메뉴 건너뛰기




Volumn 4, Issue 3, 2003, Pages 291-299

Role of cytokines in the pathogenesis of autoimmune diabetes mellitus

Author keywords

Cytokines; Immunoregulation; Islet cells; Th1 Th2 cells; Type 1 diabetes

Indexed keywords

CYTOKINE;

EID: 0042839568     PISSN: 13899155     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025160614313     Document Type: Review
Times cited : (98)

References (79)
  • 1
    • 0023520177 scopus 로고
    • Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus
    • Foulis AK, Farquharson MA, Meager A. Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus. Lancet 1987;2:1423-1427.
    • (1987) Lancet , vol.2 , pp. 1423-1427
    • Foulis, A.K.1    Farquharson, M.A.2    Meager, A.3
  • 3
    • 0028278373 scopus 로고
    • Pancreas in recent onset insulin-dependent diabetes mellitus: Changes in HLA, adhesion molecules and autoantigens, restricted TCR Vb usage, and cytokine profile
    • Somoza N, Vargas F, Roura-Mir C, Vives-Pi M, Fernandez-Figueras MT, Ariza A, Gomis R, Bragado R, Marti M, Jaraquemada D. Pancreas in recent onset insulin-dependent diabetes mellitus: Changes in HLA, adhesion molecules and autoantigens, restricted TCR Vb usage, and cytokine profile. J Immunol 1994;153:1360-1377.
    • (1994) J Immunol , vol.153 , pp. 1360-1377
    • Somoza, N.1    Vargas, F.2    Roura-Mir, C.3    Vives-Pi, M.4    Fernandez-Figueras, M.T.5    Ariza, A.6    Gomis, R.7    Bragado, R.8    Marti, M.9    Jaraquemada, D.10
  • 4
    • 0025951776 scopus 로고
    • Insulitis in type 1 (insulin-dependent) diabetes mellitus in man: Macrophages, lymphocytes, and interferon-γ containing cells
    • Foulis AK, McGill M, Farquharson MA. Insulitis in type 1 (insulin-dependent) diabetes mellitus in man: Macrophages, lymphocytes, and interferon-γ containing cells. J Pathol 1991;165:97-103.
    • (1991) J Pathol , vol.165 , pp. 97-103
    • Foulis, A.K.1    McGill, M.2    Farquharson, M.A.3
  • 6
    • 0029764082 scopus 로고    scopus 로고
    • + T cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction
    • + T cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction. Diabetes 1996;45:1350-1357.
    • (1996) Diabetes , vol.45 , pp. 1350-1357
    • Suarez-Pinzon, W.1    Rajotte, R.V.2    Mosmann, T.R.3    Rabinovitch, A.4
  • 8
    • 0000836601 scopus 로고
    • Roles of cytokines in IDDM pathogenesis and islet β-cell destruction
    • Rabinovitch A. Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev 1993;1:215-240.
    • (1993) Diabetes Rev , vol.1 , pp. 215-240
    • Rabinovitch, A.1
  • 9
    • 0022457462 scopus 로고
    • Progressive damage of cultured pancreatic islets after single early exposure to streptozotocin
    • Bolaffi JL, Nowlain RE, Cruz L, Grodsky GM. Progressive damage of cultured pancreatic islets after single early exposure to streptozotocin. Diabetes 1986;35:1027-1033.
    • (1986) Diabetes , vol.35 , pp. 1027-1033
    • Bolaffi, J.L.1    Nowlain, R.E.2    Cruz, L.3    Grodsky, G.M.4
  • 10
    • 0013492650 scopus 로고
    • Pancreatic β-cells possess defense mechanisms against cell-specific toxicity
    • Pipeleers D, Van de Winkel M. Pancreatic β-cells possess defense mechanisms against cell-specific toxicity. Proc Natl Acad Sci USA 1986;83:5267-5271.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 5267-5271
    • Pipeleers, D.1    Van de Winkel, M.2
  • 11
    • 0027393063 scopus 로고
    • Interaction of interleukin- 1 with islet β-cells. Distinction between indirect, aspecific cytotoxicity and direct, specific functional suppression
    • Ling Z, In't Veld PA, Pipeleers DG. Interaction of interleukin- 1 with islet β-cells. Distinction between indirect, aspecific cytotoxicity and direct, specific functional suppression. Diabetes 1993;42:56-65.
