Application of mass spectrometry for metabolite identification

Current Drug Metabolism

Volumn 7, Issue 5, 2006, Pages 503-523

  Ma, Shuguang ^a   Chowdhury, Swapan K ^a   Alton, Kevin B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Accurate mass measurement; APPI; CRIMS; H D exchange; ICPMS; LC MS MS; LC NMR MS; Mass spectrometry; Metabolite identification

Indexed keywords

ANILINE DERIVATIVE; DRUG METABOLITE; NEW DRUG; PEGINTERFERON ALPHA2B; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN;

ANALYTIC METHOD; ANALYZER; DRUG DESIGN; DRUG EFFICACY; DRUG METABOLISM; DRUG SAFETY; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFORMATION PROCESSING; IONIZATION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; REVIEW; SAMPLE; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEUTERIUM EXCHANGE MEASUREMENT; FOURIER ANALYSIS; HUMANS; INFORMATION STORAGE AND RETRIEVAL; ISOTOPE LABELING; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROCHEMISTRY; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; SPECIMEN HANDLING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TECHNOLOGY, PHARMACEUTICAL;

EID: 33745758232     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920006777697891     Document Type: Review

References (170)

1. Caldwell, J.; Gardner, I. and Swales, N. (1995) Toxicol. Pathol., 23(2), 102-114.
2. Gibson, G.G. and Skett, P.S. (1994) In Introduction to Drug Metabolism, (Gibson, G.G. and Skett, P.S. Eds.), Blackie Academic and Professional, London, pp. 35-76.
3. Gibson, G.G. and Skett, P.S. (1994) in Introduction to Drug Metabolism, (Gibson, G.G. and Skett, P.S. Eds.), Blackie Academic and Professional, London, pp. 1-34.
4. Lin, J.H. and Lu, A.Y. (1997) Pharmacol. Rev., 49(4), 403-449.
5. Watt, A.P.; Mortishire-Smith, R.J.; Gerhard, U. and Thomas, S.R. (2003) Curr. Opin. Drug Discov. Devel., 6(1), 57-65.
6. Clarke, N.J.; Rindgen, D.; Korfmacher, W.A. and Cox, K.A. (2001) Anal. Chem., 73(15), 430A-439A.
7. Kostiainen, R.; Kotiaho, T.; Kuuranne, T. and Auriola, S. (2003) J. Mass Spectrom., 38(4), 357-372.
8. Nassar, A.E. and Talaat, R.E. (2004) Drug Discov. Today, 9(7), 317-327.
9. Lee, M.S. and Kerns, E.H. (1999) Mass Spectrom. Rev., 18(3-4), 187-279.
10. Vestal, M.L. (2001) Chem. Rev., 101(2), 361-375.
11. Rossi, D.T. (2002) In Mass Spectrometry in Drug Discovery, (Rossi, D.T. and Sinz, M.W. Eds.), Marcel Dekker, New York, pp. 15-24.
12. Poon, G.K. (1997) In Electrospray Ionization Mass Spectrometry: Fundamentals, Instrumentation, and Applications, (Cole, R.B. Ed.), Wiley-Interscience, New York, pp. 499-525.
13. Voyksner, R.D. (1997) In Electrospray Ionization Mass Spectrometry: Fundamentals, Instrumentation, and Applications, (Cole, R.B. Ed.), Wiley-Interscience, New York, pp. 323-341.
14. Dole, M.; Mack, L.L.; Hines, R.L.; Mobley, R.C.; Ferguson, L.D. and Alice, M.B. (1968) J. Chem. Phys., 49(5), 2240-2249.
15. Whitehouse, C.M.; Dreyer, R.N.; Yamashita, M. and Fenn, J.B. (1985) Anal. Chem., 57(3), 675-679.
16. Yamashita, M. and Fenn, J.B. (1984) J. Phys. Chem., 88(20), 4451-4459.
17. Yamaguchi, K. and Fenn, J.B. (1984) J. Phys. Chem., 88(20), 4671-4675.
18. Kebarle, P. and Ho, Y. (1997) In Electrospray Ionization Mass Spectrometry: Fundamentals, Instrumentation, and Applications, (Cole, R.B. Ed.), Wiley-Interscience, New York, pp. 1-63.
