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Volumn 28, Issue 5, 2002, Pages 945-951
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Application of semi-automated metabolite identification software in the drug discovery process for rapid identification of metabolites and the cytochrome P450 enzymes responsible for their formation
a
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Author keywords
Automated metabolite identification software; Chemical inhibition; CYP450; Drug discovery; Drug metabolism; LC MS MS; Structure elucidation
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Indexed keywords
CYTOCHROME P450;
CYTOCHROME P450 1A2;
CYTOCHROME P450 2C9;
CYTOCHROME P450 2D6;
CYTOCHROME P450 2E1;
CYTOCHROME P450 3A4;
CYTOCHROME P450 INHIBITOR;
DIETHYLDITHIOCARBAMIC ACID;
DRUG;
DRUG METABOLITE;
FURAFYLLINE;
QUINIDINE;
SULFAPHENAZOLE;
TROLEANDOMYCIN;
ARTICLE;
COMPUTER PROGRAM;
DEMETHYLATION;
DRUG IDENTIFICATION;
DRUG METABOLISM;
ENZYME ACTIVITY;
MASS SPECTROMETER;
METABOLITE;
OXYGENATION;
PRIORITY JOURNAL;
AUTOMATION;
BIOTRANSFORMATION;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
CYTOCHROME P-450 ENZYME SYSTEM;
MASS SPECTROMETRY;
PHARMACEUTICAL PREPARATIONS;
SOFTWARE;
SPECTROPHOTOMETRY, ULTRAVIOLET;
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EID: 0036605551
PISSN: 07317085
EISSN: None
Source Type: Journal
DOI: 10.1016/S0731-7085(01)00707-5 Document Type: Article |
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Times cited : (15)
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References (14)
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