    • (1993) Diabetes , vol.42 , pp. 56-65
    • Ling, Z.1    In't Veld, P.A.2    Pipeleers, D.G.3
  • 12
    • 0023881127 scopus 로고
    • Receptor-directed focusing of lymphokine release by helper T cells
    • Poo W-J, Conrad L, Janeway CA. Receptor-directed focusing of lymphokine release by helper T cells. Nature 1988;332:378-380.
    • (1988) Nature , vol.332 , pp. 378-380
    • Poo, W.-J.1    Conrad, L.2    Janeway, C.A.3
  • 14
    • 0024281428 scopus 로고
    • A novel form of TNF/cachetin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF
    • Kriegler M, Perez C, DeFay K, Albert I, Lu SD. A novel form of TNF/cachetin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF. Cell 1988;53:45-53.
    • (1988) Cell , vol.53 , pp. 45-53
    • Kriegler, M.1    Perez, C.2    DeFay, K.3    Albert, I.4    Lu, S.D.5
  • 15
    • 0024431241 scopus 로고
    • The specificity of rejection and the absence of susceptibility of pancreatic islet β-cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat
    • Sutton R, Gray DWR, McShane P, Dallman MJ, Morris PJ. The specificity of rejection and the absence of susceptibility of pancreatic islet β-cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat. J Exp Med 1989;170:751-762.
    • (1989) J Exp Med , vol.170 , pp. 751-762
    • Sutton, R.1    Gray, D.W.R.2    McShane, P.3    Dallman, M.J.4    Morris, P.J.5
  • 16
    • 0028231199 scopus 로고
    • Characterization of mixed syngeneic-allogeneic and syngeneic-xenogeneic islet-graft rejections in mice. Evidence of functional impairment of the remaining syngeneic islets in xenograft rejections
    • Korsgren O, Jansson L. Characterization of mixed syngeneic-allogeneic and syngeneic-xenogeneic islet-graft rejections in mice. Evidence of functional impairment of the remaining syngeneic islets in xenograft rejections. J Clin Invest 1994;93:1113-1119.
    • (1994) J Clin Invest , vol.93 , pp. 1113-1119
    • Korsgren, O.1    Jansson, L.2
  • 17
    • 0032531099 scopus 로고    scopus 로고
    • IFN-γ action on pancreatic beta cells causes class I MHC upregulation but not diabetes
    • Thomas HE, Parker JL, Schreiber RD, Kay TWH. IFN-γ action on pancreatic beta cells causes class I MHC upregulation but not diabetes. J Clin Invest 1998;102:1249-1257.
    • (1998) J Clin Invest , vol.102 , pp. 1249-1257
    • Thomas, H.E.1    Parker, J.L.2    Schreiber, R.D.3    Kay, T.W.H.4
  • 19
    • 0028900805 scopus 로고
    • Intraislet release of IL-1 inhibits-β cell function by inducing β-cell expression of iNOS
    • Corbett JA, McDaniel ML. Intraislet release of IL-1 inhibits-β cell function by inducing β-cell expression of iNOS. J Exp Med 1995;181:559-568.
    • (1995) J Exp Med , vol.181 , pp. 559-568
    • Corbett, J.A.1    McDaniel, M.L.2
  • 21
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996;39:1005-1029.
    • (1996) Diabetologia , vol.39 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 22
    • 0031426764 scopus 로고    scopus 로고
    • Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM?
    • Eizirik DL, Pavlovic D. Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM? Diabetes Metab Rev 1997;13:293-307.
    • (1997) Diabetes Metab Rev , vol.13 , pp. 293-307
    • Eizirik, D.L.1    Pavlovic, D.2
  • 23
    • 0032523104 scopus 로고    scopus 로고
    • Cytokines and their roles in pancreatic islet β-cell destruction and insulin-dependent diabetes mellitus
    • Rabinovitch A, Suarez-Pinzon WL. Cytokines and their roles in pancreatic islet β-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol 1998;55:1139-1149.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1139-1149
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2
  • 24
    • 0023879559 scopus 로고
    • Defective activation of T suppressor cell function in nonobese diabetic mice: Potential relation to cytokine deficiencies
    • Serreze DV, Leiter EH. Defective activation of T suppressor cell function in nonobese diabetic mice: Potential relation to cytokine deficiencies. J Immunol 1988;140:3801-3807.
