Genetics of exceptional longevity

Experimental Gerontology

Volumn 38, Issue 7, 2003, Pages 725-730

  Perls, Thomas ^a   Terry, Dellara ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Centenarian; Clustering; Demography; Genetics; Heritability; Longevity; Oldest old

Indexed keywords

APOLIPOPROTEIN E4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

AGING; BEHAVIOR; CLUSTER ANALYSIS; COHORT ANALYSIS; CONFERENCE PAPER; DEMOGRAPHY; DIABETES MELLITUS; DISEASE PREDISPOSITION; DOMINANT INHERITANCE; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENETICS; GERONTOLOGY; HEART DISEASE; HEREDITY; HUMAN; HYPERTENSION; LIFE EXPECTANCY; LONGEVITY; MOLECULAR GENETICS; MORBIDITY; MORTALITY; PEDIGREE; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; PROGENY; SIBLING; SURVIVAL RATE; VERTICAL TRANSMISSION;

EID: 0038349415     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(03)00098-6     Document Type: Conference Paper

References (16)

1. Barzilai N., Gabriely I., Gabriely M., Iankowitz N., Sorkin J.D. Offspring of centenarians have a favorable lipid profile. J. Am. Geriatr. Soc. 49:2001;1-4.
2. Cutler R.G. Evolution of human longevity and the genetic complexity governing aging rate. Proc. Natl. Acad. Sci. USA. 72:1975;4664-4668.
3. Evert J., Lawler E., Bogan H., Perls T. Morbidity profiles of centenarians: survivors, delayers and escapers. J. Gerontol.: A Biol. Sci. Med. Sci. 58:2003;232-237.
4. Fraser G.E., Shavlik D.J. Ten years of life: is it a matter of choice? Arch. Intern. Med. 161:2001;1645-1652.
5. Hitt R., Young-Xu Y., Perls T. Centenarians: the older you get, the healthier you've been. Lancet. 354:(9179):1999;652.
6. Lee C.K., Klopp R.G., Weindruch R., Prolla T.A. Gene expression profile of aging and its retardation by caloric restriction. Science. 27:(285):1999;1390-1393.
7. Ljungquist B., Berg S., Lanke J., Mc Clearn G.E., Pedersen N.L. The effect of genetic factors for longevity: a comparison of identical and fraternal twins in the Swedish Twin Registry. J. Gerontol. A Biol. Sci. Med. Sci. 53:1998;M441-M446.
8. Martin G.M. Keynote, mechanisms of senescence: complicationists versus simplificationists. Mech. Ageing Dev. 123:2002;65-73.
9. McCarthy M.I., Kruglyak L., Lander E.S. Sib-pair collection strategies for complex diseases. Genet. Epidemiol. 15:1998;317-340.
10. Perls T., Fretts R. Why women live longer than men. Sci. Am. Press. June:1998;100-107.
11. Perls T., Shea-Drinkwater M., Bowen-Flynn J., Ridge S.B., Kang S., Joyce E., Daly M., Brewster S.J., Kunkel L., Puca A.A. Exceptional familial clustering for extreme longevity in humans. J. Am. Geriatr. Soc. 48:2000;1483-1485.
12. Perls T.T., Wilmoth J., Levenson R., Drinkwater M., Cohen M., Bogan H., Joyce E., Brewster S., Kunkel L., Puca A. Life-long sustained mortality advantage of siblings of centenarians. Proc. Natl. Acad. Sci. USA. 99:2002;8442-8447.
13. Puca A.A., Daly M.J., Brewster S.J., Matise T.C., Barrett J., Shea-Drinkwater M., Kang S., Joyce E., Nicoli J., Benson E., Kunkel L.M., Perls T. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc. Natl. Acad. Sci. USA. 98:2001;10505-10508.
14. Schachter F., Faure-Delanef L., Guenot F., Roug M., Froguel P., Lesueur-Ginot L., Cohen D. Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6:1994;29-32.
15. Terry D.F., Wilcox M., McCormick M.A., Lawler E., Perls T.T. Cardiovascular advantages among the offspring of centenarians. J. Gerontol. A Biol. Sci. Med. Sci. 58:2003;425-431.
16. Vita A.J., Terry R.B., Hubert H.B., Fries J.F. Aging, health risks, and cumulative disability. N. Engl. J. Med. 338:1998;1035-1041.