-
1
-
-
0032900661
-
Drug selection in early drug development: Screening for acceptable pharmacokinetic properties using combined in vitro and computational approaches
-
Sinko PJ. Drug selection in early drug development: screening for acceptable pharmacokinetic properties using combined in vitro and computational approaches. Curr. Opin. Drug Discov. Dev. 1999; 2: 42.
-
(1999)
Curr. Opin. Drug Discov. Dev.
, vol.2
, pp. 42
-
-
Sinko, P.J.1
-
2
-
-
0030886937
-
Managing the drug discovery/development interface
-
Kennedy T. Managing the drug discovery/development interface. Drug Discove. Today 1997; 2: 436.
-
(1997)
Drug Discove. Today
, vol.2
, pp. 436
-
-
Kennedy, T.1
-
3
-
-
0034919009
-
Emerging role of pharmacoeconomics in the research and development decision-making process
-
DiMasi JA, Caglarcan E, Wood-Armany M. Emerging role of pharmacoeconomics in the research and development decision-making process. Pharmacoeconomics 2001; 19: 753.
-
(2001)
Pharmacoeconomics
, vol.19
, pp. 753
-
-
DiMasi, J.A.1
Caglarcan, E.2
Wood-Armany, M.3
-
4
-
-
0001846197
-
Pathways of Drug Metabolism
-
Gibson GG, Skett P (eds). Blackie Academic and Professional: London
-
Gibson GG, Skett P. Pathways of Drug Metabolism. In Introduction to Drug Metabolism, Gibson GG, Skett P (eds). Blackie Academic and Professional: London, 1994; 1-34.
-
(1994)
Introduction to Drug Metabolism
, pp. 1-34
-
-
Gibson, G.G.1
Skett, P.2
-
5
-
-
0001177611
-
The uridine diphosphate glucuronosyltransferase multigene family: Function and regulation in conjugation-deconjugation reactions
-
Kauffman FC (ed). Springler: Berlin
-
Clarke BC, Burchell B. The uridine diphosphate glucuronosyltransferase multigene family: function and regulation in conjugation-deconjugation reactions. In Drug Metabolism and Toxicity, Kauffman FC (ed). Springler: Berlin, 1994; 3-43.
-
(1994)
Drug Metabolism and Toxicity
, pp. 3-43
-
-
Clarke, B.C.1
Burchell, B.2
-
6
-
-
0000889408
-
Biotransformation of xenobiotics
-
Klaassen CD (ed). McGraw-Hill: New York
-
Parkinson A. Biotransformation of xenobiotics. In Casarett & Doull's Toxicology, Klaassen CD (ed). McGraw-Hill: New York, 2001; 133-224.
-
(2001)
Casarett & Doull's Toxicology
, pp. 133-224
-
-
Parkinson, A.1
-
7
-
-
0030834058
-
Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors
-
Rendic S, Di Carlo FJ. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab. Rev. 1997; 29: 413.
-
(1997)
Drug Metab. Rev.
, vol.29
, pp. 413
-
-
Rendic, S.1
Di Carlo, F.J.2
-
8
-
-
0020620944
-
Assay for codeine, morphine, and ten potential urinary metabolites by gas chromatography-mass fragmentography
-
Cone EJ, Darwin WD, Buchwald WF. Assay for codeine, morphine, and ten potential urinary metabolites by gas chromatography-mass fragmentography. J. Chromatogr. 1983; 275: 307.
-
(1983)
J. Chromatogr.
, vol.275
, pp. 307
-
-
Cone, E.J.1
Darwin, W.D.2
Buchwald, W.F.3
-
9
-
-
0024369341
-
Pharmacological characterization of morphine-6-β-glucuronide, a very potent morphine metabolite
-
Paul D, Standifer KM, Inturrisi CE, Pasternak GW. Pharmacological characterization of morphine-6-β-glucuronide, a very potent morphine metabolite. J. Pharmacol. Exp. Ther. 1989; 251: 477.
-
(1989)
J. Pharmacol. Exp. Ther.
, vol.251
, pp. 477
-
-
Paul, D.1
Standifer, K.M.2
Inturrisi, C.E.3
Pasternak, G.W.4
-
10
-
-
0028875109
-
Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation
-
Burchell B, Brierley CH, Rance D. Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation. Life Sci. 1995; 57: 1819.
-
(1995)
Life Sci.
, vol.57
, pp. 1819
-
-
Burchell, B.1
Brierley, C.H.2
Rance, D.3
-
12
-
-
0037723237
-
The mass spectrometer in drug metabolism
-
Rossi DT, Sinz MW (eds). Marcel Dekker: New York
-
Sinz MW, Podoll T. The mass spectrometer in drug metabolism. In Mass Spectrometry in Drug Discovery, Rossi DT, Sinz MW (eds). Marcel Dekker: New York, 2002; 271-335.
-
(2002)
Mass Spectrometry in Drug Discovery
, pp. 271-335
-
-
Sinz, M.W.1
Podoll, T.2
-
13
-
-
0034458681
-
Present and future in vitro approaches for drug metabolism
-
Ekins S, Ring BJ, Grace J, McRobie-Belle DJ, Wrighton SA. Present and future in vitro approaches for drug metabolism. J. Pharmacol. Toxicol. Methods 2000; 44: 313.
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.44
, pp. 313
-
-
Ekins, S.1
Ring, B.J.2
Grace, J.3
McRobie-Belle, D.J.4
Wrighton, S.A.5
-
14
-
-
26844503278
-
Molecular beams of macroions
-
Dole M, Mack LL, Hines RL, Mobley RC, Ferguson LD, Alice MB. Molecular beams of macroions. J. Chem. Phys. 1968; 49: 2240.
-
(1968)
J. Chem. Phys.
, vol.49
, pp. 2240
-
-
Dole, M.1
Mack, L.L.2
Hines, R.L.3
Mobley, R.C.4
Ferguson, L.D.5
Alice, M.B.6
-
15
-
-
33748168091
-
Electrospray ion source. Another variation on the free-jet theme
-
Yamashita M, Fenn JB. Electrospray ion source. Another variation on the free-jet theme. J. Phys. Chem. 1984; 88: 4451.
-
(1984)
J. Phys. Chem.
, vol.88
, pp. 4451
-
-
Yamashita, M.1
Fenn, J.B.2
-
16
-
-
0001681723
-
Ion extraction from solutions at atmospheric pressure-a method for mass-spectrometric analysis of bioorganic substances
-
Aleksandrov ML, Gall LN, Krasnov VN, Nikolaev VI, Pavlenko VA, Shkurov VA. Ion extraction from solutions at atmospheric pressure-a method for mass-spectrometric analysis of bioorganic substances. Dokl. Akad. Nauk SSSR 1984; 277: 379.
-
(1984)
Dokl. Akad. Nauk SSSR
, vol.277
, pp. 379
-
-
Aleksandrov, M.L.1
Gall, L.N.2
Krasnov, V.N.3
Nikolaev, V.I.4
Pavlenko, V.A.5
Shkurov, V.A.6
-
17
-
-
0001474833
-
Ion-molecule interaction in the cathode region of a glow discharge
-
Shahin MM. Ion-molecule interaction in the cathode region of a glow discharge. J. Chem. Phys. 1965; 43: 1798.
-
(1965)
J. Chem. Phys.
, vol.43
, pp. 1798
-
-
Shahin, M.M.1
-
18
-
-
0002168795
-
Liquid chromatograph-mass spectrometer-computer analytical systems. Continuous flow system based on atmospheric pressure ionization mass spectrometry
-
Horning EC, Carroll DI, Dzidic I, Haegele KD, Horning MG, Stillwell RN. Liquid chromatograph-mass spectrometer-computer analytical systems. Continuous flow system based on atmospheric pressure ionization mass spectrometry. J. Chromatogr. 1974; 99: 13.
