Cell-dependent functional roles of HIV-1 Nef for virus replication (Review)

International Journal of Molecular Medicine

Volumn 3, Issue 4, 1999, Pages 427-430

  Adachi, Akio ^a   Oshima, Yoko ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

HIV 1; Nef

Indexed keywords

NEF PROTEIN;

ANIMAL; CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION; PATHOGENICITY; PHYSIOLOGY; REVIEW; VIRION; VIROLOGY; VIRUS REPLICATION;

ANIMALS; CELLS; GENE PRODUCTS, NEF; HIV-1; HUMANS; MUTATION; VIRION; VIRUS REPLICATION;

EID: 0033110824     PISSN: 11073756     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijmm.3.4.427     Document Type: Article

References (30)

1. Harris M: From negative factor to a critical role in virus pathogenesis: the changing fortunes of Nef. J Gen Virol 77: 2379-2392, 1996.
2. Inubushi R, Tamaki M, Shimano R, Koyama AH, Akari H and Adachi A: Functional roles of HIV accessory proteins for viral replication (Review). Int J Mol Med 2: 429-433, 1998.
3. Cullen BR: HIV-1 auxiliary proteins: making connections in a dying cell. Cell 93: 685-692, 1998.
4. Emerman M and Malim MH: HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology. Science 280: 1880-1884, 1998.
5. Tenvilligcr E, Sodroski JG, Rosen C and Haseltine WA: Effects of mutations within the 3′ orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity. J Virol 60: 754-760, 1986.
6. Ahmad N and Venkatessan S: Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR. Science 241: 1481-1485, 1988.
7. Niederman TMJ, Thielan BJ and Ratner L: Human immunodeficiency virus type 1 negative factor is a transcriptional silencer. Proc Natl Acad Sci USA 86: 1128-1132, 1989.
8. Hammes SR, Dixon EP, Malim MH, Cullen BR and Greene WC: Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor. Proc Natl Acad Sci USA 86: 9549-9553, 1989.
9. De Ronde A, Klaver B, Keulen W, Smit L and Goudsmit J: Natural HIV-1 Nef accelerates virus replication in primary human lymphocytes. Virology 188: 391-395, 1992.
10. Kim S, Ikeuchi K, Byrn R, Groopman J and Baltimore D: Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 86: 9544-9548, 1989.
11. Terwilliger EF, Langhoff E, Gabuzda D, Azopoulos E and Haseltine WA: Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 88: 10971-10975, 1991.
12. Zazop'oulos E and Haseltine WA: Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function. Proc Natl Acad Sci USA 89: 6634-6638, 1992.
13. Zazppoulos E and Haseltine WA: Effect of nef alleles on replication of human immunodeficiency virus type 1. Virology 194: 20-27, 1993.
14. Kestler HW III, Ringler DJ, Mori K, Panicali DL, Sehgal PK, Daniel MD and Desrosiers RC: Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65: 651-662, 1991.
15. Jamieson BD, Aldrovandi GM, Planelies V, Jowett JBM, Gao L, Blo'ch LM, Chen ISM and Zack JA: Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J Virol 68: 3478-3485, 1994.
16. Miller MD, Warmerdam MT, Gaston I, Greene WC and Feinberg MB: The human immunodeficiency virus type 1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J Exp Med 179: 101-113, 1994.
17. Spina CA, Kwoli TJ, Chowers MY, Guatelli JC and Richman DD: The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J Exp Med 179: 115-123, 1994.
18. Chowers MY, Spina CA, Kwoh TJ, Fitch NJS, Richman DD and Guatelli JC: Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef. gene. J Virol 68: 2906-2914, 1994.
19. Tokunaga K, Kojima A, Kurata T, Ikuta K, Akari H, Koyama AH, Kawamura M, Inubushi R, Shimano R and Adachi A: Enhancement of human immunodeficiency virus type 1 infectivity by Nef is producer cell-dependent. J Gen Virol 79: 2447-2453, 1998.
20. Gottlinger HG, Dorfman T, Cohen EA and Maschine WA: Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses. Proc Natl Acad Sci USA 90: 7381-7385, 1993.
21. Sakai H, Tokunaga K, Kawamura M and Adachi A: Function of human immunodeficiency virus type 1 Vpu protein in various cell types. J Gen Virol 76: 2717-2722, 1995.
22. Miller MD, Warmerdam MT, Page KA, Feinberg MB and Greene WC: Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J Virol 69: 579-584, 1995.
23. Schwanz O, Marechal V, Danos O and Heard J-M: Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cells. J Virol 69: 4053-4059, 1995.
24. Aiken C and Trono D: Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J Virol 69: 5048-5056, 1995.
25. Chowers MY, Pandori MW, Spina CA, Richman DD and Guatelli JC: The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology 212: 451-457, 1995.
26. Tokunaga K, Kojima A, Kurata T, Ikuta K, Inubushi R, Shimano R, Kawamura M, Akari H, Koyama AH and Adachi A: Producer cell-dependent requirement of the Nef protein for efficient entry of HIV-1 into cells. Biochem Biophys Res Commun 250: 565-568, 1998.
27. Kimpton J and Emerman M: Detection of replication-competent and pseudotype human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated-galactosidase gene. J Virol 66: 2232-2239, 1992.
28. Adachi A, Kawamura M, Tokunaga K and Sakai H: Methods for HIV/SIV gene analysis. In: Viral Genome Methods. Adolph KW (ed). CRC Press, Boca Raton, pp43-53, 1996.
29. Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A and Martin MA: Production of acquired immunodeficiency syndrome-associated retrovirus in human and non-human cells transfected with an infectious molecular clone. J Virol 59: 284-291, 1986.
30. Adachi A, Ono N, Sakai H, Ogawa K, Shibata R, Kiyomasu T, Masuike H and Ueda S: Generation and characterization of the human immunodeficiency virus type 1 mutants. Arch Virol 117: 45-58, 1991.