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Volumn 53, Issue 1, 2006, Pages 51-75

NEF: A pleiotropic modulator of primate lentivirus infectivity and pathogenesis

Author keywords

AIDS therapy; Attenuated retrovirus; Defective HIV (dHIV); HIV; Long term non progressor; Master regulator; Nef; SIV; Viral interference

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; LENTIVIRUS; PRIMATES;

EID: 33744986058     PISSN: 12178950     EISSN: 15882640     Source Type: Journal    
DOI: 10.1556/AMicr.53.2006.1.4     Document Type: Article
Times cited : (4)

References (117)
  • 1
    • 0030001569 scopus 로고    scopus 로고
    • From negative factor to a critical role in virus pathogenesis: The changing fortunes of Nef
    • Harris, M.: From negative factor to a critical role in virus pathogenesis: the changing fortunes of Nef. J Gen Virol 77, 2379 (1996).
    • (1996) J Gen Virol , vol.77 , pp. 2379
    • Harris, M.1
  • 2
    • 0028006247 scopus 로고
    • The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
    • Miller, M. D., Warmerdam, M. T., Gaston, I., Greene, W. C., Feinberg, M. B.: The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J Exp Med 179, 101 (1994).
    • (1994) J Exp Med , vol.179 , pp. 101
    • Miller, M.D.1    Warmerdam, M.T.2    Gaston, I.3    Greene, W.C.4    Feinberg, M.B.5
  • 3
    • 2942635646 scopus 로고    scopus 로고
    • Multiple human immunodeficiency virus type 1 Nef functions contribute to efficient replication in primary human macrophages
    • Brown, A., Moghaddam, S., Kawano, T., Cheng-Mayer, C.: Multiple human immunodeficiency virus type 1 Nef functions contribute to efficient replication in primary human macrophages. J Gen Virol 85, 1463 (2004).
    • (2004) J Gen Virol , vol.85 , pp. 1463
    • Brown, A.1    Moghaddam, S.2    Kawano, T.3    Cheng-Mayer, C.4
  • 5
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • Kirchhoff, F., Greenough, T. C., Brettler, D. B., Sullivan, J. L., Desrosiers, R. C.: Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 332, 228 (1995).
    • (1995) N Engl J Med , vol.332 , pp. 228
    • Kirchhoff, F.1    Greenough, T.C.2    Brettler, D.B.3    Sullivan, J.L.4    Desrosiers, R.C.5
  • 7
    • 0031979771 scopus 로고    scopus 로고
    • Grossly defective nef gene sequences in a human immunodeficiency virus type 1 seropositive long-term nonprogressor
    • Salvi, R., Garbuglia, A. R., Di Caro, A., Pulciani, S., Montella, F., Benedetto, A.: Grossly defective nef gene sequences in a human immunodeficiency virus type 1 seropositive long-term nonprogressor. J Virol 72, 3646 (1998).
    • (1998) J Virol , vol.72 , pp. 3646
    • Salvi, R.1    Garbuglia, A.R.2    Di Caro, A.3    Pulciani, S.4    Montella, F.5    Benedetto, A.6
  • 11
    • 0031964791 scopus 로고    scopus 로고
    • Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease
    • Hanna, Z., Kay, D. G., Cool, M., Jothy, S., Rebai, N., Jolicoeur, P.: Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease. J Virol 72, 121 (1998a).
    • (1998) J Virol , vol.72 , pp. 121
    • Hanna, Z.1    Kay, D.G.2    Cool, M.3    Jothy, S.4    Rebai, N.5    Jolicoeur, P.6
  • 12
    • 0032538278 scopus 로고    scopus 로고
    • Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
    • Hanna, Z., Kay, D. G., Rebai, N., Guimond, A., Jothy, S., Jolicoeur, P.: Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95, 163 (1998b).
    • (1998) Cell , vol.95 , pp. 163
    • Hanna, Z.1    Kay, D.G.2    Rebai, N.3    Guimond, A.4    Jothy, S.5    Jolicoeur, P.6
  • 13
    • 0027955426 scopus 로고
    • Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3′-long terminal repeat transgene
    • Lindermann, D., Wilhelm, R., Renard, P., Althage, A., Zinkernagel, R., Mous, J.: Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene. J Exp Med 179, 797 (1994).
    • (1994) J Exp Med , vol.179 , pp. 797
    • Lindermann, D.1    Wilhelm, R.2    Renard, P.3    Althage, A.4    Zinkernagel, R.5    Mous, J.6
  • 14
    • 0028913817 scopus 로고
    • The human immunodeficiency virus type 1 (HIV1) CD4 receptor and its central role in promotion of HIV-1 infection
    • Bour, S., Geleziunas, R., Wainberg, M. A.: The human immunodeficiency virus type 1 (HIV1) CD4 receptor and its central role in promotion of HIV-1 infection. Microbiological Reviews 59, 63 (1995).
    • (1995) Microbiological Reviews , vol.59 , pp. 63
    • Bour, S.1    Geleziunas, R.2    Wainberg, M.A.3
  • 16
    • 0034312298 scopus 로고    scopus 로고
    • The plasma membrane as a combat zone in the HIV battlefield
    • Doms, R. W., Trono, D.: The plasma membrane as a combat zone in the HIV battlefield. Genes and Development 14, 2677 (2000).
