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Volumn 380, Issue 7-8, 1999, Pages 803-813

IL-6 type cytokine receptor complexes: Hexamer, tetramer or both?

Author keywords

CNTF; Cytokine; IL 6; Receptor complex

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYTOKINE RECEPTOR; IMMUNOGLOBULIN; INTERLEUKIN 6 RECEPTOR; RECEPTOR SUBUNIT; TETRAMER;

EID: 0038642195     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.1999.100     Document Type: Review
Times cited : (108)

References (77)
  • 2
    • 0033605109 scopus 로고    scopus 로고
    • Identification of three distinct receptor binding sites of murine interleukin-11
    • Barton, V.A., Hudson, K.R., and Heath, J.K. (1999). Identification of three distinct receptor binding sites of murine interleukin-11. J. Biol. Chem. 274, 5755-5761.
    • (1999) J. Biol. Chem. , vol.274 , pp. 5755-5761
    • Barton, V.A.1    Hudson, K.R.2    Heath, J.K.3
  • 3
    • 0025102756 scopus 로고
    • Haemopoietic receptors and helical cytokines
    • Bazan, J.F. (1990a). Haemopoietic receptors and helical cytokines. Immunol. Today 11, 350-354.
    • (1990) Immunol. Today , vol.11 , pp. 350-354
    • Bazan, J.F.1
  • 4
    • 0025162844 scopus 로고
    • Structural design and molecular evolution of a cytokine receptor superfamily
    • Bazan, J.F. (1990b). Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87, 6934-6938.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6934-6938
    • Bazan, J.F.1
  • 5
    • 0025895320 scopus 로고
    • Neuropoietic cytokines in the hematopoietic fold
    • Bazan, J.F. (1991). Neuropoietic cytokines in the hematopoietic fold. Neuron 7, 197-208.
    • (1991) Neuron , vol.7 , pp. 197-208
    • Bazan, J.F.1
  • 6
    • 0023605142 scopus 로고
    • Three-dimensional structure of interleukin-2
    • Brandhuber, B.J., Boone, T., Kenney, W.C., and McKay, D.B. (1987). Three-dimensional structure of interleukin-2. Science 238, 1707-1709.
    • (1987) Science , vol.238 , pp. 1707-1709
    • Brandhuber, B.J.1    Boone, T.2    Kenney, W.C.3    McKay, D.B.4
  • 7
    • 0032536814 scopus 로고    scopus 로고
    • Crystal structure of a cytokine-binding region of gp130
    • Bravo, J., Staunton, D., Heath, J.K., and Jones, E.Y. (1998). Crystal structure of a cytokine-binding region of gp130. EMBO J. 17, 1665-1674.
    • (1998) EMBO J. , vol.17 , pp. 1665-1674
    • Bravo, J.1    Staunton, D.2    Heath, J.K.3    Jones, E.Y.4
  • 9
    • 0028916599 scopus 로고
    • A hot spot of binding energy in a hormone-receptor interface
    • Clackson, T., and Wells, J.A. (1995). A hot spot of binding energy in a hormone-receptor interface. Science 267, 383-386.
    • (1995) Science , vol.267 , pp. 383-386
    • Clackson, T.1    Wells, J.A.2
  • 10
    • 0030668919 scopus 로고    scopus 로고
    • Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist
    • Curtis, D.J., Hilton, D.J., Roberts, B., Murray, L., Nicola, N., and Begley, C.G. (1997). Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist. Blood 90, 4403-4412.
    • (1997) Blood , vol.90 , pp. 4403-4412
    • Curtis, D.J.1    Hilton, D.J.2    Roberts, B.3    Murray, L.4    Nicola, N.5    Begley, C.G.6
  • 11
    • 0028018978 scopus 로고
    • Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells
    • de Hon, F.D., Ehlers, M., Rose-John, S., Ebeling, S.B., Bos, H.K., Aarden, L.A., and Brakenhoff, J.P. (1994). Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells. J. Exp. Med. 180, 2395-2400.
