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Volumn 87, Issue 11, 1996, Pages 4510-4519

Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; SANT 7; UNCLASSIFIED DRUG;

EID: 9344259121     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.11.4510.bloodjournal87114510     Document Type: Article
Times cited : (97)

References (58)
  • 1
    • 0029084805 scopus 로고
    • Interleukin-6 family of cytokines and gp130
    • Kishimoto T, Akira S, Narazaki M, Taga T: Interleukin-6 family of cytokines and gp130. Blood 86:1243, 1995
    • (1995) Blood , vol.86 , pp. 1243
    • Kishimoto, T.1    Akira, S.2    Narazaki, M.3    Taga, T.4
  • 2
    • 3643131994 scopus 로고
    • IL-6 deficient mice show immunologic abnormalities
    • Kopf M, Lamers M, Bluethman H, Kohler G: IL-6 deficient mice show immunologic abnormalities. Nature 376:339, 1994
    • (1994) Nature , vol.376 , pp. 339
    • Kopf, M.1    Lamers, M.2    Bluethman, H.3    Kohler, G.4
  • 4
  • 6
    • 0025853227 scopus 로고
    • Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: Correlation with disease activity and other prognostic parameters
    • Nachbaur DM, Herold M, Maneschg A: Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: Correlation with disease activity and other prognostic parameters. Ann Hematol 62:54, 1991
    • (1991) Ann Hematol , vol.62 , pp. 54
    • Nachbaur, D.M.1    Herold, M.2    Maneschg, A.3
  • 11
    • 0026062164 scopus 로고
    • Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266
    • Schwab G, Siegall CB, Aarden LA, Neckers LM, Nordan R: Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266. Blood 77:587, 1991
    • (1991) Blood , vol.77 , pp. 587
    • Schwab, G.1    Siegall, C.B.2    Aarden, L.A.3    Neckers, L.M.4    Nordan, R.5
  • 13
    • 0027133422 scopus 로고
    • Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion
    • Uchiyama H, Barut BA, Mohrbacher AF, Chauhan D, Anderson KC: Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. Blood 82:3712, 1993
    • (1993) Blood , vol.82 , pp. 3712
    • Uchiyama, H.1    Barut, B.A.2    Mohrbacher, A.F.3    Chauhan, D.4    Anderson, K.C.5
  • 15
    • 0026558680 scopus 로고
    • Interleukin-6 dependence of advanced malignant plasma cell dyscrasias
    • Zhang XG, Bataille R, Wijdenes J, Klein B: Interleukin-6 dependence of advanced malignant plasma cell dyscrasias. Cancer 69:1373, 1992
    • (1992) Cancer , vol.69 , pp. 1373
    • Zhang, X.G.1    Bataille, R.2    Wijdenes, J.3    Klein, B.4
  • 17
    • 0029069307 scopus 로고
    • Interleukin-6 is essential for in vivo development of B lineage neoplasms
    • Hilbert DM, Kopf M, Mock BA, Kohler G, Rudikoff S: Interleukin-6 is essential for in vivo development of B lineage neoplasms. J Exp Med 182:243, 1995
    • (1995) J Exp Med , vol.182 , pp. 243
    • Hilbert, D.M.1    Kopf, M.2    Mock, B.A.3    Kohler, G.4    Rudikoff, S.5
  • 18
    • 0028954279 scopus 로고
    • Immunotherapy of multiple myeloma
    • Huang Y-W, Vitetta ES: Immunotherapy of multiple myeloma. Stem Cells 13:123, 1995
    • (1995) Stem Cells , vol.13 , pp. 123
    • Huang, Y.-W.1    Vitetta, E.S.2
  • 20
    • 0024832002 scopus 로고
    • Serum levels of interleukin-6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias
    • Bataille R, Jourdan M, Zhang XG, Klein B: Serum levels of interleukin-6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias. J Clin Invest 84:2008, 1989
