Effects of the exogenous Nef protein on HIV-1 target cells

Cell Biochemistry and Function

Volumn 17, Issue 3, 1999, Pages 183-192

  Pugliese, Agostino ^a   Cantamessa, Carla ^b   Saini, Andrea ^b   Piragino, Alessandra ^b   Gennero, Luisa ^b   Martini, Caterina ^a   Torre, Donato ^b  

^a AMEDEO DI SAVOIA HOSPITAL   (Italy)

^b NONE

Author keywords

CD4; CD71; Fibronectin (FN); Interferons (IFNs); Nef protein; T lymphocytes

Indexed keywords

ALPHA INTERFERON; CD4 ANTIGEN; CD71 ANTIGEN; GAMMA INTERFERON; NEF PROTEIN; RECOMBINANT PROTEIN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BLOOD; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION SENSITIVITY; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TARGET CELL; VIRUS REPLICATION;

ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CELL DIVISION; FIBRONECTINS; GENE PRODUCTS, NEF; HIV-1; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; RECEPTORS, TRANSFERRIN; RECOMBINANT PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0032841195     PISSN: 02636484     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0844(199909)17:3<183::AID-CBF827>3.0.CO;2-R     Document Type: Article

References (14)

1. Haseltine, W. C. (1992). Molecular biology of the AIDS virus: ten years of discovery Hope for the future. In: Science Challenging AIDS. (Gilardo, G., ed.). Karger: Basel (Switzerland), pp. 71-106.
2. Pugliese, A., Comito, G., Savarino, A., Cantamessa, C. and Torre, D. (1996). Expression of fibronectin and its receptor in some tumor cell lines and in HIV-1 infected cells. Cell Biochem. Function, 14, 105-110.
3. Huang, Y., Zhang, I. and Ho, D. D. (1995). Biological characterization of nef in long-term survivors of HIV-1 infection. Nature, 373, 123-126.
4. Greenway, A., Azard, A., Millis, J. and McOhee, D. (1996). Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity. J. Virology, 70, 6701-6708.
5. Pugliese, A., Savarino, A., Cantamessa, C. and Torre, D. (1996). Influence of fibronectin on HIV-1 infection and capability of binding to platelets. Cell Biochem. Function. 14, 291-296.
6. Cano, E., Pizzarro, A. and Fresno, M. (1990). Induction of T cell activation by monoclonal antibodies specific for transferrin receptor. Eur. J. Immunol., 20, 765-770.
7. Pauwels, R., De Clerq, E., Desmyter, J., Balzarini, J., Goubau, P. and Herdewijn, P. (1987). Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus. J. Virol. Methods, 16, 171-185.
8. Pugliese, A., Biglino, A., Uslenghi, C., Martinelli, L., Forno, B. and Girardello, R. (1992). Evaluation of the effect of pidotimod on the immune system. Int. J. Immunotherapy, 8, 212-219.
9. Pugliese, A., Uslenghi, C., Torre, D., D'Alonzo, L. and Corgnati, F. (1995). Evaluation of the effect of pidotimod on the in vitro production of interferons. Int. J. Immunotherapy, 11, 71-76.
10. Gorczyca, W., Bigman, K., Mittelman, A., Ahmed, T., Gong, J., Melamed, M. and Darynkiewicz, Z. (1993). Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia, 7, 659-670.
11. Torres, B. A., Tanabe, T. and Johnson, H. M. (1996). Characterization of Nef-induced CD4 T-cell proliferation. Biochem. Biophys. Res. Commun., 225(1), 54-61.
12. Fujii, Y., Otake, K., Taschiro, M. and Adachi, A. (1996). Soluble Nef antigen of HIV-1 is cytotoxic for human CD4(+) T cells. Biochem. Biophys., 393, 93-96.
13. Collins, K. L., Chen, B. K., Kalams, S. A., Walker, B. D. and Baltimore, W. (1998). HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T-lymphocytes. Nature, 391, 397-401.
14. Murphy, K. M., Sweet, M. J., Ross, I. L. and Hume, D. A. (1993). Effects of the tat and nef gene products of human immunodeficiency virus type I (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages. J. Virol, 67, 6956-6964.