Liquid chromatography/chemical reaction interface mass spectrometry as an alternative to radioisotopes for quantitative drug metabolism studies

Analytical Chemistry

Volumn 68, Issue 17, 1996, Pages 2996-3001

  Goldthwaite Jr , Charles A ^a   Hsieh, Feng Yin ^a   Womble, Scott W ^a,d   Nobes, Brian J ^a   Blair, Ian A ^a,b   Klunk, Lewis J ^c   Mayol, Robert F ^c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; DRUG INTERACTIONS; INTERFACES (MATERIALS); MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; PARTICLE BEAMS; RADIOISOTOPES; SOLVENTS;

CHEMICAL REACTION INTERFACE MASS SPECTROMETRY; HELIUM ASSISTED NEBULIZER; QUANTITATIVE DRUG METABOLISM; THERMOSPRAY NEBULIZER; VESTEC PARTICLE BEAM INTERFACE;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

BUSPIRONE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTERMETHOD COMPARISON; ISOTOPE LABELING; LIVER METABOLISM; MASS SPECTROMETRY; NONHUMAN; QUANTITATIVE ASSAY; RAT;

ANIMALS; BUSPIRONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; RATS; SEROTONIN AGONISTS; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 9544238227     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac960044j     Document Type: Article

References (32)

1. Wolfe, R. R. Radioactive and Stable Isotope Tracers in Biomedicine: Wiley-Liss: New York, 1992.
2. Hendee, W. R. Radioactive Isotopes in Biological Research: Wiley-Interscience: New York, 1973.
3. Baillie, T. A. Pharm. Rev. 1981, 33, 81-132.
4. Goodman, K. J.; Brenna, J. T. Anal. Chem. 1992, 64, 1088-1095.
5. Chapman, T. E.; Berger, R.; Reijgoud, D. J.; Okken, A. Stable Isotopes in Paediatric Nutritional and Metabolic Research; Intercept: Andover, NH, 1990.
6. Ehleringer, J. R.; Rundel, P. W. In Stable Isotopes: History, Units and Instrumentation: Rundel, P. W., Ehleringer, J. R., Nagy, K. A., Eds.; Springer-Verlag: New York, 1988: pp 1-15.
7. Markey, S. P.; Abramson, F. P. Anal. Chem. 1982, 54, 2375-2376.
8. Heppner, R. A. Anal. Chem. 1983, 55, 2170.
9. Teffera, Y.; Abramson, F. P.; McLean, M.; Vestal, M.J. Chromatogr. 1993. 620, 89-96.
10. Song, H.; Abramson, F. P. Proceedings of the 42nd ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, IL. May 29-June 3, 1994: p 1027.
11. Chace, D. H.: Abramson, F. P. Biomed. Environ. Mass Spectrom. 1990, 19, 117-122.
12. Abramson, F. P.; McLean, M.; Vestal, M. In Synthesis and Applications of Isotopically Labeled Compounds 1991; Buncel, E., Kabalka, G. W., Eds.; Elsevier: Amsterdam, 1992; pp 133-137.
13. McFadden, W. H.; Schwartz, H. L.; Evans, S.J. Chromatogr. 1976, 122, 389-392.
14. Millington, D. S.; Yorke, D. A.; Burns, P. In Advances in Mass Spectrometry, Vol. 8B; Quayle, A., Ed.; Heyden and Son Ltd.: London, 1985; p 119.
15. Moini, M.; Abramson, F. P. Biol. Mass Spectrom. 1991, 20, 308-312.
16. Voyksner, R. D.; Smith, C. S.: Knox, P. C. Biomed. Environ. Mass Spectrom. 1990, 19, 523.
17. Ho, Z. S.; Clarke, A.; Browner, R. F. Proceedings of the 42nd Conference on Mass Spectrometry and Allied Topics, Chicago, IL, May 29-June 3, 1994; p 777.
18. Song, H.; Abramson, F. P. Anal. Chem. 1993, 65, 447-450.
19. Santone, K.; Stocking, L.; Cole, C.; Mayol, R. F. ISSX Proc. 1992, 2, 77.
20. Santone, K.; Mayol, R. F. ISSX Proc. 1993, 4, 228.
21. Eison, A. S.; Temple, D. L., Jr. Am. J. Med. 1986. 80 (Suppl. 3B), 1.
22. Taylor, D. P. FASEB J. 1988, 2, 2445.
23. Weissman, B. A.; Barrett, J. E.; Bardy, L. S.; Witkin, J. M.; Mendelson, W. B.; Paul, S. M.; Skolnick, P. Drug Dev. Res. 1984, 4, 83.
24. Gammans, R. E.; Mayol, R. F.; Eison, M. E. Fed. Proc. 1983, 42, 377.
25. Jajoo, H. K.; Mayol, R. F.; LaBudde, J. A.; Blair, I. A. Drug Metab. Dispos. 1989, 17, 625.
26. Jajoo, H. K.; Mayol, R. F.; LaBudde, J. A.; Blair, I. A. Drug Metab. Dispos. 1989, 17, 634.
27. Mayol, R. F.; Adamson, D. S.; Gammans, R. E.; LaBudde, J. A. Clin. Pharmacol. Ther. 1985, 37, 210.
28. Mayol, R. F.; Marvel, C. J.; LaBudde, J. A. Fed. Proc. 1981, 40, 684.
29. Gammans, R. E.; Lister, K. E.; Marvel, C. J.; Mayol, R. F.; LaBudde, J. A. Fed. Proc. 1981, 40, 634.
30. Jajoo, H. K.; Klunk, L. J.; Mayol, R. F.; Blair, I. A. Xenobiotica 1990, 20, 779.
31. Huang, E. C.; Wachs T.; Conboy J. J.; Henion, J. D. Anal. Chem. 1990, 62, 713A-725A.
32. Moseley, M. A.; Jorgensen, J. W.; Shabanowitz, J.; Hunt, D. F.; Tomer, K. B. J. Am. Soc. Mass Spectrom. 1992, 3, 289-300.