    • (1994) J. Exp. Med. , vol.180 , pp. 2395-2400
    • De Hon, F.D.1    Ehlers, M.2    Rose-John, S.3    Ebeling, S.B.4    Bos, H.K.5    Aarden, L.A.6    Brakenhoff, J.P.7
  • 13
    • 0028146822 scopus 로고
    • The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling
    • De Meyts, P. (1994). The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia 37, 135-148.
    • (1994) Diabetologia , vol.37 , pp. 135-148
    • De Meyts, P.1
  • 14
    • 0029584357 scopus 로고
    • In vitro binding of ciliary neurotrophic factor to its receptors: Evidence for the formation of an IL-6-type hexameric complex
    • De Serio, A., Graziani, R., Laufer, R., Ciliberto, G., and Paonessa, G. (1995). In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complex. J. Mol. Biol. 254, 795-800.
    • (1995) J. Mol. Biol. , vol.254 , pp. 795-800
    • De Serio, A.1    Graziani, R.2    Laufer, R.3    Ciliberto, G.4    Paonessa, G.5
  • 15
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • De Vos, A.M., Ultsch, M., and Kossiakoff, A.A. (1992). Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312.
    • (1992) Science , vol.255 , pp. 306-312
    • De Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 17
    • 0029938639 scopus 로고    scopus 로고
    • Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3
    • Feng, Y., Klein, B.K., and McWherter, C.A. (1996). Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3. J. Mol. Biol. 259, 524-541.
    • (1996) J. Mol. Biol. , vol.259 , pp. 524-541
    • Feng, Y.1    Klein, B.K.2    McWherter, C.A.3
  • 19
    • 0027959283 scopus 로고
    • Identification of a regulatory domain of the interleukin-6 receptor
    • Grube, B.J., and Cochrane, C.G. (1994). Identification of a regulatory domain of the interleukin-6 receptor. J. Biol. Chem. 269, 20791-20797.
    • (1994) J. Biol. Chem. , vol.269 , pp. 20791-20797
    • Grube, B.J.1    Cochrane, C.G.2
  • 20
    • 0033574713 scopus 로고    scopus 로고
    • Crystal structure of the interleukin-4/receptor chain complex reveals a mosaic binding interface
    • Hage, T., Sebald, W., and Reinemer, P. (1999). Crystal structure of the interleukin-4/receptor chain complex reveals a mosaic binding interface. Cell 97, 271-281.
    • (1999) Cell , vol.97 , pp. 271-281
    • Hage, T.1    Sebald, W.2    Reinemer, P.3
  • 22
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    • Heinrich, P.C., Behrmann, I., Muller Newen, G., Schaper, F., and Graeve, L. (1998). Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J. 334, 297-314.
    • (1998) Biochem. J. , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller Newen, G.3    Schaper, F.4    Graeve, L.5
  • 23
    • 0027258762 scopus 로고
    • The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors
    • Hill, C.P., Osslund, T.D., and Eisenberg, D. (1993). The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors. Proc. Natl. Acad. Sci. USA 90, 5167-5171.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5167-5171
    • Hill, C.P.1    Osslund, T.D.2    Eisenberg, D.3
  • 25
    • 0028897161 scopus 로고
    • The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor
    • Horsten, U., Schmitz-Van de Leur, H., Müllberg, J., Heinrich, P.C., and Rose-John, S. (1995). The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor. FEBS Lett. 360, 43-46.
    • (1995) FEBS Lett. , vol.360 , pp. 43-46
    • Horsten, U.1    Schmitz-Van De Leur, H.2    Müllberg, J.3    Heinrich, P.C.4    Rose-John, S.5
  • 26
    • 1842301081 scopus 로고    scopus 로고
    • Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex
    • Horsten, U., Muller Newen, G., Gerhartz, C., Wollmer, A., Wijdenes, J., Heinrich, P.C., and Grötzinger, J. (1997). Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex. J. Biol. Chem. 272, 23748-23757.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23748-23757
    • Horsten, U.1    Muller Newen, G.2    Gerhartz, C.3    Wollmer, A.4    Wijdenes, J.5    Heinrich, P.C.6    Grötzinger, J.7
  • 27
    • 15844420218 scopus 로고    scopus 로고
    • Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists
    • Hudson, K.R., Vernallis, A.B., and Heath, J.K. (1996). Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists. J. Biol. Chem. 271, 11971-11978.