    • (2000) Genes and Development , vol.14 , pp. 2677
    • Doms, R.W.1    Trono, D.2
  • 17
    • 0034894379 scopus 로고    scopus 로고
    • Structure-function relationships in HIV-1 Nef
    • Geyer, M., Fackler, O. T., Peterlin, B. M.: Structure-function relationships in HIV-1 Nef. EMBO Rep 2, 580 (2001).
    • (2001) EMBO Rep , vol.2 , pp. 580
    • Geyer, M.1    Fackler, O.T.2    Peterlin, B.M.3
  • 18
    • 0036187980 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis
    • Greenway, A. L., McPhee, D. A., Allen, K., Johnstone, R., Holloway, G., Mills, J., Azad, A., Sankovich, S., Lambert, P.: Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis. J Virol 76, 2692 (2002).
    • (2002) J Virol , vol.76 , pp. 2692
    • Greenway, A.L.1    McPhee, D.A.2    Allen, K.3    Johnstone, R.4    Holloway, G.5    Mills, J.6    Azad, A.7    Sankovich, S.8    Lambert, P.9
  • 19
    • 0030014162 scopus 로고    scopus 로고
    • Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein
    • Pandori, M. W., Fitch, N. J., Craig, H. M., Richmann, D. D., Spina, C. A., Guatelli, J. C.: Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein. J Virol 70, 4283 (1996).
    • (1996) J Virol , vol.70 , pp. 4283
    • Pandori, M.W.1    Fitch, N.J.2    Craig, H.M.3    Richmann, D.D.4    Spina, C.A.5    Guatelli, J.C.6
  • 20
    • 0029975546 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase
    • Welker, R., Kottler, H., Kalbitzer, H. R., Krausslich, H. G.: Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase. Virology 219, 228 (1996).
    • (1996) Virology , vol.219 , pp. 228
    • Welker, R.1    Kottler, H.2    Kalbitzer, H.R.3    Krausslich, H.G.4
  • 21
    • 0031015224 scopus 로고    scopus 로고
    • Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease
    • Bukovsky, A. A., Dorfman, T., Weimann, A., Gottlinger, H. G.: Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease. J Virol 71, 1013 (1997).
    • (1997) J Virol , vol.71 , pp. 1013
    • Bukovsky, A.A.1    Dorfman, T.2    Weimann, A.3    Gottlinger, H.G.4
  • 22
    • 0031057814 scopus 로고    scopus 로고
    • The positive influence of Nef on viral infectivity
    • Guatelli, J. C.: The positive influence of Nef on viral infectivity. Res Virol 148, 34 (1997).
    • (1997) Res Virol , vol.148 , pp. 34
    • Guatelli, J.C.1
  • 23
    • 0030580595 scopus 로고    scopus 로고
    • Evidence for the association of Nef protein with HIV-2 virions
    • Fackler, O. T., Kremmer, E., Mueller-Lantzsch, N.: Evidence for the association of Nef protein with HIV-2 virions. Virus Res 46, 105 (1996).
    • (1996) Virus Res , vol.46 , pp. 105
    • Fackler, O.T.1    Kremmer, E.2    Mueller-Lantzsch, N.3
  • 24
    • 0032987238 scopus 로고    scopus 로고
    • The Nef protein of primate lentiviruses
    • Piguet, V., Trono, D.: The Nef protein of primate lentiviruses. Rev Med Virol 9, 111 (1999).
    • (1999) Rev Med Virol , vol.9 , pp. 111
    • Piguet, V.1    Trono, D.2
  • 25
    • 0032999976 scopus 로고    scopus 로고
    • The downregulation of CD4 and MHC-I by primate lentiviruses: A paradigm for the modulation of cell surface receptors
    • Piguet, V., Schwartz, O., Le Gall, S., Trono, D.: The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors. Immunol Rev 168, 51 (1999).
    • (1999) Immunol Rev , vol.168 , pp. 51
    • Piguet, V.1    Schwartz, O.2    Le Gall, S.3    Trono, D.4
  • 28
    • 0031053938 scopus 로고    scopus 로고
    • Regulation of Nef function
    • Luo, T., Garcia, J. V.: Regulation of Nef function. Res Virol 148, 64 (1997).
    • (1997) Res Virol , vol.148 , pp. 64
    • Luo, T.1    Garcia, J.V.2
  • 29
    • 0032577444 scopus 로고    scopus 로고
    • HIV1 auxiliary proteins: Making connections in a dying cell
    • Cullen, B. R.: HIV1 auxiliary proteins: Making connections in a dying cell. Cell 93, 685 (1998).
    • (1998) Cell , vol.93 , pp. 685
    • Cullen, B.R.1
  • 30
    • 0028076866 scopus 로고
    • Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1
    • Little, S. J., Riggs, N. L., Chowers, M. Y., Fitch, N. J., Richman, D. D., Spina, C. A., Guatelli, J. C.: Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1. Virology 205, 578 (1994).
