-
1
-
-
0032168152
-
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
-
Heinrich, P.C., Behrmann, I., Muller Newen, G., Schaper, F., Graeve, L. (1998) Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J. 334: 297-314.
-
(1998)
Biochem. J.
, vol.334
, pp. 297-314
-
-
Heinrich, P.C.1
Behrmann, I.2
Muller Newen, G.3
Schaper, F.4
Graeve, L.5
-
2
-
-
0037064542
-
The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex
-
Jones, S.A., Rose-John, S. (2002) The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochim. Biophys. Acta 1592: 251-263.
-
(2002)
Biochim. Biophys. Acta
, vol.1592
, pp. 251-263
-
-
Jones, S.A.1
Rose-John, S.2
-
3
-
-
0342264579
-
IL-6-Receptor Independent Stimulation of Human gp130 by Viral IL-6
-
Müllberg, J., Geib, T., Jostock, T., Hoischen, S.H., Vollmer, P., Voltz, N., Heinz, D., Galle, P.R., Klouche, M., Rose-John, S. (2000) IL-6-Receptor Independent Stimulation of Human gp130 by Viral IL-6. J. Immunol. 164: 4672-4677.
-
(2000)
J. Immunol.
, vol.164
, pp. 4672-4677
-
-
Müllberg, J.1
Geib, T.2
Jostock, T.3
Hoischen, S.H.4
Vollmer, P.5
Voltz, N.6
Heinz, D.7
Galle, P.R.8
Klouche, M.9
Rose-John, S.10
-
4
-
-
0030890718
-
Gp130 and the interleukin-6 family of cytokines
-
Taga, T., Kishimoto, T. (1997) gp130 and the Interleukin-6 Family of Cytokines. Annu. Rev. Immunol. 15: 797-819.
-
(1997)
Annu. Rev. Immunol.
, vol.15
, pp. 797-819
-
-
Taga, T.1
Kishimoto, T.2
-
5
-
-
0037434888
-
The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane
-
Schuster, B., Meinert, W., Rose-John, S., Kallen, K.J. (2003) The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane. FEBS Lett. 538: 113-116.
-
(2003)
FEBS Lett.
, vol.538
, pp. 113-116
-
-
Schuster, B.1
Meinert, W.2
Rose-John, S.3
Kallen, K.J.4
-
6
-
-
0030183049
-
Cardiotrophin-1: A multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways
-
Pennica, D., Wood, W.I., Chien, K.R. (1996) Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways. Cytokine Growth Factor Rev. 7: 81-91.
-
(1996)
Cytokine Growth Factor Rev.
, vol.7
, pp. 81-91
-
-
Pennica, D.1
Wood, W.I.2
Chien, K.R.3
-
7
-
-
0031053811
-
Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component
-
Robledo, O., Fourcin, M., Chevalier, S., Guillet, C., Auguste, P., Pouplard Barthelaix, A., Pennica, D., Gascan, H. (1997) Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component. J. Biol. Chem. 272: 4855-4863.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4855-4863
-
-
Robledo, O.1
Fourcin, M.2
Chevalier, S.3
Guillet, C.4
Auguste, P.5
Pouplard Barthelaix, A.6
Pennica, D.7
Gascan, H.8
-
8
-
-
10744222574
-
WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27
-
Pflanz, S., Hibbert, L., Mattson, J., Rosales, R., Vaisberg, E., Bazan, J.F., Phillips, J.H., McClanahan, T.K., de Waal Malefyt, R., Kastelein, R.A. (2004) WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J. Immunol. 172: 2225-2231.
-
(2004)
J. Immunol.
, vol.172
, pp. 2225-2231
-
-
Pflanz, S.1
Hibbert, L.2
Mattson, J.3
Rosales, R.4
Vaisberg, E.5
Bazan, J.F.6
Phillips, J.H.7
McClanahan, T.K.8
De Waal Malefyt, R.9
Kastelein, R.A.10
-
9
-
-
4143150831
-
Characterization of the signaling capacities of the novel gp130-like cytokine receptor
-
Dreuw, A., Radtke, S., Pflanz, S., Lippok, B.E., Heinrich, P.C., Hermanns, H.M. (2004) Characterization of the signaling capacities of the novel gp130-like cytokine receptor. J. Biol. Chem. 279: 36112-36120.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36112-36120
-
-
Dreuw, A.1
Radtke, S.2
Pflanz, S.3
Lippok, B.E.4
Heinrich, P.C.5
Hermanns, H.M.6
-
10
-
-
18444385868
-
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
-
Pflanz, S., Timans, J.C., Cheung, J., Rosales, R., Kanzler, H., Gilbert, J., Hibbert, L., Churakova, T., Travis, M., Vaisberg, E., Blumenschein, W.M., Mattson, J.D., Wagner, J.L., To, W., Zurawski, S., McClanahan, T.K., Gorman, D.M., Bazan, J.F., de Waal Malefyt, R., Rennick, D., Kastelein, R.A. (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16: 779-790.
-
(2002)
Immunity
, vol.16
, pp. 779-790
-
-
Pflanz, S.1
Timans, J.C.2
Cheung, J.3
Rosales, R.4
Kanzler, H.5
Gilbert, J.6
Hibbert, L.7
Churakova, T.8
Travis, M.9
Vaisberg, E.10
Blumenschein, W.M.11
Mattson, J.D.12
Wagner, J.L.13
To, W.14
Zurawski, S.15
McClanahan, T.K.16
Gorman, D.M.17
Bazan, J.F.18
De Waal Malefyt, R.19
Rennick, D.20
Kastelein, R.A.21
more..
-
11
-
-
0342735253
-
CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex
-
Elson, G.C., Lelievre, E., Guillet, C., Chevalier, S., Plun-Favreau, H., Froger, J., Suard, I., de Coignac, A.B., Delneste, Y., Bonnefoy, J.Y., Gauchat, J.F., Gascan, H. (2000) CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Nat. Neurosci. 3: 867-872.
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 867-872
-
-
Elson, G.C.1
Lelievre, E.2
Guillet, C.3
Chevalier, S.4
Plun-Favreau, H.5
Froger, J.6
Suard, I.7
De Coignac, A.B.8
Delneste, Y.9
Bonnefoy, J.Y.10
Gauchat, J.F.11
Gascan, H.12
-
12
-
-
17744368457
-
The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine
-
Plun-Favreau, H., Elson, G., Chabbert, M., Froger, J., deLapeyriere, O., Lelievre, E., Guillet, C., Hermann, J., Gauchat, J.F., Gascan, H., Chevalier, S. (2001) The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. EMBO J. 20: 1692-1703.
-
(2001)
EMBO J.
, vol.20
, pp. 1692-1703
-
-
Plun-Favreau, H.1
Elson, G.2
Chabbert, M.3
Froger, J.4
Delapeyriere, O.5
Lelievre, E.6
Guillet, C.7
Hermann, J.8
Gauchat, J.F.9
Gascan, H.10
Chevalier, S.11
-
13
-
-
0030668919
-
Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist
-
Curtis, D.J., Hilton, D.J., Roberts, B., Murray, L., Nicola, N., Begley, C.G. (1997) Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist. Blood 90: 4403-4412.
-
(1997)
Blood
, vol.90
, pp. 4403-4412
-
-
Curtis, D.J.1
Hilton, D.J.2
Roberts, B.3
Murray, L.4
Nicola, N.5
Begley, C.G.6
-
14
-
-
0027293104
-
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
-
Narazaki, M., Yasukawa, K., Saito, T., Ohsugi, Y., Fukui, H., Koishihara, Y., Yancopoulos, G.D., Taga, T., Kishimoto, T. (1993) Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 82: 1120-1126.
-
(1993)
Blood
, vol.82
, pp. 1120-1126
-
-
Narazaki, M.1
Yasukawa, K.2
Saito, T.3
Ohsugi, Y.4
Fukui, H.5
Koishihara, Y.6
Yancopoulos, G.D.7
Taga, T.8
Kishimoto, T.9
-
15
-
-
0027428924
-
Differential shedding of the two subunits of the interleukin-6 receptor
-
Müllberg, J., Dittrich, E., Graeve, L., Gerhartz, C., Yasukawa, K., Taga, T., Kishimoto, T., Heinrich, P.C., Rose-John, S. (1993) Differential shedding of the two subunits of the interleukin-6 receptor. FEBS Lett. 332: 174-178.
-
(1993)
FEBS Lett.
, vol.332
, pp. 174-178
-
-
Müllberg, J.1
Dittrich, E.2
Graeve, L.3
Gerhartz, C.4
Yasukawa, K.5
Taga, T.6
Kishimoto, T.7
Heinrich, P.C.8
Rose-John, S.9
-
16
-
-
0028981894
-
Stage specific expression of cytokine and receptor messenger ribonucleic acids in human pre-implantation embryos
-
Sharkey, A.M., Delow, K., Blayney, M., Macnamee, M., Charnock-Jones, S., Smith, S.K. (1995) Stage specific expression of cytokine and receptor messenger ribonucleic acids in human pre-implantation embryos. Biol. Reprod. 53: 974-982.
-
(1995)
Biol. Reprod.
, vol.53
, pp. 974-982
-
-
Sharkey, A.M.1
Delow, K.2
Blayney, M.3
Macnamee, M.4
Charnock-Jones, S.5
Smith, S.K.6
-
17
-
-
0030808992
-
Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin-6 signal transducer gp130
-
Diamant, M., Rieneck, K., Mechti, N., Zhang, X.G., Svenson, M., Bendtzen, K., Klein, B. (1997) Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin-6 signal transducer gp130. FEBS Lett. 412: 379-384.
-
(1997)
FEBS Lett.
, vol.412
, pp. 379-384
-
-
Diamant, M.1
Rieneck, K.2
Mechti, N.3
Zhang, X.G.4
Svenson, M.5
Bendtzen, K.6
Klein, B.7
-
18
-
-
0032562601
-
Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma
-
Zhang, J.G., Zhang, Y., Owczarek, C.M., Ward, L.D., Moritz, R.L., Simpson, R.J., Yasukawa, K., Nicola, N.A. (1998) Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma. J. Biol. Chem. 273: 10798-10805.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10798-10805
-
-
Zhang, J.G.1
Zhang, Y.2
Owczarek, C.M.3
Ward, L.D.4
Moritz, R.L.5
Simpson, R.J.6
Yasukawa, K.7
Nicola, N.A.8
-
19
-
-
0033916898
-
Cloning of novel soluble gp130 and detection of its neutralising autoantibodies in rheumatoid arthritis
-
Tanaka, M., Kishimura, M., Ozaki, S., Osakada, F., Hashimoto, H., Okubo, M., Murakami, M., Nakao, K. (2000) Cloning of novel soluble gp130 and detection of its neutralising autoantibodies in rheumatoid arthritis. J. Clin. Invest. 106: 137-144.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 137-144
-
-
Tanaka, M.1
Kishimura, M.2
Ozaki, S.3
Osakada, F.4
Hashimoto, H.5
Okubo, M.6
Murakami, M.7
Nakao, K.8
-
20
-
-
0033621731
-
Soluble glycoprotein 130 (gp130) attenuates OSM- and LIF-induced cartilage proteoglycan catabolism
-
Hui, W., Bell, M., Carroll, G. (2000) Soluble glycoprotein 130 (gp130) attenuates OSM- and LIF-induced cartilage proteoglycan catabolism. Cytokine 12: 151-155.
-
(2000)
Cytokine
, vol.12
, pp. 151-155
-
-
Hui, W.1
Bell, M.2
Carroll, G.3
-
21
-
-
0035160256
-
Soluble gp130 is the natural inhibitor of soluble IL-6R transsignaling responses
-
Jostock, T., Müllberg, J., Özbek, S., Atreya, R., Blinn, G., Voltz, N., Fischer, M., Neurath, M.F., Rose-John, S. (2001) Soluble gp130 is the natural inhibitor of soluble IL-6R transsignaling responses. Eur. J. Biochem. 268: 160-167.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 160-167
-
-
Jostock, T.1
Müllberg, J.2
Özbek, S.3
Atreya, R.4
Blinn, G.5
Voltz, N.6
Fischer, M.7
Neurath, M.F.8
Rose-John, S.9
-
22
-
-
10644250867
-
No inhibition of IL-27 signaling by soluble gp130
-
Scheller, J., Schuster, B., Holscher, C., Yoshimoto, T., S., R.-J. (2005) No inhibition of IL-27 signaling by soluble gp130. Biochem. Biophys. Res. Commun. 326: 724-728.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.326
, pp. 724-728
-
-
Scheller, J.1
Schuster, B.2
Holscher, C.3
Yoshimoto, T.4
S., R.-J.5
-
23
-
-
0027467218
-
Structure-function analysis of human IL-6 receptor: Dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130
-
Yawata, H., Yasukawa, K., Natsuka, S., Murakami, M., Yamasaki, K., Hibi, M., Taga, T., Kishimoto, T. (1993) Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130. EMBO J. 12: 1705-1712.