    • (1996) J. Biol. Chem. , vol.271 , pp. 11971-11978
    • Hudson, K.R.1    Vernallis, A.B.2    Heath, J.K.3
  • 30
    • 0031043061 scopus 로고    scopus 로고
    • Analysis of the human interleukin-6/-human interleukin-6 receptor binding interface at the amino acid level: Proposed mechanism of interaction
    • Kalai, M., Montero Julian, F.A., Grötzinger, J., Fontaine, V., Vandenbussche, P., Deschuyteneer, R., Wollmer, A., Brailly, H., and Content, J. (1997b). Analysis of the human interleukin-6/-human interleukin-6 receptor binding interface at the amino acid level: proposed mechanism of interaction. Blood 89, 1319-1333.
    • (1997) Blood , vol.89 , pp. 1319-1333
    • Kalai, M.1    Montero Julian, F.A.2    Grötzinger, J.3    Fontaine, V.4    Vandenbussche, P.5    Deschuyteneer, R.6    Wollmer, A.7    Brailly, H.8    Content, J.9
  • 34
    • 0033083941 scopus 로고    scopus 로고
    • Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes
    • Kurth, I., Horsten, U., Pflanz, S., Dahmen, H., Kuster, A., Grötzinger, J., Heinrich, P.C., and Muller-Newen, G. (1999). Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes. J. Immunol. 162, 1480-1487.
    • (1999) J. Immunol. , vol.162 , pp. 1480-1487
    • Kurth, I.1    Horsten, U.2    Pflanz, S.3    Dahmen, H.4    Kuster, A.5    Grötzinger, J.6    Heinrich, P.C.7    Muller-Newen, G.8
  • 35
    • 0033548259 scopus 로고    scopus 로고
    • Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
    • Livnah, O., Stura, E.A., Middleton, S.A., Johnson, D.L., Jolliffe, L.K., and Wilson, I.A. (1999). Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283, 987-990.
    • (1999) Science , vol.283 , pp. 987-990
    • Livnah, O.1    Stura, E.A.2    Middleton, S.A.3    Johnson, D.L.4    Jolliffe, L.K.5    Wilson, I.A.6
  • 36
    • 0032826994 scopus 로고    scopus 로고
    • Neuronal activities of IL-6 type cytokines often depend on soluble cytokine receptors
    • in press
    • März, P., Otten, U., and Rose-John, S. (1999). Neuronal activities of IL-6 type cytokines often depend on soluble cytokine receptors. Eur. J. Neurosci., in press.
    • (1999) Eur. J. Neurosci.
    • März, P.1    Otten, U.2    Rose-John, S.3
  • 37
    • 0029046795 scopus 로고
    • Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing
    • McDonald, N.Q., Panayotatos, N., and Hendrickson, W.A. (1995). Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J. 14, 2689-2699.
    • (1995) EMBO J. , vol.14 , pp. 2689-2699
    • McDonald, N.Q.1    Panayotatos, N.2    Hendrickson, W.A.3
  • 38
    • 0027155448 scopus 로고
    • A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5
    • Milburn, M.V., Hassell, A.M., Lambert, M.H., Jordan, S.R., Proudfoot, A.E., Graber, P., and Wells, T.N. (1993). A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature 363, 172-176.
    • (1993) Nature , vol.363 , pp. 172-176
    • Milburn, M.V.1    Hassell, A.M.2    Lambert, M.H.3    Jordan, S.R.4    Proudfoot, A.E.5    Graber, P.6    Wells, T.N.7
  • 39
    • 12644294970 scopus 로고    scopus 로고
    • Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation
    • Mosley, B., De Imus, C., Friend, D., Boiani, N., Thoma, B., Park, L.S., and Cosman, D. (1996). Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 271, 32635-32643.