    • (1989) J Clin Invest , vol.84 , pp. 2008
    • Bataille, R.1    Jourdan, M.2    Zhang, X.G.3    Klein, B.4
  • 23
    • 0028885888 scopus 로고
    • Measurement of whole body interleukin-6 (IL-6) production: Prediction of the efficacy of anti-IL-6 treatments
    • Lu ZY, Brailly J, Wijdenes J, Bataille R, Rossi J-F, Klein B: Measurement of whole body interleukin-6 (IL-6) production: Prediction of the efficacy of anti-IL-6 treatments. Blood 86:3123, 1995
    • (1995) Blood , vol.86 , pp. 3123
    • Lu, Z.Y.1    Brailly, J.2    Wijdenes, J.3    Bataille, R.4    Rossi, J.-F.5    Klein, B.6
  • 24
    • 0025102756 scopus 로고
    • Haemopoietic receptors and helical cytokines
    • Bazan JF: Haemopoietic receptors and helical cytokines. Immunol Today 11:350, 1990
    • (1990) Immunol Today , vol.11 , pp. 350
    • Bazan, J.F.1
  • 25
    • 0028202123 scopus 로고
    • Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation
    • Savino R, Lahm A, Salvati AL, Ciapponi L, Sporeno E, Altamura S, Paonessa G, Toniatti C, Ciliberto G: Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation. EMBO J 13:1357, 1994
    • (1994) EMBO J , vol.13 , pp. 1357
    • Savino, R.1    Lahm, A.2    Salvati, A.L.3    Ciapponi, L.4    Sporeno, E.5    Altamura, S.6    Paonessa, G.7    Toniatti, C.8    Ciliberto, G.9
  • 27
    • 0028117163 scopus 로고
    • Cytokine signal transduction
    • Kishimoto T, Taga T, Akira S: Cytokine signal transduction. Cell 76:253, 1994
    • (1994) Cell , vol.76 , pp. 253
    • Kishimoto, T.1    Taga, T.2    Akira, S.3
  • 28
    • 0028064835 scopus 로고
    • High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130
    • Ward LD, Howlett GJ, Discolo G, Yasukawa K, Hammacher A, Moritz R, Simpson RJ: High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J Biol Chem 269:23286, 1994
    • (1994) J Biol Chem , vol.269 , pp. 23286
    • Ward, L.D.1    Howlett, G.J.2    Discolo, G.3    Yasukawa, K.4    Hammacher, A.5    Moritz, R.6    Simpson, R.J.7
  • 30
    • 0028260226 scopus 로고
    • Structural and functional basis for hormone binding and receptor oligomerization
    • Wells JA: Structural and functional basis for hormone binding and receptor oligomerization. Curr Opin Cell Biol 6:163, 1994
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 163
    • Wells, J.A.1
  • 31
    • 0028838012 scopus 로고
    • Dimerization of cell surface receptors in signal transduction
    • Heldin CH: Dimerization of cell surface receptors in signal transduction. Cell 80:587, 1995
    • (1995) Cell , vol.80 , pp. 587
    • Heldin, C.H.1
  • 34
    • 0023461268 scopus 로고
    • Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction
    • Mullis KB, Faloona FA: Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol 155:335, 1987
    • (1987) Methods Enzymol , vol.155 , pp. 335
    • Mullis, K.B.1    Faloona, F.A.2
  • 36
    • 0026806781 scopus 로고
    • Analysis of human/mouse IL-6 hybrid proteins: Only amino- and carboxy-termini of human IL-6 are required for species-specific receptor binding
    • Fiorillo MT, Cabibbo A, Iacopetti P, Fattori E, Ciliberto G: Analysis of human/mouse IL-6 hybrid proteins: only amino- and carboxy-termini of human IL-6 are required for species-specific receptor binding. Eur J Immunol 22:2609, 1992
    • (1992) Eur J Immunol , vol.22 , pp. 2609
    • Fiorillo, M.T.1    Cabibbo, A.2    Iacopetti, P.3    Fattori, E.4    Ciliberto, G.5
