Sex-specific regulation of aging and apoptosis

Mechanisms of Ageing and Development

Volumn 127, Issue 9, 2006, Pages 705-718

  Tower, John ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

dIAP2; Endosymbiosis; ESS; Game theory; Replicator

Indexed keywords

AGING; ALLELE; APOPTOSIS; ARTICLE; DROSOPHILA; ENVIRONMENT; EVOLUTION; GAMETOGENESIS; GENE INTERACTION; GENE MUTATION; GENE SEGREGATION; GENETIC ANALYSIS; GENOTYPE; HUMAN; LIFESPAN; MAMMAL; MITOCHONDRIAL GENETICS; MITOCHONDRION; MORTALITY; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; SEX CHROMOSOMAL INHERITANCE; SEX DETERMINATION; TRANSGENE; X CHROMOSOME;

AGING; ANIMALS; APOPTOSIS; CELL NUCLEUS; CHROMOSOMES, HUMAN, X; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LONGEVITY; MALE; MITOCHONDRIA; OXIDATIVE STRESS; QUANTITATIVE TRAIT LOCI; SEX CHARACTERISTICS; SPECIES SPECIFICITY; X CHROMOSOME;

DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 33746896640     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2006.05.001     Document Type: Article

References (144)

1. Abraham M.C., and Shaham S. Death without caspases, caspases without death. Trends Cell Biol. 14 (2004) 184-193
2. Ackermann M., Stearns S.C., and Jenal U. Senescence in a bacterium with asymmetric division. Science 300 (2003) 1920
3. Adams J.M. Ways of dying: multiple pathways to apoptosis. Genes Dev. 17 (2003) 2481-2495
4. Adams J.M., and Cory S. Apoptosomes: engines for caspase activation. Curr. Opin. Cell Biol. 14 (2002) 715-720
5. Aigaki T., Seong K.H., and Matsuo T. Longevity determination genes in Drosophila melanogaster. Mech. Aging Dev. 123 (2002) 1531-1541
6. Amador-Noguez D., Zimmerman J., Venable S., and Darlington G. Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice. Biochem. Biophys. Res. Commun. 332 (2005) 1086-1100
7. Amikura R., Sato K., and Kobayashi S. Role of mitochondrial ribosome-dependent translation in germline formation in Drosophila embryos. Mech. Dev. 122 (2005) 1087-1093
8. An J.H., Vranas K., Lucke M., Inoue H., Hisamoto N., Matsumoto K., and Blackwell T.K. Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc. Natl. Acad. Sci. USA 102 (2005) 16275-16280
9. Arama E., Agapite J., and Steller H. Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev. Cell 4 (2003) 687-697
10. Arama E., Bader M., Srivastava M., Bergmann A., and Steller H. The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J. 25 (2006) 232-243
11. Arbeitman M.N., Furlong E.E., Imam F., Johnson E., Null B.H., Baker B.S., Krasnow M.A., Scott M.P., Davis R.W., and White K.P. Gene expression during the life cycle of Drosophila melanogaster. Science 297 (2002) 2270-2275
12. Ayyadevara S., Ayyadevara R., Vertino A., Galecki A., Thaden J.J., and Shmookler Reis R.J. Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms. Genetics 163 (2003) 557-570
13. Baehrecke E.H. How death shapes life during development. Nat. Rev. Mol. Cell Biol. 3 (2002) 779-787
14. Baehrecke E.H. Autophagic programmed cell death in Drosophila. Cell Death Differ. 10 (2003) 940-945
15. Bartke A. Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology 146 (2005) 3718-3723
16. Bartke A., and Brown-Borg H. Life extension in the dwarf mouse. Curr. Top. Dev. Biol. 63 (2004) 189-225
17. Bauer J.H., Poon P.C., Glatt-Deeley H., Abrams J.M., and Helfand S.L. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15 (2005) 2063-2068
18. Bazinet C. Endosymbiotic origins of sex. Bioessays 26 (2004) 558-566
19. Bazinet C., and Rollins J.E. Rickettsia-like mitochondrial motility in Drosophila spermiogenesis. Evol. Dev. 5 (2003) 379-385
