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Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways
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Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
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Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders
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The gp130 stimulating designer cytokine Hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells
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Maintenance of ES cell pluripotentiality is regulated by the number and types of gp130-mediated signaling complexes
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Liver regeneration induced by a designed hIL-6/shIL-6R fusion protein reverses severe hepatocellular injury
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