Heparan sulfate: Decoding a dynamic multifunctional cell regulator

Trends in Cell Biology

Volumn 11, Issue 2, 2001, Pages 75-82

  Turnbull, Jeremy ^a   Powell, Andrew ^a   Guimond, Scott ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARAN SULFATE;

AMINO ACID SEQUENCE; COMPLEX FORMATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW;

ANIMALS; EXTRACELLULAR MATRIX PROTEINS; HEPARIN; HEPARITIN SULFATE; HUMANS; ISOENZYMES; POLYSACCHARIDES; PROTEIN BIOSYNTHESIS; PROTEOGLYCANS; SEQUENCE ANALYSIS;

METAZOA;

EID: 0035253193     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(00)01897-3     Document Type: Review

References (53)

1. Glycosaminoglycan-protein interactions: A question of specificity
2. Functions of cell surface heparan sulfate proteoglycans
3. Regulated diversity of heparan sulfate
4. The elusive functions of proteoglycans: In vivo veritas
5. Specificities of heparan sulphate proteoglycans in developmental processes
6. Proteoglycans and pattern formation: Sugar biochemistry meets developmental genetics
7. The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate
8. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/N-sulfotransferase family
9. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine
10. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci
11. Molecular cloning and expression of Chinese hamster ovary cell heparan-sulfate 2-sulfotransferase
12. Biosynthesis of heparin/heparan sulfate. cDNA cloning and expression of D-glucuronyl C5-epimerase from bovine lung
13. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities
14. Distribution of iduronate-2-sulphate residues in heparan sulphate: Evidence for an ordered polymeric structure
15. Heparin sequencing brings structure to the function of complex oligosaccharides
16. Domain structure of heparan sulfates from bovine organs
17. Cell surface syndecan-1 on distinct cell types differs in fine structure and ligand binding of its heparan sulfate chains
18. Fine structure of heparan sulfate regulates syndecan-1 function and cell behavior
19. Heparan sulfate undergoes specific structural changes during the progression from adenoma to carcinoma in vitro
20. Metabolism of proteoglycans in rat ovarian granulosa cell culture: Multiple intracellular degradative pathways and the effect of chloroquine
21. Heparan sulfate proteoglycan synthesis and metabolism by mouse uterine epithelial cells cultured in vitro
22. Basic fibroblast growth factor controls the expression and molecular structure of heparan sulfate in corneal endothelial cells
23. Age-dependent modulation of heparan sulfate structure and function
24. Structural modification of fibroblast growth factor-binding heparan sulfate at a determinative stage of neural development
25. Heparan sulfate mediates bFGF transport through basement membrane by diffusion with rapid reversible binding
26. Heparan sulfate proteoglycan and FGF receptor target basic FGF to different intracellular destinations
27. Microbial adherence to and invasion through proteoglycans
28. Heparin decreases the blood clearance of interferon-gamma and increases its activity by limiting the processing of its carboxyl-terminal sequence
29. Cell surface heparan sulfate proteoglycans: Selective regulators of ligand-receptor encounters
30. sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis
31. Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase
32. Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
33. Heparin is essential for the storage of specific granule proteases in mast cells
34. Numbers, time and neocortical neuronogenesis: A general developmental and evolutionary model
35. A strategy for rapid sequencing of heparan sulfate and heparin saccharides
36. Sequence analysis of heparan sulphate and heparin oligosaccharides
37. Highly sensitive sequencing of the sulfated domains of heparan sulfate
38. Mass spectrometric and capillary electrophoretic investigation of the enzymatic degradation of heparin-like glycosaminoglycans
39. Sequencing complex polysaccharides
40. Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides
41. Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin
42. Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity
43. Interaction of heparan sulfate from mammary cells with acidic fibroblast growth factor (FGF) and basic FGF. Regulation of the activity of basic FGF by high and low affinity binding sites in heparan sulfate
44. Differential ability of heparan sulfate proteoglycans to assemble the fibroblast growth factor receptor complex in situ
45. Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney
46. Heparan sulfate heterogeneity in skeletal muscle basal lamina: Demonstration by phage display-derived antibodies
47. Synthesis of thrombin-inhibiting heparin mimetics without side effects
48. Fibroblast growth factor-2 stimulation of p42/44MAPK phosphorylation and Iκ B degradation is regulated by heparan sulfate/heparin in rat mammary fibroblasts
49. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
50. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
51. Direct isolation and sequencing of specific protein-binding glycosaminoglycans on a chip