20. Bhadra M.P., Bhadra U., Kundu J., and Birchler J.A. Gene expression analysis of the function of the male-specific lethal complex in Drosophila. Genetics 169 (2005) 2061-2074
21. Birchler J.A., Pal-Bhadra M., and Bhadra U. Dosage dependent gene regulation and the compensation of the X chromosome in Drosophila males. Genetica 117 (2003) 179-190
22. Brookes P.S. Mitochondrial H(+) leak and ROS generation: an odd couple. Free Radic. Biol. Med. 38 (2005) 12-23
23. Burger J.M., and Promislow D.E. Sex-specific effects of interventions that extend fly life span. Sci. Aging Knowledge Environ. (2004) pe30
24. Burt A., and Trivers R. Genes and Conflict (2006), Harvard Press, Belknap
25. Busuttil R.A., Rubio M., Dolle M.E., Campisi J., and Vijg J. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell 2 (2003) 287-294
26. Buszczak M., and Cooley L. Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ. 7 (2000) 1071-1074
27. Carrel L., and Willard H.F. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434 (2005) 400-404
28. Cashio P., Lee T.V., and Bergmann A. Genetic control of programmed cell death in Drosophila melanogaster. Semin. Cell Dev. Biol. 16 (2005) 225-235
29. Charlesworth D., and Charlesworth B. Sex chromosomes: evolution of the weird and wonderful. Curr. Biol. 15 (2005) R129-R131
30. Chippindale A.K., Gibson J.R., and Rice W.R. Negative genetic correlation for adult fitness between sexes reveals ontogenetic conflict in Drosophila. Proc. Natl. Acad. Sci. USA 98 (2001) 1671-1675
31. Chow J.C., Yen Z., Ziesche S.M., and Brown C.J. Silencing of the mammalian X chromosome. Annu. Rev. Genom. Hum. Genet. 6 (2005) 69-92
32. Clancy D.J., Gems D., Harshman L.G., Oldham S., Stocker H., Hafen E., Leevers S.J., and Partridge L. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292 (2001) 104-106
33. Corona M., Hughes K.A., Weaver D.B., and Robinson G.E. Gene expression patterns associated with queen honey bee longevity. Mech. Aging Dev. 126 (2005) 1230-1238
34. Cox R.T., and Spradling A.C. A Balbiani body and the fusome mediate mitochondrial inheritance during Drosophila oogenesis. Development 130 (2003) 1579-1590
35. Cypser J.R., and Johnson T.E. Hormesis in Caenorhabditis elegans dauer-defective mutants. Biogerontology 4 (2003) 203-214
36. Dawkins R. The Selfish Gene (1976), Oxford University Press, Oxford
37. De Luca M., Roshina N.V., Geiger-Thornsberry G.L., Lyman R.F., Pasyukova E.G., and Mackay T.F. Dopa decarboxylase (Ddc) affects variation in Drosophila longevity. Nat. Genet. 34 (2003) 429-433
38. Dillin A., Hsu A.L., Arantes-Oliveira N., Lehrer-Graiwer J., Hsin H., Fraser A.G., Kamath R.S., Ahringer J., and Kenyon C. Rates of behavior and aging specified by mitochondrial function during development. Science 298 (2002) 2398-2401
39. Drummond-Barbosa D., and Spradling A.C. Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis. Dev. Biol. 231 (2001) 265-278
40. Drysdale R.A., and Crosby M.A. FlyBase: genes and gene models. Nucl. Acids Res. 33 (2005) D390-D395
41. Fabrizio J.J., Hime G., Lemmon S.K., and Bazinet C. Genetic dissection of sperm individualization in Drosophila melanogaster. Development 125 (1998) 1833-1843
42. Finch C.E. Longevity, Senescence and the Genome (1990), University of Chicago Press, Chicago
43. Finch C.E., and Sapolsky R.M. The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms. Neurobiol. Aging 20 (1999) 407-428
44. Flatt T., Tu M.P., and Tatar M. Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history. Bioessays 27 (2005) 999-1010
45. Ford D., and Tower J. Genetic manipulation of life span in Drosophila melanogaster. In: Masoro E.J., and Austad S.N. (Eds). Handbook of the Biology of Aging (2006), Elsevier, Burlington, MA 400-412
