HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system

Journal of Immunology

Volumn 163, Issue 3, 1999, Pages 1237-1245

  Koedel, Uwe ^a   Kohleisen, Birgit ^b   Sporer, Bernd ^a   Lahrtz, Fritz ^c   Ovod, Vladimir ^c   Fontana, Adriano ^d   Erfle, Volker ^b   Pfister, Hans Walter ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 160; INTERLEUKIN 6; MONOCLONAL ANTIBODY; NEF PROTEIN; NEUROTOXIN; TUMOR NECROSIS FACTOR ALPHA; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; ASTROCYTOMA CELL; CARBOXY TERMINAL SEQUENCE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEAT TREATMENT; HUMAN IMMUNODEFICIENCY VIRUS 1; MALE; MONONUCLEAR CELL; NEUROPATHOLOGY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THERMOSTABILITY;

ANIMALS; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; CISTERNA MAGNA; DIFFUSION CHAMBERS, CULTURE; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GENE PRODUCTS, NEF; HIV-1; HUMANS; INJECTIONS; INTERFERON TYPE II; INTERLEUKIN-6; LEUKOCYTE COUNT; LEUKOCYTES, MONONUCLEAR; MALE; NEUTROPHILS; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033179226     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. Michaels, J., L. R. Sharer, and L. G. Epstein. 1988. Human immunodeficiency virus type 1 (HIV-1) infection of the nervous system: a review. Immunodefic. Rev. 1:71.
2. Wiley, C. A., M. Baldwin, and C. L. Achim. 1996. Expression of HIV regulatory and structural mRNA in the central nervous system. AIDS 10:843.
3. Gray, F., F. Scaravilli, I. Everall, F. Chretien, S. An, D. Boche, H. Adle-Biassette, L. Wingertsmann, M. Durigon, B. Hurtrel, et al. 1996. Neuropathology of early HIV-1 infection. Brain Pathol. 6:1.
4. Sharer, L. R., Y. Saito, A. da-Cunha, P. C. Ung, H. A. Gelbard, L. G. Epstein, and B. M. Blumberg. 1996. In situ amplification and detection of HIV-1 DNA in fixed pediatric AIDS brain tissue. Hum. Pathol. 27:614.
5. Brack-Werner, R., A. Kleinschmidt, A. Ludvigsen, W. Mellert, M. Neumann, R. Herrmann, M. C. Khim, A. Burny, N. Muller-Lantzsch, D. Stavrou, et al. 1992. Infection of human brain cells by HIV-1: restricted virus production in chronically infected human glial cell lines. AIDS 6:273.
6. Cheng-Mayer, C., J. T. Rutka, M. L. Rosenblum, T. McHugh, D. P. Stites, and J. A. Levy. 1987. Human immunodeficiency virus can productively infect cultured human glial cells. Proc. Natl. Acad. Sci. USA 84:3526.
7. Dewhurst, S., K. Sakai, J. Bresser, M. Stevenson, M. J. Evinger-Hodges, and D. J. Volsky. 1987. Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV. J. Virol. 61:3774.
8. Neumann, M., B. K. Felber, A. Kleinschmidt, B. Froese, V. Erfle, G. N. Pavlakis, and R. Brack-Werner. 1995. Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function. J. Virol. 69:2159.
9. Tornatore, C., K. Meyers, W. Atwood, K. Conant, and E. Major. 1994. Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes. J. Virol. 68:93.
10. Tornatore, C., R. Chandra, J. R. Berger, and E. O. Major. 1994. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 44: 481.
11. Saito, Y., L. R. Sharer, L. G. Epstein, J. Michaels, M. Mintz, M. Louder, K. Golding, T. A. Cvetkovich, and B. M. Blumberg. 1994. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 44:474.
12. + channels. AIDS 5:1301.
13. Klotman, M. E., S. Kim, A. Buchbinder, A. DeRossi, D. Baltimore, and F. Wong-Staal. 1991. Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc. Natl. Acad. Sci. USA 88:5011.
14. Kestler, H. W., III, D. J. Ringler, K. Mori, D. L. Panicali, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651.
15. Glass, J. D., H. Fedor, S. L. Wesselingh, and J. C. McArthur. 1995. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann. Neurol. 38:755.
16. Gallo, P., K. Frei, C. Rordorf, I. Lazdins, B. Tavolato, and A. Fontana. 1989. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. J. Neuroimmunol. 23: 109.
17. Sasseville, V. G., M. M. Smith, C. R. Mackay, D. R. Pauley, K. G. Mansfield, D. J. Ringler, and A. A. Lackner. 1996. Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis. Am. J. Pathol. 149:1459.