-
(1993)
EMBO J.
, vol.12
, pp. 1705-1712
-
-
Yawata, H.1
Yasukawa, K.2
Natsuka, S.3
Murakami, M.4
Yamasaki, K.5
Hibi, M.6
Taga, T.7
Kishimoto, T.8
-
24
-
-
0033565363
-
A role for the immunoglobulin-like domain of the human IL-6 receptor: Intracellular protein transport and shedding
-
Vollmer, P., Oppmann, B., Voltz, N., Fischer, M., Rose-John, S. (1999) A role for the immunoglobulin-like domain of the human IL-6 receptor: intracellular protein transport and shedding. Eur. J. Biochem. 263: 438-446.
-
(1999)
Eur. J. Biochem.
, vol.263
, pp. 438-446
-
-
Vollmer, P.1
Oppmann, B.2
Voltz, N.3
Fischer, M.4
Rose-John, S.5
-
25
-
-
0038609651
-
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
-
Boulanger, M.J., Chow, D.C., Brevnova, E.E., Garcia, K.C. (2003) Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 300: 2101-2104.
-
(2003)
Science
, vol.300
, pp. 2101-2104
-
-
Boulanger, M.J.1
Chow, D.C.2
Brevnova, E.E.3
Garcia, K.C.4
-
26
-
-
0037987019
-
The family of the IL-6-type cytokines: Specificity and Promiscuity of the Receptor Complexes
-
Grötzinger, J., Kurapkat, G., Wollmer, A., Kalai, M., Rose-John, S. (1997) The family of the IL-6-type cytokines: Specificity and Promiscuity of the Receptor Complexes. Proteins: Struct., Funct., Genet. 27: 96-109.
-
(1997)
Proteins: Struct., Funct., Genet.
, vol.27
, pp. 96-109
-
-
Grötzinger, J.1
Kurapkat, G.2
Wollmer, A.3
Kalai, M.4
Rose-John, S.5
-
28
-
-
0029086449
-
A region within the cytoplasmic domain of the interleukin-6 signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor
-
Dittrich, E., Gerhartz, C., Rose-John, S., Müllberg, J., Stoyan, T., Heinrich, P.C., Graeve, L. (1995) A region within the cytoplasmic domain of the interleukin-6 signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor. Ann. N. Y. Acad. Sci. 762: 410-412.
-
(1995)
Ann. N. Y. Acad. Sci.
, vol.762
, pp. 410-412
-
-
Dittrich, E.1
Gerhartz, C.2
Rose-John, S.3
Müllberg, J.4
Stoyan, T.5
Heinrich, P.C.6
Graeve, L.7
-
29
-
-
0029087735
-
Stoichiometry of the interleukin-6 high affinity receptor complex
-
Ward, L.D., Hewlett, G.J., Hammacher, A., Moritz, R.L., Simpson, R.J. (1995) Stoichiometry of the interleukin-6 high affinity receptor complex. Ann. N. Y. Acad. Sci. 762: 471-473.
-
(1995)
Ann. N. Y. Acad. Sci.
, vol.762
, pp. 471-473
-
-
Ward, L.D.1
Hewlett, G.J.2
Hammacher, A.3
Moritz, R.L.4
Simpson, R.J.5
-
30
-
-
0029002866
-
Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling
-
Paonessa, G., Graziani, R., De Serio, A., Savino, R., Ciapponi, L., Lahm, A., Salvati, A.L., Toniatti, C., Ciliberto, G. (1995) Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling. EMBO J. 14: 1942-1951.
-
(1995)
EMBO J.
, vol.14
, pp. 1942-1951
-
-
Paonessa, G.1
Graziani, R.2
De Serio, A.3
Savino, R.4
Ciapponi, L.5
Lahm, A.6
Salvati, A.L.7
Toniatti, C.8
Ciliberto, G.9
-
31
-
-
16544369800
-
Shared cytokine signaling receptors: Structural insights from the gp130 system
-
Boulanger, M.J., Garcia, K.C. (2004) Shared cytokine signaling receptors: structural insights from the gp130 system. Adv. Protein Chem. 68: 107-146.
-
(2004)
Adv. Protein Chem.
, vol.68
, pp. 107-146
-
-
Boulanger, M.J.1
Garcia, K.C.2
-
32
-
-
0028064835
-
High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130
-
Ward, L.D., Hewlett, G.J., Discolo, G., Yasukawa, K., Hammacher, A., Moritz, R.L., Simpson, R.J. (1994) High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J. Biol Chem. 269: 23286-23289.
-
(1994)
J. Biol Chem.
, vol.269
, pp. 23286-23289
-
-
Ward, L.D.1
Hewlett, G.J.2
Discolo, G.3
Yasukawa, K.4
Hammacher, A.5
Moritz, R.L.6
Simpson, R.J.7
-
33
-
-
0029584357
-
In vitro binding of ciliary neurotrophic factor to its receptors: Evidence for the formation of an IL-6-type hexameric complex
-
De Serio, A., Graziani, R., Laufer, R., Ciliberto, G., Paonessa, G. (1995) In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complex. J. Mol. Biol. 254: 795-800.
-
(1995)
J. Mol. Biol.
, vol.254
, pp. 795-800
-
-
De Serio, A.1
Graziani, R.2
Laufer, R.3
Ciliberto, G.4
Paonessa, G.5
-
34
-
-
0029046795
-
Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing
-
McDonald, N.Q., Panayotatos, N., Hendrickson, W.A. (1995) Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J. 14: 2689-2699.
-
(1995)
EMBO J.
, vol.14
, pp. 2689-2699
-
-
McDonald, N.Q.1
Panayotatos, N.2
Hendrickson, W.A.3
-
35
-
-
0038642195
-
IL-6 type cytokine receptor complexes: Hexamer or tetramer or both?
-
Grötzinger, J., Kernebeck, T., Kallen, K.-J., Rose-John, S. (1999) IL-6 type Cytokine Receptor Complexes: Hexamer or Tetramer or Both? Biol. Chem. 380: 803-813.
-
(1999)
Biol. Chem.
, vol.380
, pp. 803-813
-
-
Grötzinger, J.1
Kernebeck, T.2
Kallen, K.-J.3
Rose-John, S.4
-
36
-
-
1842301081
-
Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex
-
Horsten, U., Muller Newen, G., Gerhartz, C., Wollmer, A., Wijdenes, J., Heinrich, P.C., Grotzinger, J. (1997) Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex. J. Biol. Chem. 272: 23748-23757.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 23748-23757
-
-
Horsten, U.1
Muller Newen, G.2
Gerhartz, C.3
Wollmer, A.4
Wijdenes, J.5
Heinrich, P.C.6
Grotzinger, J.7
-
37
-
-
0033083941
-
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes
-
Kurth, I., Horsten, U., Pflanz, S., Dahmen, H., Kuster, A., Grotzinger, J., Heinrich, P.C., Muller-Newen, G. (1999) Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes. J. Immunol. 162: 1480-1487.
-
(1999)
J. Immunol.
, vol.162
, pp. 1480-1487
-
-
Kurth, I.1
Horsten, U.2
Pflanz, S.3
Dahmen, H.4
Kuster, A.5
Grotzinger, J.6
Heinrich, P.C.7
Muller-Newen, G.8
-
38
-
-
0034672091
-
Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation
-
Pflanz, S., Kurth, I., Grötzinger, J., Heinrich, P.C., Müller-Newen, G. (2000) Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation. J. Immunol. 165: 7042-7049.
-
(2000)
J. Immunol.
, vol.165
, pp. 7042-7049
-
-
Pflanz, S.1
Kurth, I.2
Grötzinger, J.3
Heinrich, P.C.4
Müller-Newen, G.5
-
39
-
-
14144251446
-
Dynamics of the gp130 cytokine complex: A model for assembly on the cellular membrane
-
Schroers, A., Hecht, O., Kallen, K.J., Pachta, M., Rose-John, S., Grotzinger, J. (2005) Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane. Protein Sci. 14: 783-790.
-
(2005)
Protein Sci.
, vol.14
, pp. 783-790
-
-
Schroers, A.1
Hecht, O.2
Kallen, K.J.3
Pachta, M.4
Rose-John, S.5
Grotzinger, J.6
-
40
-
-
27944444522
-
Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells
-
Giese, B., Roderburg, C., Sommerauer, M., Wortmann, S.B., Metz, S., Heinrich, P.C., Muller-Newen, G. (2005) Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells. J. Cell. Sci. 118: 5129-5140.
-
(2005)
J. Cell. Sci.
, vol.118
, pp. 5129-5140
-
-
Giese, B.1
Roderburg, C.2
Sommerauer, M.3
Wortmann, S.B.4
Metz, S.5
Heinrich, P.C.6
Muller-Newen, G.7
-
41
-
-
0027303256
-
Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding
-
van Dam, M., Müllberg, J., Schooltink, H., Stoyan, T., Brakenhoff, J.P., Graeve, L., Heinrich, P.C., Rose-John, S. (1993) Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding. J. Biol. Chem. 268: 15285-15290.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 15285-15290
-
-
Van Dam, M.1
Müllberg, J.2
Schooltink, H.3
Stoyan, T.4
Brakenhoff, J.P.5
Graeve, L.6
Heinrich, P.C.7
Rose-John, S.8
-
42
-
-
0040886437
-
Receptor recognition sites of cytokines are organized as exchangeable moduls: Transfer of the LIFR binding site from CNTF to IL-6
-
Kallen, K.-J., Grötzinger, J., Lelièvre, E., Vollmer, P., Aasland, D., Renné, C., Müllberg, J., Meyer zum Büschenfelde, K.-H., Gascan, H., Rose-John, S. (1999) Receptor recognition sites of cytokines are organized as exchangeable moduls: transfer of the LIFR binding site from CNTF to IL-6. J. Biol. Chem. 274: 11859-11867.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11859-11867
-
-
Kallen, K.-J.1
Grötzinger, J.2
Lelièvre, E.3
Vollmer, P.4
Aasland, D.5
Renné, C.6
Müllberg, J.7
Meyer Zum Büschenfelde, K.-H.8
Gascan, H.9
Rose-John, S.10
-
43
-
-
0035836645
-
Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain
-
Constantinescu, S.N., Keren, T., Socolovsky, M., Nam, H., Henis, Y.I., Lodish, H.F. (2001) Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc. Natl. Acad. Sci. U. S. A. 98: 4379-4384.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 4379-4384
-
-
Constantinescu, S.N.1
Keren, T.2
Socolovsky, M.3
Nam, H.4
Henis, Y.I.5
Lodish, H.F.6
-
44
-
-
0033548259
-
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
-
Livnah, O., Stura, E.A., Middleton, S.A., Johnson, D.L., Jolliffe, L.K., Wilson, I.A. (1999) Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283: 987-990.
-
(1999)
Science
, vol.283
, pp. 987-990
-
-
Livnah, O.1
Stura, E.A.2
Middleton, S.A.3
Johnson, D.L.4
Jolliffe, L.K.5
Wilson, I.A.6
-
45
-
-
0033548048
-
Erythropoietin receptor activation by a ligand-induced conformation change
-
Remy, I., Wilson, I.A., Michnick, S.W. (1999) Erythropoietin receptor activation by a ligand-induced conformation change. Science 283: 990-993.
-
(1999)
Science
, vol.283
, pp. 990-993
-
-
Remy, I.1
Wilson, I.A.2
Michnick, S.W.3
-
46
-
-
85047682496
-
Receptor dimerization in GH and erythropoietin action - It takes two to tango, but how?
-
Frank, S.J. (2002) Receptor dimerization in GH and erythropoietin action - it takes two to tango, but how? Endocrinology 143: 2-10.
-
(2002)
Endocrinology
, vol.143
, pp. 2-10
-
-
Frank, S.J.1
-
47
-
-
0012263559
-
Seeing the light: Preassembly and ligand-induced changes of the interferon gamma receptor complex in cells
-
Krause, C.D., Mei, E., Xie, J., Jia, Y., Bopp, M.A., Hochstrasser, R.M., Pestka, S. (2002) Seeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cells. Mol. Cell. Proteomics 1: 805-815.
-
(2002)
Mol. Cell. Proteomics
, vol.1
, pp. 805-815
-
-
Krause, C.D.1
Mei, E.2
Xie, J.3
Jia, Y.4
Bopp, M.A.5
Hochstrasser, R.M.6
Pestka, S.7
-
48
-
-
17744386517
-
Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration
-
Carr, P.D., Gustin, S.E., Church, A.P., Murphy, J.M., Ford, S.C., Mann, D.A., Woltring, D.M., Walker, I., Ollis, D.L., Young, I.G. (2001) Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. Cell 104: 291-300.
