Nef and the Nef-associated kinase

Research in Virology

Volumn 148, Issue 1, 1997, Pages 47-52

  Sawai, E T ^a   Cheng Mayer, C ^b   Luciw, P A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AARON DIAMOND AIDS RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEF PROTEIN; PROTEIN KINASE;

ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS CELL INTERACTION; VIRUS PATHOGENESIS; VIRUS REPLICATION;

EID: 0031039875     PISSN: 09232516     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2516(97)81913-9     Document Type: Conference Paper

References (59)

1. Aiken, C., Konner, J., Landau, N.R., Lenburg, M.E. & Trono, D. (1994), Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell, 76, 853-864.
2. Anderson, S.J., Lenburg, M., Landau, N.R. & Garcia, J.V. (1994), The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef. J. Virol., 68, 3092-3101.
3. Bagrodia, S., Derijard, B., Davis, R.J. & Cerione, R.A. (1995), Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem., 270, 27995-27998.
4. Bandres, J.C. & Ratner, L. (1994), Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation. J. Virol., 68, 3243-3249.
5. Baur, A.S., Sawai, E.T., Dazin, P., Fantl, W.J., Cheng-Mayer, C. & Peterlin, B.M. (1994), HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity, 1, 373-384.
6. Benichou, S., Bomsel, M., Bodeus, M., Durand, H., Doute, M., Letourneur, F., Camonis, J. & Benarous, R. (1994), Physical interaction of the HIV-1 Nef protein with β-COP, a component of non-clathrin-coated vesicles essential for membrane traffic. J. Biol. Chem., 269, 30073-30076.
7. Bodeus, M., Marie-Cardine, A., Bougeret, C., Ramos-Morales, F. & Benarous, R. (1995), In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine-threonine protein kinase. J. Gen. Virol., 76, 1137-1344.
8. Bukrinskaya, A.G., Ghorpade, A., Heinzinger, N.K., Smithgall, T.E., Lewis, R.E. & Stevenson, M. (1996), Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. Proc. Natl. Acad. Sci. USA, 93, 367-371.
9. Chowers, M.Y., Spina, C.A., Kwoh, T.J., Fitch, N.J., Richman, D.D. & Guatelli, J.C. (1994), Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J. Virol., 68, 2906-2914.
10. Collette, Y., Dutartre, H., Benziane, A., Ramos-Morales, F. & Olive, D. (1996), Physical and functional interaction of Nef with Lck-HIV-1 Nef-induced T-cell signaling defects. J. Biol. Chem., 271, 6333-6341.
11. Cullen, B.R. (1994), The role of Nef in the replication cycle of the human and simian immunodeficiency viruses. Virology, 205, 1-6.
12. De, S.K. & Marsh, J.W. (1994), HIV-1 Nef inhibits a common activation pathway in NIH-3T3 cells. J. Biol. Chem., 269, 6656-6660.
13. Deacon, N.J., Tsykin, A., Solomon, A., Smith, K., Ludford-Menting, M., Hooker, D.J., McPhee, D.A., Greenway, A.L., Ellett, A., Chatfield, C., Lawson, V.A., Crowe, S., Maerz, A., Sonza, S., Learmont, J., Sullivan, J.S., Cunningham, A., Dwyer, D., Dowton, D. & Mills, J. (1995), Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science, 270, 988-991.
14. Du, Z., Lang, S.M., Sasseville, V.G., Lackner, A.A., Ilynskii, P.O., Daniel, M.D., Jung, J.U. & Desrosiers, R.C. (1995), Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell, 82, 665-674.
15. Franchini, G., Robert, G.M., Ghrayeb, J., Chang, N.T. & Wong, S.F. (1986), Cytoplasmic localization of the HTLV-III 3' orf protein in cultured T cells. Virology, 155, 593-599.
16. Freund, J., Kellner, R., Konvalinka, J., Wolber, V., Krausslich, H.G. & Kalbitzer, H.R. (1994). A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease. Eur. J. Biochem., 223, 589-593.
17. Gallay, P., Swingler, S., Aiken, C. & Trono, D. (1995a). HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Cell, 80, 379-388.