    • (1988) J Immunol , vol.140 , pp. 3801-3807
    • Serreze, D.V.1    Leiter, E.H.2
  • 26
    • 0025020303 scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): Similarities between TNF-α and interleukin-1
    • Jacob CO, Asiso S, Michie SA, McDevitt HO, Acha-Orbea H. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): Similarities between TNF-α and interleukin-1. Proc Natl Acad Sci USA 1990;87:968-972.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 968-972
    • Jacob, C.O.1    Asiso, S.2    Michie, S.A.3    McDevitt, H.O.4    Acha-Orbea, H.5
  • 28
    • 0026758579 scopus 로고
    • Tumor necrosis factor production is deficient in diabetes-prone BB rats and can be corrected by complete Freund's adjuvant: A possible immunoregulatory role of tumor necrosis factor in the prevention of diabetes
    • Lapchak PH, Guilbert LJ, Rabinovitch A. Tumor necrosis factor production is deficient in diabetes-prone BB rats and can be corrected by complete Freund's adjuvant: A possible immunoregulatory role of tumor necrosis factor in the prevention of diabetes. Clin Immunol Immunopathol 1992;65:129-134.
    • (1992) Clin Immunol Immunopathol , vol.65 , pp. 129-134
    • Lapchak, P.H.1    Guilbert, L.J.2    Rabinovitch, A.3
  • 30
    • 0031573072 scopus 로고    scopus 로고
    • IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
    • Cameron MJ, Arreaza GA, Zuker P, Chensue SW, Strieter RM, Chakrabarti S, Delrvitan TL. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J Immunol 1997;159:4686-4692.
    • (1997) J Immunol , vol.159 , pp. 4686-4692
    • Cameron, M.J.1    Arreaza, G.A.2    Zuker, P.3    Chensue, S.W.4    Strieter, R.M.5    Chakrabarti, S.6    Delrvitan, T.L.7
  • 32
    • 0029979838 scopus 로고    scopus 로고
    • IFN-α induces autoimmune T cells through the induction of intracellular adhesion molecule- 1 and B7.2
    • Chakrabarti D, Hultgren B, Stewart TA. IFN-α induces autoimmune T cells through the induction of intracellular adhesion molecule- 1 and B7.2. J Immunol 1996;157:522-528.
    • (1996) J Immunol , vol.157 , pp. 522-528
    • Chakrabarti, D.1    Hultgren, B.2    Stewart, T.A.3
  • 33
    • 0031737908 scopus 로고    scopus 로고
    • α-interferon inhibits the development of diabetes in NOD mice
    • Sobel DO, Ahvazi B. α-Interferon inhibits the development of diabetes in NOD mice. Diabetes 1998;47:1867-1872.
    • (1998) Diabetes , vol.47 , pp. 1867-1872
    • Sobel, D.O.1    Ahvazi, B.2
  • 34
    • 0032489608 scopus 로고    scopus 로고
    • Alpha interferon administration paradoxically inhibits the development of diabetes in BB rats
    • Sobel DO, Creswell K, Yoon J-W, Holterman D. Alpha interferon administration paradoxically inhibits the development of diabetes in BB rats. Life Sci 1998;62:1293-1302.
    • (1998) Life Sci , vol.62 , pp. 1293-1302
    • Sobel, D.O.1    Creswell, K.2    Yoon, J.-W.3    Holterman, D.4
  • 35
    • 0025734694 scopus 로고
    • Reduction in insulitis following administration of IFN-gamma and TNF-alpha in the NOD mouse
    • Campbell IL, Oxbrow L, Harrison LC. Reduction in insulitis following administration of IFN-gamma and TNF-alpha in the NOD mouse. J Autoimmun 1991;4:249-262.
    • (1991) J Autoimmun , vol.4 , pp. 249-262
    • Campbell, I.L.1    Oxbrow, L.2    Harrison, L.C.3
  • 37
    • 0029075492 scopus 로고
    • + T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis
    • + T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest 1995;95:2711-2719.