18. Schmidtmayerova, H., H. S. Nottet, G. Nuovo, T. Raabe, C. R. Flanagan, L. Dubrovsky, H. E. Gendelman, A. Cerami, M. Bukrinsky, and B. Sherry. 1996. Human immunodeficiency virus type 1 infection alters chemokine β peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc. Natl. Acad. Sci. USA 93:700.
19. Achim, C. L., M. P. Heyes, and C. A. Wiley. 1993. Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains. J. Clin. Invest. 91:2769.
20. Lafrenie, R. M., L. M. Wahl, J. S. Epstein, I. K. Hewlett, K. M. Yamada, and S. Dhawan. 1996. HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes. J. Immunol. 157:974.
21. Pfister, H. W., K. Frei, B. Ottnad, U. Koedel, A. Tomasz, and A. Fontana. 1992. Transforming growth factor β2 inhibits cerebrovascular changes and brain edema formation in the tumor necrosis factor α-independent early phase of experimental pneumococcal meningitis. J. Exp. Med. 176:265.
22. Koedel, U., A. Bernatowicz, R. Paul, K. Frei, A. Fontana, and H.-W. Pfister. 1995. Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide. Ann. Neurol. 37:313.
23. Koedel, U., A. Bernatowicz, K. Frei, A. Fontana, and H.-W. Pfister. 1996. Systemically (but not intrathecally) administered IL-10 attenuates pathophysiologic alterations in experimental pneumococcal meningitis. J. Immunol. 157:5185.
24. Koedel, U., and H.-W. Pfister. 1997. Protective eflect of the antioxidant N-acetyl-L-cysteine in pneumococcal meningitis in the rat. Neurosci. Lett. 225:33.
25. Frei, K., D. Nadal, and A. Fontana. 1990. Intracerebral synthesis of tumor necrosis factor-α and interleukin-6 in infectious meningitis. Ann. NY Acad. Sci. 594:326.
26. Frei, K., U. V. Malipiero, T. P. Leist, R. M. Zinkernagel, M. E. Schwab, and A. Fontana. 1989. On the cellular source and function of interleukin-6 produced in the central nervous system in viral diseases. Eur. J. Immunol. 19:689.
27. Cuzzocrea, S., A. Tailor, B. Zingarelli, A. L. Salzman, R. J. Flower, C. Szabo, and M. Perretti. 1997. Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration. J. Immunol. 159:5089.
28. Weissman, D., R. L. Rabin, J. Arthos, A. Rubbert, M. Dybul, R. Swofford, S. Venkatesan, J. M. Farber, and A. S. Fauci. 1997. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389:981.
29. Täuber, M. G., U. Borschberg, and M. A. Sande. 1988. Influence of granulocytes on brain edema, intracranial pressure, and cerebrospinal fluid concentrations of lactate and protein in experimental meningitis. J. Infect. Dis. 157:456.
30. Gamache, D. A., J. T. Povlishock, and E. F. Ellis. 1986. Carrageenan-induced brain inflammation: characterization of the model. J. Neurosurg. 65:679.
31. Adams, D. H., and A. R. Lloyd. 1997. Chemokines: leukocyte recruitment and activation cytokines. Lancet 349:490.
32. Kohleisen, B., M. Neumann, R. Herrmann, R. Brack-Werner, K. J. Krohn, V. Ovod, A. Ranki, and V. Erfle. 1992. Cellular localization of Nef expressed in persistently HIV-1-infected low-producer astrocytes. AIDS 6:1427.
33. Kohleisen, B., G. Sutter, B. Koettgen, E. Shumay, and V. Erfle. 1996. Stable expression of HIV-1 Nef in a human astrocytoma cell line. In ECEAR First European Conference on Experimental AIDS Research, Cannes.
34. Seebach, J., D. Bartholdi, K. Frei, K. S. Spanaus, E. Ferrero, U. Widmer, S. Isenmann, R. M. Stricter, M. Schwab, H. Pfister, et al. 1995. Experimental Listeria meningoencephalitis: macrophage inflammatory protein-1α and -2 are produced intrathecally and mediate chemotactic activity in cerebrospinal fluid of infected mice. J. Immunol. 155:4367.
35. Ovod, V., A. Lagerstedt, A. Ranki, F. O. Gombert, R. Spohn, M. Tahtinen, G. Jung, and K. J. Krohn. 1992. Immunological variation and immunohistochemical localization of HIV-1 Nef demonstrated with monoclonal antibodies. AIDS 6:25.
36. Guy, B., M. P. Kieny, Y. Riviere, C. Le-Peuch, K. Dott, M. Girard, L. Montagnier, and J. P. Lecocq. 1987. HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature 330:266.