    • (1996) J. Biol. Chem. , vol.271 , pp. 32635-32643
    • Mosley, B.1    De Imus, C.2    Friend, D.3    Boiani, N.4    Thoma, B.5    Park, L.S.6    Cosman, D.7
  • 41
    • 0030751496 scopus 로고    scopus 로고
    • The unusual species cross-reactivity of the leukemia inhibitory factor receptor alpha-chain is determined primarily by the immunoglobulin-like domain
    • Owczarek, C.M., Zhang, Y., Layton, M.J., Metcalf, D., Roberts, B., and Nicola, N.A. (1997). The unusual species cross-reactivity of the leukemia inhibitory factor receptor alpha-chain is determined primarily by the immunoglobulin-like domain. J. Biol. Chem. 272, 23976-23985.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23976-23985
    • Owczarek, C.M.1    Zhang, Y.2    Layton, M.J.3    Metcalf, D.4    Roberts, B.5    Nicola, N.A.6
  • 42
    • 0032516865 scopus 로고    scopus 로고
    • The membrane proximal cytokine receptor domain of the human interleukin-6-receptor is sufficient for ligand binding but not for gp130 association
    • Özbek, S., Grötzinger, J., Krebs, B., Fischer, M., Wollmer, A., Jostock, T., Müllberg, J., and Rose-John, S. (1998). The membrane proximal cytokine receptor domain of the human interleukin-6-receptor is sufficient for ligand binding but not for gp130 association. J. Biol. Chem. 273, 21374-21379.
    • (1998) J. Biol. Chem. , vol.273 , pp. 21374-21379
    • Özbek, S.1    Grötzinger, J.2    Krebs, B.3    Fischer, M.4    Wollmer, A.5    Jostock, T.6    Müllberg, J.7    Rose-John, S.8
  • 45
    • 0026764439 scopus 로고
    • Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy
    • Powers, R., Garrett, D.S., March, C. J., Frieden, E.A., Gronenborn, A.M., and Clore, G.M. (1992). Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy. Science 256, 1673-1677.
    • (1992) Science , vol.256 , pp. 1673-1677
    • Powers, R.1    Garrett, D.S.2    March, C.J.3    Frieden, E.A.4    Gronenborn, A.M.5    Clore, G.M.6
  • 46
    • 0030008683 scopus 로고    scopus 로고
    • Identification of residues critical to the activity of human granulocytecolony-stimulating factor
    • Reidhaar-Olson, J.F., De Souza-Hart, J.A., and Selick, H.E. (1996). Identification of residues critical to the activity of human granulocytecolony-stimulating factor. Biochemistry 35, 9034-9041.
    • (1996) Biochemistry , vol.35 , pp. 9034-9041
    • Reidhaar-Olson, J.F.1    De Souza-Hart, J.A.2    Selick, H.E.3
  • 47
    • 0033548048 scopus 로고    scopus 로고
    • Erythropoietin receptor activation by a ligand-induced conformation change
    • Remy, I., Wilson, I.A., and Michnick, S.W. (1999). Erythropoietin receptor activation by a ligand-induced conformation change. Science 263, 990-993.
    • (1999) Science , vol.263 , pp. 990-993
    • Remy, I.1    Wilson, I.A.2    Michnick, S.W.3
  • 50
    • 0028226196 scopus 로고
    • Soluble receptors for cytokines and growth factors: Generation and biological function
    • Rose-John, S., and Heinrich, P.C. (1994). Soluble receptors for cytokines and growth factors: generation and biological function. Biochem. J. 300, 281-290.
    • (1994) Biochem. J. , vol.300 , pp. 281-290
    • Rose-John, S.1    Heinrich, P.C.2
  • 53
    • 0028202123 scopus 로고
    • Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation
    • Savino, R., Lahm, A., Salvati, A.L., Ciapponi, L., Sporeno, E., Altamura, S., Paonessa, G., Toniatti, C., and Ciliberto, G. (1994b). Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation. EMBO J. 13, 1357-1367.
    • (1994) EMBO J. , vol.13 , pp. 1357-1367
    • Savino, R.1    Lahm, A.2    Salvati, A.L.3    Ciapponi, L.4    Sporeno, E.5    Altamura, S.6    Paonessa, G.7    Toniatti, C.8    Ciliberto, G.9
  • 55
    • 0028032203 scopus 로고
    • The X-ray structure of a growth hormone-prolactin receptor complex
    • Somers, W., Ultsch, M., De Vos, A.M., and Kossiakoff, A.A. (1994). The X-ray structure of a growth hormone-prolactin receptor complex. Nature 372, 478-481.