    • (1994) Virology , vol.205 , pp. 578
    • Little, S.J.1    Riggs, N.L.2    Chowers, M.Y.3    Fitch, N.J.4    Richman, D.D.5    Spina, C.A.6    Guatelli, J.C.7
  • 31
    • 0028840643 scopus 로고
    • A nonproducer, interfering human immunodeficiency virus (HIV) type 1 provirus can be transduced through a murine leukemia virus-based retroviral vector: Recovery of an anti-HIV mouse/human pseudotype retrovirus
    • Federico, M., Nappi, F., Ferrari, G., Chelucci, C., Mavilio, F., Verani, P.: A nonproducer, interfering human immunodeficiency virus (HIV) type 1 provirus can be transduced through a murine leukemia virus-based retroviral vector: recovery of an anti-HIV mouse/human pseudotype retrovirus. J Virol 69, 6618 (1995).
    • (1995) J Virol , vol.69 , pp. 6618
    • Federico, M.1    Nappi, F.2    Ferrari, G.3    Chelucci, C.4    Mavilio, F.5    Verani, P.6
  • 33
    • 0027158904 scopus 로고
    • Downregulation of surface CD4 expression by simian immunodeficiency virus Nef prevents viral superinfection
    • Benson, R. E., Sanfridson, A., Ottinger, J. S., Doyle, C., Cullen, B. R.: Downregulation of surface CD4 expression by simian immunodeficiency virus Nef prevents viral superinfection. J Exp Med 177, 1561 (1993).
    • (1993) J Exp Med , vol.177 , pp. 1561
    • Benson, R.E.1    Sanfridson, A.2    Ottinger, J.S.3    Doyle, C.4    Cullen, B.R.5
  • 34
    • 18044378256 scopus 로고    scopus 로고
    • The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4
    • Michel, N., Allespach, I., Venzke, S., Fackler, O. T., Keppler, O. T.: The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4. Curr Biol 15, 714 (2005).
    • (2005) Curr Biol , vol.15 , pp. 714
    • Michel, N.1    Allespach, I.2    Venzke, S.3    Fackler, O.T.4    Keppler, O.T.5
  • 35
    • 0031054649 scopus 로고    scopus 로고
    • The multifaceted role of HIV Nef
    • Mangasarian, A., Trono, D.: The multifaceted role of HIV Nef. Res Virol 148, 30 (1997).
    • (1997) Res Virol , vol.148 , pp. 30
    • Mangasarian, A.1    Trono, D.2
  • 36
    • 0031047621 scopus 로고    scopus 로고
    • Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein
    • Benichou, S., Liu, L. X., Erdtmann, L., Selig, L., Benarous, R.: Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein. Res Virol 148, 71 (1997).
    • (1997) Res Virol , vol.148 , pp. 71
    • Benichou, S.1    Liu, L.X.2    Erdtmann, L.3    Selig, L.4    Benarous, R.5
  • 37
    • 0031039988 scopus 로고    scopus 로고
    • HIV1 Nef: The Machiavelli of cellular activation
    • Greenway, A., McPhee, D.: HIV1 Nef: the Machiavelli of cellular activation. Res Virol 148, 58 (1997).
    • (1997) Res Virol , vol.148 , pp. 58
    • Greenway, A.1    McPhee, D.2
  • 38
    • 0031039987 scopus 로고    scopus 로고
    • Analysis of Nef-induced MHC-I endocytosis
    • Le Gall, S., Heard, J. M., Schwartz, O.: Analysis of Nef-induced MHC-I endocytosis. Res Virol 148, 43 (1997).
    • (1997) Res Virol , vol.148 , pp. 43
    • Le Gall, S.1    Heard, J.M.2    Schwartz, O.3
  • 39
    • 3343019387 scopus 로고    scopus 로고
    • Human immunodeficiency virus 1 downregulates cell surface expression of the non-classical major histocompatibility class I molecule HLA-G1
    • Derrien, M., Pizzato, N., Dolcini, G., Menu, E., Chaouat, G., Lenfant, F., Barre-Sinoussi, F., Bouteiller, P. L.: Human immunodeficiency virus 1 downregulates cell surface expression of the non-classical major histocompatibility class I molecule HLA-G1. J Gen Virol 85, 1945 (2004).
    • (2004) J Gen Virol , vol.85 , pp. 1945
    • Derrien, M.1    Pizzato, N.2    Dolcini, G.3    Menu, E.4    Chaouat, G.5    Lenfant, F.6    Barre-Sinoussi, F.7    Bouteiller, P.L.8
  • 40
    • 0036889125 scopus 로고    scopus 로고
    • Direct binding of HIV1 Nef to the Major Histocompatibility Complex ClassI (MHC-I) cytoplasmic tail disrupts MHC-I trafficking
    • Williams, M., Roeth, J. F., Kasper, M. R., Fleis, R. I., Przybycin, C. G., Collins, K. L.: Direct binding of HIV1 Nef to the Major Histocompatibility Complex ClassI (MHC-I) cytoplasmic tail disrupts MHC-I trafficking. J Virol 76, 12173 (2002).
