The positive influence of Nef on viral infectivity

Research in Virology

Volumn 148, Issue 1, 1997, Pages 34-37

  Guatelli, J C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEF PROTEIN;

HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; VIRUS CELL INTERACTION; VIRUS INFECTIVITY; VIRUS PATHOGENESIS;

EID: 0031057814     PISSN: 09232516     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2516(97)81910-3     Document Type: Conference Paper

References (34)

1. Ahmad, N. & Venkatesan, S. (1988), Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR. Science, 241, 1481-1485.
2. Aiken, C. & Trono, D. (1995), Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J. Virol., 69, 5048-5056.
3. Baur, A.S., Sawai, E.T., Dazin, P., Fantl, W.J., Cheng-Mayer, C. & Peterlin, B.M. (1994), HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1, 373-384.
4. Benson, R.E., Sanfridson, A., Ottinger, J.S., Doyle, C. & Cullen, B.R. (1993), Downregulation of cell-surface CD4 expression by simian immunodeficiency virus nef prevents viral super infection. J. Exp. Med., 177, 1561-1566.
5. Chowers, M.Y., Pandori, M.W., Spina, C.A., Richman, D.D. & Guatelli, J.C. (1995), The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology, 212, 451-457.
6. Chowers, M.Y., Spina, C.A., Kwoh, T.J., Fitch, N.J.S., Richman, D.D. & Guatelli, J.C. (1994), Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J. Virol., 68, 2906-2914.
7. Deacon, N.J., Tsykin, A., Solomon, A., Smith, K., Ludford-Menting, M., Hooker, D.J., McPhee, D.A., Greenway, A.L., Ellett, A., Chatfield, C., Lawson, V.A., Crowe, S., Maerz, A., Sonza, S., Learmont, J., Sullivan, J.S., Cunningham, A., Dwyer, D., Dowton, D. & Mills, J. (1995), Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science, 270, 988-991.
8. Du, Z., Lang, S.M., Sasseville, V.G., Lackner, A.A., Ilynskii, P.O., Daniel, M.D., Jung, J.U. & Desrosiers, R.C. (1995), Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell, 82, 655-674.
9. Freund, J., Kellner, R., Konvalinka, J., Wolber, V., Kräusslich, H.-G. & Kalbitzer, H.R. (1994), A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease. Eur. J. Blochem., 223, 589-593.
10. Gaedigk-Nitschko, K., Schön, A., Wachinger, G., Erfle, V. & Kohleisen, B. (1995), Cleavage of recombinant and cell derived human immunodeficiency virus 1 (HIV-1) Nef protein by HIV-1 protease. FEBS Lett., 357, 275-278.
11. Gallay, P., Swingles, S., Aiken, C. & Trono, D. (1995), HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Cell, 80, 379-388.
12. Garcia, J.V. & Miller, A.D. (1991), Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature (Lond.), 350, 508-511.
13. Goldsmith, M.A., Warmerdam, M.T., Atchison, R.E., Miller, M.D. & Greene, W.C. (1995), Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J. Virol., 69, 4112-4121.
14. Greenway, A., Azad, A. & McPhee, D. (1995), Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines. J. Virol., 69, 1842-1850.
15. Guy, B., Kieny, M.-P., Reviere, Y., La Peuch, C., Dott, K., Girand, M., Montagnier, L. & Lecocq, J.-P. (1987), HIV F/3'orf encodes a phosphorylase GTP-binding protein resembling an oncogene product. Nature (Lond.) 330, 266-269.
16. Ho, D.D., Neumann, A.U., Perelson, A.S., Chen, W., Leonard, J.M. & Markowitz, M. (1995), Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (Lond.) 373, 123-126.
17. Kestler H.W. III, Ringler, D.J., Mori, K., Panicali, D.L., Sehgal, P.K., Daniel, M.D. & Desrosiers, R.C. (1991). Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell, 65, 651-662.
18. Liu, H., Wu, X., Newman, M., Shaw, G.M., Hahn, B.H. & Kappes, J.C. (1995), The vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures. J. Virol., 69, 7630-7638.
19. Luria, S., Chambers, I. & Berg, P. (1991), Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA. Proc. Natl. Acad. Sci. USA, 88, 5326-5330.
20. Miller, M.D., Warmerdam, M.T., Gaston, I., Greene, W.C. & Feinberg, M.B. (1994), The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med., 179, 101-113.
21. Miller, M.D., Warmerdam, M.T., Page, K.A., Feinberg, M.B. & Greene, W.C. (1995), Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J. Virol., 69, 579-584.
22. Niederman, T.M.J., Thielan, B.J. & Ratner, L. (1989), Human immunodeficiency virus type 1 negative factor is a transcriptional silencer. Proc. Natl. Acad, Sci. USA, 86, 1128-1132.
23. Pandori, M.W., Fitch, N.J.S., Craig, H.M., Richman, D.D., Spina, C.A. & Guatelli, J.C. (1996), Producer-cell modification of human immunodeficiency virus type I: Nef is a virion protein. J. Virol., 70, 4283-4290.
24. Rhee, S.S. & Marsh, J.W. (1994), HIV-1 Nef activity in murine T cells. J. Immunol., 152, 5128-5134.
25. + viruses but not for down-regulation of CD4. EMBO J., 14, 484-491.
26. Sawai, E.T., Baur, A.S., Peterlin, M., Levy, J.A. & Cheng-Mayer, C. (1995), A conserved domain and membrane targeting of nef from HIV and SIV are required for association with a cellular serine kinase activity. J. Biol. Chem., 270, 15307-15314.
27. Swartz, O., Maréchal, V., Danos, O. & Heard, J.-M. (1995), Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell. J. Virol., 69, 4053-4059.
28. Shugars, D.C., Smith, M.S., Glueck, D.H., Nantermet, P.V., Seillier-Moiseiwitsch, F. & Swanstrom, R. (1993), Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo. J. Virol., 67, 4639-4650.
29. Skowronski, J., Parks, D. & Mariani, R. (1993), Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J., 12, 703-713.
30. Spina, C.A., Guatelli, J.C. & Richman, D.D. (1995). Establishment of a stable, inducible form of HIV-1 DNA in quiescent CD4 lymphocytes in vitro. J. Virol., 69, 2977-2988.
31. Spina, C.A., Kwoh, T.J., Chowers, M.Y., Guatelli, J.C. & Richman, D.D. (1994), The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J. Exp. Med., 179, 115-123.
32. Wei, X., Ghosh, S.K., Taylor, M.E., Jonson, V.A., Emini, E.A., Deutsch, P., Lifson, J.D., Bonhoeffer, S., Nowak, M.A., Hahn, B.H., Saag, M.S. & Shaw, G.M. (1995), Viral dynamics in human immunodeficiency virus type 1 infection. Nature (Lond.), 373, 117-122.
33. Yang, X., Goncalves, J. & Gabuzda, D.H. (1996), Phosphorylation of Vif and its role in HIV-1 replication. J. Biol. Chem., 27, 10121-10129.
34. Zack, J.A., Arrigo, S.J., Weitsman, S.R., Go, A.S., Haislip, A. & Chen, I.S.Y. (1990), HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell, 61, 213-222.