  • 37
    • 0023042283 scopus 로고
    • Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes
    • Studier FW, Moffatt BA: Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J Mol Biol 189:113, 1986
    • (1986) J Mol Biol , vol.189 , pp. 113
    • Studier, F.W.1    Moffatt, B.A.2
  • 39
    • 0025859083 scopus 로고
    • Single step purification and structural characterization of human interleukin-6 produce in E. coli from a T7 RNA polymerase expression vector
    • Arcone R, Pucci P, Zappacosta F, Fontaine V, Malorni A, Marino G, Ciliberto G: Single step purification and structural characterization of human interleukin-6 produce in E. coli from a T7 RNA polymerase expression vector. Eur J Biochem 198:541, 1991
    • (1991) Eur J Biochem , vol.198 , pp. 541
    • Arcone, R.1    Pucci, P.2    Zappacosta, F.3    Fontaine, V.4    Malorni, A.5    Marino, G.6    Ciliberto, G.7
  • 40
    • 0029616481 scopus 로고
    • Monovalent phage display of human in-terleukin (hIL)-6: Selection superbinder variants for a complex molecular repertoire in hIL-6 D-Helix
    • Cabibbo A, Sporeno E, Toniatti C, Altamura S, Savino R, Paonessa G, Ciliberto G: Monovalent phage display of human in-terleukin (hIL)-6: Selection superbinder variants for a complex molecular repertoire in hIL-6 D-Helix. Gene 167:41, 1995
    • (1995) Gene , vol.167 , pp. 41
    • Cabibbo, A.1    Sporeno, E.2    Toniatti, C.3    Altamura, S.4    Savino, R.5    Paonessa, G.6    Ciliberto, G.7
  • 41
    • 0028316421 scopus 로고
    • A fast and sensitive colorimetric assay for IL-6 on hepatoma cells based on the production of a secreted form of alkaline phosphatase (SEAP)
    • Gregory B, Savino R, Ciliberto G: A fast and sensitive colorimetric assay for IL-6 on hepatoma cells based on the production of a secreted form of alkaline phosphatase (SEAP). J Immunol Methods 170:47, 1994
    • (1994) J Immunol Methods , vol.170 , pp. 47
    • Gregory, B.1    Savino, R.2    Ciliberto, G.3
  • 44
    • 0000449348 scopus 로고
    • Ribbon models of macromolecules
    • Carson M: Ribbon models of macromolecules. J Mol Graphics 5:103, 1987
    • (1987) J Mol Graphics , vol.5 , pp. 103
    • Carson, M.1
  • 45
    • 0027252635 scopus 로고
    • Saturation mutagenesis of the human interleukin 6 receptor binding site implications for its three-dimensional structure
    • Savino R, Lahm A, Giorgio M, Cabibbo A, Tramontano A, Ciliberto G: Saturation mutagenesis of the human interleukin 6 receptor binding site implications for its three-dimensional structure. Proc Natl Acad Sci USA 90:4067, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4067
    • Savino, R.1    Lahm, A.2    Giorgio, M.3    Cabibbo, A.4    Tramontano, A.5    Ciliberto, G.6
  • 47
    • 0024819021 scopus 로고
    • Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6
    • Ganter U, Arcone R, Toniatti C, Morrone G, Ciliberto G: Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J 8:3773, 1989
    • (1989) EMBO J , vol.8 , pp. 3773
    • Ganter, U.1    Arcone, R.2    Toniatti, C.3    Morrone, G.4    Ciliberto, G.5
  • 48
    • 0026653151 scopus 로고
    • Oncostatin M is a differentiation factor for myeloid leukemia cells
    • Bruce AG, Hoggatt IH, Rose TM: Oncostatin M is a differentiation factor for myeloid leukemia cells. J Immunol 149:1271, 1992
    • (1992) J Immunol , vol.149 , pp. 1271
    • Bruce, A.G.1    Hoggatt, I.H.2    Rose, T.M.3