-
(1974)
J. Chromatogr.
, vol.99
, pp. 13
-
-
Horning, E.C.1
Carroll, D.I.2
Dzidic, I.3
Haegele, K.D.4
Horning, M.G.5
Stillwell, R.N.6
-
19
-
-
0016125497
-
Atmospheric pressure ionization (API) mass spectrometry. Solvent-mediated ionization of samples introduced in solution and in a liquid chromatograph effluent stream
-
Horning EC, Carroll DI, Dzidic I, Haegele KD, Horning MG, Stillwell RN. Atmospheric pressure ionization (API) mass spectrometry. Solvent-mediated ionization of samples introduced in solution and in a liquid chromatograph effluent stream. J. Chromatogr. Sci. 1974; 12: 725.
-
(1974)
J. Chromatogr. Sci.
, vol.12
, pp. 725
-
-
Horning, E.C.1
Carroll, D.I.2
Dzidic, I.3
Haegele, K.D.4
Horning, M.G.5
Stillwell, R.N.6
-
21
-
-
0002102760
-
Higher throughput metabolite identification in drug discovery: Current capabilities and future trends
-
45, 46, 48, 50
-
Cox KA, Clarke NJ, Rindgen D, Korfmacher WA. Higher throughput metabolite identification in drug discovery: current capabilities and future trends. Am. Pharm. Rev. 2001; 4: 45, 46, 48, 50, 52.
-
(2001)
Am. Pharm. Rev.
, vol.4
, pp. 52
-
-
Cox, K.A.1
Clarke, N.J.2
Rindgen, D.3
Korfmacher, W.A.4
-
22
-
-
0037723240
-
Electrospray mass spectrometry in contemporary drug metabolism and pharmacokinetics
-
Pramanik BN, Ganguly AK, Gross ML (eds). Marcel Dekker Inc.: New York
-
Cole MJ, Janiszewski JS, Fouda HG. Electrospray mass spectrometry in contemporary drug metabolism and pharmacokinetics. In Appl. Electrospray Mass Spectrom, Pramanik BN, Ganguly AK, Gross ML (eds). Marcel Dekker Inc.: New York, 2002; 211-249.
-
(2002)
Appl. Electrospray Mass Spectrom
, pp. 211-249
-
-
Cole, M.J.1
Janiszewski, J.S.2
Fouda, H.G.3
-
23
-
-
0033832991
-
Liquid chromatography-mass spectrometry in the study of the metabolism of drugs and other xenobiotics
-
Oliveira EJ, Watson DG. Liquid chromatography-mass spectrometry in the study of the metabolism of drugs and other xenobiotics. Biomed. Chromatogr. 2000; 14: 351.
-
(2000)
Biomed. Chromatogr.
, vol.14
, pp. 351
-
-
Oliveira, E.J.1
Watson, D.G.2
-
24
-
-
0034254295
-
Atmospheric pressure photoionization: An ionization method for liquid chromatography-mass spectrometry
-
Robb DB, Covey TR, Bruins AP. Atmospheric pressure photoionization: an ionization method for liquid chromatography-mass spectrometry. Anal. Chem. 2000; 72: 3653.
-
(2000)
Anal. Chem.
, vol.72
, pp. 3653
-
-
Robb, D.B.1
Covey, T.R.2
Bruins, A.P.3
-
25
-
-
24044550717
-
Photoionization mass spectrometry as a powerful new tool for drug discovery
-
Syage JA, Evans MD. Photoionization mass spectrometry as a powerful new tool for drug discovery. Spectroscopy 2001; 16: 14.
-
(2001)
Spectroscopy
, vol.16
, pp. 14
-
-
Syage, J.A.1
Evans, M.D.2
-
26
-
-
0036829717
-
Atmospheric pressure photoionization mass spectrometry. Ionization mechanism and the effect of solvent on the ionization of naphthalenes
-
Kauppila T, Kuuranne T, Meurer EC, Eberlin MN, Kotiaho T, Kostiainen R. Atmospheric pressure photoionization mass spectrometry. Ionization mechanism and the effect of solvent on the ionization of naphthalenes. Anal. Chem. 2002; 74: 5470.
-
(2002)
Anal. Chem.
, vol.74
, pp. 5470
-
-
Kauppila, T.1
Kuuranne, T.2
Meurer, E.C.3
Eberlin, M.N.4
Kotiaho, T.5
Kostiainen, R.6
-
27
-
-
0037099357
-
Comparison of electrospray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization in the identification of apomorphine, dobutamide, and entacapone phase II metabolites in biological samples
-
Keski-Hynnilä H, Kurkela M, Elovaara E, Antonio L, Magdalou J, Luukkanen L, Taskinen J, Kostiainen R. Comparison of electrospray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization in the identification of apomorphine, dobutamide, and entacapone phase II metabolites in biological samples. Anal. Chem. 2002; 74: 3449.
-
(2002)
Anal. Chem.
, vol.74
, pp. 3449
-
-
Keski-Hynnilä, H.1
Kurkela, M.2
Elovaara, E.3
Antonio, L.4
Magdalou, J.5
Luukkanen, L.6
Taskinen, J.7
Kostiainen, R.8
-
28
-
-
0037073086
-
Atmospheric pressure photoionization liquid chromatographic-mass spectrometric determination of idoxifene and its metabolites in human plasma
-
Yang C, Henion J. Atmospheric pressure photoionization liquid chromatographic-mass spectrometric determination of idoxifene and its metabolites in human plasma. J Chromatogr A 2002; 970: 155.
-
(2002)
J. Chromatogr. A
, vol.970
, pp. 155
-
-
Yang, C.1
Henion, J.2
-
29
-
-
0025482937
-
Systematic delineation of scan modes in multidimensional mass spectrometry
-
Schwartz JC, Wade AP, Enke CG, Cooks RG. Systematic delineation of scan modes in multidimensional mass spectrometry. Anal. Chem. 1990; 62: 1809.
-
(1990)
Anal. Chem.
, vol.62
, pp. 1809
-
-
Schwartz, J.C.1
Wade, A.P.2
Enke, C.G.3
Cooks, R.G.4
-
30
-
-
0019982067
-
Structural elucidation of drug metabolites by triple quadrupole mass spectrometry
-
Perhalski RJ, Yost RA, Wilder BJ. Structural elucidation of drug metabolites by triple quadrupole mass spectrometry. Anal. Chem. 1982; 54: 1466.
-
(1982)
Anal. Chem.
, vol.54
, pp. 1466
-
-
Perhalski, R.J.1
Yost, R.A.2
Wilder, B.J.3
-
31
-
-
0023858064
-
Rapid identification of drug metabolites with tandem mass spectrometry
-
Lee MS, Yost RA. Rapid identification of drug metabolites with tandem mass spectrometry. Biomed. Environ. Mass Spectrom. 1988; 15: 193.
-
(1988)
Biomed. Environ. Mass Spectrom.
, vol.15
, pp. 193
-
-
Lee, M.S.1
Yost, R.A.2
-
33
-
-
0002574886
-
Advances in the application of mass spectrometry to studies of drug metabolism, pharmacokinetics and toxicology
-
Baillie TA. Advances in the application of mass spectrometry to studies of drug metabolism, pharmacokinetics and toxicology. Int. J. Mass Spectrom. Ion Processes 1992; 118-119: 289.
-
(1992)
Int. J. Mass Spectrom. Ion Processes
, vol.118-119
, pp. 289
-
-
Baillie, T.A.1
-
35
-
-
0001007567
-
Atmospheric pressure ionization time-of-flight mass spectrometry with a supersonic ion beam
-
Sin CH, Lee ED, Lee ML. Atmospheric pressure ionization time-of-flight mass spectrometry with a supersonic ion beam. Anal. Chem. 1991; 63: 2897.
-
(1991)
Anal. Chem.
, vol.63
, pp. 2897
-
-
Sin, C.H.1
Lee, E.D.2
Lee, M.L.3
-
36
-
-
0034652244
-
Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS
-
Zhang N, Fountain ST, Bi H, Rossi DT. Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS. Anal. Chem. 2000; 72: 800.
-
(2000)
Anal. Chem.
