Vaccine protection by a triple deletion mutant of simian immunodeficiency virus

Journal of Virology

Volumn 70, Issue 6, 1996, Pages 3724-3733

  Wyand, Michael S ^a   Manson, Kelledy H ^a   Garcia Moll, Maria ^c   Montefiori, David ^d   Desrosiers, Ronald C ^b  

^a TSI Mason Laboratories   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Bio Molec Technology Inc   (United States)

^d DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIMIAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; INFECTION CONTROL; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

EID: 0029951823     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.6.3724-3733.1996     Document Type: Article

References (44)

1. Ahmad, S., B. Lohman, M. Marthas, L. Giavedoni, Z. El-Amad, N. L. Haigwood, C. J. Scandella, M. B. Gardner, P. A. Luciw, and T. Yilma. 1994. Reduced virus load in rhesus macaques immunized wilh recombinant gp160 and challenged with simian immunodeficiency virus. AIDS Res. Hum. Retroviruses 19:195.
2. Almond, N., K. Kent, M. Cranage, E. Rud, B. Clarke, and E. J. Stott. 1995. Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells. Lancet 345:1342-1344.
3. Arthur, L. O., J. W. Bess, Jr., R. G. Urban, J. L. Strominger, W. R. Morton. D. L. Mann, L. E. Henderson, and R. E. Benveniste. 1995. Macaques immunized with HLA-DR are protected from simian immunodeficiency virus challenge. J. Virol. 69:3117-3124.
4. Burns, D. P. W., C. Collignon, and R. C. Desrosiers. 1993. Simian immunodeficiency virus mutants resistant to serum neutralization arise during persistent infection of rhesus monkeys. J. Virol. 67:4104-4113.
5. Clerici, M., E. A. Clark, P. Polacino, I. Axberg, L. Kuller, N. I. Casey, W. R. Morton, G. M. Shearer, and R. E. Benveniste. 1994. T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques. AIDS 8:1391-1395.
6. Cranage, M. P., N. Polyanskaya, B. McBride, N. Cook, L. A. E. Ashworth, M. Dennis, A. Baskerville, P. J. Greenaway, T. Corcoran, P. Kitchin, J. Rose, M. Murphey-Corb, R. C. Desrosiers, E. J. Stott, and G. H. Farrar. 1993. Studies on the specificity of the vaccine effect elicited by inactivated simian immunodeficiency virus. AIDS Res. Hum. Retroviruses 9:13-22.
7. Daniel, M. D., F. Kirchhof, S. C. Czajak, P. K. Sehgal, and R. C. Desrosiers. 1992. Protective effects of a live-attenuated SIV vaccine with a deletion in the nef gene. Science 258:1938-1941.
8. Daniel, M. D., N. L. Letvin, P. K. Sehgal, G. Hunsmann, D. K. Schmidt, N. W. King, and R. C. Desrosiers. 1987. Long-term persistent infection of macaque monkeys with the simian immunodeficiency virus. J. Gen. Virol. 68:3183-3189.
9. Daniel, M. D., G. P. Mazzara, M. A. Simon, P. K. Sehgal, T. Kodama, D. L. Panicali, and R. C. Desrosiers. 1994. High tiler immune responses elicited by recombinant vaccinia virus priming and particle boosting are ineffective in prevent-ing virulent SIV infection. AIDS Res. Hum. Retroviruses 10:839-851.
10. Daniel, M. D., P. K. Sehgal, T. Kodama, M. S. Wyand, D. J. Ringler, N. W. King, D. K. Schmidt, C. D. Troup, and R. C. Desrosiers. 1990. Use of simian immunodeficiency virus for vaccine research. J. Med. Primatol. 19:395-399.
11. Desrosiers, R. 1994. Yes, it is time to consider use of a live-attenuated virus vaccine against HIV-1. NIH Res. 6:54-59.
12. Desrosiers, R. C. 1990. The simian immunodeficiency viruses. Annu. Rev. Immunol. 8:557-578.