-
(2001)
Cell
, vol.104
, pp. 291-300
-
-
Carr, P.D.1
Gustin, S.E.2
Church, A.P.3
Murphy, J.M.4
Ford, S.C.5
Mann, D.A.6
Woltring, D.M.7
Walker, I.8
Ollis, D.L.9
Young, I.G.10
-
49
-
-
0030916177
-
Signaling of type II oncostatin M receptor
-
Auguste, P., Guillet, C., Fourcin, M., Olivier, C., Veziers, J., Pouplard Barthelaix, A., Gascan, H. (1997) Signaling of type II oncostatin M receptor. J. Biol. Chem. 272: 15760-15764.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 15760-15764
-
-
Auguste, P.1
Guillet, C.2
Fourcin, M.3
Olivier, C.4
Veziers, J.5
Pouplard Barthelaix, A.6
Gascan, H.7
-
50
-
-
0033975858
-
Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130
-
Kurth, I., Horsten, U., Pflanz, S., Timmermann, A., Kuster, A., Dahmen, H., Tacken, I., Heinrich, P.C., Muller-Newen, G. (2000) Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130. J. Immunol. 164: 273-282.
-
(2000)
J. Immunol.
, vol.164
, pp. 273-282
-
-
Kurth, I.1
Horsten, U.2
Pflanz, S.3
Timmermann, A.4
Kuster, A.5
Dahmen, H.6
Tacken, I.7
Heinrich, P.C.8
Muller-Newen, G.9
-
51
-
-
0028957771
-
The conserved box 1 motif of cytokine receptors is required for association with JAK kinases
-
Tanner, J.W., Chen, W., Young, R.L., Longmore, G.D., Shaw, A.S. (1995) The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J. Biol. Chem. 270: 6523-6530.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 6523-6530
-
-
Tanner, J.W.1
Chen, W.2
Young, R.L.3
Longmore, G.D.4
Shaw, A.S.5
-
52
-
-
22444442637
-
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
-
Skiniotis, G., Boulanger, M.J., Garcia, K.C., Walz, T. (2005) Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat. Struct. Mol. Biol 12: 545-551.
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 545-551
-
-
Skiniotis, G.1
Boulanger, M.J.2
Garcia, K.C.3
Walz, T.4
-
53
-
-
0036772849
-
GP130 stimulation and the maintenance of stem cells
-
Rose-John, S. (2002) GP130 stimulation and the maintenance of stem cells. Trends Biotechnol. 20: 417-419.
-
(2002)
Trends Biotechnol.
, vol.20
, pp. 417-419
-
-
Rose-John, S.1
-
54
-
-
0031201133
-
Soluble IL-6 Receptor leads to a paracrine modulation of the hepatic acute phase response in double transgenic mice
-
Peters, M., Odenthal, M., Schirmacher, P., Blessing, M., Ciliberto, G., Meyer zum Büschenfelde, K.H., Rose-John, S. (1997) Soluble IL-6 Receptor leads to a paracrine modulation of the hepatic acute phase response in double transgenic mice. J. Immunol. 159: 1474-1481.
-
(1997)
J. Immunol.
, vol.159
, pp. 1474-1481
-
-
Peters, M.1
Odenthal, M.2
Schirmacher, P.3
Blessing, M.4
Ciliberto, G.5
Meyer Zum Büschenfelde, K.H.6
Rose-John, S.7
-
55
-
-
0032533949
-
Interleukin-6 and soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis
-
Peters, M., Müller, A., Rose-John, S. (1998) Interleukin-6 and soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis. Blood 92: 3495-3504.
-
(1998)
Blood
, vol.92
, pp. 3495-3504
-
-
Peters, M.1
Müller, A.2
Rose-John, S.3
-
56
-
-
0032539893
-
Sympathetic Neurons can produce and respond to Interleukin-6
-
März, P., Cheng, J.-C., Gadient, R.A., Patterson, P., Stoyan, T., Otten, U., Rose-John, S. (1998) Sympathetic Neurons can produce and respond to Interleukin-6. Proc. Natl. Acad. Sci. U. S. A. 95: 3251-3256.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 3251-3256
-
-
März, P.1
Cheng, J.-C.2
Gadient, R.A.3
Patterson, P.4
Stoyan, T.5
Otten, U.6
Rose-John, S.7
-
57
-
-
0345104338
-
Role of interleukin-6 and soluble IL-6 receptor in region specific induction of astrocytic differentiation and neurotrophin expression
-
März, P., Heese, K., Dimitriades-Schmutz, B., Rose-John, S., Otten, U. (1999) Role of Interleukin-6 and soluble IL-6 Receptor in Region Specific Induction of Astrocytic Differentiation and Neurotrophin Expression. Glia 26: 191-200.
-
(1999)
Glia
, vol.26
, pp. 191-200
-
-
März, P.1
Heese, K.2
Dimitriades-Schmutz, B.3
Rose-John, S.4
Otten, U.5
-
58
-
-
0032846613
-
Novel Path of activation of primary human smooth muscle cells: Upregulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor
-
Klouche, M., Bhakdi, S., Hemmes, M., Rose-John, S. (1999) Novel Path of activation of primary human smooth muscle cells: upregulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J. Immunol. 163: 4583-4589.
-
(1999)
J. Immunol.
, vol.163
, pp. 4583-4589
-
-
Klouche, M.1
Bhakdi, S.2
Hemmes, M.3
Rose-John, S.4
-
59
-
-
18644385612
-
IL-6 transsignaling: The in vivo consequences
-
Jones, S.A., Richards, P.J., Scheller, J., Rose-John, S. (2005) IL-6 transsignaling: the in vivo consequences. J. Interferon Cytokine Res. 25: 241-253.
-
(2005)
J. Interferon Cytokine Res.
, vol.25
, pp. 241-253
-
-
Jones, S.A.1
Richards, P.J.2
Scheller, J.3
Rose-John, S.4
-
60
-
-
0026828552
-
Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
-
Lust, J.A., Donovan, K.A., Kline, M.P., Greipp, P.R., Kyle, R.A., Maihle, N.J. (1992) Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 4: 96-100.
-
(1992)
Cytokine
, vol.4
, pp. 96-100
-
-
Lust, J.A.1
Donovan, K.A.2
Kline, M.P.3
Greipp, P.R.4
Kyle, R.A.5
Maihle, N.J.6
-
61
-
-
0028226196
-
Soluble receptors for cytokines and growth factors: Generation and biological function
-
Rose-John, S., Heinrich, P.C. (1994) Soluble receptors for cytokines and growth factors: generation and biological function. Biochem. J. 300: 281-290.
-
(1994)
Biochem. J.
, vol.300
, pp. 281-290
-
-
Rose-John, S.1
Heinrich, P.C.2
-
62
-
-
0034020230
-
The importance of shedding of membrane proteins for cytokine biology
-
Müllberg, J., Althoff, K., Jostock, T., Rose-John, S. (2000) The Importance of Shedding of Membrane Proteins for Cytokine Biology. Eur. Cyt. Netw. 11: 27-38.
-
(2000)
Eur. Cyt. Netw.
, vol.11
, pp. 27-38
-
-
Müllberg, J.1
Althoff, K.2
Jostock, T.3
Rose-John, S.4
-
63
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., Kishimoto, T. (1989) Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58: 573-581.
-
(1989)
Cell
, vol.58
, pp. 573-581
-
-
Taga, T.1
Hibi, M.2
Hirata, Y.3
Yamasaki, K.4
Yasukawa, K.5
Matsuda, T.6
Hirano, T.7
Kishimoto, T.8
-
64
-
-
0026782577
-
Complex of soluble human IL-6-receptor/IL-6 upregulates expression of acute-phase proteins
-
Mackiewicz, A., Schooltink, H., Heinrich, P.C., Rose-John, S. (1992) Complex of soluble human IL-6-receptor/IL-6 upregulates expression of acute-phase proteins. J. Immunol. 149: 2021-2027.
-
(1992)
J. Immunol.
, vol.149
, pp. 2021-2027
-
-
Mackiewicz, A.1
Schooltink, H.2
Heinrich, P.C.3
Rose-John, S.4
-
65
-
-
0038739858
-
Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses
-
Müller-Newen, G., Küster, A., Hemmann, U., Keul, R., Horsten, U., Martens, A., Graeve, L., Wijdenes, J., Heinrich, P.C. (1998) Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses. J. Immunol. 161: 6347-6355.
-
(1998)
J. Immunol.
, vol.161
, pp. 6347-6355
-
-
Müller-Newen, G.1
Küster, A.2
Hemmann, U.3
Keul, R.4
Horsten, U.5
Martens, A.6
Graeve, L.7
Wijdenes, J.8
Heinrich, P.C.9
-
66
-
-
0028950484
-
Cytokine, cytokine receptors, transduction signals, and oncogenes in human multiple myeloma
-
Klein, B. (1995) Cytokine, cytokine receptors, transduction signals, and oncogenes in human multiple myeloma. Semin. Hematol. 32: 4-19.
-
(1995)
Semin. Hematol.
, vol.32
, pp. 4-19
-
-
Klein, B.1
-
67
-
-
0035378160
-
The soluble IL-6 receptors: Serum levels and biological function
-
Montero-Julian, F.A. (2001) The soluble IL-6 receptors: serum levels and biological function. Cell. Mol. Biol. 47: 583-597.
-
(2001)
Cell. Mol. Biol.
, vol.47
, pp. 583-597
-
-
Montero-Julian, F.A.1
-
68
-
-
26244445339
-
Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130
-
Lehmann, U., Sommer, U., Smyczek, T., Hortner, M., Frisch, W., Volkmer-Engert, R., Heinrich, P.C., Schaper, F., Haan, S. (2006) Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130. Cell. Signalling 18: 40-49.
-
(2006)
Cell. Signalling
, vol.18
, pp. 40-49
-
-
Lehmann, U.1
Sommer, U.2
Smyczek, T.3
Hortner, M.4
Frisch, W.5
Volkmer-Engert, R.6
Heinrich, P.C.7
Schaper, F.8
Haan, S.9
-
69
-
-
0028296179
-
Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
-
Lütticken, C., Wegenka, U.M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A.G., Wilks, A.F., Yasukawa, K., Taga, T., Heinrich, P.C., Horn, F. (1994) Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263: 89-92.
-
(1994)
Science
, vol.263
, pp. 89-92
-
-
Lütticken, C.1
Wegenka, U.M.2
Yuan, J.3
Buschmann, J.4
Schindler, C.5
Ziemiecki, A.6
Harpur, A.G.7
Wilks, A.F.8
Yasukawa, K.9
Taga, T.10
Heinrich, P.C.11
Horn, F.12
-
70
-
-
0028281794
-
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
-
Stahl, N., Boulton, T.G., Farruggella, T., Ip, N.Y., Davis, S., Witthuhn, B.A., Quelle, F.W., Silvennoinen, O., Barbieri, G., Pellegrini, S., Ihle, J.N., Yancopoulos, G.D. (1994) Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science 263: 92-95.
-
(1994)
Science
, vol.263
, pp. 92-95
-
-
Stahl, N.1
Boulton, T.G.2
Farruggella, T.3
Ip, N.Y.4
Davis, S.5
Witthuhn, B.A.6
Quelle, F.W.7
Silvennoinen, O.8
Barbieri, G.9
Pellegrini, S.10
Ihle, J.N.11
Yancopoulos, G.D.12
-
71
-
-
0041677606
-
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
-
Heinrich, P.C., Behrmann, I., Haan, S., Hermanns, H.M., Muller-Newen, G., Schaper, F. (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374: 1-20.
-
(2003)
Biochem. J.
, vol.374
, pp. 1-20
-
-
Heinrich, P.C.1
Behrmann, I.2
Haan, S.3
Hermanns, H.M.4
Muller-Newen, G.5
Schaper, F.6
-
72
-
-
0026735084
-
JAK2, a third member of the JAK family of protein tyrosine kinases
-
Harpur, A.G., Andres, A.C., Ziemiecki, A., Aston, R.R., Wilks, A.F. (1992) JAK2, a third member of the JAK family of protein tyrosine kinases. Oncogene 7: 1347-1353.
-
(1992)
Oncogene
, vol.7
, pp. 1347-1353
-
-
Harpur, A.G.1
Andres, A.C.2
Ziemiecki, A.3
Aston, R.R.4
Wilks, A.F.5
-
73
-
-
0035813208
-
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction
-
Haan, C., Is'harc, H., Hermanns, H.M., Schmitz-Van De Leur, H.K., I.M., Heinrich, P.C., Grotzinger, J., Behrmann, I. (2001) Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction. J. Biol. Chem. 276: 37451-37458.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37451-37458
-
-
Haan, C.1
Is'harc, H.2
Hermanns, H.M.3
Schmitz-Van De Leur, H.K.4
M., I.5
Heinrich, P.C.6
Grotzinger, J.7
Behrmann, I.8
-
74
-
-
0028922433
-
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6
-
Guschin, D., Rogers, N., Briscoe, J., Witthuhn, B., Watling, D., Horn, F., Pellegrini, S., Yasukawa, K., Heinrich, P., Stark, G.R., Ihle, J.N., Kerr, I.A. (1995) A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J. 14: 1421-1429.
-
(1995)
EMBO J.