, vol.72
, pp. 800
-
-
Zhang, N.1
Fountain, S.T.2
Bi, H.3
Rossi, D.T.4
-
37
-
-
0034661928
-
Application of atmospheric pressure ionisation time-of-flight mass spectrometry coupled with liquid chromatography for the characterization of in vitro drug metabolites
-
Zhang H, Henion J, Yang Y, Spooner N. Application of atmospheric pressure ionisation time-of-flight mass spectrometry coupled with liquid chromatography for the characterization of in vitro drug metabolites. Anal. Chem. 2000; 72: 3342.
-
(2000)
Anal. Chem.
, vol.72
, pp. 3342
-
-
Zhang, H.1
Henion, J.2
Yang, Y.3
Spooner, N.4
-
38
-
-
0003856282
-
Physico-chemical properties of drugs and metabolites and their extraction from biological material
-
Venn RV (ed). Taylor and Francis: London
-
Wilshire H. Physico-chemical properties of drugs and metabolites and their extraction from biological material. In Principles and Practice of Bioanalysis, Venn RV (ed). Taylor and Francis: London, 2000; 1-27.
-
(2000)
Principles and Practice of Bioanalysis
, pp. 1-27
-
-
Wilshire, H.1
-
39
-
-
0035882773
-
Quantitation of entacapone glucuronide in rat plasma by on-line coupled restricted-access media column and liquid chromatography-tandem mass spectrometry
-
Keski-Hynnilä H, Raanaa K, Forsberg M, Männistö P, Taskinen J, Kostiainen R. Quantitation of entacapone glucuronide in rat plasma by on-line coupled restricted-access media column and liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2001; 759: 227.
-
(2001)
J. Chromatogr. B
, vol.759
, pp. 227
-
-
Keski-Hynnilä, H.1
Raanaa, K.2
Forsberg, M.3
Männistö, P.4
Taskinen, J.5
Kostiainen, R.6
-
40
-
-
0345390262
-
Determination of propafenone and its main metabolite 5-hydroxypropafenone in human serum with direct injection into a column-switching chromatographic system
-
Kubalec P, Brandsteterova E. Determination of propafenone and its main metabolite 5-hydroxypropafenone in human serum with direct injection into a column-switching chromatographic system. J. Chromatogr. B 1999; 726: 211.
-
(1999)
J. Chromatogr. B
, vol.726
, pp. 211
-
-
Kubalec, P.1
Brandsteterova, E.2
-
41
-
-
0033565621
-
Liquid-liquid-liquid microextraction for sample preparation of biological fluids prior to capillary electrophoresis
-
Pedersen-Bjergaard S, Rasmussen KE. Liquid-liquid-liquid microextraction for sample preparation of biological fluids prior to capillary electrophoresis. Anal. Chem. 1999; 71: 2650.
-
(1999)
Anal. Chem.
, vol.71
, pp. 2650
-
-
Pedersen-Bjergaard, S.1
Rasmussen, K.E.2
-
42
-
-
0034002699
-
Development of a simple in-vial liquid-phase microextraction device for drug analysis compatible with capillary gas chromatography, capillary electrophoresis and high-performance liquid chromatography
-
Rasmussen KE, Pedersen-Bjergaard S, Krogh M, Ugland HG, Grønhaug T. Development of a simple in-vial liquid-phase microextraction device for drug analysis compatible with capillary gas chromatography, capillary electrophoresis and high-performance liquid chromatography. J. Chromatogr. A 2000; 873: 3.
-
(2000)
J. Chromatogr. A
, vol.873
, pp. 3
-
-
Rasmussen, K.E.1
Pedersen-Bjergaard, S.2
Krogh, M.3
Ugland, H.G.4
Grønhaug, T.5
-
43
-
-
0037827685
-
Feasibility of a liquid-phase microextraction sample clean-up and LC-MS/MS screening method for selected anabolic steroid glucuronides in biological samples
-
Kuuranne T, Kotiaho T, Pedersen-Bjergaard S, Rasmussen KE, Leinonen A, Westwood S, Kostiainen R. Feasibility of a liquid-phase microextraction sample clean-up and LC-MS/MS screening method for selected anabolic steroid glucuronides in biological samples. J. Mass Spectrom. 2003; 38: 16.
-
(2003)
J. Mass Spectrom.
, vol.38
, pp. 16
-
-
Kuuranne, T.1
Kotiaho, T.2
Pedersen-Bjergaard, S.3
Rasmussen, K.E.4
Leinonen, A.5
Westwood, S.6
Kostiainen, R.7
-
44
-
-
0032988679
-
In vivo microdialysis/liquid chromatography/tandem mass spectrometry for the online monitoring of melatonin in rat
-
Wong PSH, Yoshioka K, Xie F, Kissinger PT. In vivo microdialysis/liquid chromatography/tandem mass spectrometry for the online monitoring of melatonin in rat. Rapid Commun. Mass Spectrom. 1999; 13: 407.
-
(1999)
Rapid Commun. Mass Spectrom.
, vol.13
, pp. 407
-
-
Wong, P.S.H.1
Yoshioka, K.2
Xie, F.3
Kissinger, P.T.4
-
45
-
-
0037173540
-
On-line coupling of microdialysis to packed capillary column liquid chromatography-tandem mass spectrometry demonstrated by measurement of free concentrations of ropivacaine and metabolite from spiked plasma samples
-
Bergström SK, Markides KE. On-line coupling of microdialysis to packed capillary column liquid chromatography-tandem mass spectrometry demonstrated by measurement of free concentrations of ropivacaine and metabolite from spiked plasma samples. J. Chromatogr. B 2002; 775: 79.
-
(2002)
J. Chromatogr. B
, vol.775
, pp. 79
-
-
Bergström, S.K.1
Markides, K.E.2
-
46
-
-
0001737962
-
The use of restricted-access media in HPLC, part I-classification and review
-
Boos KS, Rudolphi A. The use of restricted-access media in HPLC, part I-classification and review. LC-GC Int. 1997; 15: 602.
-
(1997)
LC-GC Int.
, vol.15
, pp. 602
-
-
Boos, K.S.1
Rudolphi, A.2
-
47
-
-
0036381102
-
Determination of the plasma levels of metyrapone and its enantiomeric metyrapone metabolites by direct plasma injection and multi-dimensional achiral-chiral chromatography
-
Cassiano NM, Cass QB, Degani ALG, Wainer IW. Determination of the plasma levels of metyrapone and its enantiomeric metyrapone metabolites by direct plasma injection and multi-dimensional achiral-chiral chromatography. Chirality 2002; 14: 731.
-
(2002)
Chirality
, vol.14
, pp. 731
-
-
Cassiano, N.M.1
Cass, Q.B.2
Degani, A.L.G.3
Wainer, I.W.4
-
48
-
-
0029690248
-
Microdialysis sampling for pharmacological studies: HPLC and CE analysis
-
Lunte SM, Lunte CE. Microdialysis sampling for pharmacological studies: HPLC and CE analysis. Adv. Chromatogr. 1996; 36: 383.
-
(1996)
Adv. Chromatogr.
, vol.36
, pp. 383
-
-
Lunte, S.M.1
Lunte, C.E.2
-
49
-
-
0036803891
-
A review of membrane sampling from biological tissues with applications in pharmacokinetics, metabolism and pharmacodynamics
-
Garrison KE, Pasas SA, Cooper JD, Davies MI. A review of membrane sampling from biological tissues with applications in pharmacokinetics, metabolism and pharmacodynamics. Eur. J. Pharm. Sci. 2002; 17: 1.
-
(2002)
Eur. J. Pharm. Sci.
, vol.17
, pp. 1
-
-
Garrison, K.E.1
Pasas, S.A.2
Cooper, J.D.3
Davies, M.I.4
-
50
-
-
0030852291
-
Low picogram determination of Ro 48-6791 and its major metabolite, Ro 48-6792, in plasma with column switching microbore high performance liquid chromatography coupled to ion spray tandem mass spectrometry
-
Zell M, Husser C, Hopfgartner G. Low picogram determination of Ro 48-6791 and its major metabolite, Ro 48-6792, in plasma with column switching microbore high performance liquid chromatography coupled to ion spray tandem mass spectrometry. Rapid Commun. Mass Spectrom. 1997; 11: 1107.
