Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130

Journal of Immunology

Volumn 164, Issue 1, 2000, Pages 273-282

  Kurth, Ingo ^a   Horsten, Ursula ^a,b   Pflanz, Stefan ^a   Timmermann, Andreas ^a   Küster, Andrea ^a   Dahmen, Heike ^a   Tacken, Ingrid ^a   Heinrich, Peter C ^a   Müller Newen, Gerhard ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 11; INTERLEUKIN 6;

ANIMAL CELL; ARTICLE; GENE DELETION; IMMUNE RESPONSE; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033975858     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.1.273     Document Type: Article

References (41)

1. Bazan, J. F. 1990. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl Acad. Sci. USA 87:6934.
2. Ihle, J. N. 1995. Cytokine receptor signaling. Nature 377:591.
3. Wells, J. A., and A. M. de Vos. 1996. Hematopoietic receptor complexes. Annu. Rev. Biochem. 65:609.
4. Heinrich, P. C., I. Behrmann, G. Müller-Newen, F. Schaper, and L. Graeve. 1998. IL-6-type cytokine signaling through the gp130/JAK/STAT pathway. Biochem. J. 334:297.
5. Hibi, M., M. Murakami, M. Saito, T. Hirano, T. Taga, and T. Kishimoto. 1990. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63: 1149.
6. Murakami, M., M. Hibi, N. Nakagawa, T. Nakawaga, K. Yasukawa, K. Yamanishi, T. Taga, and T. Kishimoto. 1993. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260:1808.
7. Yin, T., T. Taga, M. L. Tsang, K. Yasukawa, T. Kishimoto, and Y. C. Yang. 1993. Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction. J. Immunol. 151:2555.
8. Gearing, D. P., M. R. Comeau, D. J. Friend, S. D. Gimpel, C. J. Thut, J. McGourty, K. K. Brasher, J. A. King, S. Gillis, B. Mosley. et al. 1992, The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the L1F receptor. Science 255:1434.
9. Davis, S., T. H. Aldrich, N. Stahl, L. Pan, T. Taga, T. Kishimoto, N. Y. Ip, and G. D. Yancopoulos. 1993. LIFRβ and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 260:1805.
10. Pennica, D., K. J. Shaw, T. A. Swanson, M. W. Moore, D. L. Shelton, K. A. Zioncheck, A. Rosenthal, T. Taga, N. F. Paoni, and W. I. Wood. 1995. Cardiotrophin-1: biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J. Biol. Chem. 270:10915.
11. Mosley, B., C. De Imus, D. Friend, N. Boiani, B. Thoma, L. S. Park, and D. Cosman. 1996. Dual oncostatin M (OSM) receptors: cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 271:32635.
12. Taga, T., M. Hibi, Y. Hirata, K. Yamasaki, K. Yasukawa, T. Matsuda, T. Hirano, and T. Kishimoto. 1989. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58:573.
13. Horsten, U., H. Schmitz-Van de Leur, J. Müllberg, P. C. Heinrich, and S. Rose-John. 1995. The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor. FEBS Lett. 360:43.
14. Hammacher, A., R. T. Richardson, J. E. Layton, D. K. Smith, L. J. L. Angus, D. J. Hilton, N. A. Nicola, J. Wijdenes, and R. J. Simpson. 1998. The immunoglobulin-like module of gp130 is required for signaling by interleukin-6 but not by leukemia inhibitory factor. J. Biol. Chem. 273.
15. Kurth, I., U. Horsten, S. Pflanz, H. Dahmen, A. Küster, J. Grötzinger, P. C. Heinrich, and G. Müller-Newen. 1999. Activation of the signal transducer gp130 by both interleukin-6 and interleukin-11 requires two distinct binding epitopes. J. Immunol. 162:1480.
16. Dahmen, H., U. Horsten, A. Küster, Y. Jacques, S. Minvielle, I. M. Kerr, G. Ciliberto, G. Paonessa, P. C. Heinrich, and G. Müller-Newen. 1998. Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions. Biochem. J. 331:695.
17. Staunton, D., K. R. Hudson, and J. K. Heath. 1998. The interactions of the cytokine-binding homology region and immunoglobulin-like domains of gp130 with oncostatin M: implications for receptor complex formation. Protein Eng. 11:1093.
18. Horsten, U., G. Müller-Newen, C. Gerhartz, A. Wollmer, J. Wijdenes, P. C. Heinrich, and J. Grötzinger. 1997. Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6)/IL-6 receptor/gp130 complex. J. Biol Chem. 272:23748.
19. Bravo, J., D. Staunton, J. K. Heath, and E. Y. Jones. 1998. Crystal structure of a cytokine-binding region of gp130. EMBO J. 17:1665.
20. Kernebeck, T., S. Pflanz, G. Müller-Newen, G. Kurapkat, R. M. Scheek, K. Dijkstra, P. C. Heinrich, A. Wollmer, S. Grzesiek, and J. Grötzinger. 1999. The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region. Protein Sci. 8:1.