, vol.14
, pp. 1421-1429
-
-
Guschin, D.1
Rogers, N.2
Briscoe, J.3
Witthuhn, B.4
Watling, D.5
Horn, F.6
Pellegrini, S.7
Yasukawa, K.8
Heinrich, P.9
Stark, G.R.10
Ihle, J.N.11
Kerr, I.A.12
-
75
-
-
0034650929
-
The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction
-
Schmitz, J., Dahmen, H., Grimm, C., Gendo, C., Muller-Newen, G., Heinrich, P.C., Schaper, F. (2000) The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction. J. Immunol. 164: 848-854.
-
(2000)
J. Immunol.
, vol.164
, pp. 848-854
-
-
Schmitz, J.1
Dahmen, H.2
Grimm, C.3
Gendo, C.4
Muller-Newen, G.5
Heinrich, P.C.6
Schaper, F.7
-
76
-
-
0028931604
-
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
-
Stahl, N., Farruggella, T.J., Boulton, T.G., Zhong, Z., Darnell, J.E., Jr., Yancopoulos, G.D. (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267: 1349-1353.
-
(1995)
Science
, vol.267
, pp. 1349-1353
-
-
Stahl, N.1
Farruggella, T.J.2
Boulton, T.G.3
Zhong, Z.4
Darnell Jr., J.E.5
Yancopoulos, G.D.6
-
77
-
-
0029887373
-
Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation
-
Gerhartz, C., Heesel, B., Sasse, J., Hemmann, U., Landgraf, C., Schneider Mergener, J., Horn, F., Heinrich, P.C., Graeve, L. (1996) Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation. J. Biol. Chem. 271: 12991-12998.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12991-12998
-
-
Gerhartz, C.1
Heesel, B.2
Sasse, J.3
Hemmann, U.4
Landgraf, C.5
Schneider Mergener, J.6
Horn, F.7
Heinrich, P.C.8
Graeve, L.9
-
78
-
-
0033556386
-
Characterization and binding specificity of the monomeric STAT3-SH2 domain
-
Haan, S., Hemmann, U., Hassiepen, U., Schaper, F., Schneider-Mergener, J., Wollmer, A., Heinrich, P.C., Grotzinger, J. (1999) Characterization and binding specificity of the monomeric STAT3-SH2 domain. J. Biol. Chem. 274: 1342-1348.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1342-1348
-
-
Haan, S.1
Hemmann, U.2
Hassiepen, U.3
Schaper, F.4
Schneider-Mergener, J.5
Wollmer, A.6
Heinrich, P.C.7
Grotzinger, J.8
-
79
-
-
0027493650
-
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma
-
Shuai, K., Stark, G.R., Kerr, I.M., Darnell, J.E.J. (1993) A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 261: 1744-1746.
-
(1993)
Science
, vol.261
, pp. 1744-1746
-
-
Shuai, K.1
Stark, G.R.2
Kerr, I.M.3
Darnell, J.E.J.4
-
80
-
-
0029960028
-
Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction
-
Kaptein, A., Paillard, V., Saunders, M. (1996) Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction. J. Biol. Chem. 271: 5961-5964.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5961-5964
-
-
Kaptein, A.1
Paillard, V.2
Saunders, M.3
-
81
-
-
0028349735
-
Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong, Z., Wen, Z., Darnell, J.E.J. (1994) Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264: 95-98.
-
(1994)
Science
, vol.264
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell, J.E.J.3
-
82
-
-
0027441586
-
Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
-
Wegenka, U.M., Buschmann, J., Lütticken, C., Heinrich, P.C., Horn, F. (1993) Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level. Mol. Cell. Biol. 13: 276-288.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 276-288
-
-
Wegenka, U.M.1
Buschmann, J.2
Lütticken, C.3
Heinrich, P.C.4
Horn, F.5
-
83
-
-
24344499530
-
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
-
Haan, S., Keller, J.F., Behrmann, I., Heinrich, P.C., Haan, C. (2005) Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation. Cell. Signalling 17: 1542-1550.
-
(2005)
Cell. Signalling
, vol.17
, pp. 1542-1550
-
-
Haan, S.1
Keller, J.F.2
Behrmann, I.3
Heinrich, P.C.4
Haan, C.5
-
84
-
-
0029117304
-
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
-
Wen, Z., Zhong, Z., Darnell, J.E.J. (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241-250.
-
(1995)
Cell
, vol.82
, pp. 241-250
-
-
Wen, Z.1
Zhong, Z.2
Darnell, J.E.J.3
-
85
-
-
0032212797
-
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
-
Schaper, F., Gendo, C., Eck, M., Schmitz, J., Grimm, C., Anhuf, D., Kerr, I.M., Heinrich, P.C. (1998) Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression. Biochem. J. 335: 557-565.
-
(1998)
Biochem. J.
, vol.335
, pp. 557-565
-
-
Schaper, F.1
Gendo, C.2
Eck, M.3
Schmitz, J.4
Grimm, C.5
Anhuf, D.6
Kerr, I.M.7
Heinrich, P.C.8
-
86
-
-
0030960333
-
Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras
-
Schiemann, W.P., Bartoe, J.L., Nathanson, N.M. (1997) Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras. J. Biol. Chem. 272: 16631-16636.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16631-16636
-
-
Schiemann, W.P.1
Bartoe, J.L.2
Nathanson, N.M.3
-
87
-
-
0030028790
-
A Grb2-associated docking protein in EGF- and insulin-receptor signalling
-
Holgado-Madruga, M., Emlet, D.R., Moscatello, D.K., Godwin, A.K., Wong, A.J. (1996) A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379: 560-564.
-
(1996)
Nature
, vol.379
, pp. 560-564
-
-
Holgado-Madruga, M.1
Emlet, D.R.2
Moscatello, D.K.3
Godwin, A.K.4
Wong, A.J.5
-
88
-
-
0032238298
-
Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
-
Gu, H., Pratt, J.C., Burakoff, S.J., Neel, B.G. (1998) Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol. Cell 2: 729-740.
-
(1998)
Mol. Cell
, vol.2
, pp. 729-740
-
-
Gu, H.1
Pratt, J.C.2
Burakoff, S.J.3
Neel, B.G.4
-
89
-
-
0031966041
-
LIM domains: Multiple roles as adapters and functional modifiers in protein interactions
-
Dawid, I.B., Breen, J.J., Toyama, R. (1998) LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Trends Genet. 14: 156-162.
-
(1998)
Trends Genet.
, vol.14
, pp. 156-162
-
-
Dawid, I.B.1
Breen, J.J.2
Toyama, R.3
-
90
-
-
16844380139
-
Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction
-
Novotny-Diermayr, V., Lin, B., Gu, L., Cao, X. (2005) Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction. J. Biol. Chem. 280: 12747-12757.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 12747-12757
-
-
Novotny-Diermayr, V.1
Lin, B.2
Gu, L.3
Cao, X.4
-
91
-
-
0032433499
-
Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130
-
Thiel, S., Dahmen, H., Martens, A., Muller-Newen, G., Schaper, F., Heinrich, P.C., Graeve, L. (1998) Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130. FEBS Lett. 441: 231-234.
-
(1998)
FEBS Lett.
, vol.441
, pp. 231-234
-
-
Thiel, S.1
Dahmen, H.2
Martens, A.3
Muller-Newen, G.4
Schaper, F.5
Heinrich, P.C.6
Graeve, L.7
-
92
-
-
0028305730
-
Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor
-
Dittrich, E., Rose-John, S., Gerhartz, C., Müllberg, J., Stoyan, T., Yasukawa, K., Heinrich, P.C., Graeve, L. (1994) Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor. J. Biol. Chem. 269: 19014-19020.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 19014-19020
-
-
Dittrich, E.1
Rose-John, S.2
Gerhartz, C.3
Müllberg, J.4
Stoyan, T.5
Yasukawa, K.6
Heinrich, P.C.7
Graeve, L.8
-
93
-
-
0032519717
-
Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway
-
Thiel, S., Behrmann, I., Dittrich, E., Muys, L., Tavernier, J., Wijdenes, J., Heinrich, P.C., Graeve, L. (1998) Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway. Biochem. J. 330: 47-54.
-
(1998)
Biochem. J.
, vol.330
, pp. 47-54
-
-
Thiel, S.1
Behrmann, I.2
Dittrich, E.3
Muys, L.4
Tavernier, J.5
Wijdenes, J.6
Heinrich, P.C.7
Graeve, L.8
-
94
-
-
0034698036
-
Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling
-
Gibson, R.M., Schiemann, W.P., Prichard, L.B., Reno, J.M., Ericsson, L.H., Nathanson, N.M. (2000) Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling. J. Biol. Chem. 275: 22574-22582.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 22574-22582
-
-
Gibson, R.M.1
Schiemann, W.P.2
Prichard, L.B.3
Reno, J.M.4
Ericsson, L.H.5
Nathanson, N.M.6
-
95
-
-
22844442807
-
Calmodulin-dependent protein kinases phosphorylate gp130 at the serine-based dileucine internalization motif
-
Gibson, R.M., Laszlo, G.S., Nathanson, N.M. (2005) Calmodulin-dependent protein kinases phosphorylate gp130 at the serine-based dileucine internalization motif. Biochim. Biophys. Acta 1714: 56-62.
-
(2005)
Biochim. Biophys. Acta
, vol.1714
, pp. 56-62
-
-
Gibson, R.M.1
Laszlo, G.S.2
Nathanson, N.M.3
-
96
-
-
0035905767
-
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
-
Irie-Sasaki, J., Sasaki, T., Matsumoto, W., Opavsky, A., Cheng, M., Welstead, G., Griffiths, E., Krawczyk, C., Richardson, C.D., Aitken, K., Iscove, N., Koretzky, G., Johnson, P., Liu, P., Rothstein, D.M., Penninger, J.M. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 409: 349-354.
-
(2001)
Nature
, vol.409
, pp. 349-354
-
-
Irie-Sasaki, J.1
Sasaki, T.2
Matsumoto, W.3
Opavsky, A.4
Cheng, M.5
Welstead, G.6
Griffiths, E.7
Krawczyk, C.8
Richardson, C.D.9
Aitken, K.10
Iscove, N.11
Koretzky, G.12
Johnson, P.13
Liu, P.14
Rothstein, D.M.15
Penninger, J.M.16
-
97
-
-
0035930501
-
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
-
Myers, M.P., Andersen, J.N., Cheng, A., Tremblay, M.L., Horvath, C.M., Parisien, J.P., Salmeen, A., Barford, D., Tonks, N.K. (2001) TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J. Biol. Chem. 276: 47771-47774.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47771-47774
-
-
Myers, M.P.1
Andersen, J.N.2
Cheng, A.3
Tremblay, M.L.4
Horvath, C.M.5
Parisien, J.P.6
Salmeen, A.7
Barford, D.8
Tonks, N.K.9
-
98
-
-
0034671546
-
A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b
-
Aoki, N., Matsuda, T. (2000) A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b. J. Biol. Chem. 275: 39718-39726.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39718-39726
-
-
Aoki, N.1
Matsuda, T.2
-
99
-
-
0034724677
-
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
-
Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P.C., Schaper, F. (2000) SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 275: 12848-12856.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12848-12856
-
-
Schmitz, J.1
Weissenbach, M.2
Haan, S.3
Heinrich, P.C.4
Schaper, F.5
-
100
-
-
0037162397
-
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities
-
De Souza, D., Fabri, L.J., Nash, A., Hilton, D.J., Nicola, N.A., Baca, M. (2002) SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry 41:9229-9236.
-
(2002)
Biochemistry
, vol.41
, pp. 9229-9236
-
-
De Souza, D.1
Fabri, L.J.2
Nash, A.3
Hilton, D.J.4
Nicola, N.A.5
Baca, M.6
-
101
-
-
0033555258
-
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
-
Nicholson, S.E., Willson, T.A., Parley, A., Starr, R., Zhang, J.G., Baca, M., Alexander, W.S., Metcalf, D., Hilton, D.J., Nicola, N.A. (1999) Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18: 375-385.
-
(1999)
EMBO J.
, vol.18
, pp. 375-385
-
-
Nicholson, S.E.1
Willson, T.A.2
Parley, A.3
Starr, R.4
Zhang, J.G.5
Baca, M.6
Alexander, W.S.7
Metcalf, D.8
Hilton, D.J.9
Nicola, N.A.10
-
102
-
-
0034612271
-
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
-
Nicholson, S.E., De Souza, D., Fabri, L.J., Corbin, J., Willson, T.A., Zhang, J.G., Silva, A., Asimakis, M., Farley, A., Nash, A.D., Metcalf, D., Hilton, D.J., Nicola, N.A., Baca, M. (2000) Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. U. S. A. 97: 6493-6498.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 6493-6498
-
-
Nicholson, S.E.1
De Souza, D.2
Fabri, L.J.3
Corbin, J.4
Willson, T.A.5
Zhang, J.G.6
Silva, A.7
Asimakis, M.8
Farley, A.9
Nash, A.D.10
Metcalf, D.11
Hilton, D.J.12
Nicola, N.A.13
Baca, M.14
-
103
-
-
0001903105
-
Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses
-
Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., Itoh, M., Okano, H., Hibi, M., Hirano, T. (2000) Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12: 95-105.