-
(1997)
Rapid Commun. Mass Spectrom.
, vol.11
, pp. 1107
-
-
Zell, M.1
Husser, C.2
Hopfgartner, G.3
-
51
-
-
0035161466
-
Fragmentation of N-oxides (deoxygenation) in atmospheric pressure ionization: Investigation of the activation process
-
Tong W, Chowdhury SK, Chen J-C, Zhong R, Alton KB, Patrick JE. Fragmentation of N-oxides (deoxygenation) in atmospheric pressure ionization: investigation of the activation process. Rapid Commun. Mass Spectrom. 2001; 15: 2085.
-
(2001)
Rapid Commun. Mass Spectrom.
, vol.15
, pp. 2085
-
-
Tong, W.1
Chowdhury, S.K.2
Chen, J.-C.3
Zhong, R.4
Alton, K.B.5
Patrick, J.E.6
-
52
-
-
0036006592
-
Interference of a carbamoyl glucuronide metabolite in quantitative liquid chromatography/tandem mass spectrometry
-
Liu DQ, Pereira T. Interference of a carbamoyl glucuronide metabolite in quantitative liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2002; 16: 142.
-
(2002)
Rapid Commun. Mass Spectrom.
, vol.16
, pp. 142
-
-
Liu, D.Q.1
Pereira, T.2
-
53
-
-
0002110673
-
Mass spectrometry with ion sources operating at atmospheric pressure
-
Bruins AP. Mass spectrometry with ion sources operating at atmospheric pressure. Mass Spectrom. Rev. 1991; 10: 53.
-
(1991)
Mass Spectrom. Rev.
, vol.10
, pp. 53
-
-
Bruins, A.P.1
-
54
-
-
0036007823
-
In vitro metabolite identification using fast gradient high performance liquid chromatography combined with tandem mass spectrometry
-
Hop CECA, Tiller PR, Romanyshyn L. In vitro metabolite identification using fast gradient high performance liquid chromatography combined with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2002; 16: 212.
-
(2002)
Rapid Commun. Mass Spectrom.
, vol.16
, pp. 212
-
-
Hop, C.E.C.A.1
Tiller, P.R.2
Romanyshyn, L.3
-
55
-
-
0035157254
-
A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry
-
Dierks EA, Stams KR, Lim HK, Cornelius G, Zhang H, Ball SE. A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry. Drug Metab. Dispos. 2001; 29: 23.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 23
-
-
Dierks, E.A.1
Stams, K.R.2
Lim, H.K.3
Cornelius, G.4
Zhang, H.5
Ball, S.E.6
-
56
-
-
0035159084
-
Selected reaction monitoring LC-MS determination of idoxifene and its pyrrolidinone metabolite in human plasma using robotic high-throughput, sequential sample injection
-
Onorato JM, Henion JD, Lefebvre PM, Kiplinger JP. Selected reaction monitoring LC-MS determination of idoxifene and its pyrrolidinone metabolite in human plasma using robotic high-throughput, sequential sample injection. Anal. Chem. 2001; 73: 119.
-
(2001)
Anal. Chem.
, vol.73
, pp. 119
-
-
Onorato, J.M.1
Henion, J.D.2
Lefebvre, P.M.3
Kiplinger, J.P.4
-
57
-
-
0035416832
-
Monolithic LC columns, a new type of chromatographic support could lead to higher separation efficiencies
-
Tanaka N, Kobayashi H, Nakanishi K, Minakuchi H, Ishizuka N. Monolithic LC columns, a new type of chromatographic support could lead to higher separation efficiencies. Anal. Chem. 2001; 73: 420A.
-
(2001)
Anal. Chem.
, vol.73
-
-
Tanaka, N.1
Kobayashi, H.2
Nakanishi, K.3
Minakuchi, H.4
Ishizuka, N.5
-
58
-
-
0035155866
-
Use of monolithic silica columns to increase analytical throughput for metabolite identification by liquid chromatography/tandem mass spectrometry
-
Dear G, Plumb R, Mallett D. Use of monolithic silica columns to increase analytical throughput for metabolite identification by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2001; 15: 152.
-
(2001)
Rapid Commun. Mass Spectrom.
, vol.15
, pp. 152
-
-
Dear, G.1
Plumb, R.2
Mallett, D.3
-
59
-
-
0036012891
-
Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromatography/tandem mass spectrometry
-
Hsieh Y, Wang G, Wang Y, Chackalamannil S, Brisson J-M, Ng K, Korfmacher WA. Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spcctrom. 2002; 16: 944.
-
(2002)
Rapid Commun. Mass Spcctrom.
, vol.16
, pp. 944
-
-
Hsieh, Y.1
Wang, G.2
Wang, Y.3
Chackalamannil, S.4
Brisson, J.-M.5
Ng, K.6
Korfmacher, W.A.7
-
60
-
-
0031453346
-
The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma
-
Ayrton J, Dear GJ, Leavens WJ, Mallett DN, Plumb RS. The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma. Rapid Commun. Mass Spectrom. 1997; 11: 1953.
-
(1997)
Rapid Commun. Mass Spectrom.
, vol.11
, pp. 1953
-
-
Ayrton, J.1
Dear, G.J.2
Leavens, W.J.3
Mallett, D.N.4
Plumb, R.S.5
-
61
-
-
0035326323
-
Simultaneous screen for microsomal stability and metabolite profile by direct injection turbulent-laminar flow LC-LC and automated tandem mass spectrometry
-
Lim HK, Chan KW, Sisenwine S, Scatina JA. Simultaneous screen for microsomal stability and metabolite profile by direct injection turbulent-laminar flow LC-LC and automated tandem mass spectrometry. Anal. Chem. 2001; 73: 2140.
-
(2001)
Anal. Chem.
, vol.73
, pp. 2140
-
-
Lim, H.K.1
Chan, K.W.2
Sisenwine, S.3
Scatina, J.A.4
-
62
-
-
0032777586
-
Ultrahigh flow rate capillary liquid chromatography with mass spectrometric detection for the direct analysis of pharmaceuticals in plasma at sub-nanogram per millilitre concentrations
-
Ayrton J, Clare RA, Dear GJ, Mallett DN, Plumb RS. Ultrahigh flow rate capillary liquid chromatography with mass spectrometric detection for the direct analysis of pharmaceuticals in plasma at sub-nanogram per millilitre concentrations. Rapid Commun. Mass Spectrom. 1999; 13: 1657.
-
(1999)
Rapid Commun. Mass Spectrom.
, vol.13
, pp. 1657
-
-
Ayrton, J.1
Clare, R.A.2
Dear, G.J.3
Mallett, D.N.4
Plumb, R.S.5
-
63
-
-
0032988166
-
The rapid identification of drug metabolites using capillary liquid chromatography coupled to an ion trap mass spectrometer
-
Dear GJ, Ayrton J, Plumb R, Fraser IJ. The rapid identification of drug metabolites using capillary liquid chromatography coupled to an ion trap mass spectrometer. Rapid Commun. Mass Spectrom. 1999; 13: 456.
-
(1999)
Rapid Commun. Mass Spectrom.
, vol.13
, pp. 456
-
-
Dear, G.J.1
Ayrton, J.2
Plumb, R.3
Fraser, I.J.4
-
64
-
-
0004124102
-
Applications of tandem liquid chromatography/mass spectrometry in drug biotransformation and quantification studies
-
Burlingame AL, Carr SA (eds). Humana Press: Totowa, NJ
-
Dulik DM, Schaefer WH, Bordas-Nagy J, Simpson RC, Murphy DM, Rhodes GR. Applications of tandem liquid chromatography/mass spectrometry in drug biotransformation and quantification studies. In Mass Spectrometry in the Biological Sciences, Burlingame AL, Carr SA (eds). Humana Press: Totowa, NJ, 1996; 425-449.