19. Chowdhury, S.K. and Chait, B.T. (1991) Anal. Chem., 63(15), 1660-1664.
20. Chowdhury, S.K.; Katta, V. and Chait, B.T. (1990) Rapid Commun. Mass Spectrom., 4(3), 81-87.
21. Emmett, M.R. and Caprioli, R.M. (1994) J. Am. Soc. Mass Spectrom., 5(7), 605-613.
22. Wilm, M. and Mann, M. (1996) Anal. Chem., 68(1), 1-8.
23. Rosenberg, E. (2003) J. Chromatogr. A, 1000(1-2), 841-889.
24. Horning, E.C.; Carroll, D.I.; Dzidic, I.; Haegele, K.D.; Horning, M.G. and Stillwell, R.N. (1974) J. Chromatogr. Sci., 12(11), 725-729.
25. Dams, R.; Huestis, M.A.; Lambert, W.E. and Murphy, C.M. (2003) J. Am. Soc. Mass Spectrom., 14(11), 1290-1294.
26. Hsieh, Y.; Chintala, M.; Mei, H.; Agans, J.; Brisson, J.M.; Ng, K. and Korfmacher, W.A. (2001) Rapid Commun. Mass Spectrom., 15(24), 2481-2487.
27. Brewer, E. and Henion, J. (1998) J. Pharm. Sci., 87(4), 395-402.
28. Robb, D.B.; Covey, T.R. and Bruins, A.P. (2000) Anal. Chem., 72(15), 3653-3659.
29. Raffaelli, A. and Saba, A. (2003) Mass Spectrom. Rev., 22(5), 318-331.
30. Kauppila, T.J.; Kuuranne, T.; Meurer, E.C.; Eberlin, M.N.; Kotiaho, T. and Kostiainen, R. (2002) Anal. Chem., 74(21), 5470-5479.
31. Van Berkel, G.J. (2003) Eur. J. Mass Spectrom., 9(6), 539-562.
32. Keski-Hynnila, H.; Kurkela, M.; Elovaara, E.; Antonio, L.; Magdalou, J.; Luukkanen, L.; Taskinen, J. and Kostiainen, R. (2002) Anal. Chem., 74(14), 3449-3457.
33. Wang, G.; Hsieh, Y. and Korfmacher, W.A. (2005) Anal. Chem., 77(2), 541-548.
34. Straube, E.A.; Dekant, W. and Volkel, W. (2004) J. Am. Soc. Mass Spectrom., 15(12), 1853-1862.
35. Geyer, R.; Peacock, A.D.; White, D.C.; Lytle, C. and Van Berkel, G.J. (2004) J. Mass Spectrom., 39(8), 922-929.
36. Rauha, J.P.; Vuorela, H. and Kostiainen, R. (2001) J. Mass Spectrom., 36(12), 1269-1280.
37. Yang, C. and Henion, J. (2002) J. Chromatogr. A, 970(1-2), 155-165.
38. McLuckey, S.A. and Wells, J.M. (2001) Chem. Rev., 101(2), 571-606.
39. Guihaus, M.; Selby, D. and Mlynski, V. (2000) Mass Spectrom. Rev., 19(2), 65-107.
40. Weickhardt, C.; Moritz, F. and Grotemeyer, J. (1996) Mass Spectrom. Rev., 15(3), 139-162.
41. Busch, K.L.; Glish, G.L. and McLuckey, S.A. (1988) Mass Spectrometry: Techniques and Applications of Tandem Mass Spectrometry, VCH, New York.
42. Glish, G.L. and Vachet, R.W. (2003) Nat. Rev. Drug Discov., 2(2), 140-150.
43. Watson, J.T. (1997) Introduction to Mass Spectrometry, Lippincott-Raven, Philadelphia.
44. March, R.E. and Hughes, R.J. (1989) Quadrupole Storage Mass Spectrometry, John Wiley & Sons, New York.
45. Cooks, R.G. and Kaiser, R.E. (1990) Acc. Chem. Res., 23(7), 213-219.
46. Douglas, D.J.; Frank, A.J. and Mao, D. (2005) Mass Spectrom. Rev., 24(1), 1-29.
47. Marshall, A.G.; Hendrickson, C.L. and Shi, S.D. (2002) Anal. Chem., 74(9), 252A-259A.
48. Marshall, A.G.; Hendrickson, C.L. and Jackson, G.S. (1998) Mass Spectrom. Rev., 17(1), 1-35.
49. Hu, Q.; Noll, R.J.; Li, H.; Makarov, A.; Hardman, M. and Cooks, R.G. (2005) J. Mass Spectrom., 40(4), 430-443.
50. Makarov, A. (2000) Anal. Chem., 72(6), 1156-1162.
51. Hardman, M. and Makarov, A.A. (2003) Anal. Chem., 75(7), 1699-1705.
52. de Hoffmann, E. (1996) J. Mass Spectrom., 31(2), 129-215.