-
(2000)
Immunity
, vol.12
, pp. 95-105
-
-
Ohtani, T.1
Ishihara, K.2
Atsumi, T.3
Nishida, K.4
Kaneko, Y.5
Miyata, T.6
Itoh, S.7
Narimatsu, M.8
Maeda, H.9
Fukada, T.10
Itoh, M.11
Okano, H.12
Hibi, M.13
Hirano, T.14
-
104
-
-
0036796060
-
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated tre-foil gene activation in gp130 mutant mice
-
Tebbutt, N.C., Giraud, A.S., Inglese, M., Jenkins, B., Waring, P., Clay, F.J., Malki, S., Alderman, B.M., Grail, D., Hollande, F., Heath, J.K., Ernst, M. (2002) Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated tre-foil gene activation in gp130 mutant mice. Nat. Med. 8: 1089-1097.
-
(2002)
Nat. Med.
, vol.8
, pp. 1089-1097
-
-
Tebbutt, N.C.1
Giraud, A.S.2
Inglese, M.3
Jenkins, B.4
Waring, P.5
Clay, F.J.6
Malki, S.7
Alderman, B.M.8
Grail, D.9
Hollande, F.10
Heath, J.K.11
Ernst, M.12
-
105
-
-
18244383058
-
The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis
-
Jenkins, B.J., Roberts, A.W., Najdovska, M., Grail, D., Ernst, M. (2005) The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis. Blood 105: 3512-3520.
-
(2005)
Blood
, vol.105
, pp. 3512-3520
-
-
Jenkins, B.J.1
Roberts, A.W.2
Najdovska, M.3
Grail, D.4
Ernst, M.5
-
106
-
-
0035898315
-
Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation
-
Ernst, M., Inglese, M., Waring, P., Campbell, I.K., Bao, S., Clay, F.J., Alexander, W.S., Wicks, I.P., Tarlinton, D.M., Novak, U., Heath, J.K., Dunn, A.R. (2001) Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J. Exp. Med. 194: 189-203.
-
(2001)
J. Exp. Med.
, vol.194
, pp. 189-203
-
-
Ernst, M.1
Inglese, M.2
Waring, P.3
Campbell, I.K.4
Bao, S.5
Clay, F.J.6
Alexander, W.S.7
Wicks, I.P.8
Tarlinton, D.M.9
Novak, U.10
Heath, J.K.11
Dunn, A.R.12
-
107
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signalling
-
Starr, R., Willsonm, TA., Viney, E.M., Murray, L.J., Rayner, J.R., Jenkins, B.J., Gonda, T.J., Alexander, W.S., Metcalf, D., Nicola, N.A., Hilton, D.J. (1997) A family of cytokine-inducible inhibitors of signalling. Nature 387: 917-921.
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
Willsonm, T.A.2
Viney, E.M.3
Murray, L.J.4
Rayner, J.R.5
Jenkins, B.J.6
Gonda, T.J.7
Alexander, W.S.8
Metcalf, D.9
Nicola, N.A.10
Hilton, D.J.11
-
108
-
-
0037938816
-
SOCS3 negatively regulates IL-6 signaling in vivo
-
Croker, B.A., Krebs, D.L., Zhang, J.G., Wormald, S., Willson, TA., Stanley, E.G., Robb, L., Greenhalgh, C.J., Forster, I., Clausen, B.E., Nicola, N.A., Metcalf, D., Hilton, D.J., Roberts, A.W., Alexander, W.S. (2003) SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol. 4: 540-545.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 540-545
-
-
Croker, B.A.1
Krebs, D.L.2
Zhang, J.G.3
Wormald, S.4
Willson, T.A.5
Stanley, E.G.6
Robb, L.7
Greenhalgh, C.J.8
Forster, I.9
Clausen, B.E.10
Nicola, N.A.11
Metcalf, D.12
Hilton, D.J.13
Roberts, A.W.14
Alexander, W.S.15
-
109
-
-
0037600741
-
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
-
Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Kanada, T., Takeda, K., Akira, S., Hoshijima, M., Hirano, T., Chien, K.R., Yoshimura, A. (2003) IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat. Immunol. 4: 551-556.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 551-556
-
-
Yasukawa, H.1
Ohishi, M.2
Mori, H.3
Murakami, M.4
Chinen, T.5
Aki, D.6
Kanada, T.7
Takeda, K.8
Akira, S.9
Hoshijima, M.10
Hirano, T.11
Chien, K.R.12
Yoshimura, A.13
-
110
-
-
33646581368
-
Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumour necrosis factor alpha and nitric oxide production by macrophages
-
Qasimi, P., Ming-Lum, A., Ghanipour, A., Ong, C.J., Cox, M.E., Ihle, J., Cacalano, N., Yoshimura, A., Mui, A.L. (2005) Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumour necrosis factor alpha and nitric oxide production by macrophages. J. Biol. Chem. 281: 6316-6324.
-
(2005)
J. Biol. Chem.
, vol.281
, pp. 6316-6324
-
-
Qasimi, P.1
Ming-Lum, A.2
Ghanipour, A.3
Ong, C.J.4
Cox, M.E.5
Ihle, J.6
Cacalano, N.7
Yoshimura, A.8
Mui, A.L.9
-
111
-
-
24744466507
-
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases
-
Sommer, U., Schmid, C., Sobota, R.M., Lehmann, U., Stevenson, N.J., Johnston, J.A., Schaper, F., Heinrich, P.C., Haan, S. (2005) Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases. J. Biol. Chem. 280: 31478-31478.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31478-31478
-
-
Sommer, U.1
Schmid, C.2
Sobota, R.M.3
Lehmann, U.4
Stevenson, N.J.5
Johnston, J.A.6
Schaper, F.7
Heinrich, P.C.8
Haan, S.9
-
112
-
-
0042357098
-
Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation
-
Haan, S., Ferguson, P., Sommer, U., Hiremath, M., McVicar, D.W., Heinrich, P.C., Johnston, J.A., Cacalano, N.A. (2003) Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. J. Biol. Chem. 278: 31972-31979.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31972-31979
-
-
Haan, S.1
Ferguson, P.2
Sommer, U.3
Hiremath, M.4
McVicar, D.W.5
Heinrich, P.C.6
Johnston, J.A.7
Cacalano, N.A.8
-
113
-
-
13044263097
-
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
-
Zhang, J.G., Farley, A., Nicholson, S.E., Willson, T.A., Zugaro, L.M., Simpson, R.J., Moritz, R.L., Cary, D., Richardson, R., Hausmann, G., Kile, B.J., Kent, S.B., Alexander, W.S., Metcalf, D., Hilton, D.J., Nicola, N.A., Baca, M. (1999) The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. U. S. A. 96: 2071-2076.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 2071-2076
-
-
Zhang, J.G.1
Farley, A.2
Nicholson, S.E.3
Willson, T.A.4
Zugaro, L.M.5
Simpson, R.J.6
Moritz, R.L.7
Cary, D.8
Richardson, R.9
Hausmann, G.10
Kile, B.J.11
Kent, S.B.12
Alexander, W.S.13
Metcalf, D.14
Hilton, D.J.15
Nicola, N.A.16
Baca, M.17
-
114
-
-
0035918239
-
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2
-
Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Hatakeyama, S., Yada, M., Morita, S., Kitamura, T., Kato, H., Nakayama, K., Yoshimura, A. (2001) The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J. Biol. Chem. 276: 12530-12538.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 12530-12538
-
-
Kamizono, S.1
Hanada, T.2
Yasukawa, H.3
Minoguchi, S.4
Kato, R.5
Minoguchi, M.6
Hattori, K.7
Hatakeyama, S.8
Yada, M.9
Morita, S.10
Kitamura, T.11
Kato, H.12
Nakayama, K.13
Yoshimura, A.14
-
115
-
-
0030725378
-
Specific inhibition of Stat3 signal transduction by PIAS3
-
Chung, C.D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., Shuai, K. (1997) Specific inhibition of Stat3 signal transduction by PIAS3. Science 278: 1803-1805.
-
(1997)
Science
, vol.278
, pp. 1803-1805
-
-
Chung, C.D.1
Liao, J.2
Liu, B.3
Rao, X.4
Jay, P.5
Berta, P.6
Shuai, K.7
-
116
-
-
0032169599
-
Inhibition of Stat1-mediated gene activation by PIAS1
-
Liu, B., Liao, J., Rao, X., Kushner, S.A., Chung, C.D., Chang, D.D., Shuai, K. (1998) Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. U. S. A. 95: 10626-10631.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 10626-10631
-
-
Liu, B.1
Liao, J.2
Rao, X.3
Kushner, S.A.4
Chung, C.D.5
Chang, D.D.6
Shuai, K.7
-
117
-
-
0035853098
-
Atranscriptional corepressor of Stat1 with an essential LXXLL signature motif
-
Liu, B., Gross, M., ten Hoeve, J., Shuai, K. (2001) Atranscriptional corepressor of Stat1 with an essential LXXLL signature motif. Proc. Natl. Acad. Sci. U. S. A. 98: 3203-3207.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 3203-3207
-
-
Liu, B.1
Gross, M.2
Ten Hoeve, J.3
Shuai, K.4
-
118
-
-
23444461182
-
Regulation of gene-activation pathways by PIAS proteins in the immune system
-
Shuai, K., Liu, B. (2005) Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol. 5: 593-603.
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 593-603
-
-
Shuai, K.1
Liu, B.2
-
119
-
-
10044251281
-
Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes
-
Sonnenblick, A., Levy, C., Razin, E. (2004) Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes. Mol. Cell. Biol. 24: 10584-10592.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 10584-10592
-
-
Sonnenblick, A.1
Levy, C.2
Razin, E.3
-
120
-
-
33645500772
-
Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3
-
Levy, C., Lee, Y.N., Nechushtan, H., Schueler-Furman, O., Sonnenblick, A., Hacohen, S., Razin, E. (2005) Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3. Blood 107: 2839-2845.
-
(2005)
Blood
, vol.107
, pp. 2839-2845
-
-
Levy, C.1
Lee, Y.N.2
Nechushtan, H.3
Schueler-Furman, O.4
Sonnenblick, A.5
Hacohen, S.6
Razin, E.7
-
121
-
-
20444476625
-
SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling
-
Tanaka, T., Soriano, M.A., Grusby, M.J. (2005) SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity 22: 729-736.
-
(2005)
Immunity
, vol.22
, pp. 729-736
-
-
Tanaka, T.1
Soriano, M.A.2
Grusby, M.J.3
-
122
-
-
0022499547
-
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
-
Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S., Nakajima, K., Koyama, K., Iwamatsu, A., Tsunasawa, S., Sakiyama, F., Matsui, H., Takahara, Y., Taniguchi, T., Kishimoto, T. (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73-76.
-
(1986)
Nature
, vol.324
, pp. 73-76
-
-
Hirano, T.1
Yasukawa, K.2
Harada, H.3
Taga, T.4
Watanabe, Y.5
Matsuda, T.6
Kashiwamura, S.7
Nakajima, K.8
Koyama, K.9
Iwamatsu, A.10
Tsunasawa, S.11
Sakiyama, F.12
Matsui, H.13
Takahara, Y.14
Taniguchi, T.15
Kishimoto, T.16
-
123
-
-
0345317621
-
IgG1 plasmacytosis in interleukin 6 transgenic mice
-
Suematsu, S., Matsuda, T., Aozasa, K., Akira, S., Nakano, N., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., Kishimoto, T. (1989) IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 86: 7547-7551.
-
(1989)
Proc. Natl. Acad. Sci. U. S. A.
, vol.86
, pp. 7547-7551
-
-
Suematsu, S.1
Matsuda, T.2
Aozasa, K.3
Akira, S.4
Nakano, N.5
Ohno, S.6
Miyazaki, J.7
Yamamura, K.8
Hirano, T.9
Kishimoto, T.10
-
124
-
-
0023849455
-
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
-
Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., Kuramoto, A., Kishimoto, T. (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332: 83-85.
-
(1988)
Nature
, vol.332
, pp. 83-85
-
-
Kawano, M.1
Hirano, T.2
Matsuda, T.3
Taga, T.4
Horii, Y.5
Iwato, K.6
Asaoku, H.7
Tang, B.8
Tanabe, O.9
Tanaka, H.10
Kuramoto, A.11
Kishimoto, T.12
-
125
-
-
19644389279
-
Interleukin-6 supports the maintenance of p53 tumor suppressor gene promoter methylation
-
Hodge, D.R., Peng, B., Cherry, J.C., Hurt, E.M., Fox, S.D., Kelley, J.A., Munroe, D.J., Farrar, W.L. (2005) Interleukin-6 supports the maintenance of p53 tumor suppressor gene promoter methylation. Cancer Res. 65: 4673-4682.