    • (1995) J Clin Invest , vol.95 , pp. 2711-2719
    • Balashov, K.E.1    Khoury, S.J.2    Hafler, D.A.3    Weiner, H.L.4
  • 38
    • 0030587910 scopus 로고    scopus 로고
    • IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Willenborg DO, Fordham S, Bernard CCA, Cowden WB, Ramshaw IA. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol 1996;157:3223-3227.
    • (1996) J Immunol , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.A.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 39
    • 0030777296 scopus 로고    scopus 로고
    • Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2
    • Rothe H, Jenkins NA, Copeland NG, Kolb H. Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2. J Clin Invest 1997;99:469-474.
    • (1997) J Clin Invest , vol.99 , pp. 469-474
    • Rothe, H.1    Jenkins, N.A.2    Copeland, N.G.3    Kolb, H.4
  • 40
    • 0033178614 scopus 로고    scopus 로고
    • IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis
    • Rothe H, Hausmann A, Casteels K, Okamura H, Kurimoto M, Burkart V, Mathieu C, Kolb H. IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis. J Immunol 1999;163:1230-1236.
    • (1999) J Immunol , vol.163 , pp. 1230-1236
    • Rothe, H.1    Hausmann, A.2    Casteels, K.3    Okamura, H.4    Kurimoto, M.5    Burkart, V.6    Mathieu, C.7    Kolb, H.8
  • 45
    • 0027177008 scopus 로고
    • IL-12: Initiation cytokine for cell-mediated immunity
    • Scott P. IL-12: Initiation cytokine for cell-mediated immunity. Science 1993;260:496-497.
    • (1993) Science , vol.260 , pp. 496-497
    • Scott, P.1
  • 46
    • 0028926524 scopus 로고
    • Interleukin-12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
    • Trembleau S, Penna G, Bosi E, Mortara A, Gately MK, Adorini L. Interleukin-12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J Exp Med 1995;181:817-821.
    • (1995) J Exp Med , vol.181 , pp. 817-821
    • Trembleau, S.1    Penna, G.2    Bosi, E.3    Mortara, A.4    Gately, M.K.5    Adorini, L.6
  • 47
    • 0030465405 scopus 로고    scopus 로고
    • Prevention of a Th1 disease by a Th1 cytokine: IL-12 and diabetes in NOD mice
    • O'Hara RM, Henderson SL, Nagelin AM. Prevention of a Th1 disease by a Th1 cytokine: IL-12 and diabetes in NOD mice. Ann NY Acad Sci 1996;795:241-249.
    • (1996) Ann NY Acad Sci , vol.795 , pp. 241-249
    • O'Hara, R.M.1    Henderson, S.L.2    Nagelin, A.M.3
  • 50
    • 0027990811 scopus 로고
    • Effect of tumor necrosis factor α on insulin-dependent diabetes mellitus in NOD mice. 1. The early development of autoimmunity and the diabetogenic process
    • Yang X-D, Tisch R, Singer SM, Cao ZA, Liblau RS, Schreiber RD, McDevitt HO. Effect of tumor necrosis factor α on insulin-dependent diabetes mellitus in NOD mice. 1. The early development of autoimmunity and the diabetogenic process. J Exp Med 1994;180:995-1004.
    • (1994) J Exp Med , vol.180 , pp. 995-1004
    • Yang, X.-D.1    Tisch, R.2    Singer, S.M.3    Cao, Z.A.4    Liblau, R.S.5    Schreiber, R.D.6    McDevitt, H.O.7
  • 52
    • 0031573621 scopus 로고    scopus 로고
    • TNF-α down-regulates type 1 cytokines and prolongs survival of syngeneic islet grafts in nonobese diabetic mice
    • Rabinovitch A, Suarez-Pinzon WL, Sorenson O, Rajotte RV, Power RF. TNF-α down-regulates type 1 cytokines and prolongs survival of syngeneic islet grafts in nonobese diabetic mice. J Immunol 1997;159:6298-6303.
    • (1997) J Immunol , vol.159 , pp. 6298-6303
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorenson, O.3    Rajotte, R.V.4    Power, R.F.5
  • 53
    • 0032531423 scopus 로고    scopus 로고
    • TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice
    • Piccirillo CA, Chang Y, Prud'homme GJ. TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J Immunol 1998;161:3950-3956.
