Increased β-secretase activity in cerebrospinal fluid of Alzheimer's disease subjects [3]

Annals of Neurology

Volumn 55, Issue 6, 2004, Pages 898-899

  Holsinger, R M Damian ^a   McLean, Catriona A ^a   Collins, Steven J ^a   Masters, Colin L ^a   Evin, Geneviève ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BIOCHEMICAL MARKER;

ALZHEIMER DISEASE; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; HUMAN; LETTER; PRIORITY JOURNAL; PROTEIN METABOLISM;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; BRAIN; CASE-CONTROL STUDIES; CELL LINE; ENZYME INHIBITORS; HUMANS; POSTMORTEM CHANGES; TIME FACTORS; TRANSFECTION;

EID: 2542604678     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.20144     Document Type: Letter

References (5)

1. Holsinger RMD, McLean CA, Beyreuther K, Masters CL et al. Increased expression of amyloid precursor β-secretase in Alzheimer's disease. Ann Neurol 2002; 51:783-786.
2. Fukumoto H, Cheung BS, Hyman BT and Irizarry, MC. β-secretase protein and activity are increased in the neocortex in Alzheimer's disease. Arch Neurol 2002; 59:1381-1389.
3. Yang L-B, Lindholm K, Yan R, Citron M, et al., Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med 2003; 9(1):3-4.
4. Chyung JH and Selkoe DJ. Inhibition of receptor mediated endocytosis demonstrates generation of amyloid β-protein at the cell surface. J Biol Chem 2003; 278(51):51035-51043.
5. Huang X, Chang W, Koelsch G and Tang J. Endocytosis of exogenously added memapsin 2 (β-secretase) catalytic domain by cultured cells. International Conference on Aspartic Proteases and Inhibitors, Kyoto, Japan. Abstract P-19. November 14-16, 2003.