18. Gallay, P., Swingler, S., Song, J., Bushman, F. & Trono, D. (1995b), HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell, 83, 569-576.
19. Garcia, J.V. & Miller, A.D. (1991), Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature (Lond.) 350, 508-11.
20. Greenway, A., Azad, A. & McPhee, D. (1995), Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines. J. Virol., 69, 1842-1850.
21. Grzesiek, G., Bax, A., Clore, G.M., Gronenborn, A.M., Hu, J.S., Kaufman, J., Palmer, I., Stahl, S.J. & Wingfield, P.T. (1996), The solution structure of HIV-1 nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of hck tyrosine protein kinase. Nature Med., 3, 340-345.
22. Guy, B., Kieny, M.P., Rivière, Y., Le Peuch, C., Dott, K., Girard, M. & Montagnier, L. (1987), HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature (Lond.) 330, 266-269.
23. Guy, B., Rivière, Y., Dott, K., Regnault, A. & Kieny, M.P. (1990), Mutational analysis of the HIV nef protein. Virology, 176, 413-425.
24. Harris, M.P. & Neil, J.C. (1994), Myristoylation-dependent binding of HIV-1 Nef to CD4. J. Mol. BIol., 241, 136-142.
25. Huang, Y., Zhang, L. & Ho, D.D. (1995), Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J. Virol., 69, 93-100.
26. Jamieson, B.D., Aldrovandi, G.M., Planelles, V., Jowett, J.B., Gao, L., Bloch, L.M., Chen, I.S. & Zack, J.A. (1994), Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J. Virol., 68, 3478-3485.
27. Kestler, H.W., Ringler, D.J., Mon, K., Panicali, D.L., Sehgal, P.K., Daniel, M.D. & Desrosiers, R.C. (1991), Importance of the nef gene for maintenance of high virus loads and for the development of AIDS. Cell, 65, 651-662.
28. Kirchhoff, F., Greenough, T.C., Brettler, D.B., Sullivan, J.L. & Desrosiers, R.C. (1995), Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N. Engl. J. Med., 332, 228-232.
29. Lee, C.H., Leung, B., Lemmon, M.A., Zheng, J., Cowburn, D., Kuriyan, J. & Saksela, K. (1995), A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HPV-1 Nef protein. EMBO J., 14, 5006-5015.
30. Lee, C.H., Saksela, K., Mirza, U.A., Chait, B.T. & Kuriyan, J. (1996), Crystal structure of the conserved core of HIV-1 Nef complexed with a src-family SH3 domain. Cell, 85, 981-992.
31. Luciw, P.A., Cheng-Mayer, C. & Levy, J.A. (1987), Mutational analysis of the human immunodeficiency virus : the orf-B region down-regulates virus replication. Proc. Natl. Acad. Sci. USA, 84, 1434-8.
32. Luria, S., Chambers, I. & Berg, P. (1991), Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA. Proc. Natl. Acad. Sci. USA, 88, 5326-5330.
33. Manser, E., Leung, T., Salihuddin, H., Zhao, Z.S. & Lim, L. (1994), A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367, 40-46.
34. Mariani, R. & Skowronski, J. (1993), CD4 down-regulation by nef alleles isolated from HIV-1 infected individuals. Proc. Natl. Acad. Sci. USA, 90, 5549-5553.
35. Martin, G. A., Bollag, G., McCormick, F. & Abo, A. (1995), A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J., 14, 1970-1978.
36. Matsuura, Y., Maekawa, M., Hattori, N., Ikegami, N., Hayashi, A., Yamazaki, S., Morita, C. & Takebe, Y. (1991), Purification and characterization of human immunodeficiency virus type 1 nef gene product expressed by a recombinant baculovirus. Virology, 184, 580-586.
37. Miller, M.D., Warmerdam, M.T., Gaston, I., Greene, W.C. & Feinberg, M.B. (1994), The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med., 179, 101-113.
38. Miller, M.D., Warmerdam, M.T., Page, K.A., Feinberg, M.B. & Greene, W.C. (1995), Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HTV-I production increases progeny particle infectivity independently of gp160 or viral entry. J. Virol., 69, 579-584.
