A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil™ (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) in the rat

Journal of Pharmaceutical and Biomedical Analysis

Volumn 28, Issue 1, 2002, Pages 31-43

  Lenz, E M ^a,b   Wilson, I D ^b   Wright, B ^b   Partridge, E A ^b   Rodgers, C T ^b   Haycock, P R ^c   Lindon, J C ^a   Nicholson, J K ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

1H and 19F NMR spectroscopy; Metabolites; Quantitation; Scintillation counting; Statil

Indexed keywords

GLUCURONIDE; PONALRESTAT;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE; CONTROLLED STUDY; DOSE CALCULATION; DRUG BILE LEVEL; DRUG EXCRETION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; ISOTOPE LABELING; MALE; MICELLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SCINTILLATION; URINALYSIS;

ANIMALS; BILE; CARBON RADIOISOTOPES; ENZYME INHIBITORS; FEMALE; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHTHALAZINES; RATS; RATS, WISTAR; SCINTILLATION COUNTING;

EID: 0036533298     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(01)00637-9     Document Type: Article

References (12)