-
(2005)
Cancer Res.
, vol.65
, pp. 4673-4682
-
-
Hodge, D.R.1
Peng, B.2
Cherry, J.C.3
Hurt, E.M.4
Fox, S.D.5
Kelley, J.A.6
Munroe, D.J.7
Farrar, W.L.8
-
126
-
-
0032125757
-
Interleukin-6 induced inhibition of multiple myeloma cell apoptosis: Support for the hypothesis that protection is mediated via inhibition of the JNK/SAPK pathway
-
Xu, F.H., Sharma, S., Gardner, A., al, e. (1998) Interleukin-6 induced inhibition of multiple myeloma cell apoptosis: support for the hypothesis that protection is mediated via inhibition of the JNK/SAPK pathway. Blood 92: 241-251.
-
(1998)
Blood
, vol.92
, pp. 241-251
-
-
Xu, F.H.1
Sharma, S.2
Gardner, A.3
-
127
-
-
0027133422
-
Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion
-
Uchiyama, H., Barut, B.A., Mohrbacher, A.F., Chauhan, D., Anderson, K.C. (1993) Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. Blood 82: 3712-3720.
-
(1993)
Blood
, vol.82
, pp. 3712-3720
-
-
Uchiyama, H.1
Barut, B.A.2
Mohrbacher, A.F.3
Chauhan, D.4
Anderson, K.C.5
-
128
-
-
0037064550
-
The role of transsignalling via the agonistic soluble IL-6 receptor
-
Kallen, K.-J. (2002) The role of transsignalling via the agonistic soluble IL-6 receptor. Biochim. Biophys. Acta 1592: 323-343.
-
(2002)
Biochim. Biophys. Acta
, vol.1592
, pp. 323-343
-
-
Kallen, K.-J.1
-
129
-
-
9044222888
-
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders
-
Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Hirata, M., Yamagami, T., Nakahata, T., Hirabayashi, T., Yoneda, Y., Tanaka, K., Wang, W.Z., Mori, C., Shiota, K., Yoshida, N., Kishimoto, T. (1996) Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. U. S. A. 93: 407-411.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 407-411
-
-
Yoshida, K.1
Taga, T.2
Saito, M.3
Suematsu, S.4
Kumanogoh, A.5
Tanaka, T.6
Fujiwara, H.7
Hirata, M.8
Yamagami, T.9
Nakahata, T.10
Hirabayashi, T.11
Yoneda, Y.12
Tanaka, K.13
Wang, W.Z.14
Mori, C.15
Shiota, K.16
Yoshida, N.17
Kishimoto, T.18
-
130
-
-
0032076183
-
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
-
Rodig, S.J., Meraz, M.A., White, J.M., Lampe, P.A., Riley, J.K., Arthur, C.D., King, K.L., Sheehan, K.C., Yin, L., Pennica, D., Johnson, E.M.J., Schreiber, R.D. (1998) Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93: 373-383.
-
(1998)
Cell
, vol.93
, pp. 373-383
-
-
Rodig, S.J.1
Meraz, M.A.2
White, J.M.3
Lampe, P.A.4
Riley, J.K.5
Arthur, C.D.6
King, K.L.7
Sheehan, K.C.8
Yin, L.9
Pennica, D.10
Johnson, E.M.J.11
Schreiber, R.D.12
-
131
-
-
0030935260
-
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
-
Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., Akira, S. (1997) Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. U. S. A. 94: 3801-3804.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 3801-3804
-
-
Takeda, K.1
Noguchi, K.2
Shi, W.3
Tanaka, T.4
Matsumoto, M.5
Yoshida, N.6
Kishimoto, T.7
Akira, S.8
-
132
-
-
0035979275
-
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
-
Roberts, A.W., Robb, L., Rakar, S., Hartley, L., Cluse, L., Nicola, N.A., Metcalf, D., Hilton, D.J., Alexander, W.S. (2001) Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc. Natl. Acad. Sci. U. S. A. 98: 9324-9329.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 9324-9329
-
-
Roberts, A.W.1
Robb, L.2
Rakar, S.3
Hartley, L.4
Cluse, L.5
Nicola, N.A.6
Metcalf, D.7
Hilton, D.J.8
Alexander, W.S.9
-
133
-
-
0032539008
-
Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects
-
Betz, U.A.K., Bloch, W., van den Broek, M., Yoshida, K., Taga, T., Kishimoto, T., Addicks, K., Rajewsky, K., Muller, W. (1998) Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J. Exp. Med. 188: 1955-1965.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1955-1965
-
-
Betz, U.A.K.1
Bloch, W.2
Van Den Broek, M.3
Yoshida, K.4
Taga, T.5
Kishimoto, T.6
Addicks, K.7
Rajewsky, K.8
Muller, W.9
-
134
-
-
28844476756
-
Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells
-
Yao, L., Yokota, T., Xia, L., Kincade, P.W., McEver, R.P. (2005) Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells. Blood 106: 4093-4101.
-
(2005)
Blood
, vol.106
, pp. 4093-4101
-
-
Yao, L.1
Yokota, T.2
Xia, L.3
Kincade, P.W.4
McEver, R.P.5
-
135
-
-
0028675983
-
Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system
-
Bernad, A., Kopf, M., Kulbacki, R., Weich, N., Koehler, G., Gutierrez Ramos, J.C. (1994) Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. Immunity 1: 725-731.
-
(1994)
Immunity
, vol.1
, pp. 725-731
-
-
Bernad, A.1
Kopf, M.2
Kulbacki, R.3
Weich, N.4
Koehler, G.5
Gutierrez Ramos, J.C.6
-
136
-
-
0028266906
-
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion
-
Poli, V., Balena, R., Fattori, E., Markatos, A., Yamamoto, M., Tanaka, H., Ciliberto, G., Rodan, G.A., Costantini, F. (1994) Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 13: 1189-1196.
-
(1994)
EMBO J.
, vol.13
, pp. 1189-1196
-
-
Poli, V.1
Balena, R.2
Fattori, E.3
Markatos, A.4
Yamamoto, M.5
Tanaka, H.6
Ciliberto, G.7
Rodan, G.A.8
Costantini, F.9
-
137
-
-
0029846756
-
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
-
Cressman, D.E., Greenbaum, L.E., DeAngelis, R.A., Ciliberto, G., Furth, E.E., Poli, V., Taub, R. (1996) Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274: 1379-1383.
-
(1996)
Science
, vol.274
, pp. 1379-1383
-
-
Cressman, D.E.1
Greenbaum, L.E.2
Deangelis, R.A.3
Ciliberto, G.4
Furth, E.E.5
Poli, V.6
Taub, R.7
-
138
-
-
0028328436
-
Impaired immune and acute-phase responses in interleukin-6-deficient mice
-
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., Kohler, G. (1994) Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368: 339-342.
-
(1994)
Nature
, vol.368
, pp. 339-342
-
-
Kopf, M.1
Baumann, H.2
Freer, G.3
Freudenberg, M.4
Lamers, M.5
Kishimoto, T.6
Zinkernagel, R.7
Bluethmann, H.8
Kohler, G.9
-
139
-
-
0027984754
-
Defective inflammatory response in interleukin 6-deficient mice
-
Fattori, E., Cappelletti, M., Costa, P., Sellitto, C., Cantoni, L., Carelli, M., Faggioni, R., Fantuzzi, G., Ghezzi, P., Poli, V. (1994) Defective inflammatory response in interleukin 6-deficient mice. J. Exp. Med. 180: 1243-1250.
-
(1994)
J. Exp. Med.
, vol.180
, pp. 1243-1250
-
-
Fattori, E.1
Cappelletti, M.2
Costa, P.3
Sellitto, C.4
Cantoni, L.5
Carelli, M.6
Faggioni, R.7
Fantuzzi, G.8
Ghezzi, P.9
Poli, V.10
-
140
-
-
0034658698
-
STATs in oncogenesis
-
Bowman, T., Garcia, R., Turkson, J., Jove, R. (2000) STATs in oncogenesis. Oncogene 19: 2474-2488.
-
(2000)
Oncogene
, vol.19
, pp. 2474-2488
-
-
Bowman, T.1
Garcia, R.2
Turkson, J.3
Jove, R.4
-
141
-
-
0033529704
-
Stat3 as an oncogene
-
Bromberg, J.F., Wrzeszczynska, M.H., Devgan, G., Zhao, Y., Pestell, R.G.,
-
(1999)
Cell
, vol.98
, pp. 295-303
-
-
Bromberg, J.F.1
Wrzeszczynska, M.H.2
Devgan, G.3
Zhao, Y.4
Pestell, R.G.5
Albanese, C.6
Darnell, J.E.J.7
-
142
-
-
4944239032
-
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
-
Chan, K.S., Sano, S., Kiguchi, K., Anders, J., Komazawa, N., Takeda, J., DiGiovanni, J. (2004) Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J. Clin. Invest. 114: 720-728.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 720-728
-
-
Chan, K.S.1
Sano, S.2
Kiguchi, K.3
Anders, J.4
Komazawa, N.5
Takeda, J.6
Digiovanni, J.7
-
143
-
-
20944435271
-
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
-
Chiarle, R., Simmons, W.J., Cai, H., Dhall, G., Zamo, A., Raz, R., Karras, J.G., Levy, D.E., Inghirami, G. (2005) Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat. Med. 11: 623-629.
-
(2005)
Nat. Med.
, vol.11
, pp. 623-629
-
-
Chiarle, R.1
Simmons, W.J.2
Cai, H.3
Dhall, G.4
Zamo, A.5
Raz, R.6
Karras, J.G.7
Levy, D.E.8
Inghirami, G.9
-
144
-
-
0023432812
-
Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
-
Gauldie, J., Richards, C., Harnish, D., Lansdorp, P., Baumann, H. (1987) Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. U. S. A. 84: 7251-7255.
-
(1987)
Proc. Natl. Acad. Sci. U. S. A.
, vol.84
, pp. 7251-7255
-
-
Gauldie, J.1
Richards, C.2
Harnish, D.3
Lansdorp, P.4
Baumann, H.5
-
145
-
-
0023262644
-
Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-beta 2) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells
-
Andus, T., Geiger, T., Hirano, T., Northoff, H., Ganter, U., Bauer, J., Kishimoto, T., Heinrich, P.C. (1987) Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-beta 2) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells. FEBS Lett. 221: 18-22.
-
(1987)
FEBS Lett.
, vol.221
, pp. 18-22
-
-
Andus, T.1
Geiger, T.2
Hirano, T.3
Northoff, H.4
Ganter, U.5
Bauer, J.6
Kishimoto, T.7
Heinrich, P.C.8
-
146
-
-
0032190524
-
Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver
-
Maione, D., Di Carlo, E., Li, W., Musiani, P., Modesti, A., Peters, M., Rose-John, S., Della Rocca, C., Tripodi, M., Lazzaro, D., Taub, R., Savino, R., Ciliberto, G. (1998) Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J. 17: 5588-5597.
-
(1998)
EMBO J.
, vol.17
, pp. 5588-5597
-
-
Maione, D.1
Di Carlo, E.2
Li, W.3
Musiani, P.4
Modesti, A.5
Peters, M.6
Rose-John, S.7
Della Rocca, C.8
Tripodi, M.9
Lazzaro, D.10
Taub, R.11
Savino, R.12
Ciliberto, G.13
-
147
-
-
0031858640
-
Hepatocellular hyperplasia, plasmacytoma formation, and extracellular hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice
-
Schirmacher, P., Peters, M., Ciliberto, G., Fattori, E., Lotz, J., Meyer zum Büschenfelde, K.H., Rose-John, S. (1998) Hepatocellular Hyperplasia, Plasmacytoma Formation, and Extracellular Hematopoiesis in Interleukin (IL)-6/Soluble IL-6 Receptor Double-Transgenic Mice. Am. J. Pathol. 153: 639-648.
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 639-648
-
-
Schirmacher, P.1
Peters, M.2
Ciliberto, G.3
Fattori, E.4
Lotz, J.5
Meyer Zum Büschenfelde, K.H.6
Rose-John, S.7
-
148
-
-
0028331014
-
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice
-
Fattori, E., Della Rocca, C., Costa, P., Giorgio, M., Dente, B., Pozzi, L., Ciliberto, G. (1994) Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice. Blood 83: 2570-2579.
-
(1994)
Blood
, vol.83
, pp. 2570-2579
-
-
Fattori, E.1
Della Rocca, C.2
Costa, P.3
Giorgio, M.4
Dente, B.5
Pozzi, L.6
Ciliberto, G.7
-
149
-
-
0030929261
-
Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice
-
Lattanzio, G., Libert, C., Aquilina, M., Cappelletti, M., Ciliberto, G., Musiani, P., Poli, V. (1997) Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice. Am. J. Pathol. 151: 689-696.