53. Schwartz, J.C.; Wade, A.P.; Enke, C.G. and Cooks, R.G. (1990) Anal. Chem., 62(17), 1809-1818.
54. Korfmacher, W.A.; Cox, K.A.; Bryant, M.S.; Veals, J.; Ng, K.; Watkins, R. and Lin, C.-C. (1997) Drug Discov. Today, 2(12), 532-537.
55. Bryant, M.S.; Korfmacher, W.A.; Wang, S.; Nardo, C.; Nomeir, A.A. and Lin, C.C. (1997) J. Chromatogr. A, 777(1), 61-66.
56. Kantharaj, E.; Tuytelaars, A.; Proost, P.E.; Ongel, Z.; Van Assouw, H.P. and Gilissen, R.A. (2003) Rapid Commun. Mass Spectrom., 17(23), 2661-2668.
57. Shearer, T.W.; Smith, K.S.; Diaz, D.; Asher, C. and Ramirez, J. (2005) Comb. Chem. High Throughput Screen, 8(1), 89-98.
58. Chovan, L.E.; Black-Schaefer, C.; Dandliker, P.J. and Lau, Y.Y. (2004) Rapid Commun. Mass Spectrom., 18(24), 3105-3112.
59. Xia, Y.Q.; Miller, J.D.; Bakhtiar, R.; Franklin, R.B. and Liu, D.Q. (2003) Rapid Commun. Mass Spectrom., 17(11), 1137-1145.
60. Hopfgartner, G.; Varesio, E.; Tschappat, V.; Grivet, C.; Bourgogne, E. and Leuthold, L.A. (2004) J. Mass Spectrom., 39(8), 845-855.
61. Hopfgartner, G.; Husser, C. and Zell, M. (2003) J. Mass Spectrom., 38(2), 138-150.
62. Cox, K.A. (2005) In Using Mass Spectrometry for Drug Metabolism Studies, (Korfmacher, W.A. Ed.), CRC Press, Boca Raton, pp. 229-252.
63. Taylor, E.W.; Jia, W.; Bush, M. and Dollinger, G.D. (2002) Anal. Chem., 74(13), 3232-3238.
64. Yu, L.J.; Chen, Y.; Deninno, M.P.; O'Connell, T.N. and Hop, C.E. (2005) Drug Metab. Dispos., 33(4), 484-488.
65. Borlak, J.; Walles, M.; Elend, M.; Thum, T.; Preiss, A. and Levsen, K. (2003) Xenobiotica, 33(6), 655-676.
66. Liu, D.Q.; Karanam, B.V.; Doss, G.A.; Sidler, R.R.; Vincent, S.H. and Hop, C.E. (2004) Drug Metab. Dispos., 32(9), 1023-1031.
67. Evans, D.C.; Watt, A.P.; Nicoll-Griffith, D.A. and Baillie, T.A. (2004) Chem. Res. Toxicol., 17(1), 3-16.
68. Sahali-Sahly, Y.; Balani, S.K.; Lin, J.H. and Baillie, T.A. (1996) Chem. Res. Toxicol., 9(6), 1007-1012.
69. Lee, S.K.; Jin, C.H.; Hyun, S.H.; Lee, D.W.; Kim, G.H.; Jeon, T.W.; Lee, J.; Kim, D.H.; Jeong, H.G.; Lee, E.S. and Jeong, T.C. (2005) Xenobiotica, 35(1), 97-105.
70. Alvarez-Diez, T.M. and Zheng, J. (2004) Drug Metab. Dispos., 32(12), 1345-1350.
71. Smith, P.C.; Benet, L.Z. and McDonagh, A.F. (1990) Drug Metab. Dispos., 18(5), 639-644.
72. Castillo, M. and Smith, P.C. (1995) Drug Metab. Dispos., 23(5), 566-572.
73. Lasser, K,E.; Allen, P.D.; Woolhandler, S.J.; Himmelstein, D.U.; Wolfe, S.M. and Bor, D.H. (2002) J. Am. Med. Associa., 287(17), 2215-20.