46. Fridovich I. Mitochondria: are they the seat of senescence?. Aging Cell 3 (2004) 13-16
47. Fry A.J., Palmer M.R., and Rand D.M. Variable fitness effects of Wolbachia infection in Drosophila melanogaster. Heredity 93 (2004) 379-389
48. Fry A.J., and Rand D.M. Wolbachia interactions that determine Drosophila melanogaster survival. Evol. Int. J. Org. Evol. 56 (2002) 1976-1981
49. Garigan D., Hsu A.L., Fraser A.G., Kamath R.S., Ahringer J., and Kenyon C. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161 (2002) 1101-1112
50. Gaspari L., Pedotti P., Bonafe M., Franceschi C., Marinelli D., Mari D., Garte S., and Taioli E. Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls. Biomarkers 8 (2003) 522-528
51. Gatza C., Hinkel G., Moore L., Dumble M., and Donehower L.A. p53 and mouse aging models. In: Masoro E.J., and Austad S.N. (Eds). Handbook of the Biology of Aging (2006), Elsevier, Burlington, MA 149-171
52. Gems D., and McElwee J.J. Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?. Mech. Aging Dev. 126 (2005) 381-387
53. Gerdes K., Christensen S.K., and Lobner-Olesen A. Prokaryotic toxin-antitoxin stress response loci. Nat. Rev. Microbiol. 3 (2005) 371-382
54. Gibson J.R., Chippindale A.K., and Rice W.R. The X chromosome is a hot spot for sexually antagonistic fitness variation. Proc. Biol. Sci. 269 (2002) 499-505
55. Good J.M., and Nachman M.W. Rates of protein evolution are positively correlated with developmental timing of expression during mouse spermatogenesis. Mol. Biol. Evol. 22 (2005) 1044-1052
56. Graham P., Penn J.K., and Schedl P. Masters change, slaves remain. Bioessays 25 (2003) 1-4
57. Graves J.A. Sex chromosome specialization and degeneration in mammals. Cell 124 (2006) 901-914
58. Gray M.W., Burger G., and Lang B.F. Mitochondrial evolution. Science 283 (1999) 1476-1481
59. Hekimi S., and Guarente L. Genetics and the specificity of the aging process. Science 299 (2003) 1351-1354
60. Helfand S.L., and Rogina B. Genetics of aging in the fruit fly, Drosophila melanogaster. Annu. Rev. Genet. 37 (2003) 329-348
61. Herndon L.A., Schmeissner P.J., Dudaronek J.M., Brown P.A., Listner K.M., Sakano Y., Paupard M.C., Hall D.H., and Driscoll M. Stochastic and genetic factors influence tissue-specific decline in aging C. elegans. Nature 419 (2002) 808-814
62. Hogeweg P., and Takeuchi N. Multilevel selection in models of prebiotic evolution: compartments and spatial self-organization. Orig. Life Evol. Biosph. 33 (2003) 375-403
63. Honda Y., and Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13 (1999) 1385-1393
64. Hsu H.C., Li L., Zhang H.G., and Mountz J.D. Genetic regulation of thymic involution. Mech. Aging Dev. 126 (2005) 87-97
65. Hughes K.A., and Reynolds R.M. Evolutionary and mechanistic theories of aging. Annu. Rev. Entomol. 50 (2005) 421-445
66. Hussein M.R. Apoptosis in the ovary: molecular mechanisms. Hum. Reprod. Update 11 (2005) 162-177
67. Hwangbo D.S., Gersham B., Tu M.P., Palmer M., and Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429 (2004) 562-566
68. Jackson A.U., Galecki A.T., Burke D.T., and Miller R.A. Mouse loci associated with life span exhibit sex-specific and epistatic effects. J. Gerontol. A: Biol. Sci. Med. Sci. 57 (2002) B9-B15
69. Jones A. Does the plant mitochondrion integrate cellular stress and regulate programmed cell death?. Trends Plant Sci. 5 (2000) 225-230
70. Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 120 (2005) 449-460
71. Kirkwood T.B.L., and Austad S.N. Why do we age?. Nature 409 (2000) 233-238
72. Kloc M., Bilinski S., and Etkin L.D. The Balbiani body and germ cell determinants: 150 years later. Curr. Top. Dev. Biol. 59 (2004) 1-36