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 689-696
-
-
Lattanzio, G.1
Libert, C.2
Aquilina, M.3
Cappelletti, M.4
Ciliberto, G.5
Musiani, P.6
Poli, V.7
-
150
-
-
0024269961
-
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
-
Hirano, T., Matsuda, T., Turner, M., Miyasaka, N., Buchan, G., Tang, B., Sato, K., Shimizu, M., Maini, R., Feldmann, M., Kishimoto, T. (1988) Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18: 1797-1801.
-
(1988)
Eur. J. Immunol.
, vol.18
, pp. 1797-1801
-
-
Hirano, T.1
Matsuda, T.2
Turner, M.3
Miyasaka, N.4
Buchan, G.5
Tang, B.6
Sato, K.7
Shimizu, M.8
Maini, R.9
Feldmann, M.10
Kishimoto, T.11
-
151
-
-
0024459013
-
Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease
-
Yoshizaki, K., Matsuda, T., Nishimoto, N., Kuritani, T., Taeho, L., Aozasa, K., Nakahata, T., Kawai, H., Tagoh, H., Komori, T. (1989) Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74: 1360-1367.
-
(1989)
Blood
, vol.74
, pp. 1360-1367
-
-
Yoshizaki, K.1
Matsuda, T.2
Nishimoto, N.3
Kuritani, T.4
Taeho, L.5
Aozasa, K.6
Nakahata, T.7
Kawai, H.8
Tagoh, H.9
Komori, T.10
-
152
-
-
0032536542
-
Interleukin 6 is required for the development of collagen-induced arthritis
-
Alonzi, T., Fattori, E., Lazzaro, D., Costa, P., Probert, L., Kollias, G., De Benedetti, F., Poli, V., Ciliberto, G. (1998) Interleukin 6 is required for the development of collagen-induced arthritis. J. Exp. Med. 187: 461-468.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 461-468
-
-
Alonzi, T.1
Fattori, E.2
Lazzaro, D.3
Costa, P.4
Probert, L.5
Kollias, G.6
De Benedetti, F.7
Poli, V.8
Ciliberto, G.9
-
153
-
-
13144259627
-
Interleukin 6 plays a key role in the development of antigen-induced arthritis
-
Ohshima, S., Saeki, Y., Mima, T., Sasai, M., Nishioka, K., Nomura, S., Kopf, M., Katada, Y., Tanaka, T., Suemura, M., Kishimoto, T. (1998) Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl. Acad. Sci. U. S. A. 95: 8222-8226.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 8222-8226
-
-
Ohshima, S.1
Saeki, Y.2
Mima, T.3
Sasai, M.4
Nishioka, K.5
Nomura, S.6
Kopf, M.7
Katada, Y.8
Tanaka, T.9
Suemura, M.10
Kishimoto, T.11
-
154
-
-
18344410191
-
Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of the antiapoptotic resistance of lamina propria T cells
-
Atreya, R., Mudter, J., Finotto, S., Müllberg, J., Jostock, T., Wirtz, S., Schütz, M., Bartsch, B., Holtmann, M., Becker, C., Strand, D., Czaja, J., Schlaak, J.F., Lehr, H.A., Autschbach, F., Schürmann, G., Nishimoto, N., Yoshizaki, K., Ito, H., Kishimoto, T., Galle, P.R., Rose-John, S., Neurath, M.F. (2000) Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of the antiapoptotic resistance of lamina propria T cells. Nat. Med. 6: 583-588.
-
(2000)
Nat. Med.
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Müllberg, J.4
Jostock, T.5
Wirtz, S.6
Schütz, M.7
Bartsch, B.8
Holtmann, M.9
Becker, C.10
Strand, D.11
Czaja, J.12
Schlaak, J.F.13
Lehr, H.A.14
Autschbach, F.15
Schürmann, G.16
Nishimoto, N.17
Yoshizaki, K.18
Ito, H.19
Kishimoto, T.20
Galle, P.R.21
Rose-John, S.22
Neurath, M.F.23
more..
-
155
-
-
0042834261
-
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: Blockade of arthritis severity by soluble glycoprotein 130
-
Nowell, M.A., Richards, P.J., Horiuchi, S., Yamamoto, N., Rose-John, S., Topley, N., Williams, A.S., Jones, S.A. (2003) Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J. Immunol. 171: 3202 -3209.
-
(2003)
J. Immunol.
, vol.171
, pp. 3202-3209
-
-
Nowell, M.A.1
Richards, P.J.2
Horiuchi, S.3
Yamamoto, N.4
Rose-John, S.5
Topley, N.6
Williams, A.S.7
Jones, S.A.8
-
156
-
-
0031861643
-
IL-6 receptor blockage inhibits the onset of autoimmune kidney disease in NZB/W F1 mice
-
Mihara, M., Takagi, N., Takeda, Y., Ohsugi, Y. (1998) IL-6 receptor blockage inhibits the onset of autoimmune kidney disease in NZB/W F1 mice. Clin Exp Immunol 112: 397-402.
-
(1998)
Clin Exp Immunol
, vol.112
, pp. 397-402
-
-
Mihara, M.1
Takagi, N.2
Takeda, Y.3
Ohsugi, Y.4
-
157
-
-
0032429668
-
Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
-
Takagi, M., Mihara, M., Moriya, Y., Nishimoto, N., Yoshizaki, K., Kishimoto, T., Takeda, Y., Ohsugi, Y. (1998) Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum. 41: 2117-2121.
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 2117-2121
-
-
Takagi, M.1
Mihara, M.2
Moriya, Y.3
Nishimoto, N.4
Yoshizaki, K.5
Kishimoto, T.6
Takeda, Y.7
Ohsugi, Y.8
-
158
-
-
0031856408
-
IL-6 functions in cynomolgus monkeys blocked by a humanized antibody to human IL-6 receptor
-
Imazeki, I., Saito, H., Hasegawa, M., Shinkura, H., Kishimoto, T., Ohsugi, Y. (1998) IL-6 functions in cynomolgus monkeys blocked by a humanized antibody to human IL-6 receptor. Int. J. Immunopharmacol. 20: 345-357.
-
(1998)
Int. J. Immunopharmacol.
, vol.20
, pp. 345-357
-
-
Imazeki, I.1
Saito, H.2
Hasegawa, M.3
Shinkura, H.4
Kishimoto, T.5
Ohsugi, Y.6
-
159
-
-
0037064550
-
The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases
-
Kallen, K.-J. (2002) The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases. Biochim. Biophys. Acta 1592: 323-343.
-
(2002)
Biochim. Biophys. Acta
, vol.1592
, pp. 323-343
-
-
Kallen, K.-J.1
-
160
-
-
9144220760
-
Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress
-
Chen, Q., Wang, W.C., Bruce, R., Li, H., Schleider, D.M., Mulbury, M.J., Bain, M.D., Wallace, P.K., Baumann, H., Evans, S.S. (2004) Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress. Immunity 20: 59-70.
-
(2004)
Immunity
, vol.20
, pp. 59-70
-
-
Chen, Q.1
Wang, W.C.2
Bruce, R.3
Li, H.4
Schleider, D.M.5
Mulbury, M.J.6
Bain, M.D.7
Wallace, P.K.8
Baumann, H.9
Evans, S.S.10
-
161
-
-
0027402917
-
Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody
-
Wendling, D., Racadot, E., Wijdenes, J. (1993) Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J. Rheumatol. 20: 259-262.
-
(1993)
J. Rheumatol.
, vol.20
, pp. 259-262
-
-
Wendling, D.1
Racadot, E.2
Wijdenes, J.3
-
162
-
-
0031787640
-
Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody
-
Yoshizaki, K., Nishimoto, N., Mihara, M., Kishimoto, T. (1998) Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody. Springer Semin. Immunopathol. 20: 247-259.
-
(1998)
Springer Semin. Immunopathol.
, vol.20
, pp. 247-259
-
-
Yoshizaki, K.1
Nishimoto, N.2
Mihara, M.3
Kishimoto, T.4
-
163
-
-
0036899812
-
Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial
-
Choy, E.H., Isenberg, D.A., Garrood, T., Farrow, S., Ioannou, Y., Bird, H., Cheung, N., Williams, B., Hazleman, B., Price, R., Yoshizaki, K., Nishimoto, N., Kishimoto, T., Panayi, G.S. (2002) Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum. 46: 3143-3150.
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 3143-3150
-
-
Choy, E.H.1
Isenberg, D.A.2
Garrood, T.3
Farrow, S.4
Ioannou, Y.5
Bird, H.6
Cheung, N.7
Williams, B.8
Hazleman, B.9
Price, R.10
Yoshizaki, K.11
Nishimoto, N.12
Kishimoto, T.13
Panayi, G.S.14
-
164
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
-
Ito, H., Takazoe, M., Fukuda, Y., Hibi, T., Kusugami, K., Andoh, A., Matsumoto, T., Yamamura, T., Azuma, J., Nishimoto, N., Yoshizaki, K., Shimoyama, T., Kishimoto, T. (2004) A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterol. 126: 989-996.
-
(2004)
Gastroenterol.
, vol.126
, pp. 989-996
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
Hibi, T.4
Kusugami, K.5
Andoh, A.6
Matsumoto, T.7
Yamamura, T.8
Azuma, J.9
Nishimoto, N.10
Yoshizaki, K.11
Shimoyama, T.12
Kishimoto, T.13
-
165
-
-
27144488346
-
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
-
Nishimoto, N., Kanakura, Y., Aozasa, K., Johkoh, T., Nakamura, M., Nakano, S., Nakano, N., Ikeda, Y., Sasaki, T., Nishioka, K., Hara, M., Taguchi, H., Kimura, Y., Kato, Y., Asaoku, H., Kumagai, S., Kodama, F., Nakahara, H., Hagihara, K., Yoshizaki, K., Kishimoto, T. (2005) Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 106: 2627-2632.
-
(2005)
Blood
, vol.106
, pp. 2627-2632
-
-
Nishimoto, N.1
Kanakura, Y.2
Aozasa, K.3
Johkoh, T.4
Nakamura, M.5
Nakano, S.6
Nakano, N.7
Ikeda, Y.8
Sasaki, T.9
Nishioka, K.10
Hara, M.11
Taguchi, H.12
Kimura, Y.13
Kato, Y.14
Asaoku, H.15
Kumagai, S.16
Kodama, F.17
Nakahara, H.18
Hagihara, K.19
Yoshizaki, K.20
Kishimoto, T.21
more..
-
166
-
-
23944483417
-
IL-6: From laboratory to bedside
-
Kishimoto, T. (2005) IL-6: from laboratory to bedside. Clin. Rev. Allergy Immunol. 28: 177-186.
-
(2005)
Clin. Rev. Allergy Immunol.
, vol.28
, pp. 177-186
-
-
Kishimoto, T.1
-
167
-
-
0009683219
-
Recent progress of the research on novel microbial metabolites
-
Omura, S., Hayashi, M., Tornado, H. (1999) Recent progress of the research on novel microbial metabolites. Pure Appl. Chem. 71: 1673-1681.
-
(1999)
Pure Appl. Chem.
, vol.71
, pp. 1673-1681
-
-
Omura, S.1
Hayashi, M.2
Tornado, H.3
-
168
-
-
23844536752
-
Binding of madindoline a to the extracellular domain of gp130
-
Saleh, A.Z., Greenman, K.L., Billings, S., Van Vranken, D.L., Krolewski, J.J. (2005) Binding of madindoline A to the extracellular domain of gp130. Biochemistry 44: 10822-10827.
-
(2005)
Biochemistry
, vol.44
, pp. 10822-10827
-
-
Saleh, A.Z.1
Greenman, K.L.2
Billings, S.3
Van Vranken, D.L.4
Krolewski, J.J.5
-
169
-
-
21144455334
-
A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth
-
Su, J.L., Lai, K.P., Chen, C.A., Yang, C.Y., Chen, P.S., Chang, C.C., Chou, C.H., Hu, C.L., Kuo, M.L., Hsieh, C.Y., Wei, LH. (2005) A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth. Cancer Res. 65: 4827-4835.
-
(2005)
Cancer Res.
, vol.65
, pp. 4827-4835
-
-
Su, J.L.1
Lai, K.P.2
Chen, C.A.3
Yang, C.Y.4
Chen, P.S.5
Chang, C.C.6
Chou, C.H.7
Hu, C.L.8
Kuo, M.L.9
Hsieh, C.Y.10
Wei, L.H.11
-
170
-
-
0029084805
-
Interleukin-6 family of cytokines and gp130
-
Kishimoto, T., Akira, S., Narazaki, M., Taga, T. (1995) Interleukin-6 family of cytokines and gp130. Blood 86: 1243-1254.
-
(1995)
Blood
, vol.86
, pp. 1243-1254
-
-
Kishimoto, T.1
Akira, S.2
Narazaki, M.3
Taga, T.4
-
171
-
-
0034960582
-
Control of leukocyte infiltration during inflammation: IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment
-
Hurst, S.M., Wilkinson, T.S., McLoughlin, R.M., Jones, S., Horiuchi, S., Yamamoto, N., Rose-John, S., Fuller, G.M., Topley, N., Jones, S.A. (2001) Control of leukocyte infiltration during inflammation: IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment. Immunity 14: 705-714.