    • (1998) J Immunol , vol.161 , pp. 3950-3956
    • Piccirillo, C.A.1    Chang, Y.2    Prud'homme, G.J.3
  • 54
    • 0032506750 scopus 로고    scopus 로고
    • Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis
    • Gallichan WS, Katri T, Krahl T, Verma IM, Sarvetnick N. Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Hum Gene Ther 1998;9:2717-2726.
    • (1998) Hum Gene Ther , vol.9 , pp. 2717-2726
    • Gallichan, W.S.1    Katri, T.2    Krahl, T.3    Verma, I.M.4    Sarvetnick, N.5
  • 55
    • 0036408818 scopus 로고    scopus 로고
    • Gene transfection and expression of transforming growth factor-β1 in nonobese diabetic mouse islets protects β-cells in syngeneic islet grafts from autoimmune destruction
    • Suarez-Pinzon WL, Marcoux Y, Ghahary A, Rabinovitch A. Gene transfection and expression of transforming growth factor-β1 in nonobese diabetic mouse islets protects β-cells in syngeneic islet grafts from autoimmune destruction. Cell Transplantation 2002;11:519-528.
    • (2002) Cell Transplantation , vol.11 , pp. 519-528
    • Suarez-Pinzon, W.L.1    Marcoux, Y.2    Ghahary, A.3    Rabinovitch, A.4
  • 57
    • 0029948898 scopus 로고    scopus 로고
    • Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice
    • Hultgren B, Huang X, Dybdal N, Stewart TA. Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice. Diabetes 1996;45:812-817.
    • (1996) Diabetes , vol.45 , pp. 812-817
    • Hultgren, B.1    Huang, X.2    Dybdal, N.3    Stewart, T.A.4
  • 60
    • 0025981388 scopus 로고
    • Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
    • Campbell IL, Kay TWH, Oxbrow L, Harrison LC. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J Clin Invest 1991;87:739-742.
    • (1991) J Clin Invest , vol.87 , pp. 739-742
    • Campbell, I.L.1    Kay, T.W.H.2    Oxbrow, L.3    Harrison, L.C.4
  • 62
    • 0031023298 scopus 로고    scopus 로고
    • Prevention of spontaneous autoimmune diabetes in diabetes-prone BB rats by prophylactic treatment with antirat interferon-γ antibody
    • Nicoletti F, Zaccone P, Di Marco R, Lunetta M, Magro G, Crasso S, Meroni PL, Garotta G. Prevention of spontaneous autoimmune diabetes in diabetes-prone BB rats by prophylactic treatment with antirat interferon-γ antibody. Endocrinology 1997;138:281-288.
    • (1997) Endocrinology , vol.138 , pp. 281-288
    • Nicoletti, F.1    Zaccone, P.2    Di Marco, R.3    Lunetta, M.4    Magro, G.5    Crasso, S.6    Meroni, P.L.7    Garotta, G.8
  • 63
    • 0030444632 scopus 로고    scopus 로고
    • The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse
    • Nicoletti F, Zaccone P, Di Marco R, Di Mauro M, Magro G, Grasso S, Mughini L, Meroni P, Garotta G. The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse. Endocrinology 1996;137:5567-5575.
    • (1996) Endocrinology , vol.137 , pp. 5567-5575
    • Nicoletti, F.1    Zaccone, P.2    Di Marco, R.3    Di Mauro, M.4    Magro, G.5    Grasso, S.6    Mughini, L.7    Meroni, P.8    Garotta, G.9
  • 64
    • 0036263328 scopus 로고    scopus 로고
    • Characterization of the T-cell response to coxsackievirus B4, evidence that effector memory cells predominate in patients with type 1 diabetes
    • Varela-Calvino R, Ellis R, Sgardi G, Dayan CM, Peakman M. Characterization of the T-cell response to coxsackievirus B4, evidence that effector memory cells predominate in patients with type 1 diabetes. Diabetes 2002;51:1745-1753.
    • (2002) Diabetes , vol.51 , pp. 1745-1753
    • Varela-Calvino, R.1    Ellis, R.2    Sgardi, G.3    Dayan, C.M.4    Peakman, M.5
  • 65
    • 0026492896 scopus 로고
    • Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus
    • Hänninen A, Jalkanen S, Salmi M, Toikkanen S, Nikolakaros G, Simell O. Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest 1992;90:1901-1910.