73. Kobayashi S., Sato K., and Hayashi Y. The role of mitochondrial rRNAs and nanos protein in germline formation in Drosophila embryos. Zool. Sci. 22 (2005) 943-954
74. Krakauer D.C., and Mira A. Mitochondria and germ-cell death. Nature 400 (1999) 125-126
75. Kujoth G.C., Hiona A., Pugh T.D., Someya S., Panzer K., Wohlgemuth S.E., Hofer T., Seo A.Y., Sullivan R., Jobling W.A., Morrow J.D., Van Remmen H., Sedivy J.M., Yamasoba T., Tanokura M., Weindruch R., Leeuwenburgh C., and Prolla T.A. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309 (2005) 481-484
76. Landis G.N., Bhole D., and Tower J. A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cct1genes. Genome Biol. 4 (2003) R8
77. Landis G.N., and Tower J. Superoxide dismutase evolution and life span regulation. Mech. Aging Dev. 126 (2005) 365-379
78. Lang B.F., Gray M.W., and Burger G. Mitochondrial genome evolution and the origin of eukaryotes. Annu. Rev. Genet. 33 (1999) 351-397
79. Larsen P.L. Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 90 (1993) 8905-8909
80. Lee S.S., Kennedy S., Tolonen A.C., and Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science 300 (2003) 644-647
81. Lee S.S., Lee R.Y., Fraser A.G., Kamath R.S., Ahringer J., and Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 33 (2003) 40-48
82. Leips J., Gilligan P., and Mackay T.F. Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster. Genetics 172 (2006) 1595-1605
83. Leips J., and Mackay T.F. Quantitative trait loci for life span in Drosophila melanogaster: interactions with genetic background and larval density. Genetics 155 (2000) 1773-1788
84. Line M.A. A hypothetical pathway from the RNA to the DNA world. Orig. Life Evol. Biosph. 35 (2005) 395-400
85. Luckinbill L.S., Arking R., Clare M., Cirocco W., and Buck S. Selection for delayed senescence in Drosophila melanogaster. Evolution 38 (1984) 996-1003
86. Mackay T.F.C. The nature of quantitative genetic variation for Drosophila longevity. Mech. Aging Dev. 123 (2002) 95-104
87. Magwere T., Chapman T., and Partridge L. Sex differences in the effect of dietary restriction on life span and mortality rates in female and male Drosophila melanogaster. J. Gerontol. A: Biol. Sci. Med. Sci. 59 (2004) 3-9
88. Maier B., Gluba W., Bernier B., Turner T., Mohammad K., Guise T., Sutherland A., Thorner M., and Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18 (2004) 306-319
89. Mair W., Goymer P., Pletcher S.D., and Partridge L. Demography of dietary restriction and death in Drosophila. Science 301 (2003) 1731-1733
90. Martin G.M. Genetic modulation of senescent phenotypes in Homo sapiens. Cell 120 (2005) 523-532
91. Masoro E.J. Overview of caloric restriction and aging. Mech. Aging Dev. 126 (2005) 913-922
92. McCulloch D., and Gems D. Evolution of male longevity bias in nematodes. Aging Cell 2 (2003) 165-173
93. Miller P.M., Gavrilets S., and Rice W.R. Sexual conflict via maternal-effect genes in ZW species. Science 312 (2006) 73
94. Miller R.A. Genetic approaches to the study of aging. J. Am. Geriatr. Soc. 53 (2005) S284-S286
95. Murphy C.T., McCarroll S.A., Bargmann C.I., Fraser A., Kamath R.S., Ahringer J., Li H., and Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424 (2003) 277-283
96. Nielsen R., Bustamante C., Clark A.G., Glanowski S., Sackton T.B., Hubisz M.J., Fledel-Alon A., Tanenbaum D.M., Civello D., White T.J., Sninsky J.J., Adams M.D., and Cargill M. A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol. 3 (2005) e170
97. Nilsen J., and Brinton R.D. Mitochondria as therapeutic targets of estrogen action in the central nervous system. Curr. Drug Targets CNS Neurol. Disord. 3 (2004) 297-313
