Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells

Cancer Letters

Volumn 151, Issue 1, 2000, Pages 31-38

  Schneider, Marlon R ^a   Hoeflich, Andreas ^a   Fischer, Jürgen R ^b   Wolf, Eckhard ^a   Sordat, Bernard ^c   Lahm, Harald ^a  

^a Gene Center   (Germany)

^b Thoraxklinik   (Germany)

^c SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

Colon carcinoma; Colony formation; Growth stimulation; Interleukin 6; Interleukin 6 receptor

Indexed keywords

INTERLEUKIN 6;

ACUTE PHASE RESPONSE; ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CARCINOMA CELL; CELL STIMULATION; CLONOGENIC ASSAY; COLON CARCINOMA; COLONY FORMATION; GROWTH REGULATION; HUMAN; HUMAN CELL; MEDIATOR RELEASE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; TUMOR GROWTH;

CELL DIVISION; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS; HUMANS; INTERLEUKIN-6; LIVER NEOPLASMS; NEOPLASM METASTASIS; PERITONEAL NEOPLASMS; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 0034599429     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00401-2     Document Type: Article

References (37)

1. Hirano T., Yasukawa K., Harada H., Taga T., Watanabe Y., Matsuda T., Kashiwamura S.-I., Nakajima K., Koyama K., Iwamatsu A., Tsunasawa S., Sakiyama F., Matsui H., Takahara Y., Taniguchi T., Kishimoto T. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 324:1986;73-76.
2. Kopf M., Baumann H., Freer G., Freudenberg M., Lamers M., Kishimoto T., Zinkernagel R., Bluethman H., Köhler G. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature. 368:1994;339-342.
3. Hirano T. Interleukin-6, 3rd edition. Thomson A.W. The Cytokine Handbook. 1998;197-228 Academic Press, San Diego, CA.
4. Kishimoto T., Akira S., Narazaki M., Taga T. Interleukin-6 family of cytokines and gp130. Blood. 86:1995;1243-1254.
5. Basolo F., Fiore L., Fontanini G., Conaldi P.G., Calvo S., Falcone V., Toniolo A. Expression of and response to interleukin 6 (IL6) in human mammary tumors. Cancer Res. 56:1996;3118-3122.
6. Schmitter D., Lauber B., Fagg B., Stahel R.A. Hematopoietic growth factors secreted by seven human pleural mesothelioma cell lines: interleukin-6 production as a common feature. Int. J. Cancer. 51:1992;296-301.
7. van Meir E., Sawamura Y., Diserens A.-C., Hamou M.-F., Tribolet N. Human glioblastoma cells release interleukin 6 in vivo and in vitro. Cancer Res. 50:1990;6683-6688.
8. Watson J.M., Sensintaffar J.L., Berek J.S., Martinez-Maza O. Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures. Cancer Res. 50:1990;6959-6965.
9. Kirnbauer R., Köck A., Schwarz T., Urbanski A., Krutmann J., Borth W., Damm D., Shipley G., Ansel J.C., Luger T.A. IFN-β2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines. J. Immunol. 142:1989;1922-1928.
10. Takizawa H., Ohtoshi T., Ohta K., Yamashita N., Hirohata S., Hirai K., Hiramatsu K., Ito K. Growth inhibition of human lung cancer cell lines by interleukin 6 in vitro: a possible role in tumor growth via an autocrine mechanism. Cancer Res. 53:1993;4175-4181.
11. Tartour E., Gey A., Sastre-Garau X., Pannetier C., Mosseri V., Kourilsky P., Fridman W.H. Analysis of interleukin 6 gene expression in cervical neoplasia using a quantitative polymerase chain reaction assay: evidence for enhanced interleukin 6 gene expression in invasive carcinoma. Cancer Res. 54:1994;6243-6248.
12. Ito R., Yasui W., Kuniyasu H., Yokozaki H., Tahara E. Expression of interleukin-6 and its effect on the cell growth of gastric carcinoma cell lines. Jpn. J. Cancer Res. 88:1997;953-958.
13. Okamoto M., Lee C., Oyasu R. Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro. Cancer Res. 57:1997;141-146.
14. Okamoto M., Hattori K., Oyasu R. Interleukin-6 functions as an autocrine growth factor in human bladder carcinoma cell lines in vitro. Int. J. Cancer. 72:1997;149-154.
15. Miki S., Iwano M., Miki Y., Yamamoto M., Tang B., Yokokawa K., Sonoda T., Hirano T., Kishimoto T. Interleukin-6 (IL-6) functions as an in vitro growth factor in renal cell carcinomas. FEBS Lett. 250:1989;607-610.
16. Kong B., Isozaki T., Sasaki S. IL-6 antisense-mediated growth inhibition of a choriocarcinoma cell line: an intracellular autocrine mechanism. Gynecol. Oncol. 63:1996;78-84.