-
(1996)
Mass Spectrometry in the Biological Sciences
, pp. 425-449
-
-
Dulik, D.M.1
Schaefer, W.H.2
Bordas-Nagy, J.3
Simpson, R.C.4
Murphy, D.M.5
Rhodes, G.R.6
-
65
-
-
0030001266
-
On-line immunoaffinity extraction-coupled column capillary liquid chromatography/tandem mass spectrometry: Trace analysis of LSD analogs and metabolites in human urine
-
Cai J, Henion J. On-line immunoaffinity extraction-coupled column capillary liquid chromatography/tandem mass spectrometry: trace analysis of LSD analogs and metabolites in human urine. Anal. Chem. 1996; 68: 72.
-
(1996)
Anal. Chem.
, vol.68
, pp. 72
-
-
Cai, J.1
Henion, J.2
-
66
-
-
0032545338
-
Column switching in capillary liquid chromatography-tandem mass spectrometry for the quantitation of pg/ml concentrations if the free basic drug tolterodine and its active 5-hydroxymethyl metabolite in microliter volumes of plasma
-
Swart R, Koivisto P, Markides KE. Column switching in capillary liquid chromatography-tandem mass spectrometry for the quantitation of pg/ml concentrations if the free basic drug tolterodine and its active 5-hydroxymethyl metabolite in microliter volumes of plasma. J. Chromatogr. A 1998; 828: 209.
-
(1998)
J. Chromatogr. A
, vol.828
, pp. 209
-
-
Swart, R.1
Koivisto, P.2
Markides, K.E.3
-
70
-
-
0036027838
-
Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites
-
Egnash LA, Ramanathan R. Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites. Pharm. Biomed. Anal. 2002; 27: 271.
-
(2002)
Pharm. Biomed. Anal.
, vol.27
, pp. 271
-
-
Egnash, L.A.1
Ramanathan, R.2
-
71
-
-
0342269828
-
Simultaneous HPLC radioactivity and mass spectrometry monitoring. A drug metabolism application
-
41st Annual ASMS Conference On Mass Spectrometry and Allied Topics, San Francisco, CA
-
Fouda HG, Avery MJ, Navetta K. Simultaneous HPLC radioactivity and mass spectrometry monitoring. A drug metabolism application. 41st Annual ASMS Conference On Mass Spectrometry and Allied Topics, San Francisco, CA, 1993; 49a.
-
(1993)
-
-
Fouda, H.G.1
Avery, M.J.2
Navetta, K.3
-
72
-
-
0037442578
-
On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development
-
Nassar AEF, Bjorge SM, Lee DY. On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development. Anal. Chem. 2003; 75: 785.
-
(2003)
Anal. Chem.
, vol.75
, pp. 785
-
-
Nassar, A.E.F.1
Bjorge, S.M.2
Lee, D.Y.3
-
73
-
-
0037723237
-
The mass spectrometer in drug metabolism
-
Rossi DT, Sinz MW (eds). Marcel Dekker: New York
-
Sinz MW, Podoll T. The mass spectrometer in drug metabolism, In Mass Spectrometry in Drug Discovery, Rossi DT, Sinz MW (eds). Marcel Dekker: New York, 2002; 271-336.
-
(2002)
Mass Spectrometry in Drug Discovery
, pp. 271-336
-
-
Sinz, M.W.1
Podoll, T.2
-
74
-
-
0033832991
-
Liquid chromatography-mass spectrometry in the study of the metabolism of drugs and other xenobiotics
-
Oliveira EJ, Watson DG. Liquid chromatography-mass spectrometry in the study of the metabolism of drugs and other xenobiotics. Biomed. Chromatogr. 2000; 14: 351.
-
(2000)
Biomed. Chromatogr.
, vol.14
, pp. 351
-
-
Oliveira, E.J.1
Watson, D.G.2
-
75
-
-
0037723240
-
2002 Electrospray mass spectrometry in contemporary drug metabolism and pharmacokinetics
-
Pramanik BN, Ganguly AK, Gross ML (eds). Marcel Dekker Inc.: New York
-
Cole MJ, Janiszewski JS, Fouda HG. 2002 Electrospray mass spectrometry in contemporary drug metabolism and pharmacokinetics. In Appl. Electrospray Mass Spectrom. Pramanik BN, Ganguly AK, Gross ML (eds). Marcel Dekker Inc.: New York, 2002; 211-249.
-
(2002)
Appl. Electrospray Mass Spectrom
, pp. 211-249
-
-
Cole, M.J.1
Janiszewski, J.S.2
Fouda, H.G.3
-
77
-
-
0038737304
-
Mass spectrometry-assisted applications of stable-labeled compounds in pharmacokinetic and drug metabolism studies
-
Rossi DT, Sinz MW (eds). Marcel Dekker: New York
-
Iyer KR, Sinz MW, Podoll T. Mass spectrometry-assisted applications of stable-labeled compounds in pharmacokinetic and drug metabolism studies, In Mass Spectrometry in Drug Discovery, Rossi DT, Sinz MW (eds). Marcel Dekker: New York, 2002; 337-356.
-
(2002)
Mass Spectrometry in Drug Discovery
, pp. 337-356
-
-
Iyer, K.R.1
Sinz, M.W.2
Podoll, T.3
-
78
-
-
0031894162
-
Stable isotope techniques in early drug development: An economic evaluation
-
Browne TR. Stable isotope techniques in early drug development: an economic evaluation. J. Clin. Pharmacol. 1998; 88: 213.
-
(1998)
J. Clin. Pharmacol.
, vol.88
, pp. 213
-
-
Browne, T.R.1
-
80
-
-
0022650991
-
Recent advances in the use of stable isotopes in drug metabolism research
-
Baillie TA, Rettenmeier AW. Recent advances in the use of stable isotopes in drug metabolism research. J. Clin. Pharmacol. 1986; 26: 481.
-
(1986)
J. Clin. Pharmacol.
, vol.26
, pp. 481
-
-
Baillie, T.A.1
Rettenmeier, A.W.2
-
81
-
-
0035201441
-
Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: Evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques
-
Baillie TA, Halpin RA, Matuszewski BK, Geer LA, Chavez-Eng CM, Dean D, Braun M, Doss G, Jones A, Marks T, Melillo D, Vyas KP. Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques. Drug Metab. Dispos. 2001; 29: 1614.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1614
-
-
Baillie, T.A.1
Halpin, R.A.2
Matuszewski, B.K.3
Geer, L.A.4
Chavez-Eng, C.M.5
Dean, D.6
Braun, M.7
Doss, G.8
Jones, A.9
Marks, T.10
Melillo, D.11
Vyas, K.P.12
-
82
-
-
0030846066
-
Oxidative metabolism of a rexinoid and rapid phase II metabolite identification by mass spectrometry
-
Shirley MA, Wheelan P, Howell SR, Murphy RC. Oxidative metabolism of a rexinoid and rapid phase II metabolite identification by mass spectrometry. Drug Metab. Dispos. 1997; 25: 1144.
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 1144
-
-
Shirley, M.A.1
Wheelan, P.2
Howell, S.R.3
Murphy, R.C.4
-
83
-
-
0037131095
-
Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry
-
Gangl E, Utkin I, Gerber N, Vouros P. Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry. J. Chromatogr. A 2002; 974: 91.
-
(2002)
J. Chromatogr. A
, vol.974
, pp. 91
-
-
Gangl, E.1
Utkin, I.2
Gerber, N.3
Vouros, P.4
-
84
-
-
0033454051
-
Mass spectrometric and tandem mass spectrometric behavior of nitrocatechol glucuronicles: A comparison of atmospheric pressure chemical ionization and electrospray ionization
-
Keski-Hynnilä H, Luukkanen L, Taskinen J, Kostiainen R. Mass spectrometric and tandem mass spectrometric behavior of nitrocatechol glucuronicles: a comparison of atmospheric pressure chemical ionization and electrospray ionization. J. Am. Soc. Mass Spectrom. 1999; 10: 537.
-
(1999)
J. Am. Soc. Mass Spectrom.
, vol.10
, pp. 537
-
-
Keski-Hynnilä, H.1
Luukkanen, L.2
Taskinen, J.3
Kostiainen, R.4
-
85
-
-
0035983392
-
Use of liquid chromatography/ion trap mass spectrometry/triple quadrupole mass spectrometry system for metabolite identification
-
Liu DQ, Xia Y-Q, Bakhtiar R. Use of liquid chromatography/ion trap mass spectrometry/triple quadrupole mass spectrometry system for metabolite identification. Rapid Commun. Mass Spectrom. 2002; 16: 1330.
