rabinovitz, I.2    Wang, H.H.3    Toker, A.4    Mercurio, A.M.5
  • 59
    • 0030869787 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
    • Mazure NM, Chen EY, Laderoute KR, Giaccia AJ (1997) Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90:3322-3331
    • (1997) Blood , vol.90 , pp. 3322-3331
    • Mazure, N.M.1    Chen, E.Y.2    Laderoute, K.R.3    Giaccia, A.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.