74. Zhang, K.E.; Naue, J.A.; Arison, B. and Vyas, K.P. (1996) Chem. Res. Toxicol., 9(2), 547-554.
75. Gorrod, J.W.; Whittlesea, C.M. and Lam, S.P. (1991) Adv. Exp. Med. Biol., 283, 657-664.
76. Bailey, M.J. and Dickinson, R.G. (2003) Chem-Biol. Interact., 145(2), 117-137.
77. Spahn-Langguth, H. and Benet, L.Z. (1992) Drug Metab. Rev., 24(1), 5-47.
78. Wainhaus, S. (2005) In Using Mass Spectrometry for Drug Metabolism Studies, (Korfmacher, W.A. Ed.), CRC Press, Boca Raton, pp. 175-202.
79. Prakash, C. and Soliman, V. (1997) Drug Metab. Dispos., 25(11), 1288-1297.
80. Ramanathan, R.; Alvarez, N.; Su, A.D.; Chowdhury, S.; Alton, K.; Stauber, K. and Patrick, J. (2005) Xenobiotica, 35(2), 155-189.
81. Ramanathan, R.; Su, A.D.; Alvarez, N.; Chowdhury, S.; Wirth, M.; Alton, K.B. and Patrick, J.E. (2004) Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics.
82. Ghantous, H. (2004) in Newsletter of the Society of Toxicology, the Society of Toxicology, Reston, pp. 5-7.
83. Zhang, J.Y.; Wang, Y.; Dudkowski, C.; Yang, D.; Chang, M.; Yuan, J.; Paulson, S.K. and Breau, A.P. (2000) J. Mass Spectrom., 35(11), 1259-1270.
84. McKillop, D.; Hutchison, M.; Partridge, E.A.; Bushby, N.; Cooper, C.M.; Clarkson-Jones, J.A.; Herron, W. and Swaisland, H.C. (2004) Xenobiotica, 34(10), 917-934.
85. Henion, J.; Brewer, E. and Rule, G. (1998) Anal. Chem., 70(19), 650A-656A.
86. Rossi, D.T. (2002) in Mass Spectrometry in Drug Discovery, (Rossi, D.T. and Sinz, M.W. Eds.), Marcel Dekker, New York, pp. 171-215.
87. Hopfgartner, G. and Bourgogne, E. (2003) Mass Spectrom. Rev., 22(3), 195-214.
88. Vielhauer, S.; Rudolphi, A.; Boos, K.S. and Seidel, D. (1995) J. Chromatogr. B, Biomed. Appl., 666(2), 315-322.
89. Hogendoorn, E.A.; van Zoonen, P.; Polettini, A.; Marrubini Bouland, G. and Montagna, M. (1998) Anal. Chem., 70(7), 1362-1368.
90. Souverain, S.; Rudaz, S. and Veuthey, J.L. (2004) J. Chromatogr. B, Analyt. Technol. Biomed. Life Sci., 801(2), 141-156.
91. Takino, M.; Daishima, S.; Yamaguchi, K. and Nakahara, T. (2003) Analyst, 128(1), 46-50.
92. Ynddal, L. and Hansen, S.H. (2003) J. Chromatogr. A, 1020(1), 59-67.
93. Ayrton, J.; Dear, G.J.; Leavens, W.J.; Mallett, D.N. and Plumb, R.S. (1997) Rapid Commun. Mass Spectrom., 11(18), 1953-1958.
94. Polson, C.; Sarkar, P.; Incledon, B.; Raguvaran, V. and Grant, R. (2003) J. Chromatogr. B, Analyt. Technol. Biomed. Life Sci., 785(2), 263-275.
95. Watt, A.P.; Morrison, D.; Locker, K.L. and Evans, D.C. (2000) Anal. Chem., 72(5), 979-84.
96. Steinborner, S. and Henion, J. (1999) Anal. Chem., 71(13), 2340-2345.
97. Fedeniuk, R.W. and Shand, P.J. (1998) J. Chromatogr. A, 812(1-2), 3-15.
98. Allanson, J.P.; Biddlecombe, R.A.; Jones, A.E. and Pleasance, S. (1996) Rapid Commun. Mass Spectrom., 10(7), 811-816.