98. Nishimura Y., Yoshinari T., Naruse K., Yamada T., Sumi K., Mitani H., Higashiyama T., and Kuroiwa T. Active digestion of sperm mitochondrial DNA in single living sperm revealed by optical tweezers. Proc. Natl. Acad. Sci. USA 103 (2006) 1382-1387
99. Nowak M.A., and Sigmund K. Evolutionary dynamics of biological games. Science 303 (2004) 793-799
100. Nuzhdin S.V., Khazaeli A.A., and Curtsinger J.W. Survival analysis of life span quantitative trait loci in Drosophila melanogaster. Genetics 170 (2005) 719-731
101. Nuzhdin S.V., Pasyukova E.G., Dilda C.L., Zeng Z.-B., and Mackay T.F.C. Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 94 (1997) 9734-9739
102. Ohki R., Tsurimoto T., and Ishikawa F. In vitro reconstitution of the end replication problem. Mol. Cell Biol. 21 (2001) 5753-5766
103. Oliver B., and Parisi M. Battle of the Xs. Bioessays 26 (2004) 543-548
104. Olovnikov A.M. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 41 (1973) 181-190
105. Parisi M., Nuttall R., Edwards P., Minor J., Naiman D., Lu J., Doctolero M., Vainer M., Chan C., Malley J., Eastman S., and Oliver B. A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Genome Biol. 5 (2004) R40
106. Parisi M., Nuttall R., Naiman D., Bouffard G., Malley J., Andrews J., Eastman S., and Oliver B. Paucity of genes on the Drosophila X chromosome showing male-biased expression. Science 299 (2003) 697-700
107. Parkes T.L., Elia A.J., Dickson D., Hilliker A.J., Phillips J.P., and Boulianne G.L. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat. Genet. 19 (1998) 171-174
108. Partridge L., Pletcher S.D., and Mair W. Dietary restriction, mortality trajectories, risk and damage. Mech. Aging Dev. 126 (2005) 35-41
109. Pepling M.E., and Spradling A.C. Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles. Dev. Biol. 234 (2001) 339-351
110. Perls T., and Terry D. Genetics of exceptional longevity. Exp. Gerontol. 38 (2003) 725-730
111. Rand D.M. Mitochondrial genetics of aging: intergenomic conflict resolution. Sci. Aging Knowledge Environ. (2005) re5
112. Rand D.M., Clark A.G., and Kann L.M. Sexually antagonistic cytonuclear fitness interactions in Drosophila melanogaster. Genetics 159 (2001) 173-187
113. Rand D.M., Fry A., and Sheldahl L. Nuclear-mitochondrial epistasis and Drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds. Genetics 172 (2006) 329-341
114. Rauser C.L., Tierney J.J., Gunion S.M., Covarrubias G.M., Mueller L.D., and Rose M.R. Evolution of late-life fecundity in Drosophila melanogaster. J. Evol. Biol. 19 (2006) 289-301
115. Reiwitch S.G., and Nuzhdin S.V. Quantitative trait loci for lifespan of mated Drosophila melanogaster affect both sexes. Genet. Res. 80 (2002) 225-230
116. Rice W.R. Sexually antagonistic genes: experimental evidence. Science 256 (1992) 1436-1439
117. Rice W.R. Male fitness increases when females are eliminated from gene pool: implications for the Y chromosome. Proc. Natl. Acad. Sci. USA 95 (1998) 6217-6221
118. Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W., Weinstock G.M., and Gibbs R.A. Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res. 15 (2005) 1-18
119. Rose M.R. Laboratory evolution of postponed senescence in Drosophila melanogaster. Evolution 38 (1984) 1004-1010
120. Scheuring I., Czaran T., Szabo P., Karolyi G., and Toroczkai Z. Spatial models of prebiotic evolution: soup before pizza?. Orig. Life Evol. Biosph. 33 (2003) 319-355
121. Searcy D.G. Metabolic integration during the evolutionary origin of mitochondria. Cell Res. 13 (2003) 229-238
122. Spees J.L., Olson S.D., Whitney M.J., and Prockop D.J. Mitochondrial transfer between cells can rescue aerobic respiration. Proc. Natl. Acad. Sci. USA 103 (2006) 1283-1288