37. Kohleisen, B., K. Gaedigk-Nitschko, M. Ohlmann, E. Götz, H. Ostolaza, F. M. Goni, and V. Erfle. 1996. Heparin-binding capacity of the HIV-1 NEF-protein allows one-step purification and biochemical characterization. J. Virol. Methods 60:89.
38. Tyor, W. R., J. D. Glass, J. W. Griffin, P. S. Becker, J. C. McArthur, L. Bezman, and D. E. Griffin. 1992. Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann. Neurol. 31:349.
39. Cinque, P., L. Vago, M. Mengozzi, V. Torri, D. Ceresa, E. Vicenzi, P. Transidico, A. Vagani, S. Sozzani, A. Mantovani, A. Lazzarin, and G. Poli. 1998. Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS 12:1327.
40. Persidsky, Y., J. Limoges, R. McComb, P. Bock, T. Baldwin, W. Tyor, A. Patil, H. S. Nottet, L. Epstein, H. Gelbard, et al. 1996. Human immunodeficiency virus encephalitis in SCID mice [see comments]. Am. J. Pathol. 149:1027.
41. Chirmule, N., N. Oyaizu, C. Saxinger, and S. Pahwa. 1994. Nef protein of HIV-1 has B-cell stimulatory activity. AIDS 8:733.
42. Torres, B. A. and H. M. Johnson. 1994. Identification of an HIV-1 Nef peptide that binds to HLA class II antigens. Biochem Biophys Res Common. 200:1059.
43. Fujinaga, K., Q. Zhong, T. Nakaya, M. Kameoka, T. Meguro, K. Yamada, and K. Ikuta. 1995. Extracellular Nef protein regulates productive HIV-1 infection from latency. J. Immunol. 155:5289.
44. + T cells. J. Immunol. 153: 5826.
45. Estaquier, J., C. Boutillon, J. C. Ameisen, M. H. Gras, A. Delanoye, J. P. Lecocq, A. Dixson, A. Tartar, A. Capron, and C. Auriault. 1992. Determination of B-cell epitopes of nef HIV-1 protein: immunogenicity related to their structure. Mol. Immunol. 29:1337.
46. + T cells. FEBS Lett. 393:105.
47. Sozzani, S., M. Introna, S. Bernasconi, N. Polentarutti, P. Cinque, G. Poli, A. Sica, and A. Mantovani. 1997. MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression. J. Leukocyte Biol. 62:30.
48. Bell, M. D., D. D. Taub, and V. H. Perry. 1996. Overriding the brain's intrinsic resistance to leukocyte recruitment with intraparenchymal injections of recombinant chemokines. Neuroscience 74:283.
49. Torres, B. A., T. Tanabe, and H. M. Johnson. 1999. Characterization of Nef-induced CD4 T cell proliferation. Biochem. Biophys. Res. Commun. 225:54.
50. Romano, M., M. Sironi, C. Toniatti, N. Polentarutti, P. Fruscella, P. Ghezzi, R. Faggioni, W. Luini, V. van-Hinsbergh, S. Sozzani, et al. 1997. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6:315.
51. Musso, T., R. Badolato, D. L. Longo, G. L. Gusella, and L. Varesio. 1995. Leukemia inhibitory factor induces interleukin-8 and monocyte chemotactic and activating factor in human monocytes: differential regulation by interferon-γ. Blood 86:1961.
52. Benelli, R., R. Mortarini, A. Anichini, D. Giunciuglio, D. M. Noonan, S. Montalti, C. Tacchetti, and A. Albini. 1998. Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides. AIDS 12:261.
53. Albini, A., S. Ferrini, R. Benelli, S. Sforzini, D. Giunciuglio, M. G. Aluigi, A. E. Proudfoot, S. Alouani, T. N. Wells, G. Mariani, et al. 1998. HIV-1 Tat protein mimicry of chemokines. Proc. Natl. Acad. Sci. USA 95:13153.
54. Mitola, S., S. Sozzani, W. Luini, L. Primo, A. Borsatti, H. Weich, and F. Bussolino. 1997. Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1. Blood 90:1365.
55. Wang, J. M., H. Ueda, O. M. Howard, M. C. Grimm, O. Chertov, X. Gong, W. Gong, J. H. Resau, C. C. Broder, G. Evans, et al. 1998. HIV-1 envelope gp 120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation. J. Immunol. 161:4309.
56. Stefano, G. B., E. M. Smith, P. Cadet, and J. Hughes. 1993. HIV gp120 alteration of DAMA and IL-1 α induced chemotaxic responses in human and invertebrate immunocytes. J. Neuroimmunol. 43:177.
