Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease

Journal of Virology

Volumn 71, Issue 2, 1997, Pages 1013-1018

  Bukovsky, Anatoly A ^b   Dorfman, Tatyana ^b   Weimann, Andreas ^b   Göttlinger, Heinrich G ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

NEF PROTEIN; PROTEINASE;

ANIMAL CELL; ARTICLE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATOR GENE; VIRION; VIRUS INFECTIVITY;

ENDOPEPTIDASES; GENE EXPRESSION REGULATION, VIRAL; GENES, NEF; HIV-1; HUMANS; VIRION;

EID: 0031015224     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Ahmad, N., and S. Venkatesan. 1988. Nef protein of HIV-1 is a transcriptional represser of HIV-1 LTR. Science 241:1481-1485.
2. Aiken, C., J. Konner, N. R. Landau, M. E. Lenburg, and D. Trono. 1994. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76:853-864.
3. Aiken, C., and D. Trono. 1995. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J. Virol. 69:5048-5056.
4. Allan, J. S., J. E. Coligan, T. H. Lee, M. F. McLane, P. J. Kanki, J. E. Groopman, and M. Essex. 1985. A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients. Science 230:810-812.
5. Andersen, S. J., M. Lenburg, N. R. Landau, and J. V. Garcia. 1994. The cytoplasmic domain of CD4 is sufficient tor its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef. J. Virol. 68:3092-3101.
6. Bandres, J. C., A. S. Shaw, and L. Ratner. 1995. HIV-1 Nef protein down-regulation of CD4 surface expression: relevance of the lck binding domain of CD4. Virology 207:338-341.
7. Benson, R. E., A. Sanfridson, J. S. Ottinger, C. Doyle, and B. R. Cullen. 1993. Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral superinfection. J. Exp. Med. 177:1561-1566.
8. Bryant, M. L., L. Ratner, R. J. Duronio, N. S. Kishore, B. Devadas, S. P. Adams, and J. I. Gordon. 1991. Incorporation of 12-methoxydodecanoate into the human immunodeficiency virus 1 gag polyprotein precursor inhibits its proteolytic processing and virus production in a chronically infected human Iymphoid cell line. Proc. Natl. Acad. Sci. USA 88:2055-2059.
9. Bukovsky, A., and H. Göttlinger. 1996. Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease. J. Virol. 70:6820-6825.
10. Bukrinskaya, A. G., A. Ghorpade, N. K. Heinzinger, T. Smithgall, R. E. Lewis, and M. Stevenson. 1996. Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. Proc. Natl. Acad. Sci. USA 93:367-371.
11. Chowers, M. Y., M. W. Pandori, C. S. Spina, D. D. Richman, and J. C. Guatelli. 1995. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology 212:451-457.
12. Chowers, M. Y., C. A. Spina, T. J. Kwoh, N. J. S. Fitch, D. D. Richman, and J. C. Guatelli. 1994. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J. Virol. 68:2906-2914.
13. Cullen, B. R. 1987. Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol. 152:684-704.
14. Cullen, B. R. 1994. The role of Net in the replication cycle of the human and simian immunodeficiency viruses. Virology 205:1-6.
15. De Ronde, A., B. Klaver, W. Keulen, L. Smit, and J. Goudsmit. 1992. Natural HIV-1 Nef accelerates virus replication in primary human lymphocytes. Virology 188:391-395.
16. Dorfman, T., F. Mammano, W. A. Haseltine, and H. G. Göttlinger. 1994. Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein. J. Virol. 68:1689-1696.
17. Du, Z., S. M. Lang, V. G. Sasseville, A. A. Lackner, P. O. Ilyinskii, M. D. Daniel, J. U. Jung, and R. C. Desrosiers. 1995. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82:665-674.
18. Franchini, G., M. Robert-Guroff, J. Ghrayeb, N. T. Chang, and F. Wong-Staal. 1986. Cytoplasmic localization of the HTLV-III 3′ orf protein in cultured T cells. Virology 155:593-599.
19. Franke, E. K., H. E. H. Yuan, and J. Luban. 1994. Specific incorporation of cyclophilin A into HIV-1 virions. Nature (London) 372:359-362.
20. Gallay, P., S. Swingler, C. Aiken, and D. Trono. 1995. HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Cell 80:379-388.
21. Garcia, J. V., J. Alfano, and A. D. Miller. 1993. The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4. J. Virol. 67: 1511-1516.
22. Garcia, J. V., and A. D. Miller. 1991. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature (London) 350:508-511.
23. Goldsmith, M. A., M. T. Warmerdam, R. E. Atchison, M. D. Miller, and W. C. Greene. 1995. Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J. Virol. 69:4112-4121.
24. Göttlinger, H. G., T. Dorfman, E. A. Cohen, and W. A. Haseltine. 1993. Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses. Proc. Natl. Acad. Sci. USA 90:7381-7385.
25. Guy, B., M. P. Kieny, Y. Rivière, C. Le Peuch, K. Dott, M. Girard, L. Montagnier, and J.-P. Lecocq. 1987. HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature (London) 330:266-269.
26. Hunter, E. 1994. Macromolecular interactions in the assembly of HIV and other relroviruses. Semin. Virol. 5:71-83.
27. Jamieson, B. D., G. M. Aldrovandi, V. Planelles, J. B. M. Jowett, L. Gao, L. M. Bloch, I. S. Y. Chen, and J. A. Zack. 1994. Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J. Virol. 68:3478-3485.