123. Spencer C.C., Howell C.E., Wright A.R., and Promislow D.E. Testing an 'aging gene' in long-lived Drosophila strains: increased longevity depends on sex and genetic background. Aging Cell 2 (2003) 123-130
124. Starr D.J., and Cline T.W. A host parasite interaction rescues Drosophila oogenesis defects. Nature 418 (2002) 76-79
125. Stewart E.J., Madden R., Paul G., and Taddei F. Aging and death in an organism that reproduces by morphologically symmetric division. PLoS Biol. 3 (2005) e45
126. Sun J., Folk D., Bradley T.J., and Tower J. Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics 161 (2002) 661-672
127. Sun J., and Tower J. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol. Cell Biol. 19 (1999) 216-228
128. Szathmary E. The evolution of replicators. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 355 (2000) 1669-1676
129. Tatar M., Khazaeli A.A., and Curtsinger J.W. Chaperoning extended life. Nature 390 (1997) 30
130. Tatar M., Kopelman A., Epstein D., Tu M.P., Yin C.M., and Garofalo R.S. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292 (2001) 107-110
131. Timmis J.N., Ayliffe M.A., Huang C.Y., and Martin W. Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes. Nat. Rev. Genet. 5 (2004) 123-135
132. Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Igelmann H., Lu X., Soron G., Cooper B., Brayton C., Hee Park S., Thompson T., Karsenty G., Bradley A., and Donehower L.A. p53 mutant mice that display early aging-associated phenotypes. Nature 415 (2002) 45-53
133. Valenzuela R.K., Forbes S.N., Keim P., and Service P.M. Quantitative trait loci affecting life span in replicated populations of Drosophila melanogaster. II. Response to selection. Genetics 168 (2004) 313-324
134. van Heemst D., Mooijaart S.P., Beekman M., Schreuder J., de Craen A.J., Brandt B.W., Slagboom P.E., and Westendorp R.G. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp. Gerontol. 40 (2005) 11-15
135. Vieira C., Pasyukova E.G., Zeng Z.B., Hackett J.B., Lyman R.F., and Mackay T.F. Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster. Genetics 154 (2000) 213-227
136. Vina J., Borras C., Gambini J., Sastre J., and Pallardo F.V. Why females live longer than males: control of longevity by sex hormones. Sci. Aging Knowledge Environ. (2005) pe17
137. Walker G.A., White T.M., McColl G., Jenkins N.L., Babich S., Candido E.P., Johnson T.E., and Lithgow G.J. Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans. J. Gerontol. A: Biol. Sci. Med. Sci. 56 (2001) B281-B287
138. Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39 (2005) 359-407
139. Walter R., Murasko D.M., and Sierra F. T-kininogen is a biomarker of senescence in rats. Mech. Aging Dev. 106 (1998) 129-144
140. Wang M.H., Lazebny O., Harshman L.G., and Nuzhdin S.V. Environment-dependent survival of Drosophila melanogaster: a quantitative genetic analysis. Aging Cell 3 (2004) 133-140
141. Wilk K., Bilinski S., Dougherty M.T., and Kloc M. Delivery of germinal granules and localized RNAs via the messenger transport organizer pathway to the vegetal cortex of Xenopus oocytes occurs through directional expansion of the mitochondrial cloud. Int. J. Dev. Biol. 49 (2005) 17-21
142. Wolfner M.F. The gifts that keep on giving: physiological functions and evolutionary dynamics of male seminal proteins in Drosophila. Heredity 88 (2002) 85-93
143. Yin V.P., and Thummel C.S. Mechanisms of steroid-triggered programmed cell death in Drosophila. Semin. Cell Dev. Biol. 16 (2005) 237-243
144. Zheng J., Edelman S.W., Tharmarajah G., Walker D.W., Pletcher S.D., and Seroude L. Differential patterns of apoptosis in response to aging in Drosophila. Proc. Natl. Acad. Sci. USA 102 (2005) 12083-12088