99. Liu, D.Q. and Hop, C.E. (2005) J. Pharm. Biomed. Anal., 37(1), 1-18.
100. Williams, D.; Lee, T.D.; Dinh, N. and Young, M.K. (2000) Rapid Commun. Mass Spectrom., 14(16), 1530-1537.
101. Johnson, D.W. (2000) Rapid Commun. Mass Spectrom., 14(21), 2019-2024.
102. Dalvie, D.K. and O'Donnell, J.P. (1998) Rapid Commun. Mass Spectrom., 12(8), 419-422.
103. Browne, T.R. (1986) J. Clin. Pharmacol., 26(6), 485-489.
104. Baillie, T.A. (1981) Pharmacol. Rev., 33(2), 81-132.
105. Iyer, K.R. (2002) In Mass Spectrometry in Drug Discovery, (Rossi, D.T. and Sinz, M.W. Eds.), Marcel Dekker, New York, pp. 337-356.
106. Branfman, A.R; McComish, M.F.; Bruni, R.J.; Callahan, M.M.; Robertson, R. and Yesair, D.W. (1983) Drug Metab. Dispos., 11(3), 206-210.
107. Baillie, T.A.; Halpin, R.A.; Matuszewski, B.K.; Geer, L.A.; Chavez-Eng, C.M.; Dean, D.; Braun, M.; Doss, G.; Jones, A.; Marks, T.; Melillo, D. and Vyas, K.P. (2001) Drug Metab. Dispos., 29(12), 1614-1628.
108. Weidolf, L. and Covey, T.R. (1992) Rapid Commun. Mass Spectrom., 6(3), 192-196.
109. Chowdhury, S.K.; Blumenkrantz, N.; Zhong, R.; Kulmatycki, K.; Wirth, M.; McNamara, P.; Gopaul, V.S.; Alton, K.B. and Patrick, J.E. (2005) In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, (Chowdhury, S.K. Ed.), Elsevier, Oxford, pp. 277-93.
110. Yan, Z. and Caldwell, G.W. (2004) Anal Chem., 76(23), 6835-6847.
111. Major, H.; Castro-Perez, J.; Nicholson, J.K. and Wilson, I.D. (2003) Xenobiotica, 33(8), 855-869.
112. Gross, M.L. (1994) J. Am. Soc. Mass Spectrom., 5(2), 57.
113. Bristow, A.W. and Webb, K.S. (2003) J. Am. Soc. Mass Spectrom., 14(10), 1086-1098.
114. Chernushevich, I.V.; Loboda, A.V. and Thomson, B.A. (2001) J. Mass Spectrom., 36(8), 849-865.
115. Eckers, C.; Wolff, J.C.; Haskins, N.J.; Sage, A.B.; Giles, K. and Bateman, R. (2000) Anal. Chem., 72(16), 3683-3688.
116. Wolff, J.C.; Eckers, C.; Sage, A.B.; Giles, K. and Bateman, R. (2001) Anal. Chem., 73(11), 2605-2612.
117. Hop, C.E.; Yu, X.; Xu, X.; Singh, R. and Wong, B.K. (2001) J. Mass Spectrom., 36(5), 575-579.
118. Clarke, N.J.; Cox, K.A.; Rindgen, D. and Korfmacher, W.A. (2000) Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics.
119. Nassar, A.E. (2003) J. Chromatogr. Sci., 41(8), 398-404.
120. Hunt, D.F.; McEwen, C.N. and Upham, R.A. (1971) Tetrahedron Lett., 12(47), 4539-4542.
121. Hemling, M.E.; Conboy, J.J.; Bean, M.F.; Mentzer, M. and Carr, S.A. (1993) J. Am. Soc. Mass Spectrom., 5(5), 434-442.
122. Lam, W. and Ramanathan, R. (2002) J. Am. Soc. Mass Spectrom., 13(4), 345-353.
123. Gianelli, L.; Mellerio, G.G.; Siviero, E.; Rossi, A.; Cabri, W. and Sogli, L. (2000) Rapid Commun. Mass Spectrom., 14(14), 1260-1265.
124. Blum, W.; Aichholz, R.; Ramstein, P.; Kuhnol, J.; Bruggen, J.; O'Reilly, T. and Florsheimer, A. (2001) Rapid Commun. Mass Spectrom., 15(1), 41-49.
