Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis

Journal of Clinical Investigation

Volumn 106, Issue 1, 2000, Pages 137-144

  Tanaka, Masao ^a   Kishimura, Masaaki ^b   Ozaki, Shoichi ^a   Osakada, Fumio ^b   Hashimoto, Hidetaka ^a   Okubo, Mitsuo ^c   Murakami, Masao ^a   Nakao, Kazuwa ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KANEKA CORPORATION   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 130;

ANTIBODY DETECTION; ARTICLE; HUMAN; HUMAN CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

EID: 0033916898     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7479     Document Type: Article

References (31)

1. Firestein, G.S. 1997. Etiology and pathogenesis of rheumatoid arthritis. In Textbook of rheumatology. Volume 1. W.N. Kelley, E.D. Harris, S. Ruddy, and C.B. Sledge, editors. W.B. Saunders Co. Philadelphia, Pennsylvania, USA. 851-888.
2. Tighe, H., and Carson, D.A. 1997. Rheumatoid factors. In Textbook of rheumatology. Volume 1. W.N. Kelley, E.D. Harris, S. Ruddy, and C.B. Sledge, editors. W.B. Saunders Co. Philadelphia, Pennsylvania, USA. 241-247.
3. Tanaka, M., et al. 1998. Cloning of follisfatin-related protein as a novel autoantigen in systemic rheumatic diseases. Int. Immunol. 10:1305-1314.
4. Taga, T., et al. 1989. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 58:573-581.
5. Ip, N.Y., et al. 1992. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell. 69:1121-1132.
6. Gearing, D.P., et al. 1992. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 255:1434-1437.
7. Liu, J., et al. 1992. Interleukin-6 signal transducer gp130 mediates oncostatin M signaling. J. Biol. Chem. 267:16763-16766.
8. Yin, T., et al. 1993. Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction. J. Immunol. 151:2555-2561.
9. Pennica, D., et al. 1995. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl. Acad. Sci. USA. 92:1142-1146.
10. Narazaki, M., et al. 1993. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood. 82:1120-1126.
11. Feldmann, M., et al. 1996. Role of cytokines in rheumatoid arthritis. In Annual review of immunology. Volume 14, W.E. Paul, C.G. Fathman, and H. Metzger, editors. Annual Review Inc. Palo Alto, California, USA. 397-440.
12. Hirano, T. 1994. Interleukin-6. In The cytokine handbook. A.W. Thomson, editor. Academic Press Ltd. London, United Kingdom. 145-161.
13. Mihara, M., Moriya, Y., Kishimoto, T., and Ohsugi, Y. 1995. Interleukin-6 (IL-6) induces the proliferation of synovial fibroblastic cells in the presence of soluble IL-6 receptor. Br. J. Rheumatol. 34:321-325.
14. Kotake, S., et al. 1996. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J. Bone Miner. Res. 11:88-95.
15. Houssiau, F.A., et al. 1988. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arrhritides. Arthritis Rheum. 31:784-788.
16. Wendling, D., Racadot, E., and Wijdenes, J. 1993. Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J. Rheumatol. 20:259-262.
17. Yoshizaki, K., Nishimoto, N., Mihara, M., and Kishimoto, T. 1998. Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody. Springer Semin. Immunopathol. 20:247-259.
18. Hibi, M., et al. 1990. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63:1149-1157.
19. Saito, M., Yoshida, K., Hibi, M., Taga, T., and Kishimoto, T. 1992. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J. Immunol. 148:4066-4071.
20. Taga, T., et al. 1992. Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130. Proc. Natl. Acad. Sci. USA. 89:10998-11001.
21. Gauldie, J., Richards, C., Harnish, D., Lansdorp, P., and Baumann, H. 1987. Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. USA. 84:7251-7255.
22. Matsuda, T., Hirano, T., and Kishimoto, T. 1988. Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL 6 monoclonal antibodies. Eur. J. Immunol. 18:951-956.
23. Spring, D.J., and Krebs, E.G. 1999. Deletion of 11 amino acids in p90(rsk-mo-1) abolishes kinase activity. Mol. Cell. Biol. 19:317-320.
24. Diamant, M. et al. 1997. Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin-6 signal transducer gp130. FEBS Lett. 412:379-384.
25. Zhang, J.G., et al. 1998. Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma. J. Biol. Chem. 273:10798-10805.
26. Paonessa, G., et al. 1995. Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling. EMBO J. 14:1942-1951.
27. Despres, N., Talbot, G., Plouffe, B., Boire, G., and Menard, H.A. 1995. Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera. J. Clin. Invest. 95:1891-1896.
28. Mimori, T., et al. 1995. Autoantibodies to calpastatin (an endogenous inhibitor for calcium-dependent neutral protease, calpain) in systemic rheumatic diseases. Proc. Natl. Acad. Sci. USA. 92:7267-7271.
29. Genome Net WWW Server. http://www.genome.ad.jp. Accessed May 12, 2000.
30. Bisno, A.L. 1997. Rheumatic fever. In Textbook of rheumatology. Volume 2. W.N. Kelley, E.D. Harris, S. Ruddy, and C.B. Sledge, editors. W.B. Saunders Co. Philadelphia, Pennsylvania, USA. 1225-1238.
31. Sternberg, E.M., et al. 1989. Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc. Natl. Acad. Sci. USA. 86:2374-2378.