13. Desrosiers, R. C. 1992. HIV with multiple gene deletions as a live attenuated vaccine for AIDS. AIDS Res. Hum. Retroviruses 8:411-421.
14. Desrosiers, R. C. 1995. Non-human primate models for AIDS vaccines. AIDS 9(Suppl. A):S137-S141.
15. Desrosiers, R. C., M. D. Daniel, M. S. Wyand, and L. O. Arthur. 1995. A radical strategy for development of a vaccine against HIV-1, p. 205-209. In M. Girard and L. Valette (ed.), Retroviruses of human AIDS and related animal diseases. Foundation Marcel Merieux, Lyon, France.
16. Desrosiers, R. C., M. S. Wyand, T. Kodama, D. J. Ringler, L. O. Arthur, P. K. Sehgal, N. L. Letvin, N. W. King, and M. D. Daniel. 1989. Vaccine protection against simian immunodeficiency virus infection. Proc. Natl. Acad. Sci. USA 86:6353-6357.
17. Giavedoni, L. D., V. Flanelles, N. L. Haigwood, S. Ahmad, I. D. Kluge, M. L. Marthas, M. B. Gardner, P. A. Luciw, and T. D. Yilma. 1993. Immune response of rhesus macaques to recombinant simian immunodeficiency virus gp130 does not protect from challenge infection. J. Virol. 67:577-583.
18. Gibbs, J. S., and R. C. Desrosiers. 1993. Auxiliary proteins of the primate immunodeficiency viruses, p. 137-158. In B. R. Cullen (ed.), Human retroviruses: frontiers in molecular biology. Oxford University Press, London.
19. Gibbs, J. S., A. A. Lackner, S. M. Lang, M. A. Simon, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1995. Progression to AIDS in the absence of genes for vpr or vpx. J. Virol. 69:2378-2383.
20. Gibbs, J. S., D. A. Regier, and R. C. Desrosiers. 1994. Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes. AIDS Res. Hum. Retroviruses 10:343-350.
21. Griffin, D. E. 1995. Roles and reactivities of antibodies to alphaviruses. Virology 6:249-255.
22. Hirsch, V. M., T. R. Fuers, G. Slitter, M. W. Carroll, L. C. Yang, S. Goldstein, M. Piatak, W. R. Elkins, D. C. Monteflori, B. Moss, and J. D. Lifson. 1996. Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. J. Virol. 70:3741-3752.
23. Hoch, J., S. M. Lang, M. Weeger, C. Slahl-Hennig, C. Coulibaly, U. Dittmer, G. Hunsmann, D. Fuchs, J. Muller, S. Sopper, B. Fleckenstein, and K. T. Liberia. 1995. vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys. J. Virol. 69:4807-4813.
24. Hu, S.-L., K. Abrans, G. N. Barber, P. Moran, J. M. Zarling, A. J. Langlois, L. Kuller, W. R. Morton, and R. E. Benveniste. 1992. Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160. Science 255:456-459.
25. Ilyinstdi, P. O., M. D. Daniel, M. A. Simon, A. A. Lackner, and R. C. Desrosiers. 1994. The role of upstream U3 sequences in the pathogenesis of simian immunodeficiency virus-induced AIDS in rhesus monkeys. J. Virol. 68:5933-5944.
26. Ilyinskii, P. O., and R. C. Desrosiers. 1996. Efficient transcription and replication of simian immunodeficiency virus in the absence of NF-κB and Sp1 binding elements. J. Virol. 70:3118-3126.
27. Israel, Z. R., P. F. Edmonson, D. H. Maul, S. P. O'Neil, S. P. Mossman, C. Thiriart, L. Fabry, O. V. Opstal, C. Bruck, F. Bex, A. Burny, P. Fultz, J. I. Mullins, and E. A. Hoover. 1994. Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines. J. Virol. 68:1843-1854.
28. 27a.Johnson, R. P. Personal communication.
29. Kestler, H. W., III, D. J. Ringler, K. Mori, D. L. Panicali, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for the development of AIDS. Cell 65:651-662.
30. Kirchhoff, F., H. W. Kestler III, and R. C. Desrosiers. 1994. Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene. J. Virol. 68:2031-2037.