125. Olsen, M.A.; Cummings, P.G.; Kennedy-Gabb, S.; Wagner, B.M.; Nicol, G.R. and Munson, B. (2000) Anal. Chem., 72(20), 5070-5078.
126. Major, H.; Castro-Perez, J.; Nicholson, J.K. and Wilson, I.D. (2003) Rapid Commun. Mass Spectrom., 17(1), 76-80.
127. Liu, D.Q.; Hop, C.E.; Beconi, M.G.; Mao, A. and Chiu, S.H. (2001) Rapid Commun. Mass Spectrom., 15(19), 1832-1839.
128. Ohashi, N.; Furuuchi, S. and Yoshikawa, M. (1998) J. Pharm. Biomed. Anal., 18(3), 325-334.
129. Zgoda-Pols, J.; Ramanathan, R.; Chowdhury, S. and Alton, K. (2004) Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics.
130. Gorrod, J.W. and Manson, D. (1986) Xenobiotica, 16(10-11), 933-955.
131. Kalgutkar, A.S.; Dalvie, D.K.; O'Donnell, J.P.; Taylor, T.J. and Sahakian, D.C. (2002) Curr. Drug Metab., 3(4), 379-424.
132. Uetrecht, J. (2002) Drug Metab. Rev., 34(3), 651-665.
133. Seaton, Q.F; Lawley, C.W. and Akers, H.A. (1984) Anal. Biochem., 138(1), 238-241.
134. Kulanthaivel, P.; Barbuch, R.J.; Davidson, R.S.; Yi, P.; Rener, G.A.; Mattiuz, E.L.; Hadden, C.E.; Goodwin, L.A. and Ehlhardt, W.J. (2004) Drug Metab. Dispos., 32(9), 966-972.
135. Ramanathan, R.; Su, A.D.; Alvarez, N.; Blumenkrantz, N.; Chowdhury, S.K.; Alton, K. and Patrick, J. (2000) Anal. Chem., 72(6), 1352-1359.
136. Tong, W.; Chowdhury, S.K.; Chen, J.C.; Zhong, R.; Alton, K.B. and Patrick, J.E. (2001) Rapid Commun. Mass Spectrom., 15(22), 2085-2090.
137. Fernandez-Metzler, C.L.; Owens, K.G.; Baillie, T.A. and King, R.C. (1999) Drug Metab. Dispos., 27(1), 32-40.
138. Tiller, P.R.; Land, A.P.; Jardine, I.; Murphy, D.M.; Sozio, R.; Ayrton, A. and Schaefer, W.H. (1998) J. Chromatogr. A, 794(1-2), 15-25.
139. Ramanathan, R.; McKenzie, D.L.; Tugnait, M. and Siebenaler, K. (2002) J. Pharm. Biomed. Anal., 28(5), 945-951.
140. Yu, X.; Cui, D. and Davis, M.R. (1999) J. Am. Soc. Mass Spectrom., 10(2), 175-183.
141. Gu, M. and Lim, H.K. (2001) J. Mass Spectrom., 36(9), 1053-1061.
142. Lopez, L.L.; Yu, X.; Cui, D. and Davis, M.R. (1998) Rapid Commun. Mass Spectrom., 12(22), 1756-1760.
143. Ma, S.; Blumenkrantz, N.; Chowdhury, S.K.; Alton, K.B. and Patrick, J.E. (2002) Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics.
144. Nassar, A.E. and Adams, P.E. (2003) Curr. Drug Metab., 4(4), 259-271.
145. Anari, M.R.; Sanchez, R.I.; Bakhtiar, R.; Franklin, R.B. and Baillie, T.A. (2004) Anal. Chem., 76(3), 823-832.
146. Zhang, H.; Zhang, D. and Ray, K. (2003) J. Mass Spectrom., 38(10), 1110-1112.
147. Dear, G.J.; Plumb, R.S.; Sweatman, B.C.; Ayrton, J.; Lindon, J.C.; Nicholson, J.K. and Ismail, I.M. (2000) J. Chromatogr. B, Biomed. Sci. Appl., 748(1), 281-293.
148. Sidelmann, U.G.; Bjornsdottir, I.; Shockcor, J.P.; Hansen, S.H.; Lindon, J.C. and Nicholson, J.K. (2001) J. Pharm. Biomed. Anal., 24(4), 569-579.
