Defective gp130-mediated Signal Transducer and Activator of Transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

Journal of Experimental Medicine

Volumn 194, Issue 2, 2001, Pages 189-203

  Ernst, Matthias ^a   Inglese, Melissa ^a   Waring, Paul ^b   Campbell, Ian K ^a   Bao, Shisan ^c   Clay, Fiona J ^a   Alexander, Warren S ^a   Wicks, Ian P ^a   Tarlinton, David M ^a   Novak, Ulrike ^d   Heath, Joan K ^a   Dunn, Ashley R ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Gene targeting; Infertility; Interleukin; Signal transduction; STAT

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE; STAT PROTEIN;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL SPECIFICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIGESTIVE SYSTEM ULCER; ENZYME ACTIVATION; GENE MUTATION; GENE TARGETING; HUMORAL IMMUNITY; INFERTILITY; KNOCKOUT MOUSE; MOUSE; NIDATION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SYNOVIOCYTE;

ANIMALS; ANTIGENS, CD; CARRIER PROTEINS; CYTOKINE RECEPTOR GP130; DNA PRIMERS; DNA-BINDING PROTEINS; EMBRYO IMPLANTATION; FEMALE; JOINT DISEASES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIC ULCER; PREGNANCY; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS;

EID: 0035898315     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.2.189     Document Type: Article

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