Genetic regulation of thymic involution

Mechanisms of Ageing and Development

Volumn 126, Issue 1, 2005, Pages 87-97

  Hsu, Hui Chen ^a   Li, Lina ^b   Zhang, Huang Ge ^a,c   Mountz, John D ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b NIH/NHLBI/LBG   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

BXD RI mice; Genetics; IL 12; Proteomics; Thymic involution; Tumor

Indexed keywords

CONCANAVALIN A; INTERLEUKIN 12; INTERLEUKIN 2; PEROXIREDOXIN;

CELL LOSS; CELL PROLIFERATION; CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 9; CHROMOSOME ANALYSIS; CHROMOSOME MAP; CONFERENCE PAPER; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC REGULATION; GENOMICS; KNOCKOUT MOUSE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; QUANTITATIVE TRAIT LOCUS; THYMIC INVOLUTION; THYMOCYTE; THYMUS DISEASE; WILD TYPE;

AGING; ANIMALS; CHROMOSOMES; CYTOKINES; MICE; MICE, KNOCKOUT; PHYSICAL CHROMOSOME MAPPING; QUANTITATIVE TRAIT LOCI; THYMUS GLAND;

ANIMALIA;

EID: 10944238537     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2004.09.016     Document Type: Conference Paper

References (51)