    • (1994) Nature , vol.372 , pp. 478-481
    • Somers, W.1    Ultsch, M.2    De Vos, A.M.3    Kossiakoff, A.A.4
  • 56
    • 0031041014 scopus 로고    scopus 로고
    • 1.9 Acrystal structure of interleukin 6: Implications for a novel mode of receptor dimerization and signaling
    • Somers, W., Stahl, M., and Seehra, J.S. (1997). 1.9 Acrystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling. EMBO J. 16, 989-997.
    • (1997) EMBO J. , vol.16 , pp. 989-997
    • Somers, W.1    Stahl, M.2    Seehra, J.S.3
  • 57
    • 0027145507 scopus 로고
    • Cytokine structural taxonomy and mechanism of receptor engagement
    • Sprang, S.R., and Bazan, J.F. (1993). Cytokine structural taxonomy and mechanism of receptor engagement. Curr. Opin. Struct. Biol. 3, 815-827.
    • (1993) Curr. Opin. Struct. Biol. , vol.3 , pp. 815-827
    • Sprang, S.R.1    Bazan, J.F.2
  • 58
    • 0031764389 scopus 로고    scopus 로고
    • The interactions of the cytokine-binding homology region and immunoglobulin-like domains of gp130 with oncostatin M: Implications for receptor complex formation
    • Staunton, D., Hudson, K.R., and Heath, J.K. (1998). The interactions of the cytokine-binding homology region and immunoglobulin-like domains of gp130 with oncostatin M: implications for receptor complex formation. Protein Eng. 11, 1093-1102.
    • (1998) Protein Eng. , vol.11 , pp. 1093-1102
    • Staunton, D.1    Hudson, K.R.2    Heath, J.K.3
  • 60
    • 0030890718 scopus 로고    scopus 로고
    • gp130 and the Interleukin-6 Family of Cytokines
    • Taga, T., and Kishimoto, T. (1997). gp130 and the Interleukin-6 Family of Cytokines. Annu. Rev. Immunol. 15, 797-819.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 61
    • 0028217202 scopus 로고
    • The crystal structure of affinity-matured human growth hormone at 2 A resolution
    • Ultsch, M.H., Somers, W., Kossiakoff, A.A., and de Vos, A.M. (1994). The crystal structure of affinity-matured human growth hormone at 2 A resolution. J. Mol. Biol. 236, 286-299.
    • (1994) J. Mol. Biol. , vol.236 , pp. 286-299
    • Ultsch, M.H.1    Somers, W.2    Kossiakoff, A.A.3    De Vos, A.M.4
  • 62
    • 0027303256 scopus 로고
    • Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding
    • van Dam, M., Müllberg, J., Schooltink, H., Stoyan, T., Brakenhoff, J.P., Graeve, L., Heinrich, P.C., and Rose-John, S. (1993). Structure-function analysis of interleukin-6 utilizing human/ murine chimeric molecules. Involvement of two separate domains in receptor binding. J. Biol. Chem. 268, 15285-15290.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15285-15290
    • Van Dam, M.1    Müllberg, J.2    Schooltink, H.3    Stoyan, T.4    Brakenhoff, J.P.5    Graeve, L.6    Heinrich, P.C.7    Rose-John, S.8
  • 63
    • 0030856734 scopus 로고    scopus 로고
    • An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M
    • Vernalis, A.B., Hudson, K.R., and Heath, J.K. (1997). An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M. J. Biol. Chem. 272, 26947-26952.
    • (1997) J. Biol. Chem. , vol.272 , pp. 26947-26952
    • Vernalis, A.B.1    Hudson, K.R.2    Heath, J.K.3
  • 65
    • 0344943889 scopus 로고    scopus 로고
    • The immunoglobulin-like domain of the human IL-6 Receptor is important for protein Stability and processing
    • in press
    • Vollmer, P., Oppmann, B., Voltz, N., Fischer, M., and Rose-John, S. (1999). The immunoglobulin-like domain of the human IL-6 Receptor is important for protein Stability and processing. Eur. J. Biochem., in press.
    • (1999) Eur. J. Biochem.