57. Glowa, J. R., L. V. Panlilio, D. E. Brenneman, I. Gozes, M. Fridkin, and J. M. Hill. 1992. Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist. Brain Res. 570:49.
58. Kimes, A. S., E. D. London, G. Szabo, L. Raymon, and B. Tabakoff. 1991. Reduction of cerebral glucose utilization by the HIV envelope glycoprotein gp120. Exp. Neurol. 112:224.
59. Toggas, S. M., E. Masliah, E. M. Rockenstein, G. F. Rail, C. R. Abraham, and L. Mucke. 1994. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367:188.
60. Harris, M. 1995. The role of myristoylation in the interactions between human immunodeficiency virus type 1 Nef and cellular proteins. Biochem. Soc. Trans. 23:557.
61. Bahraoui, E., M. Yagello, J. N. Billaud, J. M. Sabatier, B. Guy, E. Muchmore, M. Girard, and J. C. Gluckman. 1990. Immunogenicity of the human immunodeficiency virus (HIV) recombinant nef gene product. Mapping of T-cell and B-cell epitopes in immunized chimpanzees. AIDS Res. Hum. Retroviruses 6:1087.
62. Ameisen, J. C., B. Guy, S. Chamaret, M. Loche, Y. Mouton, J. L. Neyrinck, J. Khalife, C. Leprevost, G. Beaucaire, C. Boutillon, et al. 1989. Antibodies to the nef protein and to nef peptides in HIV-1-infected seronegative individuals. AIDS Res. Hum. Retroviruses 5:279.
63. Ratner, L., and T. M. Niederman. 1995. Nef. Curr. Top. Microbiol. Immunol. 193:169.
64. Guy, B., Y. Riviere, K. Dott, A. Regnault, and M. P. Kieny. 1990. Mutational analysis of the HIV nef protein. Virology 176:413.
65. Kienzle, N., M. Bachmann, W. E. Muller, and L. N. Muller. 1992. Expression and cellular localization of the Nef protein from human immunodeficiency virus-1 in stably transfected B-cells. Arch. Virol. 124:123.
66. Macreadie, I. G., L. A. Castelli, A. Lucantoni, and A. A. Azad. 1995. Stress- and sequence-dependent release into the culture medium of HIV-1 Nef produced in Saccharomyces cerevisiae. Gene 162:239.
67. + T cells. FEBS Lett. 393:93.
68. Okada, H., R. Takei, and M. Tashiro. 1997. HIV-1 Nef protein-induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95(Fas). FEBS Lett. 414:603.
69. Okada, H., S. Morikawa, and M. Tashiro. 1998. HIV-1 Nef binding protein expressed on the surface of murine blood cells. Med. Microbiol. Immunol. 186:201.
70. Brigino, E., S. Haraguchi, A. Koutsonikolis, G. J. Cianciolo, U. Owens, R. A. Good, and N. K. Day. 1997. Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway. Proc. Natl. Acad. Sci. USA 94:3178.
71. Elovaara, I., I. Seppala, E. Poutiainen, J. Suni, and S. L. Valle. 1988. Intrathecal humoral immunologic response in neurologically symptomatic and asymptomatic patients with human immunodeficiency virus infection. Neurology 38:1451.
72. McArthur, J. C., E. Sipos, D. R. Cornblath, D. Welch, M. Chupp, D. E. Griffin, and R. T. Johnson. 1989. Identification of mononuclear cells in CSF of patients with HIV infection. Neurology 39:66.
73. Epstein, L. G., and H. E. Gendelman. 1993. Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann. Neurol. 33: 429.
74. Nottet, H. S., Y. Persidsky, V. G. Sasseville, A. N. Nukuna, P. Bock, Q. H. Zhai, L. R. Sharer, R. D. McComb, S. Swindells, C. Soderland, and H. E. Gendelman. 1996. Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. J. Immunol. 156:1284.
75. Takahashi, K., S. L. Wesselingh, D. E. Griffin, J. C. McArthur, R. T. Johnson, and J. D. Glass. 1996. Localization of HIV-1 in human brain using polymerase chain reaction in situ hybridization and immunocytochemistry. Ann. Neurol. 39:705.
76. Ward, J. M., T. J. O'Leary, G. B. Baskin, R. Benveniste, C. A. Harris, P. L. Nara, and R. H. Rhodes. 1987. Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections. Am. J. Pathol. 127:199.
77. Tornatore, C., A. Nath, K. Amemiya, and E. O. Major. 1991. Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor α and interleukin-1 β. J. Virol. 65:6094.