28. Kaminchik, J., N. Bashan, A. Itach, N. Sarver, M. Gorecki, and A. Panet. 1991. Genetic characterization of human immunodeficiency virus type 1 nef gene products translated in vitro and expressed in mammalian cells. J. Virol. 65:583-588.
29. 2 symmetric inhibitors of the human immunodeficiency virus type 1 protease. Antimicrob. Agents Chemother. 35:2209-2214.
30. Kestler, H. W., D. J. Ringler, K. Mori, D. L. Panicali, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651-662.
31. Kim, S., K. Ikeuchi, R. Byrn, J. Groopman, and D. Baltimore. 1989. Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 86:9544-9548.
32. gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles. J. Virol. 69:2759-2764.
33. Langhoff, E., E. F. Terwilliger, H. J. Bos, K. H. Kalland, M. C. Posnansky, M. Bacon, and W. A. Haseltine. 1991. Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures. Proc. Natl. Acad. Sci. USA 88:7998-8002.
34. Lee, C.-H., B. Leung, M. A. Lemmon, J. Zheng, D. Cowburn, J. Kuriyan, and K. Saksela. 1995. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J. 14:5006-5015.
35. gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles. J. Virol. 69: 6873-6879.
36. Luciw, P. A., C. Cheng-Mayer, and J. A. Levy. 1987. Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication. Proc. Natl. Acad. Sci. USA 84:1434-1438.
37. Mariani, R., and J. Skowronski. 1993. CD4 downregulation by nef alleles isolated from HIV-1 infected individuals. Proc. Natl. Acad. Sci. USA 90: 5549-5553.
38. Miller, M. D., M. T. Warmerdam, I. Gaston, W. C. Greene, and M. B. Feinberg. 1994. The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med. 179:101-113.
39. Miller, M. D., M. T. Warmerdam, K. A. Page, M. B. Feinberg, and W. C. Greene. 1995. Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J. Virol. 69:579-584.
40. Niederman, T. M. J., V. J. Garcia, W. R. Hastings, S. Luria, and L. Ratner. 1992. HIV-1 Nef protein inhibits NF-κB induction in human T cells. J. Virol. 66:6213-6219.
41. Niederman, T. M. J., and L. Ratner. 1989. Human immunodeficiency virus type 1 negative factor is a transcriptional silencer. Proc. Natl. Acad. Sci. USA 86:1128-1132.
42. Obaru, K., J. E. DeClue, and W. A. Haseltine. 1992. An amino-terminal amino acid affects the electrophoretic mobility of the HIV-1 Nef protein. J. Acquired Immune Defic. Syndr. 5:308-312.
43. ELI. Virology 185:661-672.
44. Perez, L. G., M. A. O'Dnnnell, and E. B. Stephens. 1992. The transmembrane glycoprotein of human immunodeficiency virus type 1 induces syncytium formation in the absence of the receptor binding glycoprotein. J. Virol. 66:4134-4143.
45. Rhee, S. S., and J. W. Marsh. 1994. Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and gradation of surface CD4. J. Viral. 68:5156-5163.
46. + viruses but not for down-regulation of CD4. EMBO J. 14:484-491.
47. Sanfridson, A., B. R. Cullen, and C. Doyle. 1994. The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells. J. Biol. Chem. 269:3917-3920.
48. Sawai, E. T., A. S. Baur, B. M. Peterlin, J. A. Levy, and C. Cheng-Mayer. 1995. A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J. Biol. Chem. 270:15307-15314.
49. Sawai, E. T., A. Baur, H. Struble, B. M. Peterlin, J. A. Levy, and C. Cheng-Mayer. 1994. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc. Natl. Acad. Sci. USA 91:1539-1543.
50. Schwartz, O., A. Dautry-Varsat, B. Goud, V. Maréchal, A. Subtil, J.-M. Heard, and O. Danos. 1995. Human immunodeficiency virus Nef induces accumulation of CD4 in early endosomes. J. Virol. 69:528-533.
51. Schwartz, O., V. Maréchal, O. Danos, and J.-M. Heard. 1995. Human immunodeficiency virus type 1 Net increases the efficiency of reverse transcription in the infected cell. J. Virol. 69:4053-4059.
52. Spina, C. A., T. J. Kwoh, M. Y. Chowers, J. C. Guatelli, and D. D. Richman. 1994. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J. Exp. Med. 179:115-123.
53. Terwilliger, E., J. G. Sodroski, C. A. Rosen, and W. A. Haseltine. 1986. Effects of mutations within the 3′ orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity. J. Virol. 60:754-760.
54. Thali, M., A. Bukovsky, E. Kondo, B. Rosenwirth, C. Walsh, J. Sodroski, and H. G. Göttlinger. 1994. Functional association of cyclophilin A with HIV-1 virions. Nature (London) 372:363-365.
55. Yu, G., and R. L. Felsted. 1992. Effect of myristoylation on p27 nef subcellular distribution and suppression of HIV-LTR transcription. Virology 187: 46-55.
56. Zazopoulos, E., and W. A. Haseltine. 1992. Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function. Proc. Natl. Acad. Sci. USA 89:6634-6638.
57. Zazopoulos, E., and W. A. Haseltine. 1993. Effect of nef alleles on replication of human immunodeficiency virus type 1. Virology 194:20-27.
58. Zazopoulos, E., and W. A. Haseltine. 1993. Disulfide bond formation in the human immunodeficiency virus type 1 Nef protein. J. Virol. 67:1676-1680.