1. M. Aronson Hypothesis: involution of the thymus with aging-programmed and beneficial Thymus 18 1991 7 13
2. R. Aspinall, and D. Andrew Thymic involution in aging J. Clin. Immunol. 20 2000 250 256
3. G. Atzmon, I. Gabriely, W. Greiner, D. Davidson, C. Schechter, and N. Barzilai Plasma HDL levels highly correlate with cognitive function in exceptional longevity J. Gerontol. A Biol. Sci. Med. Sci. 57 2002 M712 M715
4. E.P. Blankenhorn, R.J. Butterfield, R. Rigby, L. Cort, D. Giambrone, P. McDermott, K. McEntee, N. Solowski, N.D. Meeker, J.F. Zachary, R.W. Doerge, and C. Teuscher Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints J. Immunol. 164 2000 3420 3425
5. E. Boyd The weight of the thymus gland in health and disease Am. J. Dis. Child. 43 1932 1162 1214
6. P.S. Brookes, A. Pinner, A. Ramachandran, L. Coward, S. Barnes, H. Kim, and V.M. Darley-Usmar High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes Proteomics 2 2002 969 977
7. D. Burger, and J.M. Dayer Cytokines, acute-phase proteins, and hormones: IL-1 and TNF-alpha production in contact-mediated activation of monocytes by T lymphocytes Ann. N.Y. Acad. Sci. 966 2002 464 473
8. D. Burger, and J.M. Dayer High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chronic inflammation? Autoimmun. Rev. 1 2002 111 117
9. K.E. Clemens, G. Churchill, N. Bhatt, K. Richardson, and F.P. Noonan Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci Genes Immun. 1 2000 251 259
10. R.G. Goya, K. Brooks, and J. Meites A comparison between hormone levels and T lymphocyte function in young and old rats Mech. Ageing Dev. 61 1991 275 285
11. W.E. Grizzle, J.D. Mountz, P.A. Yang, X. Xu, S. Sun, G.E. Van Zant, R.W. Williams, H.C. Hsu, and H.G. Zhang BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model Int. J. Cancer. 101 2002 270 279
12. H. Havelkova, M. Kosarova, M. Krulova, P. Demant, and M. Lipoldova T-cell proliferative response is controlled by loci Tria4 and Tria5 on mouse chromosomes 7 and 9 Mamm. Genome 10 1999 670 674
13. A. Hill, and H. Kim The UAB proteomics database Bioinformatics 19 2003 2149 2151
14. B. Hofmann, H.J. Hecht, and L. Flohe Peroxiredoxins Biol. Chem. 383 2002 347 364
15. Hsu, H.C., Mountz, J.D., Williams, R.W., Shelton, B.J., Yang, P., Matsuki, Y., Xu, X., Zhang, H.G., Geiger, H., van Zant, G., 2002. Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. Mech. Ageing Dev.
16. H.C. Hsu, H.G. Zhang, L. Li, N. Yi, P.A. Yang, Q. Wu, J. Zhou, S. Sun, X. Xu, X. Yang, L. Lu, G. Van Zant, R.W. Williams, D.B. Allison, and J.D. Mountz Age-related thymic involution in C57BL/6J × DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10 Genes Immun. 4 2003 402 410
17. B.Y. Ishida, P.J. Blanche, A.V. Nichols, M. Yashar, and B. Paigen Effects of atherogenic diet consumption on lipoproteins in mouse strains C57BL/6 and C3H J. Lipid Res. 32 1991 559 568
18. A.U. Jackson, A.T. Galecki, D.T. Burke, and R.A. Miller Mouse loci associated with life span exhibit sex-specific and epistatic effects J. Gerontol. A Biol. Sci. Med. Sci. 57 2002 B9 B15
19. J.P. Jacquot, E. Gelhaye, N. Rouhier, C. Corbier, C. Didierjean, and A. Aubry Thioredoxins and related proteins in photosynthetic organisms: molecular basis for thiol dependent regulation Biochem. Pharmacol. 64 2002 1065 1069
20. F. Joncourt, F. Bettens, F. Kristensen, and A.L. de Weck Age-related changes of mitogen responsiveness in different lymphoid organs from outbred NMRI mice Immunobiology 158 1981 439 449
21. C.W. Joyce, M.J. Amar, G. Lambert, B.L. Vaisman, B. Paigen, J. Najib-Fruchart, R.F. Hoyt Jr., E.D. Neufeld, A.T. Remaley, D.S. Fredrickson, H.B. Brewer Jr., and S. Santamarina-Fojo The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice Proc. Natl. Acad. Sci. U.S.A. 99 2002 407 412
22. P.J. Kaplan, and J.S. Garvey Age-related changes in responsiveness of various rat tissue lymphocytes to mitogens Immunol. Lett. 3 1981 357 363
23. K.W. Kelley, W.A. Meier, C. Minshall, D.H. Schacher, Q. Liu, R. VanHoy, W. Burgess, and R. Dantzer Insulin growth factor-I inhibits apoptosis in hematopoietic progenitor cells. Implications in thymic aging Ann. N.Y. Acad. Sci. 840 1998 518 524
24. L. Li, H.C. Hsu, W.E. Grizzle, C.R. Stockard, K.J. Ho, P. Lott, P.A. Yang, H.G. Zhang, and J.D. Mountz Cellular mechanism of thymic involution Scand. J. Immunol. 57 2003 410 422