-
(2001)
Immunity
, vol.14
, pp. 705-714
-
-
Hurst, S.M.1
Wilkinson, T.S.2
McLoughlin, R.M.3
Jones, S.4
Horiuchi, S.5
Yamamoto, N.6
Rose-John, S.7
Fuller, G.M.8
Topley, N.9
Jones, S.A.10
-
172
-
-
0025805971
-
Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation
-
Ulich, T.R., Yin, S., Guo, K., Yi, E.S., Remick, D., del Castillo, J. (1991) Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation. Am. J. Pathol. 138: 1097-1101.
-
(1991)
Am. J. Pathol.
, vol.138
, pp. 1097-1101
-
-
Ulich, T.R.1
Yin, S.2
Guo, K.3
Yi, E.S.4
Remick, D.5
Del Castillo, J.6
-
173
-
-
0029913685
-
Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans
-
Romani, L., Mencacci, A., Cenci, E., Spaccapelo, R., Toniatti, C., Puccetti, P., Bistoni, F., Poli, V. (1996) Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. J. Exp. Med. 183: 1345-1355.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1345-1355
-
-
Romani, L.1
Mencacci, A.2
Cenci, E.3
Spaccapelo, R.4
Toniatti, C.5
Puccetti, P.6
Bistoni, F.7
Poli, V.8
-
174
-
-
0036152683
-
Interleukin-6-deficient mice develop mature-onset obesity
-
Wallenius, V., Wallenius, K., Ahren, B., Rudling, M., Carlsten, H., Dickson, S.L., Ohlsson, C., Jansson, J.O. (2002) Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med. 8: 75-79.
-
(2002)
Nat. Med.
, vol.8
, pp. 75-79
-
-
Wallenius, V.1
Wallenius, K.2
Ahren, B.3
Rudling, M.4
Carlsten, H.5
Dickson, S.L.6
Ohlsson, C.7
Jansson, J.O.8
-
175
-
-
23044468612
-
Interleukin-6 depletion selectively improves hepatic insulin action in obesity
-
Kover, J.K., Clementi, A.H., Mooney, R.A. (2005) Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology 146: 3417-3427.
-
(2005)
Endocrinology
, vol.146
, pp. 3417-3427
-
-
Kover, J.K.1
Clementi, A.H.2
Mooney, R.A.3
-
176
-
-
0036894360
-
Interleukin-6 induces cellular insulin resistance in hepatocytes
-
Senn, J.J., Klover, P.J., Nowak, I.A., Mooney, R.A. (2002) Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51: 3391-3399.
-
(2002)
Diabetes
, vol.51
, pp. 3391-3399
-
-
Senn, J.J.1
Klover, P.J.2
Nowak, I.A.3
Mooney, R.A.4
-
177
-
-
0242268894
-
Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
-
Klover, P.J., Zimmers, T.A., Koniaris, L.G., Mooney, R.A. (2003) Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52: 2784-2789.
-
(2003)
Diabetes
, vol.52
, pp. 2784-2789
-
-
Klover, P.J.1
Zimmers, T.A.2
Koniaris, L.G.3
Mooney, R.A.4
-
178
-
-
0030735542
-
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor alpha, in vivo
-
Mohamed-Ali, V., Goodrick, S., Rawesh, A., Katz, D.R., Miles, J.M., Yudkin, J.S., Klein, S., Coppack, S.W. (1997) Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor alpha, in vivo. J. Clin. Endocrinol. Metab. 82: 4196-4200.
-
(1997)
J. Clin. Endocrinol. Metab.
, vol.82
, pp. 4196-4200
-
-
Mohamed-Ali, V.1
Goodrick, S.2
Rawesh, A.3
Katz, D.R.4
Miles, J.M.5
Yudkin, J.S.6
Klein, S.7
Coppack, S.W.8
-
179
-
-
0035023128
-
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
-
Kern, P.A., Ranganathan, S., Li, C., Wood, L., Ranganthan, G. (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. 280: 745-751.
-
(2001)
Am. J. Physiol.
, vol.280
, pp. 745-751
-
-
Kern, P.A.1
Ranganathan, S.2
Li, C.3
Wood, L.4
Ranganthan, G.5
-
180
-
-
0142187317
-
Searching for the exercise factor: Is IL-6 a candidate?
-
Pedersen, B.K., Steensberg, A., Fischer, C., Keller, C., Keller, P., Plomgaard, P., Febbraio, M., Saltin, B. (2003) Searching for the exercise factor: is IL-6 a candidate? J. Muscle Res. Cell Motil. 24: 113-119.
-
(2003)
J. Muscle Res. Cell Motil.
, vol.24
, pp. 113-119
-
-
Pedersen, B.K.1
Steensberg, A.2
Fischer, C.3
Keller, C.4
Keller, P.5
Plomgaard, P.6
Febbraio, M.7
Saltin, B.8
-
181
-
-
33646350774
-
Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
-
Weigert, C., Hennige, A.M., Lehmann, R., Brodbeck, K., Baumgartner, F., Schauble, M., Haring, H.U., Schleicher, E.D. (2006) Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. J. Biol. Chem. 281: 7060-7067.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 7060-7067
-
-
Weigert, C.1
Hennige, A.M.2
Lehmann, R.3
Brodbeck, K.4
Baumgartner, F.5
Schauble, M.6
Haring, H.U.7
Schleicher, E.D.8
-
182
-
-
0035901090
-
Inflammation and Cancer: Back to Virchow
-
Balkwill, F., Mantovani, A. (2001) Inflammation and Cancer: Back to Virchow. Lancet 357: 539-545.
-
(2001)
Lancet
, vol.357
, pp. 539-545
-
-
Balkwill, F.1
Mantovani, A.2
-
183
-
-
0037180757
-
Inflammation and cancer
-
Coussens, L.M., Werb, Z. (2002) Inflammation and cancer. Nature 420: 860-867.
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
184
-
-
4644324186
-
NF-kB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky, E., Porat, R.M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E., Urieli-Shoval, S., Galun, E., Ben-Neriah, Y. (2004) NF-kB functions as a tumour promoter in inflammation-associated cancer. Nature 431: 461-466.
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
Abramovitch, R.4
Amit, S.5
Kasem, S.6
Gutkovich-Pyest, E.7
Urieli-Shoval, S.8
Galun, E.9
Ben-Neriah, Y.10
-
185
-
-
4043088499
-
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
Greten, F.R., Eckmann, L., Greten, T.F., Park, J.M., Li, Z.W., Egan, L.J., Kagnoff, M.F., Karin, M. (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118: 285-296.
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
Eckmann, L.2
Greten, T.F.3
Park, J.M.4
Li, Z.W.5
Egan, L.J.6
Kagnoff, M.F.7
Karin, M.8
-
186
-
-
5644252874
-
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
-
Becker, C., Fantini, M.C., Schramm, C., Lehr, H.A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., Ito, H., Nishimoto, N., Yoshizaki, K., Kishimoto, T., Galle, P.R., Blessing, M., Rose-John, S., Neurath, M.F. (2004) TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 21: 491-501.
-
(2004)
Immunity
, vol.21
, pp. 491-501
-
-
Becker, C.1
Fantini, M.C.2
Schramm, C.3
Lehr, H.A.4
Wirtz, S.5
Nikolaev, A.6
Burg, J.7
Strand, S.8
Kiesslich, R.9
Huber, S.10
Ito, H.11
Nishimoto, N.12
Yoshizaki, K.13
Kishimoto, T.14
Galle, P.R.15
Blessing, M.16
Rose-John, S.17
Neurath, M.F.18
-
187
-
-
0025219434
-
Interleukin-6 and itsreceptor are expressed in human intestinal epithelial cells
-
Shirota, K., LeDuy, L., Yuan, S.Y., Jothy, S. (1990) Interleukin-6 and itsreceptor are expressed in human intestinal epithelial cells. Virch. Archiv B 58: 303-308.
-
(1990)
Virch. Archiv B
, vol.58
, pp. 303-308
-
-
Shirota, K.1
Leduy, L.2
Yuan, S.Y.3
Jothy, S.4
-
188
-
-
0042209597
-
Serum interleukin-6 levels reflect the disease status of colorectal cancer
-
Chung, Y.C., Chang, Y.F. (2003) Serum interleukin-6 levels reflect the disease status of colorectal cancer. J. Surg. Oncol. 83: 222-226.
-
(2003)
J. Surg. Oncol.
, vol.83
, pp. 222-226
-
-
Chung, Y.C.1
Chang, Y.F.2
-
189
-
-
0036176551
-
Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery
-
Galizia, G., Orditura, M., Romano, C., Lieto, E., Castellano, P., Pelosio, L., Imperatore, V., Catalano, G., Pignatelli, C., Vita, F.D. (2002) Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery. Clin. Immunol. 102: 169-178.
-
(2002)
Clin. Immunol.
, vol.102
, pp. 169-178
-
-
Galizia, G.1
Orditura, M.2
Romano, C.3
Lieto, E.4
Castellano, P.5
Pelosio, L.6
Imperatore, V.7
Catalano, G.8
Pignatelli, C.9
Vita, F.D.10
-
190
-
-
0034599429
-
Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells
-
Schneider, M.R., Hoeflich, A., Fischer, J.R., Wolf, E., Sordat, B., Lahm, H. (2000) Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells. Cancer Lett. 151: 31-38.
-
(2000)
Cancer Lett.
, vol.151
, pp. 31-38
-
-
Schneider, M.R.1
Hoeflich, A.2
Fischer, J.R.3
Wolf, E.4
Sordat, B.5
Lahm, H.6
-
191
-
-
0026585781
-
RAG-1-deficient mice have no mature B and T lymphocytes
-
Mombaerts, P., Iacomini, J., Johnson, R.S., Herrup, K., Tonegawa, S., Papaioannou, V.E. (1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68: 869-877.
-
(1992)
Cell
, vol.68
, pp. 869-877
-
-
Mombaerts, P.1
Iacomini, J.2
Johnson, R.S.3
Herrup, K.4
Tonegawa, S.5
Papaioannou, V.E.6
-
192
-
-
23644436122
-
IL-6 signaling promotes tumor growth in colorectal cancer
-
Becker, C., Fantini, M.C., Wirtz, S., Nikolaev, A., Lehr, H.A., Galle, P.R., Rose-John, S., Neurath, M.F. (2005) IL-6 signaling promotes tumor growth in colorectal cancer. Cell Cycle 4: 217-220.
-
(2005)
Cell Cycle
, vol.4
, pp. 217-220
-
-
Becker, C.1
Fantini, M.C.2
Wirtz, S.3
Nikolaev, A.4
Lehr, H.A.5
Galle, P.R.6
Rose-John, S.7
Neurath, M.F.8
-
193
-
-
0036399699
-
Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: A mechanism for metastatic initiation?
-
Dowdall, J.F., Winter, D.C., Andrews, E., Laug, W.E., Wang, J.H., Redmond, H.P. (2002) Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: a mechanism for metastatic initiation? J. Surg. Res. 107: 1-6.
-
(2002)
J. Surg. Res.
, vol.107
, pp. 1-6
-
-
Dowdall, J.F.1
Winter, D.C.2
Andrews, E.3
Laug, W.E.4
Wang, J.H.5
Redmond, H.P.6
-
194
-
-
0026604568
-
Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice
-
Suematsu, S., Matsusaka, T., Matsuda, T., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., Kishimoto, T. (1992) Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 89: 232-235.
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 232-235
-
-
Suematsu, S.1
Matsusaka, T.2
Matsuda, T.3
Ohno, S.4
Miyazaki, J.5
Yamamura, K.6
Hirano, T.7
Kishimoto, T.8
-
195
-
-
0028786577
-
Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors
-
Udagawa, N., Takahashi, N., Katagiri, T., Tamura, T., Wada, S., Findlay, D.M., Martin, T.J., Hirota, H., Taga, T., Kishimoto, T., Suda, T. (1995) Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J. Exp. Med. 182: 1461-1468.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1461-1468
-
-
Udagawa, N.1
Takahashi, N.2
Katagiri, T.3
Tamura, T.4
Wada, S.5
Findlay, D.M.6
Martin, T.J.7
Hirota, H.8
Taga, T.9
Kishimoto, T.10
Suda, T.11
-
196
-
-
0033710081
-
Astrocytic alterations in interleukin-6/soluble interleukin-6 receptor a double-transgenic mice
-
Brunello, A.G., Weissenberger, J., Kappeler, A., Franke, S., Peters, M., Rose-John, S., Weis, J. (2000) Astrocytic Alterations in Interleukin-6/soluble Interleukin-6 Receptor a Double-Transgenic Mice. Am. J. Pathol. 157: 1485-1493.
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 1485-1493
-
-
Brunello, A.G.1
Weissenberger, J.2
Kappeler, A.3
Franke, S.4
Peters, M.5
Rose-John, S.6
Weis, J.7
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