Microsomal metabolism of the 5-lipoxygenase inhibitor L-739,010: Evidence for furan bioactivation

Chemical Research in Toxicology

Volumn 9, Issue 2, 1996, Pages 547-554

  Zhang, Kanyin E ^a   Naue, Jeanne A ^a   Arison, Byron ^a   Vyas, Kamlesh P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [6 [7 CYANO 5 (3 FURYL) 2 NAPHTHOXYMETHYL] 2 PYRIDYL] 3 HYDROXY 6,8 DIOXABICYCLO[3.2.1]OCTANE; ALDEHYDE; CYTOCHROME P450; DEXAMETHASONE; DIETHYLDITHIOCARBAMIC ACID; DRUG METABOLITE; FURAN DERIVATIVE; GLUTATHIONE; LIPOXYGENASE INHIBITOR; LIVER PROTEIN; METHOXYAMINE; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TROLEANDOMYCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; COVALENT BOND; DRUG ACTIVATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TRANSFORMATION; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; METABOLIC ACTIVATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; BICYCLO COMPOUNDS; BIOTRANSFORMATION; DOGS; FURANS; HUMANS; LIPOXYGENASE INHIBITORS; MACACA MULATTA; MASS SPECTROMETRY; MICROSOMES, LIVER; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; CANIS FAMILIARIS; MACACA MULATTA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0029882427     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx950183g     Document Type: Article

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