Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine

Journal of Virology

Volumn 72, Issue 9, 1998, Pages 7501-7509

  Connor, Ruth I ^a,e   Montefiori, David C ^c   Binley, James M ^a   Moore, John P ^a   Bonhoeffer, Sebastian ^a   Gettie, Agegnehu ^a   Fenamore, Elizabeth A ^a   Sheridan, Kristine E ^a   Ho, David D ^a   Dailey, Peter J ^d   Marx, Preston A ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

^e AARON DIAMOND AIDS RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIMIAN IMMUNODEFICIENCY VIRUS VACCINE;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; DRUG POTENCY; FEMALE; IMMUNOGENICITY; MONKEY DISEASE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; STRAIN DIFFERENCE; VIREMIA; VIRUS LOAD; VIRUS NEUTRALIZATION; VIRUS REPLICATION;

EID: 0031849757     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.9.7501-7509.1998     Document Type: Article

References (36)

1. Almond, N., T. Cocoran, R. Hull, B. Walker, J. Rose, R. Sangster, K. Silvera, P. Silvera, M. Cranage, E. Rud, and E. J. Stott. 1997. Mechanisms of protection induced by attenuated simian immunodeficiency virus. I. Protection cannot be transferred with immune serum. J. Gen. Virol. 78:1919-1922.
2. Almond, N., K. Kent, M. Cranage, E. Rud, B. Clarke, and E. J. Stott. 1995. Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells. Lancet 345:1342-1344.
3. Baba, T. W., Y. S. Jeong, D. Penninck, R. Bronson, M. F. Greene, and R. M. Ruprecht. 1995. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267:1820-1825.
4. Binley, J. M., P. J. Klasse, Y. Cao, I. M. Jones, M. Markowitz, D. D. Ho, J. P. Moore. 1997. Differential regulation of the antibody response to Gag and Env proteins of human immunodeficiency virus type 1. J. Virol. 71:2799-2809.
5. Burton, D. R., and D. Montefiori. 1997. The antibody response in HIV-1 infection. AIDS 11(Suppl. A):587-598.
6. Chakrabarti, L., V. Baptiste, E. Khatissan, M.-C. Cumont, A.-M. Aubertin, L. Montagnier, and B. Hurtrel. 1995. Limited viral spread and rapid immune responses in lymph nodes of macaques inoculated with attenuated simian immunodeficiency virus. Virology 213:535-548.
7. Cheingsong-Popov, R., C. Panagiotidi, S. Bowcock, A. Aronstam, J. Wadsworth, and J. Weber. 1991. Relation between humoral responses to HIV gag and env proteins at seroconversion and clinical outcome of HIV infections. Br. Med. J. 302:23-26.
8. Clements, J. E., R. C. Montelare, M. C. Zink, A. M. Amedee, S. Miller, A. M. Trichel, B. Hagerski, D. Hauer, L. N. Martin, R. P. Bohm, and M. Murphey-Corb. 1995. Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus. J. Virol. 69:2737-2744.
9. Dailey, P. J., M. Zamround, R. Kelso, J. Kolberg, and M. Urdea. 1995. Quantitation of simian immunodeficiency virus (SIV) RNA in plasma of acute and chronically infected macaques using a branched DNA (bDNA) signal amplification assay. J. Med. Primatol. 24:209.
10. Daniel, M. D., F. Kirchoff, S. C. Czajak, P. K. Sehgal, and R. C. Desrosiers. 1992. Protective effects of a live, attenuated SIV vaccine with a deletion in the nef gene. Science 258:1938-1941.
11. Denesvre, C., R. Le Grand, F. Boisson-Cans, L. Chakrabarti, B. Hurtrel, B. Vaslin, D. Dormont, and P. Sonigo. 1995. Highly attenuated SIVmac 142 is immunogenic but does not protect against SIVmac251 challenge. AIDS Res. Hum. Retroviruses 11:1397-1406.
12. Desrosiers, R. C., J. D. Lifson, J. S. Gibbs, S. C. Czajak, A. Y. M. Howe, L. O. Arthur, and R. P. Johnson. 1998. Identification of highly attenuated mutants of simian immunodeficiency virus. J. Virol. 72:1431-1437.
13. Dittmer, U., T. Niblein, W. Bodemer, H. Petry, U. Sauermann, C. Stahl-Hennig, and G. Hunsmann. 1995. Cellular immune response of rhesus monkeys infected with a partially attenuated nef deletion mutant of the simian immunodeficiency virus. Virology 212:392-397.
14. Harris, M., P. Patenaude, P. Cooperberg, D. Filipenko, A. Thorne, J. Raboud, S. Rae, P. Dailey, D. Chernoff, J. Todd, B. Conway, J. S. G. Montaner, and the INCAS Study Group. 1997. Correlation of viral load in plasma and lymph node tissue in HIV infection. J. Infect. Dis. 176:1388-1392.
15. Hogervorst, E., S. Jurrians, F. de Wolf, A. van Wijk, A. Wiersma, M. Valk, M. Roos, B. van Gemen, R. Coutinho, F. Miedema, and J. Goudsmit. 1995. Predictors for non- and slow-progression in human immunodeficiency virus (HIV) type 1 infection: low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels. J. Infect. Dis. 171:811-821.
