Investigation of the metabolic fate of 2-, 3- and 4-bromobenzoic acids in bile-duct-cannulated rats by inductively coupled plasma mass spectrometry and high-performance liquid chromatography/inductively coupled plasma mass spectrometry/electrospray mass spectrometry

Rapid Communications in Mass Spectrometry

Volumn 19, Issue 4, 2005, Pages 519-524

  Jensen, Berit Packert ^a   Smith, Christopher J ^b   Bailey, Christopher J ^b   Rodgers, Colin ^b   Wilson, Ian D ^b   Nicholson, Jeremy K ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b ASTRAZENECA   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BODY FLUIDS; DUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDUCTIVELY COUPLED PLASMA; MASS SPECTROMETERS; METABOLISM; METABOLITES; RATS;

ALKALINE HYDROLYSIS; BILE DUCTS; BROMOBENZOIC ACID; ELECTROSPRAY MASS SPECTROMETRY; GLUCURONIDE CONJUGATES; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-INDUCTIVELY COUPLED PLASMA; INDUCTIVELY COUPLED PLASMA-MASS SPECTROMETRY; INTRAPERITONEAL ADMINISTRATION; METABOLIC FATE; METABOLITE PROFILES;

INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY;

2 BROMOBENZOIC ACID; 3 BROMOBENZOIC ACID; 4 BROMOBENZOIC ACID; BROMINE; BROMOBENZOIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANNULATION; CONJUGATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EXCRETION; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MALE; MASS SPECTROMETRY; NONHUMAN; RAT; REACTION ANALYSIS; URINALYSIS;

EID: 13944255544     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1822     Document Type: Article

References (18)

1. Wind M, Lehmann WD. J. Anal. At. Spectrom. 2004; 19: 20.
2. Corcoran O, Nicholson JK, Lenz EM, Abou-Shakra F, Castro-Perez J, Sage AB, Wilson ID. Rapid Commun. Mass Spectrom. 2000; 14: 2377.
3. Marshall P, Heudi O, Mckeown S, Amour A, Abou-Shakra F. Rapid Commun. Mass Spectrom. 2002; 16: 220.
4. Nicholson JK, Lindon JC, Scarfe GB, Wilson ID, Abou-Shakra F, Sage AB, Castro-Perez J. Anal. Chem. 2001; 73: 1491.
5. Abou-Shakra FR, Sage AB, Castro-Perez J, Nicholson JK, Lindon JC, Scarfe GB, Wilson ID. Chromatographia 2002; 55: S-9.
6. Nicholson JK, Lindon JC, Scarfe G, Wilson ID, Abou-Shakra F, Castro-Perez J, Eaton A, Preece S. Analyst 2000; 125: 235.
7. Smith CJ, Wilson ID, Abou-Shakra F, Payne R, Parry TC, Sinclair P, Roberts DW. Anal. Chem. 2003; 75: 1463.
8. Duckett CJ. PhD thesis, Imperial College, UK, 2004.
9. Jensen BP, Smith CJ, Bailey C, Rodgers C, Wilson ID, Nicholson JK. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2004; 809: 279.
10. Ghauri FY, Blackledge CA, Glen RC, Sweatman BC, Lindon JC, Beddell CR, Wilson ID, Nicholson JK. In Methodological Surveys in Biochemistry and Analysis, Reid E, Wilson ID (eds). Royal Society of Chemistry: Cambridge, 1992; 21-28.
11. Ghauri FY, Blackledge CA, Glen RC, Sweatman BC, Lindon JC, Beddell CR, Wilson ID, Nicholson JK. Biochem. Pharmacol. 1992; 44: 1935.
12. Cupid BC, Bedell CR, Wilson ID, Lindon JC, Nicholson JK. Xenobiotica 1996; 26: 157.
13. Cupid BC, Holmes E, Wilson ID, Lindon JC, Nicholson JK. Xenobiotica 1999; 29: 27.
14. Holmes E, Sweatman BC, Bollard M, Blackledge CA, Beddell CR, Wilson ID, Lindon JC, Nicholson JK. Xenobiotica 1995; 25: 985.
15. Scarfe GB, Wilson ID, Warne MA, Holmes E, Nicholson JK, Lindon JC. Xenobiotica 2002; 32: 267.
16. Kawai T, Zhang ZW, Moon CS, Shimbo S, Watanabe T, Matsuda-Inoguchi N, Higashikawa K, Ikeda M. Toxicol. Lett. 2002; 134: 285.
17. Dale O, Brown BR Jr. Clin. Pharmacokinet. 1987; 12: 145.
18. Fenselau C, Kaufmann FC (eds). Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity, Springer-Verlag: Heidelberg, 1994; 367-389.