    • (2002) J Virol , vol.76 , pp. 12173
    • Williams, M.1    Roeth, J.F.2    Kasper, M.R.3    Fleis, R.I.4    Przybycin, C.G.5    Collins, K.L.6
  • 41
    • 0036136882 scopus 로고    scopus 로고
    • IFN-α secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus
    • Keir, M. E., Stoddart, C. A., Linquist-Stepps, V., Moreno, M. E., McCune, J. M.: IFN-α secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus. J Immunol 168, 325 (2002).
    • (2002) J Immunol , vol.168 , pp. 325
    • Keir, M.E.1    Stoddart, C.A.2    Linquist-Stepps, V.3    Moreno, M.E.4    McCune, J.M.5
  • 44
    • 0030273317 scopus 로고    scopus 로고
    • HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis
    • Wiskerchen, M., Cheng-Mayer, C.: HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. Virology 224, 292 (1996).
    • (1996) Virology , vol.224 , pp. 292
    • Wiskerchen, M.1    Cheng-Mayer, C.2
  • 45
    • 0033110824 scopus 로고    scopus 로고
    • Cell-dependent functional roles of HIV-1 Nef for virus replication (review)
    • Adachi, A., Oshima, Y.: Cell-dependent functional roles of HIV-1 Nef for virus replication (review). Int J Mol Med 3, 427 (1999).
    • (1999) Int J Mol Med , vol.3 , pp. 427
    • Adachi, A.1    Oshima, Y.2
  • 46
    • 0032863144 scopus 로고    scopus 로고
    • Association of Nef with the Human Immunodeficiency Virus Type 1 Core
    • Kotov, A., Zhou, J., Flicker, P., Aiken, C.: Association of Nef with the Human Immunodeficiency Virus Type 1 Core. J Virol 73, 8824 (1999).
    • (1999) J Virol , vol.73 , pp. 8824
    • Kotov, A.1    Zhou, J.2    Flicker, P.3    Aiken, C.4
  • 48
    • 0038153856 scopus 로고    scopus 로고
    • Nef increases the synthesis of transports cholesterol to lipid rafts HIV-1 progeny virions
    • Zheng, Y. H., Plemenitas, A., Fielding, C. J., Peterlin, B. M.: Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. Proc Natl Acad Sci USA 100, 8460 (2003).
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8460
    • Zheng, Y.H.1    Plemenitas, A.2    Fielding, C.J.3    Peterlin, B.M.4
  • 49
    • 2342569731 scopus 로고    scopus 로고
    • Nef binds p6in GagPol during Replication of Human Immunodeficiency Virus Type 1
    • Costa, L. J., Zheng, Y. H., Sabotic, J., Mak, J., Fackler, O. T., Peterlin, B. M.: Nef binds p6* in GagPol during Replication of Human Immunodeficiency Virus Type 1. J Virol 78, 5311 (2004).
    • (2004) J Virol , vol.78 , pp. 5311
    • Costa, L.J.1    Zheng, Y.H.2    Sabotic, J.3    Mak, J.4    Fackler, O.T.5    Peterlin, B.M.6
  • 50
    • 0031791917 scopus 로고    scopus 로고
    • Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) ζ chain leads to TCR down-modulation
    • Bell, I., Ashman, C., Maughan, J., Hooker, E., Cook, F., Reinhart, T. A.: Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) ζ chain leads to TCR down-modulation. J Gen Virol 79, 2717 (1998).
    • (1998) J Gen Virol , vol.79 , pp. 2717
    • Bell, I.1    Ashman, C.2    Maughan, J.3    Hooker, E.4    Cook, F.5    Reinhart, T.A.6
  • 51
    • 0030887932 scopus 로고    scopus 로고
    • The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck a serine kinase
    • Baur, A. S., Sass, G., Laffert, B., Willbold, D., Cheng-Mayer, C., Peterlin, B. M.: The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6, 283 (1997).
    • (1997) Immunity , vol.6 , pp. 283
    • Baur, A.S.1    Sass, G.2    Laffert, B.3    Willbold, D.4    Cheng-Mayer, C.5    Peterlin, B.M.6
  • 52
    • 12144291075 scopus 로고    scopus 로고
    • Human immunodeficiency virus Type 1 Nef activates p21-activated kinase via recruitment into lipid rafts
    • Krautkrämer, E., Giese, S. I., Gasteier, J. E., Muranyi, W., Fackler, O. T.: Human immunodeficiency virus Type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J Virol 78, 4085 (2004).
    • (2004) J Virol , vol.78 , pp. 4085
    • Krautkrämer, E.1    Giese, S.I.2    Gasteier, J.E.3    Muranyi, W.4    Fackler, O.T.5
  • 54
    • 0032750417 scopus 로고    scopus 로고
    • Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex
    • Brown, A., Wang, X., Sawai, E., Cheng-Mayer, C.: Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex. J Virol 73, 9899 (1999).
    • (1999) J Virol , vol.73 , pp. 9899
    • Brown, A.1    Wang, X.2    Sawai, E.3    Cheng-Mayer, C.4
  • 56
    • 0036289210 scopus 로고    scopus 로고
    • Macrophages and HIV infection: Therapeutical approaches toward this strategic virus reservoir
    • Aquaro, S., Calio, R., Balzarini, J., Bellocchi, M. C., Garaci, E., Perno, C. F.: Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir. Antiviral Research 55, 209 (2002).