    • Vollmer, P.1    Oppmann, B.2    Voltz, N.3    Fischer, M.4    Rose-John, S.5
  • 66
    • 0028064835 scopus 로고
    • High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130
    • Ward, L.D., Hewlett, G.J., Discolo, G., Yasukawa, K., Hammacher, A., Moritz, R.L., and Simpson, R.J. (1994). High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J. Biol. Chem. 269, 23286-23289.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23286-23289
    • Ward, L.D.1    Hewlett, G.J.2    Discolo, G.3    Yasukawa, K.4    Hammacher, A.5    Moritz, R.L.6    Simpson, R.J.7
  • 67
  • 68
    • 0030050701 scopus 로고    scopus 로고
    • Binding inthegrowth hormone receptor complex
    • Wells, J.A. (1996a). Binding inthegrowth hormone receptor complex. Proc. Natl. Acad. Sci. USA 93, 1-6.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1-6
    • Wells, J.A.1
  • 69
    • 0029982521 scopus 로고    scopus 로고
    • Hematopoietic Receptor Complexes
    • Wells, J.A. (1996b). Hematopoietic Receptor Complexes. Annu. Rev. Biochem. 65, 609-634.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 609-634
    • Wells, J.A.1
  • 70
    • 0026661731 scopus 로고
    • Crystal structure of human recombinant interleukin-4 at 2.25 A resolution
    • Wlodaver, A., Pavlovsky, A., and Gustchina, A. (1992). Crystal structure of human recombinant interleukin-4 at 2.25 A resolution. FEBS Lett. 309, 59-64.
    • (1992) FEBS Lett. , vol.309 , pp. 59-64
    • Wlodaver, A.1    Pavlovsky, A.2    Gustchina, A.3
  • 73
    • 0031005782 scopus 로고    scopus 로고
    • Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand
    • Yamasaki, K., Naito, S., Anaguchi, H., Ohkubo, T., and Ota, Y. (1997). Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand. Nat. Struct. Biol. 4, 498-504.
    • (1997) Nat. Struct. Biol. , vol.4 , pp. 498-504
    • Yamasaki, K.1    Naito, S.2    Anaguchi, H.3    Ohkubo, T.4    Ota, Y.5
  • 74
    • 0027467218 scopus 로고
    • Structure-function analysis of human IL-6 receptor: Dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130
    • Yawata, H., Yasukawa, K., Natsuka, S., Murakami, M., Yamasaki, K., Hibi, M., Taga, T., and Kishimoto, T. (1993). Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130. EMBO J. 12, 1705-1712.
    • (1993) EMBO J. , vol.12 , pp. 1705-1712
    • Yawata, H.1    Yasukawa, K.2    Natsuka, S.3    Murakami, M.4    Yamasaki, K.5    Hibi, M.6    Taga, T.7    Kishimoto, T.8
  • 75
    • 0031008572 scopus 로고    scopus 로고
    • Characterization of the receptor binding determinants of granulocyte colony stimulating factor
    • Young, D.C., Zhan, H., Cheng, Q.L., Hou, J., and Matthews, D.J. (1997). Characterization of the receptor binding determinants of granulocyte colony stimulating factor. Protein Sci. 6, 1228-1236.
    • (1997) Protein Sci. , vol.6 , pp. 1228-1236
    • Young, D.C.1    Zhan, H.2    Cheng, Q.L.3    Hou, J.4    Matthews, D.J.5
  • 76
    • 0029995691 scopus 로고    scopus 로고
    • Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor
    • Zdanov, A., Schalk-Hihi, C., and Wlodawer, A. (1996). Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor. Protein Sci. 5, 1955-1962.
    • (1996) Protein Sci. , vol.5 , pp. 1955-1962
    • Zdanov, A.1    Schalk-Hihi, C.2    Wlodawer, A.3
  • 77
    • 0026721190 scopus 로고
    • The hepatic interleukin-6 receptor. Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand
    • Zohlnhöfer, D., Graeve, L., Rose-John, S., Schooltink, H., Dittrich, E., and Heinrich, P.C. (1992). The hepatic interleukin-6 receptor. Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand. FEBS Lett. 306, 219-222.
    • (1992) FEBS Lett. , vol.306 , pp. 219-222
    • Zohlnhöfer, D.1    Graeve, L.2    Rose-John, S.3    Schooltink, H.4    Dittrich, E.5    Heinrich, P.C.6


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