Persistence of pathogenic challenge virus in macaques protected by simian immunodeficiency virus SIVmacΔnef

Journal of Virology

Volumn 75, Issue 3, 2001, Pages 1507-1515

  Khatissian, E ^a   Monceaux, V ^a   Cumont, M C ^a   Kieny, M P ^a   Aubertin, A M ^a   Hurtrel, B ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; NEF PROTEIN; PROTEIN P27; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE; UNCLASSIFIED DRUG; VIRUS VACCINE SIVMAC251 DELTA NEF;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE INACTIVATION; IMMUNE RESPONSE; MACACA; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINATION; VIRUS ISOLATION; VIRUS LOAD; VIRUS RECOMBINATION;

ANIMALS; ANTIGENS, VIRAL; GENES, NEF; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; MACACA MULATTA; RECOMBINATION, GENETIC; SAIDS VACCINES; SIMIAN IMMUNODEFICIENCY VIRUS; TERMINAL REPEAT SEQUENCES; VACCINATION; VIRUS REPLICATION;

EID: 0035152286     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.3.1507-1515.2001     Document Type: Article

References (73)

1. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
2. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis
3. Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells
4. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques
5. Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation
6. Transmission of human immunodeficiency type 1 viruses with intersubtype recombinant long terminal repeat sequences
7. Protection from HIV-1 envelope-bearing chimeric simian immunodeficiency virus (SHIV) in rhesus macaques infected with attenuated SIV: Consequences of challenge
8. Recombination in HIV: An important viral evolutionary strategy
9. Limited viral spread and rapid immune response in lymph nodes of macaques inoculated with attenuated simian immunodeficiency virus
10. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
11. Hiv-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
12. Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus
13. Human immunodeficiency virus type 1 subtypes defined by env show high frequency of recombinant gag genes. The UNAIDS Network for HIV isolation and characterization
14. Macaques infected with live attenuated SIVmac are protected against superinfection via the rectal mucosa
15. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
16. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques
17. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
18. Cellular immune response of rhesus monkeys infected with a partially attenuated nef deletion mutant of the simian immunodeficiency virus
19. Protection of SIVmac-infected macaque monkeys against superinfection by a simian immunodeficiency virus expressing envelope glycoproteins of HIV type 1
20. Evolution of a simian immunodeficiency virus pathogen
21. Serine phosphorylation-independent downregulation of cell-surface CD4 by Nef
22. Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1
23. The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
24. Env-independent protection reduced by live, attenuated simian immunodeficiency virus vaccines
25. Zeta chain of the T-cell receptor interacts with Nef of simian immunodeficiency virus and human immunodeficiency virus type 2
26. Retroviral recombination and reverse transcription
27. Biological characterization of nef in long-term survivors of human immunodeficiency virus type 1 infection
28. Towards an HIV-1 vaccine: Lessons from studies in macaque models
29. Identification of a sequence element immediately upstream of the polypurine tract that is essential for replication of simian immunodeficiency virus
30. High rate of recombination throughout the human immunodeficiency virus type 1 genome
31. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
32. Importance of the nef gene for maintenance of high virus loads and for development of AIDS
33. Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
34. Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene
35. Cloning of HTLV-4 and its relation to simian and human immunodeficiency viruses
36. Implication of the C-terminal domain of Nef protein in the reversion to pathogenicity of attenuated SIVmacBK28-41 in macaques
37. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
38. Limited protection from a pathogenic chimeric simian-human immunodeficiency virus challenge following immunization with attenuated simian immunodeficiency virus
39. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge
40. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination
41. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection
42. Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
43. +-T-cell proliferative responses in rhesus macaques that were transiently viremic after intravaginal inoculation of SIV
44. Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression
45. Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239
46. Mosaic structure of the human immunodeficiency virus type 1 genome infecting lymphoid cells and the brain: Evidence for frequent in vivo recombination events in the evolution of regional populations
47. Protection from pathogenic SIVmac challenge following short-term infection with a nef-deficient attenuated virus
48. Characterization of a highly replicative intergroup M/O human immunodeficiency virus type 1 recombinant isolated from a Cameroonian patient
49. Reactivation of human immunodeficiency virus type 2 in macaques after simian immunodeficiency virus SIVmac superinfection
50. Sequences just upstream of the simian immunodeficiency virus core enhancer allow efficient replication in the absence of NF-κB and Sp1 binding elements
51. Long-term protection against SIV-induced disease in macaques vaccinated with a live attenuated HIV-2 vaccine
52. The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus
53. Recombination in AIDS viruses
54. Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants
55. Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor
56. The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells
57. Activation of PAK by HIV and SIV Nef: Importance for AIDS in rhesus macaques
58. Control of viremia in simian immunodeficiency virus infection by CD8(+) lymphocytes
59. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell
60. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
61. Live, Attenuated simian immunodeficiency virus vaccines elicit potent resistance against a challenge with a human immunodeficiency virus type 1 chimeric virus
62. Statistical analysis of sparse infection data and its implications for retroviral treatment trials in primates
63. Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus
64. Mechanisms of protection induced by attenuated simian immunodeficiency virus I-lymphocyte depletion does not abrogate protection
65. Evidence of Nef truncation in human immunodeficiency virus type 2 infection
66. Phylogenetic analysis of HIV type 2 in Ghana and intra-subtype recombination in HIV type 2
67. Live attenuated simian immunodeficiency virus prevents super-infection by cloned SIVmac251 in cynomolgus monkeys
68. Repair and evolution of nef in vivo modulates simian immunodeficiency virus virulence
69. Direct demonstration of retroviral recombination in a rhesus monkey
70. Protection by live, attenuated simian immunodeficiency virus against heterologous challenge
71. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus
72. Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus
73. Retrovirus recombination depends on the length of sequence identity and is not error prone