Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype

Nature Biotechnology

Volumn 21, Issue 5, 2003, Pages 559-561

  Kunath, Tilo ^a,b   Gish, Gerald ^a   Lickert, Heiko ^a   Jones, Nina ^a   Pawson, Tony ^a   Rossant, Janet ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; PROTEINS; RNA;

PLASMID-BASED SYSTEMS;

GENES;

DNA DIRECTED RNA POLYMERASE III; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; EMBRYO; GENE MUTATION; GENE SILENCING; GENE TARGETING; HOMOLOGOUS RECOMBINATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; PRIORITY JOURNAL; STEM CELL; TRANSGENE;

ANIMALS; CELL DIVISION; CELL LINE; CELLS, CULTURED; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC ENGINEERING; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PHENOTYPE; RNA INTERFERENCE; STEM CELLS; TRANSGENES;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0038708339     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt813     Document Type: Article

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