A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

Cell

Volumn 121, Issue 6, 2005, Pages 849-858

  Kolfschoten, Ingrid G M ^a   Van Leeuwen, Bart ^a   Berns, Katrien ^a   Mullenders, Jasper ^a   Beijersbergen, Roderick L ^a   Bernards, Rene ^a   Voorhoeve, P Mathijs ^a   Agami, Reuven ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PITX 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLADDER TUMOR; CANCER CELL; CARCINOGENICITY; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENETIC SCREENING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; WILD TYPE;

EID: 20444426889     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.04.017     Document Type: Article

References (31)

1. R. Agami, and R. Bernards Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage Cell 102 2000 55 66
2. D. Arun, and D.H. Gutmann Recent advances in neurofibromatosis type 1 Curr. Opin. Neurol. 17 2004 101 105
3. Barre, B., Vigneron, A., and Coqueret, O. (2005). The STAT3 transcription factor is a target for the Myc and riboblastoma proteins on the Cdc25A promoter, J. Biol. Chem. 280, 15673-15681. Published online January 26, 2005. 10.1074/jbc.M413203200.
4. K. Berns, E.M. Hijmans, J. Mullenders, T.R. Brummelkamp, A. Velds, M. Heimerikx, R.M. Kerkhoven, M. Madiredjo, W. Nijkamp, and B. Weigelt A large-scale RNAi screen in human cells identifies new components of the p53 pathway Nature 428 2004 431 437
5. J.L. Bos ras oncogenes in human cancer: a review Cancer Res. 49 1989 4682 4689
6. T.R. Brummelkamp, R. Bernards, and R. Agami Stable suppression of tumorigenicity by virus-mediated RNA interference Cancer Cell 2 2002 243 247
7. T.R. Brummelkamp, R. Bernards, and R. Agami A system for stable expression of short interfering RNAs in mammalian cells Science 296 2002 550 553 10.1126/science.1068999
8. A.M. Buchberg, L.S. Cleveland, N.A. Jenkins, and N.G. Copeland Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway Nature 347 1990 291 294
9. C.M. Counter, W.C. Hahn, W. Wei, S.D. Caddle, R.L. Beijersbergen, P.M. Lansdorp, J.M. Sedivy, and R.A. Weinberg Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization Proc. Natl. Acad. Sci. USA 95 1998 14723 14728
10. D.T. Dang, X. Chen, J. Feng, M. Torbenson, L.H. Dang, and V.W. Yang Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity Oncogene 22 2003 3424 3430
11. J. de Rooij, and J.L. Bos Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras Oncogene 14 1997 623 625
12. G.P. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E.E. Medrano, M. Linskens, I. Rubelj, and O. Pereira-Smith A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc. Natl. Acad. Sci. USA 92 1995 9363 9367
13. W.C. Hahn, and R.A. Weinberg Modelling the molecular circuitry of cancer Nat. Rev. Cancer 2 2002 331 341
14. W.C. Hahn, C.M. Counter, A.S. Lundberg, R.L. Beijersbergen, M.W. Brooks, and R.A. Weinberg Creation of human tumour cells with defined genetic elements Nature 400 1999 464 468
15. D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
16. M.C. Harrisingh, and A.C. Lloyd Ras/Raf/ERK signalling and NF1 Cell Cycle 3 2004 1255 1258
17. T. Lamonerie, J.J. Tremblay, C. Lanctot, M. Therrien, Y. Gauthier, and J. Drouin Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene Genes Dev. 10 1996 1284 1295
18. S. Ohnishi, S. Ohnami, F. Laub, K. Aoki, K. Suzuki, Y. Kanai, K. Haga, M. Asaka, F. Ramirez, and T. Yoshida Downregulation and growth inhibitory effect of epithelial-type Kruppel-like transcription factor KLF4, but not KLF5, in bladder cancer Biochem. Biophys. Res. Commun. 308 2003 251 256
19. Ramaswamy, S., Tamayo, P., Rifkin, R., Mukherjee, S., Yeang, C.H., Angelo, M., Ladd, C., Reich, M., Latulippe, E., Mesirov, J.P., et al. (2001). Multiclass cancer diagnosis using tumor gene expression signatures Proc. Natl. Acad. Sci. USA 98, 15149-15154. Published online December 11, 2001. 10.1073/pnas.211566398.
20. G.A. Repasky, E.J. Chenette, and C.J. Der Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? Trends Cell Biol. 14 2004 639 647
21. J.S. Rhim Molecular and genetic mechanisms of prostate cancer Radiat. Res. 155 2001 128 132
22. M.J. Robinson, and M.H. Cobb Mitogen-activated protein kinase pathways Curr. Opin. Cell Biol. 9 1997 180 186
23. M. Serrano, A.W. Lin, M.E. McCurrach, D. Beach, and S.W. Lowe Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Cell 88 1997 593 602
24. D. Singh, P.G. Febbo, K. Ross, D.G. Jackson, J. Manola, C. Ladd, P. Tamayo, A.A. Renshaw, A.V. D'Amico, and J.P. Richie Gene expression correlates of clinical prostate cancer behavior Cancer Cell 1 2002 203 209
25. L. Subramanian, J.W. Crabb, J. Cox, I. Durussel, T.M. Walker, P.R. van Ginkel, S. Bhattacharya, J.M. Dellaria, K. Palczewski, and A.S. Polans Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma Biochemistry 43 2004 11175 11186
26. M. Vooijs, J. Jonkers, S. Lyons, and A. Berns Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice Cancer Res. 62 2002 1862 1867
27. P.M. Voorhoeve, and R. Agami The tumor-suppressive functions of the human INK4A locus Cancer Cell 4 2003 311 319
28. Walker, S.A., Kupzig, S., Bouyoucef, D., Davies, L.C., Tsuboi, T., Bivona, T.G., Cozier, G.E., Lockyer, P.J., Buckler, A., Rutter, G.A., et al. (2004). Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca(2+) oscillations. EMBO J. 23, 1749-1760. Published online April 1, 2004. 10.1038/sj.emboj.7600197.
29. R.M. Wolthuis, and J.L. Bos Ras caught in another affair: the exchange factors for Ral Curr. Opin. Genet. Dev. 9 1999 112 117
30. J.J. Zhao, O.V. Gjoerup, R.R. Subramanian, Y. Cheng, W. Chen, T.M. Roberts, and W.C. Hahn Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase Cancer Cell 3 2003 483 495
31. W. Zhao, I.M. Hisamuddin, M.O. Nandan, B.A. Babbin, N.E. Lamb, and V.W. Yang Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer Oncogene 23 2004 395 402