25. L. Li, H.C. Hsu, C.R. Stockard, P. Yang, J. Zhou, Q. Wu, W.E. Grizzle, and J.D. Mountz IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation J. Immunol. 172 2004 2909 2916
26. B.R. Ludviksson, R.O. Ehrhardt, and W. Strober Role of IL-12 in intrathymic negative selection J. Immunol. 163 1999 4349 4359
27. P.V. Luoma Gene activation, apolipoprotein A-I/high density lipoprotein, atherosclerosis prevention and longevity Pharmacol. Toxicol. 81 1997 57 64
28. K.F. Manly, R.H. Cudmore Jr., and J.M. Meer Map Manager QTX, cross-platform software for genetic mapping Mamm. Genome 12 2001 930 932
29. K.F. Manly, and J.M. Olson Overview of QTL mapping software and introduction to map manager QT Mamm. Genome 10 1999 327 334
30. E. Maraskovsky, M. Teepe, P.J. Morrissey, S. Braddy, R.E. Miller, D.H. Lynch, and J.J. Peschon Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells J. Immunol. 157 1996 5315 5323
31. D. Metcalf, R. Moulds, and B. Pike Influence of the spleen and thymus on immune responses in ageing mice Clin. Exp. Immunol. 2 1967 109 120
32. R.A. Miller, C. Chrisp, A.U. Jackson, A.T. Galecki, and D.T. Burke Coordinated genetic control of neoplastic and nonneoplastic diseases in mice J. Gerontol. A Biol. Sci. Med. Sci. 57 2002 B3 B8
33. E.Y. Moon, Y.H. Han, D.S. Lee, Y.M. Han, and D.Y. Yu Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus Eur. J. Immunol. 34 2004 2119 2128
34. A. Morell Aging of the immunosystem and its significance for tumor genesis Aktuelle Gerontol. 11 1981 47 50 (author's translation)
35. P. Nanni, C. de Giovanni, P.L. Lollini, G. Nicoletti, and G. Prodi TS/A: a new metastasizing cell line from a B ALB/c spontaneous mammary adenocarcinoma Clin. Exp. Metastasis 1 1983 373 380
36. J.F. Oram, R.M. Lawn, M.R. Garvin, and D.P. Wade ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages J. Biol. Chem. 275 2000 34508 34511
37. C.L. Ortman, K.A. Dittmar, P.L. Witte, and P.T. Le Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments Int. Immunol. 14 2002 813 822
38. A.M. Palmer, N. Murphy, and A. Graham Triglyceride-rich lipoproteins inhibit cholesterol efflux to apolipoprotein (apo) A1 from human macrophage foam cells Atherosclerosis 173 2004 27 38
39. D.J. Pappin Peptide mass fingerprinting using MALDI-TOF mass spectrometry Methods Mol. Biol. 211 2003 211 219
40. J.Y. Park, J.K. Seong, and Y.K. Paik Proteomic analysis of diet-induced hypercholesterolemic mice Proteomics 4 2004 514 523
41. D.N. Perkins, D.J. Pappin, D.M. Creasy, and J.S. Cottrell Probability-based protein identification by searching sequence databases using mass spectrometry data Electrophoresis 20 1999 3551 3567
42. L. Piantanelli, C. Viticchi, A. Basso, and G. Rossolini Thymic involution and aging processes Int. J. Neurosci. 51 1990 283 285
43. R.J. Roper, J.J. Weis, B.A. McCracken, C.B. Green, Y. Ma, K.S. Weber, D. Fairbairn, R.J. Butterfield, M.R. Potter, J.F. Zachary, R.W. Doerge, and C. Teuscher Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses Genes Immun. 2 2001 388 397
44. T. Sasada, and E.L. Reinherz A critical role for CD2 in both thymic selection events and mature T cell function J. Immunol. 166 2001 2394 2403
45. G.D. Sempowski, M.E. Gooding, H.X. Liao, P.T. Le, and B.F. Haynes T cell receptor excision circle assessment of thymopoiesis in aging mice Mol. Immunol. 38 2002 841 848
46. K.J. Warrington, A.N. Vallejo, C.M. Weyand, and J.J. Goronzy CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation Blood 101 2003 3543 3549
47. M.C. Weksler, J.D. Innes, and G. Goldstein Immunological studies of aging. IV. The contribution of thymic involution to the immune deficiencies of aging mice and reversal with thymopoietin 32-36 J. Exp. Med. 148 1978 996 1006
48. M.E. Weksler The thymus gland and aging Ann. Intern. Med. 98 1983 105 107
49. Z.A. Wood, E. Schroder, J. Robin Harris, and L.B. Poole Structure, mechanism and regulation of peroxiredoxins Trends Biochem. Sci. 28 2003 32 40
50. S.I. Ymer, D. Huang, G. Penna, S. Gregori, K. Branson, L. Adorini, and G. Morahan Polymorphisms in the IL12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains Genes Immun. 3 2002 151 157
51. T. Zhou, C.K. Edwards III, and J.D. Mountz Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice J. Exp. Med. 182 1995 129 137