    • (2002) Antiviral Research , vol.55 , pp. 209
    • Aquaro, S.1    Calio, R.2    Balzarini, J.3    Bellocchi, M.C.4    Garaci, E.5    Perno, C.F.6
  • 57
    • 0034793925 scopus 로고    scopus 로고
    • Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat
    • Smith, D. G., Guillemin, G. J., Pemberton, L., Kerr, S., Nath, A., Smythe, G. A., Brew, B. J.: Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat. J Neurovirol 7, 56 (2001).
    • (2001) J Neurovirol , vol.7 , pp. 56
    • Smith, D.G.1    Guillemin, G.J.2    Pemberton, L.3    Kerr, S.4    Nath, A.5    Smythe, G.A.6    Brew, B.J.7
  • 59
    • 0028009187 scopus 로고
    • Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice
    • Toggas, S. M., Masliah, E., Rockenstein, E. M., Rall, G. F., Abraham, C. R., Mucke, L.: Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367, 188 (1994).
    • (1994) Nature , vol.367 , pp. 188
    • Toggas, S.M.1    Masliah, E.2    Rockenstein, E.M.3    Rall, G.F.4    Abraham, C.R.5    Mucke, L.6
  • 60
    • 0037000758 scopus 로고    scopus 로고
    • Interactions of human immunodeficiency virus-1 proteins with neurons: Possible role in the development of human immunodeficiency virus-1-associated dementia
    • van de Bovenkamp, M., Nottet, H. S., Pereira, C. F.: Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia. Eur J Clin Invest 32, 619 (2002).
    • (2002) Eur J Clin Invest , vol.32 , pp. 619
    • van de Bovenkamp, M.1    Nottet, H.S.2    Pereira, C.F.3
  • 61
    • 0037942711 scopus 로고    scopus 로고
    • Expression of simian immunodeficiency virus (SIV) Nef in astrocytes during acute and terminal infection and requirement of Nef for optimal replication of neurovirulent SIV in vitro
    • Overholser, E. D., Coleman, G. D., Bennett, J. L., Casaday, R. J., Zink, M. C., Barber, S. A., Clements, J. E.: Expression of simian immunodeficiency virus (SIV) Nef in astrocytes during acute and terminal infection and requirement of Nef for optimal replication of neurovirulent SIV in vitro. J Virol 77, 6855 (2003).
    • (2003) J Virol , vol.77 , pp. 6855
    • Overholser, E.D.1    Coleman, G.D.2    Bennett, J.L.3    Casaday, R.J.4    Zink, M.C.5    Barber, S.A.6    Clements, J.E.7
  • 62
    • 0036401929 scopus 로고    scopus 로고
    • Vpr- and NEF-dependent induction of Rantes/CCL5 in microglial cells
    • Si, Q., Kim, M. O., Zhao, M. L., Landau, N. R., Goldstein, H., Lee, S.: Vpr- and NEF-dependent induction of Rantes/CCL5 in microglial cells. Virology 301, 342 (2002).
    • (2002) Virology , vol.301 , pp. 342
    • Si, Q.1    Kim, M.O.2    Zhao, M.L.3    Landau, N.R.4    Goldstein, H.5    Lee, S.6
  • 63
    • 0033179226 scopus 로고    scopus 로고
    • HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system
    • Koedel, U., Kohleisen, B., Sporer, B., Lahrtz, F., Ovod, V., Fontana, A., Erfle, V., Pfister, H. W.: HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system. J Immunol 163, 1237 (1999).
    • (1999) J Immunol , vol.163 , pp. 1237
    • Koedel, U.1    Kohleisen, B.2    Sporer, B.3    Lahrtz, F.4    Ovod, V.5    Fontana, A.6    Erfle, V.7    Pfister, H.W.8
  • 64
    • 0034948709 scopus 로고    scopus 로고
    • Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators
    • Simmons, A., Aluvihare, V., McMichael, A.: Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 14, 763 (2001).
    • (2001) Immunity , vol.14 , pp. 763
    • Simmons, A.1    Aluvihare, V.2    McMichael, A.3
  • 65
    • 0035666190 scopus 로고    scopus 로고
    • Recent advances in the understanding of HIV accessory protein function
    • Steffens, C. M., Hope T. J.: Recent advances in the understanding of HIV accessory protein function. AIDS 15 (suppl. 5), S21 (2001).
    • (2001) AIDS , vol.15 , Issue.SUPPL. 5
    • Steffens, C.M.1    Hope, T.J.2
  • 66
    • 0035175924 scopus 로고    scopus 로고
    • HIV: Master of the host cell
    • Reviews 1030.1
    • Arendt, C. W., Littman, D. R.: HIV: master of the host cell. Genome Biology 2 (11), Reviews 1030.1 (2001).
    • (2001) Genome Biology , vol.2 , Issue.11
    • Arendt, C.W.1    Littman, D.R.2
  • 68
    • 0036247913 scopus 로고    scopus 로고
    • Extracellular Nef protein activates signal transduction pathway from Ras to mitogen-activated protein-kinase cascades that leads to activation of human immunodeficiency virus from latency
    • Tobiume, M., Fujinaga, K., Suzuki, S., Komoto, S., Mukai, T., Ikuta, K.: Extracellular Nef protein activates signal transduction pathway from Ras to mitogen-activated protein-kinase cascades that leads to activation of human immunodeficiency virus from latency. AIDS Res Hum Retroviruses 18, 461 (2002).