149. Lindon, J.C.; Nicholson, J.K. and Wilson, I.D. (2000) J. Chromatogr. B, Biomed. Sci. Appl., 748(1), 233-258.
150. Shockcor, J.P.; Unger, S.E.; Savina, P.; Nicholson, J.K. and Lindon, J.C. (2000) J. Chromatogr. B, Biomed. Sci. Appl., 748(1), 269-279.
151. Martino, R.; Malet-Martino, M. and Gilard, V. (2000) Curr. Drug Metab., 1(3), 271-303.
152. Ellis, M.K.; Naylor, J.L.; Green, T. and Collins, M.A. (1995) Drug Metab. Dispos., 23(1), 102-106.
153. Lenz, E.M.; Wilson, I.D.; Wright, B.; Partridge, E.A.; Rodgers, C.T.; Haycock, P.R.; Lindon, J.C. and Nicholson, J.K. (2002) J. Pharm. Biomed. Anal., 28(1), 31-43.
154. Scarfe, G.B.; Wright, B.; Clayton, E.; Taylor, S.; Wilson, I.D.; Lindon, J.C. and Nicholson, J.K. (1998) Xenobiotica, 28(4), 373-388.
155. Ponce de Leon, C.A.; Montes-Bayon, M. and Caruso, J.A. (2002) J. Chromatogr. A, 974(1-2), 1-21.
156. Montes-Bayon, M.; DeNicola, K. and Caruso, J.A. (2003) J. Chromatogr. A, 1000(1-2), 457-476.
157. Marshall, P.S.; Leavens, B.; Heudi, O. and Ramirez-Molina, C. (2004) J. Chromatogr. A, 1056(1-2), 3-12.
158. Nicholson, J.K.; Lindon, J.C.; Scarfe, G.B.; Wilson, I.D.; Abou-Shakra, F.; Sage, A.B. and Castro-Perez, J. (2001) Anal. Chem., 73(7), 1491-1494.
159. Corcoran, O.; Nicholson, J.K.; Lenz, E.M.; Abou-Shakra, F.; Castro-Perez, J.; Sage, A.B. and Wilson, I.D. (2000) Rapid Commun. Mass Spectrom., 14(24), 2377-2384.
160. Jensen, B.P.; Smith, C.J.; Bailey, C.J.; Rodgers, C; Wilson, I.D. and Nicholson, J.K. (2005) Rapid Commun. Mass Spectrom., 19(4), 519-524.
161. Boernsen, K.O.; Floeckher, J.M. and Bruin, G.J. (2000) Anal. Chem., 72(16), 3956-3959.
162. Zhu, M.; Zhao, W.; Vazquez, N. and Mitroka, J.G. (2005) J. Pharm. Biomed. Anal., 39(1-2), 233-245.
163. Nassar, A.E.; Bjorge, S.M. and Lee, D.Y. (2003) Anal. Chem., 75(4), 785-790.
164. Nassar, A.E.; Parmentier, Y.; Martinet, M. and Lee, D.Y. (2004) J. Chromatogr. Sci., 42(7), 348-353.
165. Axelsson, B.O.; Jornten-Karlsson, M.; Michelsen, P. and Abou-Shakra, F. (2001) Rapid Commun. Mass Spectrom., 15(6), 375-385.
166. Chen, P.; Teffera, Y.; Black, G.E. and Abramson, F.P. (1999) J. Am. Soc. Mass Spectrom., 10(2), 153-158.
167. Abramson, F.P.; Teffera, Y.; Kusmierz, J.; Steenwyk, R.C. and Pearson, P.G. (1996) Drug Metab. Dispos., 24(7), 697-701.
168. Goldthwaite, C.A., Jr.; Hsieh, F.Y.; Womble, S.W.; Nobes, B.J.; Blair, I.A.; Klunk, L.J. and Mayol, R.F. (1996) Anal. Chem., 68(17), 2996-3001.
169. McLean, M.; Vestal, M.L.; Teffera, Y. and Abramson, F.P. (1996) J. Chromatogr. A, 732(2), 189-199.
170. Browne, T.R.; Szabo, G.K.; Ajami, A. and Wagner, D. (1993) J. Clin. Pharmacol., 33(3), 246-252.