Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography-atmospheric pressure ionization tandem mass spectrometry

Journal of Chromatography A

Volumn 777, Issue 1, 1997, Pages 61-66

  Bryant, Matthew S ^a   Korfmacher, Walter A ^a   Wang, Shiyong ^a   Nardo, Cymbelene ^a   Nomeir, Amin A ^a   Lin, Chin Chung ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Enzyme inhibitors; Pharmaceutical analysis; Piperidines; SCH 44342

Indexed keywords

4 (8 CHLORO 5,6 DIHYDRO 11H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YLIDENE) 1 (4 PYRIDYLACETYL)PIPERIDINE; ENZYME INHIBITOR; PROTEIN FARNESYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOAVAILABILITY; CALCULATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG DETERMINATION; DRUG HALF LIFE; DRUG SCREENING; GAS CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MONKEY; MOUSE; NITROGEN DETECTOR; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TECHNIQUE;

ADMINISTRATION, ORAL; ALKYL AND ARYL TRANSFERASES; ANIMALS; BENZAZEPINES; CALIBRATION; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; INJECTIONS, INTRAVENOUS; MASS SPECTROMETRY; MICE; PIPERIDINES; TRANSFERASES;

ANIMALIA;

EID: 0030857345     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(97)00561-X     Document Type: Conference Paper

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