Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: A randomized trial

JAMA

Volumn 292, Issue 12, 2004, Pages 1440-1446

  Esposito, Katherine ^a   Marfella, Raffaele ^a   Ciotola, Miryam ^a   Di Palo, Carmen ^a   Giugliano, Francesco ^a   Giugliano, Giovanni ^a   D'Armiento, Massimo ^a   D'Andrea, Francesco ^a   Giugliano, Dario ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; C REACTIVE PROTEIN; CARBOHYDRATE; FAT; GLUCOSE; INSULIN; INTERLEUKIN 18; INTERLEUKIN 6; INTERLEUKIN 7; LIPID; MONOUNSATURATED FATTY ACID; OLIVE OIL; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; PROTEIN; INTERLEUKIN DERIVATIVE;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; CARBOHYDRATE DIET; CIRCULATION; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DISEASE MARKER; ENDOTHELIUM LESION; FEMALE; FIBER; FOLLOW UP; FOOD COMPOSITION; FOOD INTAKE; FRUIT; FUNCTIONAL ASSESSMENT; GRAIN; HEMOCONCENTRATION; HOSPITAL PATIENT; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; ITALY; LIPID DIET; MAJOR CLINICAL STUDY; MALE; MEDITERRANEAN DIET; METABOLIC SYNDROME X; NUT; NUTRIENT; OUTCOMES RESEARCH; PARAMETER; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DIET; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SINGLE BLIND PROCEDURE; THROMBOCYTE AGGREGATION; UNIVERSITY HOSPITAL; VASCULAR DISEASE; VEGETABLE; WEIGHT REDUCTION; BLOOD; BLOOD PRESSURE; DIET THERAPY; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ADULT; BLOOD GLUCOSE; BLOOD PRESSURE; C-REACTIVE PROTEIN; DIET, MEDITERRANEAN; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INFLAMMATION; INSULIN; INTERLEUKINS; LIPIDS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PLATELET AGGREGATION; SINGLE-BLIND METHOD;

EID: 4544288392     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.292.12.1440     Document Type: Article

References (36)

1. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey. JAMA. 2002;287:356-359.
2. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel Ill). JAMA. 2001;285:2486-2497.
3. Groop L. Genetics of the metabolic syndrome. Br J Nutr. 2000;83(suppl 1):S39-S48.
4. Lidfeldt J, Nyberg P, Nerbrand C, et al. Sociodemographic and psychological factors are associated with features of the metabolic syndrome: the Women's Health in the Lund Area (WHILA) study. Diabetes Obes Metab. 2003;5:106-112.
5. Han TS, Sattar N, Williams K, et al. Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study. Diabetes Care. 2002;25:2016-2021.
6. Esposito K, Pontillo A, Giugliano F, et al. Association of low interleukin-10 levels with the metabolic syndrome in obese women. J Clin Endocrinol Metab. 2003;88:1055-1058.
7. Tamakoshi K, Yatsuya H, Kondo T, et al. The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. Int J Obes Relat Metab Disord. 2003;27:443-449.
8. Ridker PM, Buring JE, Cook NR, et al. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women. Circulation. 2003; 107:391-397.
9. Yudkin JS, Stehouwer CD, Emeis JJ, et al. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol. 1999;19:972-978.
10. Ziccardi P, Nappo F, Giugliano G, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation. 2002; 105:804-809.
11. Wirfalt E, Hedblad B, Gullberg B, et al. Food patterns and components of the metabolic syndrome in men and women: a cross-sectional study within the Malmo Diet and Cancer cohort. Am J Epidemiol. 2001; 154:1150-1159.
12. Mennen L, Lafay L, Feskens EJ, et al. Possible protective role of bread and dairy products on the risk of the metabolic syndrome. Nutr Res. 2000;20:335-347.
13. McKeown NM, Meigs JB, Liu S, et al. Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham offspring cohort. Diabetes Care. 2004;27:538-546.
14. Krauss RM, Eckel RH, Howard B, et al. AHA Dietary Guidelines: revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation. 2000; 102:2284-2299.
15. Robertson RM, Smaha L. Can a Mediterranean-style diet reduce heart disease? Circulation. 2001; 103:1821-1822.
16. Harris TB, Ferrucci L, Tracy RP, et al. Association of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106: 506-512.
17. Blankenberg S, Tiret L, Bickel C, et al. Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina. Circulation. 2002;106:24-30.
18. Damâs JK, Væhre T, Yndestad A, et al. Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets. Circulation. 2003;107:2670-2676.
19. Giugliano D, Marfella R, Verrazzo G, et al. I-Arginine for testing endothelium-dependent vascular functions in humans. Am J Physiol. 1997;273: E606-E612.
20. Esposito K, Nappo F, Giugliano F, et al. Effect of dietary antioxidants on post-prandial endothelial dysfunction induced by a high-fat meal in healthy subjects. Am J Clin Nutr. 2003;77:139-143.
21. Matthews DR, Hosker JP, Rudenski AS, et al, Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28: 412-419.
22. Grundy SM, Hansen B, Smith SC, et al. Clinical management of the metabolic syndrome. Circulation. 2004;109:551-556.
23. Bastard JP, Jardel C, Bruckert E, et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab. 2000;85:3338-3342.
24. Dandona P, Aljada A, Mohanty P. The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm. Diabetologia. 2002;45:924-930.
25. Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA. 1997;278:1682-1686.
26. Nappo F, Esposito K, Cioffi M, et al. Postprandial endothelial activation in healthy subjects and type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol. 2002;39:1145-1150.
27. Esposito K, Nappo F, Giugliano F, et al. Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus. Am J Clin Nutr. 2003;78:1135-1140.
28. Andoh A, Bamba T, Sakasi M. Physiological and anti-inflammatory roles of dietary fiber and butyrate in intestinal functions. JPEN J Parenter Enteral Nutr. 1999;23(suppl):S70-S73.
29. Kris-Etherton PM, Harris WS, Appel U, American Heart Association Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106:2747-2757.
30. Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 2000;102:2165-2168.
31. Yeh ET, Anderson HV, Pasceri V, et al. C-reactive protein: linking inflammation to cardiovascular complications. Circulation. 2001;104:974-975.
32. Fernández-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev. 2003;24:278-301.
33. Hu FB, Willett WC. Optimal diets for prevention of cardiovascular disease. JAMA. 2002;288:2569-2578.
34. de Lorgeril M, Salen P, Martin JL, et al. Mediterranean diet, traditional risk factors, and the risk of cardiovascular complications after myocardial infarction: final report of the Lyon Heart Study. Circulation. 1999;99:779-785.
35. Singh RB, Dubnow G, Niaz MA, et al. Effect of an Indo-Mediterranean diet on progression of coronary heart disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomized single-blind trial. Lancet. 2002;360:1455-1461.
36. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003;348: 2599-2608.