    • (2002) AIDS Res Hum Retroviruses , vol.18 , pp. 461
    • Tobiume, M.1    Fujinaga, K.2    Suzuki, S.3    Komoto, S.4    Mukai, T.5    Ikuta, K.6
  • 70
    • 0034719429 scopus 로고    scopus 로고
    • Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells?
    • Azad, A. A.: Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells? Biochem Biophys Res Commun 267, 677 (2000).
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 677
    • Azad, A.A.1
  • 71
  • 72
    • 0037820578 scopus 로고    scopus 로고
    • Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS
    • Alimonti, J. B., Ball, T. B., Fowke, K. R.: Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS. J Gen Virol 84, 1649 (2003).
    • (2003) J Gen Virol , vol.84 , pp. 1649
    • Alimonti, J.B.1    Ball, T.B.2    Fowke, K.R.3
  • 73
    • 0030908348 scopus 로고    scopus 로고
    • Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway
    • Brigino, E., Haraguchi, S., Koutsonikolis, A., Cianciolo, G. J., Owens, U., Good, R. A., Day, N. K.: Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway. Proc Natl Acad Sci USA 94, 3178 (1997).
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3178
    • Brigino, E.1    Haraguchi, S.2    Koutsonikolis, A.3    Cianciolo, G.J.4    Owens, U.5    Good, R.A.6    Day, N.K.7
  • 74
    • 0030027765 scopus 로고    scopus 로고
    • Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 Nef gene-induced expression
    • Collette, Y., Chang, H. L., Cerdan, C., Chambost, H., Algarte, M., Mawas, C., Imbert, J., Burny, A., Olive, D.: Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 Nef gene-induced expression. J Immunol 156, 360 (1996).
    • (1996) J Immunol , vol.156 , pp. 360
    • Collette, Y.1    Chang, H.L.2    Cerdan, C.3    Chambost, H.4    Algarte, M.5    Mawas, C.6    Imbert, J.7    Burny, A.8    Olive, D.9
  • 80
    • 0030576919 scopus 로고    scopus 로고
    • Soluble Nef antigen of HIV-1 is cytotoxic for human CD4+ T cells
    • Fujii, Y., Otake, K., Tashiro, M., Adachi, A.: Soluble Nef antigen of HIV-1 is cytotoxic for human CD4+ T cells. FEBS Lett 393, 93 (1996).
    • (1996) FEBS Lett , vol.393 , pp. 93
    • Fujii, Y.1    Otake, K.2    Tashiro, M.3    Adachi, A.4
  • 81
    • 0033643249 scopus 로고    scopus 로고
    • Biological phenotype and coreceptor usage of human immunodeficiency virus (a short review)
    • Fenyo, E. M.: Biological phenotype and coreceptor usage of human immunodeficiency virus (a short review). Acta Microbiol Immunol Hung 47, 131 (2000).
    • (2000) Acta Microbiol Immunol Hung , vol.47 , pp. 131
    • Fenyo, E.M.1
  • 82
  • 83
    • 0037227694 scopus 로고    scopus 로고
    • A truncated form of Nef selected during pathogenic reversion of simian immunodeficiency virus SIVmac239Δnef increases viral replication
    • Chakrabarti, L. A., Metzner, K. J., Ivanovic, T., Cheng, H., Louis-Virelizier, J., Connor, R. I., Cheng-Mayer, C.: A truncated form of Nef selected during pathogenic reversion of simian immunodeficiency virus SIVmac239Δnef increases viral replication. J Virol 77, 1245 (2003).
    • (2003) J Virol , vol.77 , pp. 1245
    • Chakrabarti, L.A.1    Metzner, K.J.2    Ivanovic, T.3    Cheng, H.4    Louis-Virelizier, J.5    Connor, R.I.6    Cheng-Mayer, C.7
  • 84
    • 0141993006 scopus 로고    scopus 로고
    • Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development
    • Stove, V., Naessens, E., Stove, C., Swigut, T., Plum, J., Verhasselt, B.: Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development. Blood 102, 2925 (2003).
    • (2003) Blood , vol.102 , pp. 2925
    • Stove, V.1    Naessens, E.2    Stove, C.3    Swigut, T.4    Plum, J.5    Verhasselt, B.6
  • 86
    • 6344276677 scopus 로고    scopus 로고
    • Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase
    • Choi, H. J., Smithgall, T. E.: Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase. J Mol Biol 343, 1255 (2004).
    • (2004) J Mol Biol , vol.343 , pp. 1255
    • Choi, H.J.1    Smithgall, T.E.2
  • 88
    • 0343494918 scopus 로고    scopus 로고
    • Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
    • Lee, C. H., Saksela, K., Mirza, U. A., Chait, B. T., Kuriyan, J.: Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell 85, 931 (1996).
