Liquid chromatography/mass spectrometry methods for distinguishing N- oxides from hydroxylated compounds

Analytical Chemistry

Volumn 72, Issue 6, 2000, Pages 1352-1359

  Ramanathan, R ^a   Su, A D ^a   Alvarez, N ^a   Blumenkrantz, N ^a   Chowdhury, S K ^a   Alton, K ^a   Patrick, J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; DESLORATADINE; DRUG METABOLITE; HYDROXYL GROUP; LORATADINE; OXIDE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SCH 38554; SCH 39090; SCH 39091; SCH 41261; SCH 45581; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; DRUG DETERMINATION; DRUG STRUCTURE; HYDROXYLATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; WATER LOSS;

EID: 0034654478     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac9911692     Document Type: Article

References (12)

1. Gibson, G. G.; Skett, P. Introduction to Drug Metabolism; Chapman and Hall: London, 1986.
2. Bosin, T. R.; Maickel, R. P. Res. Commun. Chem. Pathol. Pharmacol. 1973, 6, 813.
3. Sugimura, T.; Okabe, K.; Nagao, M. Cancer Res. 1966, 26, 1717.
4. Kiese, M. Pharmacol. Rev. 1966, 18, 1091.
5. Markowitz, J. S.; Patrick, K. S. J. Chromatogr., B 1995, 668, 171.
6. Lin, G.; McKay, G.; Hubbard, J. W.; Midha, K. K. J. Pharm. Sci. 1994, 83, 1412.
7. Lay, J. O.; Holder, C. L.; Cooper, W. M. Biomed. Environ. Mass Spectrom. 1989, 18, 157.
8. Parker, C. E.; Verma, S.; Tomer, K. B.; Reed, R. L.; Buhler, D. R. Biomed. Environ. Mass Spectrom. 1990, 19, 1.
9. Whitehouse, C. M.; Dreyer, R. N.; Yamashita, M.; Fenn, J. B. Anal. Chem. 1985, 57, 675-679.
10. Covey, T. R.; Lee, E. D.; Bruins, A. P.; Henion, J. D. Anal. Chem. 1986, 58, 1451A-1461A.
11. Bruins, A. P. Trends Anal. Chem. 1994, 13, 37.
12. Piwinski, J. J.; Wong, J. K.; Chan, T-, M.; Green, M. J.; Ganguly, A. K. J. Org. Chem. 1990, 55, 3341.