-
(2002)
Rapid Commun. Mass Spectrom.
, vol.16
, pp. 1330
-
-
Liu, D.Q.1
Xia, Y.-Q.2
Bakhtiar, R.3
-
86
-
-
0037109053
-
Determination of 4-hydroxy-3-methoxyphenylethylene glycol 4-sulfate in human urine using liquid chromatography-tandem mass spectrometry
-
Jacob P III, Wilson M, Yu L, Mendelson J, Jones RT. Determination of 4-hydroxy-3-methoxyphenylethylene glycol 4-sulfate in human urine using liquid chromatography-tandem mass spectrometry. Anal. Chem. 2002; 74: 5290.
-
(2002)
Anal. Chem.
, vol.74
, pp. 5290
-
-
Jacob P. III1
Wilson, M.2
Yu, L.3
Mendelson, J.4
Jones, R.T.5
-
87
-
-
0001188062
-
Analysis of O-glucuronide conjugates in urine by electrospray ion trap mass spectrometry
-
Gu J, Zhong D, Chen X. Analysis of O-glucuronide conjugates in urine by electrospray ion trap mass spectrometry. Fresenius' J. Anal. Chem. 1999; 365: 553.
-
(1999)
Fresenius' J. Anal. Chem.
, vol.365
, pp. 553
-
-
Gu, J.1
Zhong, D.2
Chen, X.3
-
88
-
-
0034483752
-
Electrospray and atmospheric pressure chemical ionization tandem mass spectrometric behavior of eight steroid glucuronides
-
Kuuranne T, Vahermo M, Leinonen A, Kostiainen R. Electrospray and atmospheric pressure chemical ionization tandem mass spectrometric behavior of eight steroid glucuronides. J. Am. Soc. Mass Spectrom. 2000; 11: 722.
-
(2000)
J. Am. Soc. Mass Spectrom.
, vol.11
, pp. 722
-
-
Kuuranne, T.1
Vahermo, M.2
Leinonen, A.3
Kostiainen, R.4
-
89
-
-
0035154436
-
In vivo metabolism of epothilone B in tumor-bearing nude mice: Identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry
-
Blum W, Aichholz R, Ramstein P, Kühnöl J, Brüggen J, O'Reilly T, Florsheimer A. In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2001; 15: 41.
-
(2001)
Rapid Commun. Mass Spectrom.
, vol.15
, pp. 41
-
-
Blum, W.1
Aichholz, R.2
Ramstein, P.3
Kühnöl, J.4
Brüggen, J.5
O'Reilly, T.6
Florsheimer, A.7
-
90
-
-
0030781225
-
Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: Identification of phase I metabolites and glutathione conjugates
-
Kassahun K, Davis M, Hu P, Martin B, Baillie T. Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates. Chem. Res. Toxicol. 1997; 10: 1228.
-
(1997)
Chem. Res. Toxicol.
, vol.10
, pp. 1228
-
-
Kassahun, K.1
Davis, M.2
Hu, P.3
Martin, B.4
Baillie, T.5
-
91
-
-
0028944553
-
Use of electrospray ionisation and neutral loss liquid chromatography/tandem mass spectrometry in drug metabolism studies
-
Jackson PJ, Brownsill RD, Taylor AR, Walther B. Use of electrospray ionisation and neutral loss liquid chromatography/tandem mass spectrometry in drug metabolism studies. J. Mass Spectrom. 1995; 30: 446.
-
(1995)
J. Mass Spectrom.
, vol.30
, pp. 446
-
-
Jackson, P.J.1
Brownsill, R.D.2
Taylor, A.R.3
Walther, B.4
-
92
-
-
0032884327
-
Integrating qualitative and quantitative liquid chromatography/tandem mass spectrometric analysis to support drug discovery
-
Poon GK, Kwei G, Wang R, Lyons K, Chen Q, Didolkar V, Hop CECA. Integrating qualitative and quantitative liquid chromatography/tandem mass spectrometric analysis to support drug discovery. Rapid Commun. Mass Spectrom. 1999; 13: 1943.
-
(1999)
Rapid Commun. Mass Spectrom.
, vol.13
, pp. 1943
-
-
Poon, G.K.1
Kwei, G.2
Wang, R.3
Lyons, K.4
Chen, Q.5
Didolkar, V.6
Hop, C.E.C.A.7
-
93
-
-
0037073078
-
Verapamil: New insight into the molecular mechanism of drug oxidation in the human heart
-
Walles M, Thum T, Levsen K, Borlak J. Verapamil: new insight into the molecular mechanism of drug oxidation in the human heart. J. Chromatogr. A 2002; 970: 117.
-
(2002)
J. Chromatogr. A
, vol.970
, pp. 117
-
-
Walles, M.1
Thum, T.2
Levsen, K.3
Borlak, J.4
-
94
-
-
0031751849
-
Identification of drug metabolites in biological matrices by intelligent automated liquid chromatography/tandem mass spectrometry
-
Lopez LL, Yu X, Cui D, Davis MR. Identification of drug metabolites in biological matrices by intelligent automated liquid chromatography/tandem mass spectrometry Rapid Common. Mass Spectrom. 1998; 12: 1756.
-
(1998)
Rapid Common. Mass Spectrom.
, vol.12
, pp. 1756
-
-
Lopez, L.L.1
Yu, X.2
Cui, D.3
Davis, M.R.4
-
96
-
-
0041918439
-
Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates
-
Fernandez-Mezler CL, Owens KG, Baillie TA, King RC. Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates. Drug Metab. Dispos. 1999; 27: 32.
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 32
-
-
Fernandez-Mezler, C.L.1
Owens, K.G.2
Baillie, T.A.3
King, R.C.4
-
97
-
-
0036232049
-
Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry
-
Sundstrom I, Hedeland M, Bondesson U, Andren PE. Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry. J. Mass Spectrom. 2002; 37: 414.
-
(2002)
J. Mass Spectrom.
, vol.37
, pp. 414
-
-
Sundstrom, I.1
Hedeland, M.2
Bondesson, U.3
Andren, P.E.4
-
98
-
-
0034536050
-
Identification of an N-(hydroxysulfonyl)oxy metabolite using in vitro microorganism screening, high-resolution and tandem mass spectrometry
-
Pilard S, Caradec F, Jackson P, Luijten W. Identification of an N-(hydroxysulfonyl)oxy metabolite using in vitro microorganism screening, high-resolution and tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2000; 14: 2362.
-
(2000)
Rapid Commun. Mass Spectrom.
, vol.14
, pp. 2362
-
-
Pilard, S.1
Caradec, F.2
Jackson, P.3
Luijten, W.4
-
99
-
-
0030952970
-
Accurate mass measurements of some glucuronide derivatives by electrospray low resolution quadrupole mass spectrometry
-
Kostiainen R, Tuominen J, Luukkanen L, Taskinen J, Green BN. Accurate mass measurements of some glucuronide derivatives by electrospray low resolution quadrupole mass spectrometry. Rapid Commun. Mass Spectrom. 1997; 11: 283.
-
(1997)
Rapid Commun. Mass Spectrom.
, vol.11
, pp. 283
-
-
Kostiainen, R.1
Tuominen, J.2
Luukkanen, L.3
Taskinen, J.4
Green, B.N.5
-
100
-
-
2442701792
-
High accuracy mass measurements with a high resolution triple quadrupole mass spectrometer
-
Presented at the 50th ASMS Conference on Mass Spectrom. And Allied Topics, Orlando, FL
-
Schoen AE, Heller RT, Schweingruber H, Dewey H, Bui H, Maljers L, Dunyach JJ, Olney TN, Taylor DM, Campbell C, Paul G, Churchill M. High accuracy mass measurements with a high resolution triple quadrupole mass spectrometer. Presented at the 50th ASMS Conference on Mass Spectrom. And Allied Topics, Orlando, FL, 2002.
