Lentiviral-mediated RNA interference

Human Gene Therapy

Volumn 13, Issue 18, 2002, Pages 2197-2201

  Abbas Terki, Toufik ^a   Blanco Bose, William ^a   Déglon, Nicole ^a   Pralong, William ^a   Aebischer, Patrick ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED RNA POLYMERASE III; DOUBLE STRANDED RNA; GREEN FLUORESCENT PROTEIN; PLASMID VECTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE FUNCTION; GENE SILENCING; GENE THERAPY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LENTIVIRINAE; MAMMAL; RNA BINDING; RNA DEGRADATION; RNA INTERFERENCE; RNA SEQUENCE; WESTERN BLOTTING;

EUKARYOTA; LENTIVIRUS; MAMMALIA; RNA VIRUSES;

EID: 0036976008     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303402320987888     Document Type: Article

References (12)

1. BRUMMELKAMP, T.R., BERNARDS, R., and AGAMI, R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553.
2. DE ALMEIDA, L.P., ROSS, C.A., ZALA, D., AEBISCHER, P., and DÉGLON, N. (2002). Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length. J. Neurosci. 22, 3473-3483.
3. DÉGLON, N., TSENG, J.L., BENSADOUN, J.C., ZURN, A.D., ARSENIJEVIC, Y., PEREIRA DE ALMEIDA, L., ZUFFEREY, R., TRONO, D., and AEBISCHER, P. (2000). Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. Hum. Gene Ther. 11, 179-190.
4. DONZE, O., and PICARD, D. (2002). RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase. Nucleic Acids Res. 30, e46.
5. ELBASHIR, S.M., LENDECKEL, W., and TUSCHL, T. (2001). RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15, 188-200.
6. KORDOWER, J.H., EMBORG, M.E., BLOCH, J., MA, S.Y., CHU, Y., LEVENTHAL, L., MCBRIDE, J., CHEN, E.Y., PALFI, S., ROITBERG, B.Z., BROWN, W.D., HOLDEN, J.E., PYZALSKI, R., TAYLOR, M.D., CARVEY, P., LING, Z., TRONO, D., HANTRAYE, P., DÉGLON, N., and AEBISCHER, P. (2000). Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290, 767-773.
7. LOIS, C., HONG, E.J., PEASE, S., BROWN, E.J., and BALTIMORE, D. (2002). Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295, 868-872.
8. MCCAFFREY, A.P., MEUSE, L., PHAM, T.T., CONKLIN, D.S., HANNON, G.J., and KAY, M.A. (2002). Gene expression: RNA interference in adult mice. Nature 418, 38-39.
9. PADDISON, P.J., CAUDY, A.A., BERNSTEIN, E., HANNON, G.J., and CONKLIN, D.S. (2002). Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16, 948-958.
10. SUI, G., SOOHOO, C., AFFAR EL, B., GAY, F., SHI, Y., and FORRESTER, W.C. (2002). A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 99, 5515-5520.
11. YU, J.Y., DERUITER, S.L., and TURNER, D.L. (2002). RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 99, 6047-6052.
12. ZAMORE, P.D., TUSCHL, T., SHARP, P.A., and BARTEL, D.P. (2000). RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25-33.