    • (1992) J Clin Invest , vol.90 , pp. 1901-1910
    • Hänninen, A.1    Jalkanen, S.2    Salmi, M.3    Toikkanen, S.4    Nikolakaros, G.5    Simell, O.6
  • 66
    • 0027361654 scopus 로고
    • Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients
    • Itoh N, Hanafusa T, Miyazaki A, Miyagawa J, Yamagata K, Yamamoto K, Waguri M, Imagawa A, Tamura S, Inada M. Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest 1993:92:2313-2322.
    • (1993) J Clin Invest , vol.92 , pp. 2313-2322
    • Itoh, N.1    Hanafusa, T.2    Miyazaki, A.3    Miyagawa, J.4    Yamagata, K.5    Yamamoto, K.6    Waguri, M.7    Imagawa, A.8    Tamura, S.9    Inada, M.10
  • 67
    • 0030731917 scopus 로고    scopus 로고
    • Nitric oxide primes pancreatic β-cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
    • Stassi G, De Maria R, Trucco G, Rudert W, Testi R, Galluzzo A, Giordano C, Trucco M. Nitric oxide primes pancreatic β-cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J Exp Med 1997;186:1193-1200.
    • (1997) J Exp Med , vol.186 , pp. 1193-1200
    • Stassi, G.1    De Maria, R.2    Trucco, G.3    Rudert, W.4    Testi, R.5    Galluzzo, A.6    Giordano, C.7    Trucco, M.8
  • 70
    • 1842404766 scopus 로고    scopus 로고
    • Systemic bias of cytokine production toward cell-mediated immune regulation in IDDM and toward humoral immunity in Graves' disease
    • Kallmann BA, Hüther M, Tubes M, Feldkamp J, Bertrams J, Gries FA, Lampeter EF, Kolb H. Systemic bias of cytokine production toward cell-mediated immune regulation in IDDM and toward humoral immunity in Graves' disease. Diabetes 1997;46:237-243.
    • (1997) Diabetes , vol.46 , pp. 237-243
    • Kallmann, B.A.1    Hüther, M.2    Tubes, M.3    Feldkamp, J.4    Bertrams, J.5    Gries, F.A.6    Lampeter, E.F.7    Kolb, H.8
  • 71
    • 0032413626 scopus 로고    scopus 로고
    • Decreased secretion of Th2 cytokines precedes upregulated and delayed secrtion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin-dependent diabetes mellitus
    • Rapoport MJ, Mor A, Vardi P, Ramot Y, Winker R, Hindi A, Bistritzer T. Decreased secretion of Th2 cytokines precedes upregulated and delayed secrtion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin-dependent diabetes mellitus. J Autoimmun 1998;11:635-642.
    • (1998) J Autoimmun , vol.11 , pp. 635-642
    • Rapoport, M.J.1    Mor, A.2    Vardi, P.3    Ramot, Y.4    Winker, R.5    Hindi, A.6    Bistritzer, T.7
  • 74
  • 75
    • 0034089590 scopus 로고    scopus 로고
    • Th1-like dominance in high-risk first-degree relatives of type 1 diabetic patients
    • Karlsson MGE, Sederholm Lawesson S, Ludvigsson J. Th1-like dominance in high-risk first-degree relatives of type 1 diabetic patients. Diabetologia 2000;43:742-749.
    • (2000) Diabetologia , vol.43 , pp. 742-749
    • Karlsson, M.G.E.1    Sederholm Lawesson, S.2    Ludvigsson, J.3
  • 78
    • 0035041401 scopus 로고    scopus 로고
    • Cytokine expression in unstimulated PBMC of children with type 1 diabetes and subjects positive for diabetes-associated antibodies
    • Halminen M, Simell O. Knip M, Ilonen J. Cytokine expression in unstimulated PBMC of children with type 1 diabetes and subjects positive for diabetes-associated antibodies. Scand J Immunol 2001;53:510-513.
    • (2001) Scand J Immunol , vol.53 , pp. 510-513
    • Halminen, M.1    Simell, O.2    Knip, M.3    Ilonen, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.