21. Lemmon, M. A., and J. Schlessinger. 1994. Regulation of signal transduction and signal diversity by receptor oligomerization. Trends Biochem. Sci. 19:459.
22. Heldin, C.-H. 1995. Dimerization of cell surface receptors in signal transduction. Cell 80:213.
23. Arcone, R., P. Pucci, F. Zappacosta, V. Fontaine, A. Malorni, G. Marino, and G. Ciliberto. 1991. Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector. Eur. J. Biochem. 198:541.
24. Weiergräber, O., U. Hemmann, A. Küster, G. Müller-Newen, J. Schneider, S. Rose-John, P. Kurschat, J. P. J. Brakenhoff, M. H. L. Hart, S. Stabel, et al. 1995. Soluble human interleukin-6 receptor: expression in insect cells, purification and characterization. Eur. J. Biochem. 234:661.
25. Müller-Newen, G., A. Küster, U. Hemmann, R. Keul, U. Horsten, A. Martens, L. Graeve, J. Wijdenes, and P. C. Heinrich. 1998. Soluble interleukin-6 receptor potentiates the antagonistic activity of soluble gp130 on interleukin-6 responses. J. Immunol. 161:6347.
26. Wijdenes, J., P. C. Heinrich, G. Müller-Newen, C. Roche, G. Zong-Jiang, C. Clement, and B. Klein. 1995. Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 mAbs. Eur. J. Immunol. 25:3474.
27. Gerhartz, C., B. Heesel, J. Sasse, U. Hemmann, C. Landgraf, J. Schneider-Mergener, F. Horn, P. C. Heinrich, and L. Graeve. 1996. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin-6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation. J. Biol. Chem. 271:12991.
28. Yuan, J., U. M. Wegenka, C. Lütticken, J. Buschmann, T. Decker, C. Schindler, P. C. Heinrich, and F. Horn. 1994. The signaling pathways of interleukin-6 and interferon-γ converge by the activation of different transcription factors which bind to common responsive DNA elements. Mol. Cel. Biol. 14:1657.
29. 125l-containing acylating agent. Biochem. J. 133:529.
30. Wegenka, U. M., C. Lütticken, J. Buschmann, J. Yuan, F. Lottspeich, W. Müller-Esterl, C. Schindler, E. Roeb, P. C. Heinrich, and F. Horn. 1994. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transduction and transcription (Stat) factor family. Mol. Cell. Biol. 14:3186.
31. Wagner, B. J., T. E. Hayes, C. J. Hoban, and B. H. Cochran. 1990, The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9:4477.
32. Kyhse-Anderson, J. 1984. Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins form polyacrylamide to nitro-cellulose. J. Biochem. Biophys. Methods 10:203.
33. Lebeau, B., F. A. Montero-Julian, J. Wijdenes, G. Müller-Newen, H. Dahmen, M. Chérel, P. C. Heinrich, H. Brailly, M.-M. Hallet, A. Godard, et al. 1997. Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties. FEBS Lett. 407:141.
34. Owczarek, C. M., Y. Zhang, M. J. Layton, D. Metcalf, B. Roberts, and N. A. Nicola. 1997. The unusual species cross-reactivity of the leukemia inhibitory factor receptor α-chain is determined primarily by the immunoglobulin-like domain. J. Biol. Chem. 272:23976.
35. Baumann, H., A. J. Symes, M. R. Comeau, K. K. Morella, Y. Wang, D. Friend, S. F. Ziegler, J. S. Fink, and D. P. Gearing. 1993. Multiple regions within the cytoplasmic domains of leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells. Mol. Cell. Biol. 14:138.
36. Jenkins, B. J., R. J. D'Andrea, and T. J. Gonda. 1995. Activating point mutations in the common β-subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of β-subunit dimerisation and cell type-specific molecules in signaling. EMBO J. 14:4276.
37. de Vos, A. M., M. Ultsch, and A. A. Kossiakoff. 1992 Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255:306.
38. Fukunaga, R., E. Ishizaka-Ikeda, C.-X. Pan, Y. Seto, and S. Nagata. 1991. Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J. 10:2855.
39. Yoshimura, A., G. Longmore, and H. F. Lodish. 1990. Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity. Nature 348:647.
40. Souyri, M., I. Vigon, J. Pencioletti, J. Heard, P. Tambourin, and F. Wendling. 1990. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukaemia virus immortalises hematopoietic progenitors. Cell 63:1137.
41. Gonda, T. J., and R. J. D'Andrea. 1997. Activating mutations in cytokine receptors: implications for receptor function and role in disease. Blood 89:355.