-
(2002)
-
-
Schoen, A.E.1
Heller, R.T.2
Schweingruber, H.3
Dewey, H.4
Bui, H.5
Maljers, L.6
Dunyach, J.J.7
Olney, T.N.8
Taylor, D.M.9
Campbell, C.10
Paul, G.11
Churchill, M.12
-
101
-
-
0042643144
-
High performance liquid chromatography with atmospheric pressure ionization tandem mass spectrometry as a tool in quantitative bioanalytical chemistry
-
ACS Symposium Series, Snyder AP (ed). American Chemical Society: Washington, DC
-
Gilbert JD, Olah TV, McLoughlin DA. High performance liquid chromatography with atmospheric pressure ionization tandem mass spectrometry as a tool in quantitative bioanalytical chemistry. In Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry. ACS Symposium Series, vol. 619, Snyder AP (ed). American Chemical Society: Washington, DC, 1995.
-
(1995)
Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry
, vol.619
-
-
Gilbert, J.D.1
Olah, T.V.2
McLoughlin, D.A.3
-
102
-
-
0033128171
-
LC/MS applications in drug development
-
Lee MS, Kerns EH. LC/MS applications in drug development. Mass Spectrom. Rev. 1999; 18: 187.
-
(1999)
Mass Spectrom. Rev.
, vol.18
, pp. 187
-
-
Lee, M.S.1
Kerns, E.H.2
-
103
-
-
0036583670
-
Current developments in LC-MS for pharmaceutical analysis
-
Lim C-K, Lord G. Current developments in LC-MS for pharmaceutical analysis. Biol. Pharm. Bull. 2002; 25: 547.
-
(2002)
Biol. Pharm. Bull.
, vol.25
, pp. 547
-
-
Lim, C.-K.1
Lord, G.2
-
104
-
-
0032011562
-
Matrix effect in quantitative LC/MS/MS analyses of biological fluids: A method for determination of finasteride in human plasma at picogram per milliliter concentrations
-
Matuszewski BK, Constanzer ML, Chavez-Eng CM. Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations. Anal. Chem. 1998; 70: 882.
-
(1998)
Anal. Chem.
, vol.70
, pp. 882
-
-
Matuszewski, B.K.1
Constanzer, M.L.2
Chavez-Eng, C.M.3
-
105
-
-
0033168125
-
Liquid-liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma
-
Steinborner S, Henion JD. Liquid-liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma. Anal. Chem. 1999; 71: 2340.
-
(1999)
Anal. Chem.
, vol.71
, pp. 2340
-
-
Steinborner, S.1
Henion, J.D.2
-
106
-
-
0032829954
-
Quantitative analysis of pharmacokinetic study samples by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)
-
Mück W. Quantitative analysis of pharmacokinetic study samples by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Pharmazie 1999; 54: 639.
-
(1999)
Pharmazie
, vol.54
, pp. 639
-
-
Mück, W.1
-
107
-
-
0031048025
-
The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure
-
Olah TV, McLoughlin DA, Gilbert JD. The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure. Rapid Commun. Mass Spectrom. 1997; 11: 17.
-
(1997)
Rapid Commun. Mass Spectrom.
, vol.11
, pp. 17
-
-
Olah, T.V.1
McLoughlin, D.A.2
Gilbert, J.D.3
-
108
-
-
84856708910
-
Effect of multiple sprayers on dynamic range and flow rate limitations in electrospray and ionspray mass spectrometry
-
Kostiainen R, Bruins AP. Effect of multiple sprayers on dynamic range and flow rate limitations in electrospray and ionspray mass spectrometry. Rapid Commun. Mass Spectrom. 1994; 8: 549.
-
(1994)
Rapid Commun. Mass Spectrom.
, vol.8
, pp. 549
-
-
Kostiainen, R.1
Bruins, A.P.2
-
109
-
-
0032986050
-
The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds
-
Bonfiglio R, King RC, Olah TV, Merkle K. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commun. Mass Spectrom. 1999; 13: 1175.
-
(1999)
Rapid Commun. Mass Spectrom.
, vol.13
, pp. 1175
-
-
Bonfiglio, R.1
King, R.C.2
Olah, T.V.3
Merkle, K.4
-
110
-
-
0035983382
-
Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process
-
Tiller PR, Romanyshyn LA. Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process. Rapid Commun. Mass Spectrom. 2002; 16: 1225.
-
(2002)
Rapid Commun. Mass Spectrom.
, vol.16
, pp. 1225
-
-
Tiller, P.R.1
Romanyshyn, L.A.2
-
111
-
-
0036006585
-
Implications of matrix effects in ultra-fast gradient or isocratic liquid chromatography with mass spectrometry in drug discovery
-
Tiller PR, Romanyshyn LA. Implications of matrix effects in ultra-fast gradient or isocratic liquid chromatography with mass spectrometry in drug discovery. Rapid Commun. Mass Spectrom. 2002; 16: 92.
-
(2002)
Rapid Commun. Mass Spectrom.
, vol.16
, pp. 92
-
-
Tiller, P.R.1
Romanyshyn, L.A.2
-
112
-
-
0032559356
-
Analysis of catechol-type glucuronides in urine samples by liquid chromatography-electrospray ionization-tandem mass spectrometry
-
Keski-Hynnilä H, Andersin R, Luukkanen L, Taskinen J, Kostiainen R. Analysis of catechol-type glucuronides in urine samples by liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Chromatogr. A 1998; 794: 75.
-
(1998)
J. Chromatogr. A
, vol.794
, pp. 75
-
-
Keski-Hynnilä, H.1
Andersin, R.2
Luukkanen, L.3
Taskinen, J.4
Kostiainen, R.5
-
113
-
-
0036009625
-
Enzyme-assisted synthesis and characterization of glucuronide conjugates of methyl-testosterone (17α-methylandrost-4-en-17β-ol-3-one) and nandrolone (estr-4-en-17β-ol-3-one) metabolites
-
Kuuranne T, Aitio O, Vahermo M, Elovaara E, Kostiainen R. Enzyme-assisted synthesis and characterization of glucuronide conjugates of methyl-testosterone (17α-methylandrost-4-en-17β-ol-3-one) and nandrolone (estr-4-en-17β-ol-3-one) metabolites. Bioconj. Chem. 2002; 13: 194.
-
(2002)
Bioconj. Chem.
, vol.13
, pp. 194
-
-
Kuuranne, T.1
Aitio, O.2
Vahermo, M.3
Elovaara, E.4
Kostiainen, R.5
-
114
-
-
0022965089
-
High-speed liquid chromatography/tandem mass spectrometry for the determination of drugs in biological samples
-
Covey TR, Lee ED, Henion JD. High-speed liquid chromatography/tandem mass spectrometry for the determination of drugs in biological samples. Anal. Chem. 1986; 58: 2453.
-
(1986)
Anal. Chem.
, vol.58
, pp. 2453
-
-
Covey, T.R.1
Lee, E.D.2
Henion, J.D.3
-
115
-
-
0035870154
-
Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes
-
Yang L, Mann TD, Little D, Wu N, Clement RP, Rudewicz PJ. Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes. Anal. Chem. 2001; 73: 1740.
-
(2001)
Anal. Chem.
, vol.73
, pp. 1740
-
-
Yang, L.1
Mann, T.D.2
Little, D.3
Wu, N.4
Clement, R.P.5
Rudewicz, P.J.6
-
116
-
-
0030841892
-
A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system
-
McLoughlin DA, Olah TV, Gilbert JD. A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system. J. Pharm. Biomed. Anal. 1997; 15: 1893.
-
(1997)
J. Pharm. Biomed. Anal.
, vol.15
, pp. 1893
-
-
McLoughlin, D.A.1
Olah, T.V.2
Gilbert, J.D.3
-
117
-
-
0029118734
-
Enriched stable isotopes of elements used as tracers: Methods of presenting high-performance liquid chromatographic-inductively coupled argon plasma mass spectrometric data
-
Suzuki KT, Yoneda S, Itoh M, Ohmichi M. Enriched stable isotopes of elements used as tracers: methods of presenting high-performance liquid chromatographic-inductively coupled argon plasma mass spectrometric data. J. Chromatogr. B 1995; 670: 63.