  • 49
    • 0028265160 scopus 로고
    • Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130
    • Zhang XG, Gu ZJ, Lu ZY, Yasukawa K, Yancopoulos GD, Turner K, K, Shoyab M, Taga T, Kishimoto T, Bataille R, Klein B: Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130. J Exp Med 179:1337, 1994b
    • (1994) J Exp Med , vol.179 , pp. 1337
    • Zhang, X.G.1    Gu, Z.J.2    Lu, Z.Y.3    Yasukawa, K.4    Yancopoulos, G.D.5    Turner, K.K.6    Shoyab, M.7    Taga, T.8    Kishimoto, T.9    Bataille, R.10    Klein, B.11
  • 50
    • 0025737915 scopus 로고
    • Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines
    • Levy Y, Tsapis A, Briuet JC: Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines. J Clin Invest 88:696, 1991
    • (1991) J Clin Invest , vol.88 , pp. 696
    • Levy, Y.1    Tsapis, A.2    Briuet, J.C.3
  • 51
    • 0025076369 scopus 로고
    • Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants
    • Brakenhoff JPJ, Hart M, de Groot ER, Di Padova F, Aarden LA: Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants. J Immunol 145:561, 1990
    • (1990) J Immunol , vol.145 , pp. 561
    • Brakenhoff, J.P.J.1    Hart, M.2    De Groot, E.R.3    Di Padova, F.4    Aarden, L.A.5
  • 52
    • 0028950484 scopus 로고
    • Cytokine, cytokine receptors, transduction signals, and receptor in human multiple myeloma
    • Klein B: Cytokine, cytokine receptors, transduction signals, and receptor in human multiple myeloma. Semin Hematol 32:4, 1995
    • (1995) Semin Hematol , vol.32 , pp. 4
    • Klein, B.1
  • 53
    • 0028344075 scopus 로고
    • Molecular analysis of the IL-6 receptor in human multiple myeloma, an IL-6-related disease
    • Rodriguez C, Theillet C, Portier: Molecular analysis of the IL-6 receptor in human multiple myeloma, an IL-6-related disease. FEBS Lett 341:156, 1994
    • (1994) FEBS Lett , vol.341 , pp. 156
    • Rodriguez, C.1    Theillet, C.2    Portier3
  • 54
    • 0028928641 scopus 로고
    • Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis
    • Kawano MM, Miliara K, Huang N, Tsujimoto T, Kuramoto A: Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis. Blood 85:487, 1995
    • (1995) Blood , vol.85 , pp. 487
    • Kawano, M.M.1    Miliara, K.2    Huang, N.3    Tsujimoto, T.4    Kuramoto, A.5
  • 57
    • 0029038942 scopus 로고
    • l and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone
    • l and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone. Cell Growth Differ 6:647, 1995
    • (1995) Cell Growth Differ , vol.6 , pp. 647
    • Lotem, J.1    Sachs, L.2
  • 58
    • 0028938688 scopus 로고
    • Cancer research. Sensitization of human renal cell carcinoma cells to cis-diamminedi-chloroplatinum (II) by anti-interleukin-6 monoclonal antibody or anti-interleukin-6 monoclonal antibody or anti-interleukin-6 receptor monoclonal antibody
    • Mizutani Y, Bonavida B, Koishihara Y, Akamatsu K-I, Ohsugi Y, Yoshida O: Cancer research. Sensitization of human renal cell carcinoma cells to cis-diamminedi-chloroplatinum (II) by anti-interleukin-6 monoclonal antibody or anti-interleukin-6 monoclonal antibody or anti-interleukin-6 receptor monoclonal antibody. Cancer Res 55:590, 1995
    • (1995) Cancer Res , vol.55 , pp. 590
    • Mizutani, Y.1    Bonavida, B.2    Koishihara, Y.3    Akamatsu, K.-I.4    Ohsugi, Y.5    Yoshida, O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.