39. Nebreda, A.R., Bryan, T., Segade, F., Wingfield, P., Venkatesan, S. and Santos, E. (1991), Biochemical and biological comparison of HIV-1 NEF and ras gene products. Virology, 183, 151-159.
40. Niederman, T.M.J., Randall-Hastings, W. & Ratner, L. (1993), Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix. Virology, 197, 420-425.
41. Nunn, M.F. & Marsh, J.W. (1996), Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family. J. Virol., 70, 6157-6161.
42. Ratner, L. & Niederman, T.M.J. (1995), Nef. Curr. Topics Micro. Immunol., 193, 169-208.
43. Rossi, F., Gallina, A. & Milanesi, G. (1996), Nef-CD4 physical interaction sensed with the yeast two-hybrid system. Virology 217(1), 397-403.
44. Rud, E.W., Cranage, M., Yon, J., Quirk, J., Ogilvie, L., Cook, N., Webster, S., Dennis, M. & Clarke, B.E. (1994), Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants. J. Gen. Virol., 75, 529-543.
45. Saksela, K., Cheng, G. & Baltimore, D. (1995), Prolinerich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J., 14, 484-491.
46. Sanfridson, A., Cullen, B.R. & Doyle, C. (1994), The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells. J. Biol. Chem., 269, 3917-3920.
47. Sawai, E.T., Baur, A.S., Peterlin, B.M., Levy, J.A. & Cheng-Mayer, C. (1995), A conserved domain and membrane targeting of Nef from HIV and SIV are requried for association with a cellular serine kinase activity. J. Biol. Chem., 270, 15, 307-15, 314.
48. Sawai, E.T., Baur, A., Struble, H., Peterlin, B.M., Levy, J.A. & Cheng-Mayer, C. (1994), Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc. Natl. Acad. Sci. USA, 91, 1539-1543.
49. Sawai, E.T., Khan, I.H., Montbriand, P., Cheng-Mayer, C. & Luciw, P.A. (1996), Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques. Current Biology, 6, 1519-1527.
50. Schwartz, O., Marechal, V., Legall, S., Lemonnier, F. & Heard, J.M. (1996), Endocytosis of major histocompatibility complex class i molecules is induced by the HIV-1 Nef protein. Nature Med., 2, 338-342.
51. Skowronski, J., Parks, D. & Mariani, R. (1993), Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J., 12, 703-713.
52. Spina, C.A., Kwoh, T.J., Chowers, M.Y., Guatelli, J.C. & Richman, D.D. (1994), The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J. Exp. Med., 179, 115-123.
53. Trono, D. (1995), HIV accessory proteins: leading roles for the supporting cast. Cell, 82, 189-192.
54. Welker, R., Kottler, H., Kalbitzer, H.R. & Krausslich, H.G. (1996), Human immunodeficiency virus type 1 nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase. J. Virol., 219, 228-236.
55. Whatmore, A.M., Cook, N., Hall, G.A., Sharpe, S., Rud, E.W. & Cranage, M.P. (1995), Repair and evolution of nef in vivo modulates simian immunodeficiency virus virulence. J. Virol., 69, 5117-5123.
56. Wolber, V., Rensland, H., Brandmeier, B., Sagemann, M., Hoffmann, R., Kalbitzer, H.R. & Wittinghofer, A. (1992), Expression, purification and biochemical charactirization of the human immunodeficiency virus 1 nef gene product. Eur. J. Biochem., 205, 1115-1121.
57. Yu, G. & Felsted, R.L. (1992), Effect of myristoylation on p27 nef subcellular distribution and suppression of HIV-LTR transcription. Virology, 187, 46-55.
58. Zazopoulos, E. & Haseltine, W.A. (1993), Bisulfide bond formation in the human immunodeficiency virus type 1 Nef protein. J. Virol., 67, 1676-1680.
59. Zhang, S., Han, J., Sells, M.A., Chernoff, J., Knaus, U.C., Ulevitch, R.J. & Bokoch, G.M. (1995), Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem., 270, 23934-23936.