16. Johnson, R. P., R. L. Glickman, J. Q. Yang, A. Kaur, J. T. Dion, M. J. Mulligan, and R. C. Desrosiers. 1997. Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus. J. Virol. 71:7711-7718.
17. Kirchoff, F., H. W. Kestler, and R. C. Desrosiers. 1994. Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene. J. Virol. 68:2031-2037.
18. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, Y. Wu, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune response with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650-4655.
19. Lewis, M. G., S. Bellah, K. McKinnin, J. Yalley-Ogunro, P. M. Zack, W. R. Elkins, R. C. Desrosiers, and G. A. Eddy. 1994. Titration and characterization of two rhesus-derived SIVmac challenge stocks. AIDS Res. Hum. Retroviruses 10:213-220.
20. Lifson, J. D., M. A. Nowak, S. Goldstein, J. L. Rossio, A. Kinter, G. Vasquez, T. A. Wiltrout, C. Brown, D. Schneider, L. Wahl, A. L. Lloyd, J. Williams, W. R. Elkins, A. S. Fauci, and V. M. Hirsch. 1997. The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection. J. Virol. 71:9508-9514.
21. Lohman, B. L., M. B. McChesney, C. J. Miller, E. McGowan, S. M. Joye, K. K. A. Van Rompay, E. Reay, L. Antipa, N. C. Pedersen, and M. L. Marthas. 1994. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. J. Virol. 68:7021-7029.
22. Marthas, M. L., S. Sutjipto, C. J. Miller, J. Higgins, J. Torten, R. E. Unger, P. A. Marx, and N. C. Pedersen. 1992. Efficacy of live-attenuated and whole-inactivated SIV vaccines against intravenous and vaginal challenge, p. 117-122. In F. Brown, R. M. Chanock, H. S. Ginsberg, and R. A. Lerner (ed.), Vaccines 92. Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
23. Means, R. E., T. Greenough, and R. C. Desrosiers. 1997. Neutralization sensitivity of cell culture-passaged simian immunodeficiency virus. J. Virol. 71:7895-7902.
24. Montefiori, D. C., T. W. Baba, A. Li, M. Bilska, and R. M. Ruprecht. 1996. Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239Δnef in adult and infant rhesus monkeys. J. Immunol. 157:5528-5535.
25. Moore, J. P., Y. Cao, L. Qing, Q. J. Sattentau, J. Pyati, R. Koduri, J. Robinson, C. F. I. Barbas, D. R. Burton, and D. D. Ho. 1995. Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120. J. Virol. 69:101-109.
26. Norley, S., B. Beer, D. Binninger-Schinzel, C. Cosma, and R. Kurth. 1996. Protection from pathogenic SIVmac challenge following short-term infection with a nef-deficient attenuated virus. Virology 219:195-205.
27. Regier, D. A., and R. C. Desrosiers. 1990. The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus. AIDS Res. Hum. Retroviruses 6:1221-1231.
28. Reimann, K. A., K. Tenner-Racz, P. Racz, D. C. Montefiori, Y. Yasutomi, B. J. Ransil, and N. L. Letvin. 1994. Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques. J. Virol. 68:2362-2370.
29. Shibata, R., T. Matano, C. Siemon, M. Connors, H. C. Lane, and M. Martin. 1997. Effect of CD8 cells on replication of a superchallenged SHIV in macaque monkeys, p. 151. In Abstracts of the 9th Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS. Conference on Advances in AIDS Vaccine Development, Bethesda, Md.
30. Shibata, R., C. Siemon, S. C. Czajak, R. C. Desrosiers, and M. A. Martin. 1997. Live, attenuated simian immunodeficiency virus vaccines elicit potent resistance against a challenge with a human immunodeficiency virus type 1 chimeric virus. J. Virol. 71:8141-8148.
31. Stahl-Hennig, C., U. Dittmer, T. NiBlein, H. Petry, E. Jurkiewicz, D. Fuchs, H. Wachter, K. Mätz-Rensing, E. M. Kuhn, F. J. Kaup, E. W. Rud, and G. Hunsmann. 1996. Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus. J. Gen. Virol. 77:2969-2981.
32. Strathdee, S. A., J. W. Frank, J. McLaughlin, M. Leblanc, C. Major, M. V. O'Shaughnessy, and E. S. Rudd. 1995. Quantitative measures of human immunodeficiency virus-specific antibodies predict progression to AIDS. J. Infect. Dis. 172:1375-1379.
33. Wyand, M. S., K. H. Manson, G.-M. M., D. Montefiori, and R. C. Desrosiers. 1996. Vaccine protection by a triple-deletion mutant of simian immunodeficiency virus. J. Virol. 70:3724-3733.
34. + lymphocyte response in acutely infected rhesus monkeys. J. Virol. 67:1707-1711.
35. Zhang, L. Q. and D. D. Ho. Personal communication.
36. Zwart, G., L. van der Hoek, M. Valk, M. T. E. Cornelissen, E. Baan, J. Dekker, M. Koot, C. L. Kuiken, and J. Goudsmit. 1994. Antibody responses to HIV-1 envelope and gag epitopes in HIV-1 seroconvertors with rapid versus slow disease progression. Virology 201:285-293.