-
(1995)
J. Chromatogr. B
, vol.670
, pp. 63
-
-
Suzuki, K.T.1
Yoneda, S.2
Itoh, M.3
Ohmichi, M.4
-
118
-
-
0032833411
-
Liquid chromatography-inductively coupled plasma mass spectrometry
-
Sutton KL, Caruso JA. Liquid chromatography-inductively coupled plasma mass spectrometry. J. Chromatogr. A 1999; 856: 243.
-
(1999)
J. Chromatogr. A
, vol.856
, pp. 243
-
-
Sutton, K.L.1
Caruso, J.A.2
-
119
-
-
0035056780
-
The potential of inductively coupled plasma mass spectrometry detection for high-performance liquid chromatography combined with accurate mass measurement of organic pharmaceutical compounds
-
Axelsson B-O, Jörnten-Karlsson M, Michelsen P, Abou-Shakra F. The potential of inductively coupled plasma mass spectrometry detection for high-performance liquid chromatography combined with accurate mass measurement of organic pharmaceutical compounds. Rapid Commun. Mass Spectrom. 2001; 15: 375.
-
(2001)
Rapid Commun. Mass Spectrom.
, vol.15
, pp. 375
-
-
Axelsson, B.-O.1
Jörnten-Karlsson, M.2
Michelsen, P.3
Abou-Shakra, F.4
-
120
-
-
0034532968
-
Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: Application to diclofenac using chlorine and sulfur detection
-
Corcoran O, Nicholson JK, Lenz EM, Abou-Shakra F, Castro-Perez J, Sage AB, Wilson ID. Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and sulfur detection. Rapid Commun. Mass Spectrom. 2000; 14: 2377.
-
(2000)
Rapid Commun. Mass Spectrom.
, vol.14
, pp. 2377
-
-
Corcoran, O.1
Nicholson, J.K.2
Lenz, E.M.3
Abou-Shakra, F.4
Castro-Perez, J.5
Sage, A.B.6
Wilson, I.D.7
-
121
-
-
0036007560
-
Quantitation in gradient high performance liquid chromatography/inductively coupled mass spectrometry using diclofenac and chlorpromazine
-
Duckett CJ, Bailey NJC, Walker H, Abou-Shakra F, Wilson ID, Lindon JC, Nicholson JK. Quantitation in gradient high performance liquid chromatography/inductively coupled mass spectrometry using diclofenac and chlorpromazine. Rapid Commun. Mass Spectrom. 2002; 16: 245.
-
(2002)
Rapid Commun. Mass Spectrom.
, vol.16
, pp. 245
-
-
Duckett, C.J.1
Bailey, N.J.C.2
Walker, H.3
Abou-Shakra, F.4
Wilson, I.D.5
Lindon, J.C.6
Nicholson, J.K.7
-
123
-
-
0034306770
-
Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development
-
Lindon JC, Nicholson JK, Wilson ID. Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development. J. Chromatogr. B 2000; 748: 233.
-
(2000)
J. Chromatogr. B
, vol.748
, pp. 233
-
-
Lindon, J.C.1
Nicholson, J.K.2
Wilson, I.D.3
-
124
-
-
0034306614
-
Application of directly coupled LC-NMR-MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83
-
Shockcor JP, Unger SE, Savina P, Nicholson JK, Lindon JC. Application of directly coupled LC-NMR-MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83. J. Chromatogr. B 2000; 748: 269.
-
(2000)
J. Chromatogr. B
, vol.748
, pp. 269
-
-
Shockcor, J.P.1
Unger, S.E.2
Savina, P.3
Nicholson, J.K.4
Lindon, J.C.5
-
125
-
-
0034306734
-
Mass directed peak selection, an efficient method of drug metabolite identification using coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy
-
Dear GJ, Plumb RS, Sweatman BC, Ayrton J, Lindon JC, Nicholson JK, Ismail IM. Mass directed peak selection, an efficient method of drug metabolite identification using coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy. J. Chromatogr. B 2000; 748: 281.
-
(2000)
J. Chromatogr. B
, vol.748
, pp. 281
-
-
Dear, G.J.1
Plumb, R.S.2
Sweatman, B.C.3
Ayrton, J.4
Lindon, J.C.5
Nicholson, J.K.6
Ismail, I.M.7
-
126
-
-
0033059135
-
Biomedical applications of accelerator mass spectrometry-isotope measurements at the level of the atom
-
Barker J, Garner RC. Biomedical applications of accelerator mass spectrometry-isotope measurements at the level of the atom. Rapid Commun. Mass Spectrom. 1999; 13: 285.
-
(1999)
Rapid Commun. Mass Spectrom.
, vol.13
, pp. 285
-
-
Barker, J.1
Garner, R.C.2
-
127
-
-
0035987901
-
14C-labeled (R)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl]-4- (3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor
-
14C-labeled (R)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl]-4- (3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor. Drug Metab. Dispos. 2002; 30: 823.
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 823
-
-
Garner, R.C.1
Goris, I.2
Laenen, A.A.E.3
Vanhoutte, E.4
Meuldermans, W.5
Gregory, S.6
Garner, J.V.7
Leong, D.8
Whattam, M.9
Calam, A.10
Snel, C.A.W.11
-
128
-
-
0035870164
-
Evaluation of opiate separation by high-resolution electrospray ionization-ion mobility spectrometry/mass spectrometry
-
Matz LM, Herbert HH Jr. Evaluation of opiate separation by high-resolution electrospray ionization-ion mobility spectrometry/mass spectrometry. Anal. Chem. 2001; 73: 1664.
-
(2001)
Anal. Chem.
, vol.73
, pp. 1664
-
-
Matz, L.M.1
Herbert H.H., Jr.2
-
129
-
-
0036139784
-
Resolving isomeric peptide mixtures: A combined HPLC/ion mobility-TOFMS analysis of a 4000-component combinatorial library
-
Barnes CAS, Hilderbrand AE, Valentine SJ, Clemmer DE. Resolving isomeric peptide mixtures: a combined HPLC/ion mobility-TOFMS analysis of a 4000-component combinatorial library. Anal. Chem. 2002; 74: 26.
-
(2002)
Anal. Chem.
, vol.74
, pp. 26
-
-
Barnes, C.A.S.1
Hilderbrand, A.E.2
Valentine, S.J.3
Clemmer, D.E.4
-
131
-
-
0035388037
-
Increasing bioanalytical throughput using pcSFC-MS/MS: 10 minutes per 96-well plate
-
Hoke SH II, Tomlinson JA, Bolden RD, Morand KL, Pinkston JD, Wehmeyer KR. Increasing bioanalytical throughput using pcSFC-MS/MS: 10 minutes per 96-well plate. Anal. Chem. 2001; 73: 3083.
-
(2001)
Anal. Chem.
, vol.73
, pp. 3083
-
-
Hoke S.H. II1
Tomlinson, J.A.2
Bolden, R.D.3
Morand, K.L.4
Pinkston, J.D.5
Wehmeyer, K.R.6
-
134
-
-
0141886234
-
Chip-MS: Coupling the large with the small
-
de Mello AJ. Chip-MS: Coupling the large with the small. Lab on a Chip 2001; 1: 7N.
-
(2001)
Lab on a Chip
, vol.1
-
-
de Mello, A.J.1
-
135
-
-
0038082145
-
A hybrid two-dimensional quadrupole ion trap/Fourier transform ion cyclotron resonance mass spectrometer
-
Presented at PITTCON Orlando, FL
-
Horning S, Malek R, Wieghaus A, Senko MW, Marto JA, Syka JEP. A hybrid two-dimensional quadrupole ion trap/Fourier transform ion cyclotron resonance mass spectrometer. Presented at PITTCON 2003, Orlando, FL.
-
(2003)
-
-
Horning, S.1
Malek, R.2
Wieghaus, A.3
Senko, M.W.4
Marto, J.A.5
Syka, J.E.P.6
|