    • (1996) Cell , vol.85 , pp. 931
    • Lee, C.H.1    Saksela, K.2    Mirza, U.A.3    Chait, B.T.4    Kuriyan, J.5
  • 89
    • 0031572847 scopus 로고    scopus 로고
    • The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling
    • Arold, S., Franken, P., Strub, M. P., Hoh, F., Benichou, S., Benarous, R., Dumas, C.: The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure 5, 1361 (1997).
    • (1997) Structure , vol.5 , pp. 1361
    • Arold, S.1    Franken, P.2    Strub, M.P.3    Hoh, F.4    Benichou, S.5    Benarous, R.6    Dumas, C.7
  • 90
    • 0033995168 scopus 로고    scopus 로고
    • Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques
    • Carl, S., Iafrate, A. J., Lang, S. M., Stolte, N., Stahl-Hennig, C., Matz-Rensing, K., Fuchs, D., Skowronski, J., Kirchhoff, F.: Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques. J Virol 74, 4155 (2000).
    • (2000) J Virol , vol.74 , pp. 4155
    • Carl, S.1    Iafrate, A.J.2    Lang, S.M.3    Stolte, N.4    Stahl-Hennig, C.5    Matz-Rensing, K.6    Fuchs, D.7    Skowronski, J.8    Kirchhoff, F.9
  • 96
    • 0032833225 scopus 로고    scopus 로고
    • Live attenuated AIDS viruses as vaccines: Promise or peril?
    • Ruprecht, R. M.: Live attenuated AIDS viruses as vaccines: promise or peril? Immunol Rev 170, 135 (1999).
    • (1999) Immunol Rev , vol.170 , pp. 135
    • Ruprecht, R.M.1
  • 97
    • 0036633807 scopus 로고    scopus 로고
    • Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence
    • Jekle, A., Schramm, B., Jayakumar, P., Trautner, V., Schols, D., DeClercq, E., Mills, J., Crowe, S. M., Goldsmith, M. A.: Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence. J Virol 76, 6966 (2002).
    • (2002) J Virol , vol.76 , pp. 6966
    • Jekle, A.1    Schramm, B.2    Jayakumar, P.3    Trautner, V.4    Schols, D.5    DeClercq, E.6    Mills, J.7    Crowe, S.M.8    Goldsmith, M.A.9
  • 99
    • 0037455552 scopus 로고    scopus 로고
    • Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma
    • Stahl-Hennig, C., Gundlach, B. R., Dittmer, U., ten Haaft, P., Heeney, J., Zou, W., Emilie, D., Sopper, S., Uberla, K.: Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma. Virology 305, 473 (2003).
    • (2003) Virology , vol.305 , pp. 473
    • Stahl-Hennig, C.1    Gundlach, B.R.2    Dittmer, U.3    ten Haaft, P.4    Heeney, J.5    Zou, W.6    Emilie, D.7    Sopper, S.8    Uberla, K.9
  • 100
    • 0027043276 scopus 로고
    • Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
    • Daniel, M. D., Kirchhoff, F., Czajak, S. C., Sehgal, P. K., Desrosiers, R. C.: Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938 (1992).
    • (1992) Science , vol.258 , pp. 1938
    • Daniel, M.D.1    Kirchhoff, F.2    Czajak, S.C.3    Sehgal, P.K.4    Desrosiers, R.C.5
  • 102
    • 0029951823 scopus 로고    scopus 로고
    • Vaccine protection by a triple deletion mutant of simian immunodeficiency virus
    • Wyand, M. S., Manson, K. H., Garcia-Moll, M., Montefiori, D., Desrosiers, R. C.: Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J Virol 70, 3724 (1996).
    • (1996) J Virol , vol.70 , pp. 3724
    • Wyand, M.S.1    Manson, K.H.2    Garcia-Moll, M.3    Montefiori, D.4    Desrosiers, R.C.5
  • 104
    • 0028793140 scopus 로고
    • Cellular immune response of rhesus monkeys infected with a partially attenuated nef deletion mutant of the simian immunodeficiency virus
    • Dittmer, U., Nisslein, T., Bodemer, W., Petry, H., Sauermann, U., Stahl-Hennig, C., Hunsmann, G.: Cellular immune response of rhesus monkeys infected with a partially attenuated nef deletion mutant of the simian immunodeficiency virus. Virology 212, 392 (1995).
    • (1995) Virology , vol.212 , pp. 392
    • Dittmer, U.1    Nisslein, T.2    Bodemer, W.3    Petry, H.4    Sauermann, U.5    Stahl-Hennig, C.6    Hunsmann, G.7
  • 106
    • 0029953201 scopus 로고    scopus 로고
    • Protection from pathogenic SIVmac challange following short-term infection with a nef-deficient attenuated virus
    • Norley, S., Beer, B., Binninger-Schninzel, D., Cosma, C., Kurth, R.: Protection from pathogenic SIVmac challange following short-term infection with a nef-deficient attenuated virus. Virology 219, 195 (1996).