31. Lang, S. M., M. Weeger, C. Stahl-Henning, C. Coulibaly, G. Hunsmann, J. Müller, H. Müller-Hermelink, D. Fuchs, H. Wachter, M. D. Daniel, R. C. Desrosiers, and B. Fleckenstein. 1993. The importance of vpr for the infection of rhesus monkeys with simian immunodeficiency virus. J. Virol. 67:902-912.
32. Lewis, M. G., S. Bellah, K. McKinnon, J. Yalley-Ogunro, P. M. Zack, W. R. Elkins, R. C. Desrosiers, and G. E. Eddy. 1994. Titration and characterization of two rhesus derived SIVmac challenge stocks. AIDS Res. Hum. Retroviruses 10:213-220.
33. Miller, C. J., M. Marthas, J. Torten, N. J. Alexander, J. P. Moore, G. F. Doncel, and A. G. Hendrickx. 1994. Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia. J. Virol. 68:6391-6400.
34. Mills, K. H. G., M. Page, P. Kitchin, L. Chan, W. Jones, P. Silvera, T. Corcoran, B. Flanagan, C. Ling, C. Thiriart, M. DeWilde, C. Bruck, E. Rud, B. Clark, and E. J. Stott. 1993. Immunisation of macaques with SIV env recombinants: specificity of T cell and antibody responses and evaluation of protective efficacy. J. Med. Primatol. 22:104-109.
35. Mori, K., D. J. Ringler, and R. C. Desrosiers. 1993. Restricted replication of simian immunodeficiency virus strain 239 in macrophages is determined hy env but is not due to restricted entry. J. Virol. 67:2807-2814.
36. Mori, K., D. J. Ringler, T. Kodama, and R. C. Desrosiers. 1992. Complex determinants of macrophage tropism in env of simian immunodeficiency virus. J. Virol. 66:2067-2075.
37. Pauza, D., P. Trivedi, E. Johnson, K. K. Meyer, D. N. Streblow, M. Malkovsky, P. Emau, K. T. Schultz, and M. S. Salvato. 1993. Acquired resistance to mucosal SIV infection after low dose intrarectal inoculation: the roles of virus selection and CD8-mediated T cell immunity, p. 151-156. In M. Girard and L. Valette (ed.), Retroviruses of human A.I.D.S. and related animal diseases. Foundation Marcel Mcrieux, Lyon, France.
38. Pincus, S. H., R. Cole, R. Ireland, F. McAtee, R. Fujisawa, and J. Portis. 1995. Protective efficacy of nonneutralizing monoclonal antibodies in acute infection with murine leukemia virus. J. Virol. 69:7152-7158.
39. 37a.Ringler, D., D. Walsh, M. Daniel, and R. C. Desrosiers. Unpublished data.
40. Schlienger, K., D. C. Montefiori, M. Mancini, Y. Riviere, P. Tiollais, and M. Michel. 1994. Vaccine-induced neutralizing antibodies directed in part to the simian immunodeficiency virus (SIV) V2 domain were unable to protect rhesus monkeys from SIV experimental challenge. J. Virol. 68:6578-6588.
41. Shafferman, A., P. B. Jahrling, R. E. Benveniste, M. G. Lewis, T. J. Phipps, F. Eden-McCutchan, J. Sadoff, G. A. Eddy, and D. S. Burke. 1991. Protection of macaques with a simian immunodeficiency virus envelope peptide vaccine based on conserved human immunodeficiency virus type 1 sequences. Proc. Natl. Acad. Sci. USA 88:7126-7130.
42. Stahl-Hennig, C., G. Voss, U. Dittmer, C. Coulibaly, H. Petry, B. Makoschey. M. P. Cranage, A. M. Aubertin, W. Lüke, and G. Hunsmann. 1993. Protection of monkeys by a split vaccine against SIVmac depends upon biological properties of the challenge virus. AIDS 7:787-795.
43. Stott, E. J., P. A. Kitchin, M. Page, B. Flanagan, L. F. Taffs, W. L. Chan, K. H. G. Millis, P. Silvera, and A. Rodgers. 1991. Anti-cell antibody in macaques. Nature 353:393.
44. Trono, D. 1995. HIV accessory proteins: leading roles for the supporting cast. Cell 82:189-192.