Recent advances in the understanding of HIV accessory protein function

AIDS

Volumn 15, Issue SUPPL. 5, 2001, Pages

  Carolyn, M ^a   Steffens, ^a   Hope, T J ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Accessory genes; HIV; Viral proteins; Viral replication

Indexed keywords

NEF PROTEIN; VIF PROTEIN; VIRUS PROTEIN; VPR PROTEIN; VPU PROTEIN;

ACCESSORY CELL; DRUG TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; VIRUS CULTURE; VIRUS LOAD; VIRUS PATHOGENESIS; VIRUS REPLICATION;

EID: 0035666190     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200100005-00004     Document Type: Review

References (77)

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2. Importance of the nef gene for maintenance of high virus loads and for development of AIDS
3. Characterization of three nef-defective human immunodeficiency virus type 1 strains associated with long-term nonprogression
4. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene
5. Mechanism for down-regulation of CD28 by Nef
6. Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators
7. Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells
8. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
9. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis
10. Lentivirus Nef specifically activates Pak2
11. Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX
12. Activation of NFAT-dependent gene expression by Nef: Conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta
13. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
14. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
15. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
16. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
17. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
18. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
19. Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation
20. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
21. Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin
22. Nef-induced CD4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes
23. Nef-induced CD4 downregulation: A diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP
24. Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS
25. The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
26. Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein
27. Association of Nef with the human immunodeficiency virus type 1 core
28. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell
29. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A
30. Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity
31. Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions
32. Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: Evidence supporting a role for Nef at the virion envelope
33. Incorporation of Vpr into human immunodeficiency virus type 1 virions: Requirement for the p6 region of gag and mutational analysis
34. Human immunodeficiency virus type 1 Vpr protein is incorporated into the virion in significantly smaller amounts than gag and is phosphorylated in infected cells
35. Virion-associated HIV-1 Vpr: Variable amount in virus particles derived from cells upon virus infection or proviral DNA transfection
36. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
37. Isolation of human immunodeficiency virus type 1 cores: Retention of Vpr in the absence of p6(gag)
38. Viral protein R of HIV-1
39. Comparison of cell cycle arrest, transactivation, and apoptosis induced by the simian immunodeficiency virus SIVagm and human immunodeficiency virus type 1 vpr genes
40. Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest
41. Impairment of human immunodeficiency virus type 1 (HIV-1) entry into Jurkat T cells by constitutive expression of the HIV-1 vpr protein: Role of CD4 down-modulation
42. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells
43. Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1
44. Two putative alpha-helical domains of human immunodeficiency virus type 1 Vpr mediate nuclear localization by at least two mechanisms
45. Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr
46. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection
47. Nuclear export of human immunodeficiency virus type 1 vpr is not required for virion packaging
48. The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection
49. The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle
50. Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B
51. Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity
52. Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 Vpr
53. Identification and localization of vpr gene product of human immunodeficiency virus type 1
54. The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains
55. Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4
56. A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
57. The human immunodeficiency virus type 1 Vpu protein inhibits NY-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B
58. The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release
59. Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1
60. Cell surface CD4 inhibits HIV-1 particle release by interfering with Vpu activity
61. The HIV 'A' (sor) gene product is essential for virus infectivity
62. Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells
63. The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures
64. Characterization of human immunodeficiency virus type 1 Vif particle incorporation
65. Vif and the p55(Gag) polyprotein of human immunodeficiency virus type 1 are present in colocalizing membrane-free cytoplasmic complexes
66. Vif is largely absent from human immunodeficiency virus type 1 mature virions and associates mainly with viral particles containing unprocessed gag
67. An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein
68. Evidence for a newly discovered cellular anti-HIV-1 phenotype
69. The regulation of primate immunodeficiency virus infectivity by Vif is cell species restricted: A role for Vif in determining virus host range and cross-species transmission
70. Cellular and viral specificities of human immunodeficiency virus type 1 vif protein
71. Partial rescue of the Vif-negative phenotype of mutant human immunodeficiency virus type 1 strains from nonpermissive cells by intravirion reverse transcription
72. Role of vif during packing of the core of HIV-1
73. Role of Vif in stability of the human immunodeficiency virus type 1 core
74. Association of human immunodeficiency virus type 1 Vif with RNA and its role in reverse transcription
75. Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could he involved in the viral RNA folding and packaging process
76. Human immunodeficiency virus type 1 Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA
77. Feline immunodeficiency virus Vif localizes to the nucleus