    • (1996) Virology , vol.219 , pp. 195
    • Norley, S.1    Beer, B.2    Binninger-Schninzel, D.3    Cosma, C.4    Kurth, R.5
  • 107
    • 0030862752 scopus 로고    scopus 로고
    • Macaques infected with attenuated simian immunodeficiency virus resist superinfection with virulence-revertant virus
    • Sharpe, S. A., Whatmore, A. M., Hall, G. A., Cranage, M. P.: Macaques infected with attenuated simian immunodeficiency virus resist superinfection with virulence-revertant virus. J Gen Virol 78, 1923 (1997).
    • (1997) J Gen Virol , vol.78 , pp. 1923
    • Sharpe, S.A.1    Whatmore, A.M.2    Hall, G.A.3    Cranage, M.P.4
  • 108
    • 4544275103 scopus 로고    scopus 로고
    • Macaques infected long-term with attenuated simian immunodeficiency virus (SIVmac) remain resistant to wild-type challenge, despite declining cytotoxic T lymphocyte responses to an immunodominant epitope
    • Sharpe, S. A., Cope, A., Dowall, S., Berry, N., Ham, C., Heeney, J., Hopkins, D., Easterbrook, L., Dennis, M., Almond, N., Cranage, M.: Macaques infected long-term with attenuated simian immunodeficiency virus (SIVmac) remain resistant to wild-type challenge, despite declining cytotoxic T lymphocyte responses to an immunodominant epitope. J Gen Virol 85, 2591 (2004).
    • (2004) J Gen Virol , vol.85 , pp. 2591
    • Sharpe, S.A.1    Cope, A.2    Dowall, S.3    Berry, N.4    Ham, C.5    Heeney, J.6    Hopkins, D.7    Easterbrook, L.8    Dennis, M.9    Almond, N.10    Cranage, M.11
  • 111
    • 0035152286 scopus 로고    scopus 로고
    • Persistence of pathogenic challenge virus in macaques protected by simian immunodeficiency virus SIVmacDeltanef
    • Khatissian, E., Monceaux, V., Cumont, M. C., Kieny, M. P., Aubertin, A. M., Hurtrel, B.: Persistence of pathogenic challenge virus in macaques protected by simian immunodeficiency virus SIVmacDeltanef. J Virol 75, 1507 (2001).
    • (2001) J Virol , vol.75 , pp. 1507
    • Khatissian, E.1    Monceaux, V.2    Cumont, M.C.3    Kieny, M.P.4    Aubertin, A.M.5    Hurtrel, B.6
  • 113
    • 4444295087 scopus 로고    scopus 로고
    • Biased G-to-A hypermutation in HIV-1 proviral DNA from a long term non-progressor
    • Wei, M., Xing, H., Hong, K., Huang, H., Tang, H., Qin, G., Shao, Y.: Biased G-to-A hypermutation in HIV-1 proviral DNA from a long term non-progressor. AIDS 18, 1863 (2004).
    • (2004) AIDS , vol.18 , pp. 1863
    • Wei, M.1    Xing, H.2    Hong, K.3    Huang, H.4    Tang, H.5    Qin, G.6    Shao, Y.7
  • 114
    • 0029994033 scopus 로고    scopus 로고
    • Interference to human immunodeficiency virus type 1 infection in the absence of the downmodulation of the principal virus receptor, CD4
    • Volsky, D. J., Simm, M., Shahabuddin, M., Li, G., Chao, W., Potash, M. J.: Interference to human immunodeficiency virus type 1 infection in the absence of the downmodulation of the principal virus receptor, CD4. J Virol 70, 3823 (1996).
    • (1996) J Virol , vol.70 , pp. 3823
    • Volsky, D.J.1    Simm, M.2    Shahabuddin, M.3    Li, G.4    Chao, W.5    Potash, M.J.6
  • 115
    • 0024841987 scopus 로고
    • Prospects for the control of AIDS patients by introducing defective-HIV harbouring leukocytes
    • Berencsi, G., Minarovits, J., Nasz, I., Földes, I.: Prospects for the control of AIDS patients by introducing defective-HIV harbouring leukocytes. Med Hypotheses 30, 223 (1989).
    • (1989) Med Hypotheses , vol.30 , pp. 223
    • Berencsi, G.1    Minarovits, J.2    Nasz, I.3    Földes, I.4
  • 116
    • 0024216993 scopus 로고
    • Therapy of AIDS patients - Classical strategies and proposals for novel therapeutic approaches (a short review)
    • Minarovits, J., Berencsi, G., Nasz, I., Földes, I.: Therapy of AIDS patients - classical strategies and proposals for novel therapeutic approaches (a short review). Acta Microbiol Hung 35, 361 (1988).
    • (1988) Acta Microbiol Hung , vol.35 , pp. 361
    • Minarovits, J.1    Berencsi, G.2    Nasz, I.3    Földes, I.4
  • 117
    • 0028868206 scopus 로고
    • Prevention of retrovirus-induced neurological disease by infection with a nonneuropathogenic retrovirus
    • Czub, M., McAtee, F. J., Czub, S., Lynch, W. P., Portis, J. L.: Prevention of retrovirus-induced neurological disease by infection with a nonneuropathogenic retrovirus. Virology 206, 372 (1995).
    • (1995) Virology , vol.206 , pp. 372
    • Czub, M.1    McAtee, F.J.2    Czub, S.3    Lynch, W.P.4    Portis, J.L.5


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