Identification of a novel glutathione adduct of diclofenac, 4′-hydroxy-2′-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes

Drug Metabolism and Disposition

Volumn 33, Issue 4, 2005, Pages 484-488

  Yu, Li J ^a,b   Chen, Yue ^a   DeNinno, Michael P ^a   O'Connell, Thomas N ^a   Hop, Cornelis E C A ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' HYDROXY 2' GLUTATHION DESCHLORODICLOFENAC; 5 HYDROXY 4 GLUTATHIONE DICLOFENAC; 5 HYDROXY 6 GLUTATHIONE DICLOFENAC; CYTOCHROME P450; DICLOFENAC; GLUTATHIONE ADDUCT; GLUTATHIONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; CONTROLLED STUDY; DRUG METABOLISM; DRUG OXIDATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; LIVER TOXICITY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, LIQUID; DICLOFENAC; GLUTATHIONE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER;

EID: 15344348875     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.002840     Document Type: Article

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