17. Watson J.M., Berek J.S., Martinez-Maza O. Growth inhibition of ovarian cancer cells induced by antisense IL-6 oligonucleotides. Gynecol. Oncol. 49:1993;8-15.
18. Iglesias M., Plowman G.D., Woodworth C.D. Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro. Am. J. Pathol. 146:1995;944-952.
19. Molmenti E.P., Ziambaras T., Perlmutter D.H. Evidence for an acute phase response in human intestinal epithelial cells. J. Biol. Chem. 268:1993;14116-14124.
20. Dansky-Ullmann C., Salgaller M., Adams S., Schlom J., Greiner J.W. Synergistic effects of IL-6 and IFN-γ on carcinoembryonic antigen (CEA) and HLA expression by human colorectal carcinoma cells: role for endogenous IFN-β Cytokine. 7:1995;118-129.
21. Tsang K.Y., Kashmiri S.V.S., Qi C.F., Nieroda C., Calvo B., De Filippi R., Greiner J.W., Primus F.-W., Schlom J. Transfer of the IL-6 gene into a human colorectal carcinoma cell line and consequent enhancement of tumor antigen expression. Immunol. Lett. 36:1993;179-186.
22. Serve H., Steinhauser G., Oberberg D., Flegel W.A., Northoff H., Berdel W.E. Studies on the interaction between interleukin 6 and human malignant nonhematopoietic cell lines. Cancer Res. 51:1991;3862-3866.
23. Cajot J.-F., Sordat I., Silvestre T., Sordat B. Differential display cloning identifies motility-related protein (MRP1/CD9) as highly expressed in primary compared to metastatic human colon carcinoma cells. Cancer Res. 57:1997;2593-2597.
24. Lahm H., Suardet L., Laurent P.L., Fischer J.R., Ceyhan A., Givel J.-C., Odartchenko N. Growth regulation and co-stimulation of human colorectal cancer cell lines by insulin-like growth factor I, II and transforming growth factor α Br. J. Cancer. 65:1992;341-346.
25. Lahm H., Amstad P., Yilmaz A., Borbenyi Z., Wyniger J., Fischer J.R., Suardet L., Givel J.-C., Odartchenko N. Interleukin 4 down-regulates expression of c-kit and autocrine stem cell factor in human colorectal carcinoma cells. Cell Growth Diff. 6:1995;1111-1118.
26. Wong G.G., Witek-Giannotti J., Hewick R.M., Clark S.C., Ogawa M. Interleukin 6: identification as a hematopoietic colony-stimulating factor. Behring Inst. Mitt. 83:1988;40-47.
27. Lahm H., Allenbacher A., Hoeflich A., Fischer J.R., Botzler C., Multhoff G., Wolf E., Sordat B. Differential growth factor responsiveness and receptor expression in primary and metastatic human colorectal carcinoma cells. Contrib. Oncol. 54:1999;215-221.
28. Hibi M., Nakajima K., Hirano T. cytokine family and signal transduction: a model of the cytokine system. J. Mol. Med. 74:1996;1-12.
29. Kern D.H., Weisenthal L.M. Highly specific prediction of antineoplastic drug resistance with an in vitro assay using suprapharmacologic drug exposure. J. Natl. Cancer Inst. 82:1990;582-588.
30. Thomas P., Petrick A.T., Toth C.A., Fox E.S., Elting J.J., Steele G. Jr. Peptide sequence on carcinoembryonic antigen binds to a 80 kD protein on Kupffer cells. Biochem. Biophys. Res. Commun. 188:1992;671-677.
31. Gangopadhyay A., Bajenova O., Kelly T.M., Thomas P. Carcinoembryonic antigen induces cytokine expression in Kupffer cells: implications for hepatic metastasis from colorectal cancer. Cancer Res. 56:1996;4805-4810.
32. Piancatelli D., Romano P., Sebastiani P., Adorno D., Casciani C.U. Local expression of cytokines in human colorectal carcinoma: evidence of specific interleukin-6 gene expression. J. Immunother. 22:1999;25-32.
33. Naylor M.S., Stamp G.W.H., Balkwill F.R. Investigation of cytokine gene expression in human colorectal cancer. Cancer Res. 50:1990;4436-4440.
34. Barut B., Chauhan D., Uchiyama H., Anderson K.C. Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro. J. Clin. Invest. 92:1993;2346-2352.
35. Trân-Thang C., Kruithof E.K.O., Lahm H., Schuster W.-A., Tada M., Sordat B. Modulation of the plasminogen activation system by inflammatory cytokines in human colon carcinoma cells. Br. J. Cancer. 74:1996;846-852.
36. Grewe M., Czech W., Morita A., Werfel T., Klammer M., Kapp A., Ruzicka T., Schopf E., Krutmann J. Human eosinophils produce biologically active IL-12: implications for control of T cell response. J. Immunol. 161:1998;415-420.
37. Schindler R., Gelfand J.A., Dinarello C.A. Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself. Blood. 76:1990;1631-1638.