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Volumn 23, Issue 3, 2005, Pages 183-192

Mdm2 in growth signaling and cancer

Author keywords

Akt; E2F; Mdm2; p53; Steroid receptors; TGF

Indexed keywords

1,3 DIPHENYL 2 PROPEN 1 ONE DERIVATIVE; ANTISENSE OLIGONUCLEOTIDE; CHALCONE DERIVATIVE; IMIDAZOLINE DERIVATIVE; PROTEIN MDM2; STEROID RECEPTOR; TRANSCRIPTION FACTOR E2F; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 32144435931     PISSN: 08977194     EISSN: None     Source Type: Journal    
DOI: 10.1080/08977190500196218     Document Type: Review
Times cited : (49)

References (89)
  • 2
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • Bartek, J and Lukas, J. (2003) Chk1 and Chk2 kinases in checkpoint control and cancer Cancer Cell, 3, pp. 421-429.
    • (2003) Cancer Cell , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 3
    • 0034644653 scopus 로고    scopus 로고
    • Different sensitivity of the transforming growth factor-beta cell cycle arrest pathway to c-Myc and MDM-2
    • Blain, SW and Massague, J. (2000) Different sensitivity of the transforming growth factor-beta cell cycle arrest pathway to c-Myc and MDM-2 J Biol Chem, 275, pp. 32066-32070.
    • (2000) J Biol Chem , vol.275 , pp. 32066-32070
    • Blain, S.W.1    Massague, J.2
  • 4
    • 8844278362 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
    • Bond, GL and Hu, W and Bond, EE and Robins, H and Lutzker, SG and Arva, NC and Bargonetti, J and Bartel, F and Taubert, H and Wuerl, P and (2004) A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans Cell, 119, pp. 591-602.
    • (2004) Cell , vol.119 , pp. 591-602
    • Bond, G.L.1    Hu, W.2    Bond, E.E.3    Robins, H.4    Lutzker, S.G.5    Arva, N.C.6    Bargonetti, J.7    Bartel, F.8    Taubert, H.9    Wuerl, P.10
  • 5
    • 0031743951 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signal transduction: At the interface between physiology and cell biology
    • Butler, AA and Yakar, S and Gewolb, IH and Karas, M and Okubo, Y and LeRoith, D. (1998) Insulin-like growth factor-I receptor signal transduction: At the interface between physiology and cell biology Comp Biochem Physiol B Biochem Mol Biol, 121, pp. 19-26.
    • (1998) Comp Biochem Physiol B Biochem Mol Biol , vol.121 , pp. 19-26
    • Butler, A.A.1    Yakar, S.2    Gewolb, I.H.3    Karas, M.4    Okubo, Y.5    LeRoith, D.6
  • 6
    • 9744256274 scopus 로고    scopus 로고
    • Transcriptional regulation of AKT activation by E2F
    • Chaussepied, M and Ginsberg, D. (2004) Transcriptional regulation of AKT activation by E2F Mol Cell, 16, pp. 831-837.
    • (2004) Mol Cell , vol.16 , pp. 831-837
    • Chaussepied, M.1    Ginsberg, D.2
  • 7
    • 0038274163 scopus 로고    scopus 로고
    • Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads
    • Cordenonsi, M and Dupont, S and Maretto, S and Insinga, A and Imbriano, C and Piccolo, S. (2003) Links between tumor suppressors: P53 is required for TGF-beta gene responses by cooperating with Smads Cell, 113, pp. 301-314.
    • (2003) Cell , vol.113 , pp. 301-314
    • Cordenonsi, M.1    Dupont, S.2    Maretto, S.3    Insinga, A.4    Imbriano, C.5    Piccolo, S.6
  • 8
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, SR and Brunet, A and Greenberg, ME. (1999) Cellular survival: A play in three Akts Genes Dev, 13, pp. 2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 9
    • 0029590161 scopus 로고
    • MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest
    • Dubs-Poterszman, MC and Tocque, B and Wasylyk, B. (1995) MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest Oncogene, 11, pp. 2445-2449.
    • (1995) Oncogene , vol.11 , pp. 2445-2449
    • Dubs-Poterszman, M.C.1    Tocque, B.2    Wasylyk, B.3
  • 10
    • 0025853776 scopus 로고
    • Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
    • Fakharzadeh, SS. and Trusko, SP. and George, DL. 1991 Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line EMBO J, 10, pp. 1565-1569.
    • (1991) EMBO J , vol.10 , pp. 1565-1569
    • Fakharzadeh, S.S.1    Trusko, S.P.2    George, D.L.3
  • 11
    • 0033001953 scopus 로고    scopus 로고
    • Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
    • Fambrough, D and McClure, K and Kazlauskas, A and Lander, ES. (1999) Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes Cell, 97, pp. 727-741.
    • (1999) Cell , vol.97 , pp. 727-741
    • Fambrough, D.1    McClure, K.2    Kazlauskas, A.3    Lander, E.S.4
  • 12
    • 4143053880 scopus 로고    scopus 로고
    • Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
    • Feng, J and Tamaskovic, R and Yang, Z and Brazil, DP and Merlo, A and Hess, D and Hemmings, BA. (2004) Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation J Biol Chem, 279, pp. 35510-35517.
    • (2004) J Biol Chem , vol.279 , pp. 35510-35517
    • Feng, J.1    Tamaskovic, R.2    Yang, Z.3    Brazil, D.P.4    Merlo, A.5    Hess, D.6    Hemmings, B.A.7
  • 13
    • 0345824731 scopus 로고    scopus 로고
    • p53-independent functions of MDM2
    • Ganguli, G and Wasylyk, B. (2003) p53-independent functions of MDM2 Mol Cancer Res, 1, pp. 1027-1035.
    • (2003) Mol Cancer Res , vol.1 , pp. 1027-1035
    • Ganguli, G.1    Wasylyk, B.2
  • 14
    • 13744257306 scopus 로고    scopus 로고
    • Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
    • Gaughan, L and Logan, IR and Neal, DE and Robson, CN. (2005) Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation Nucleic Acids Res, 33, pp. 13-26.
    • (2005) Nucleic Acids Res , vol.33 , pp. 13-26
    • Gaughan, L.1    Logan, I.R.2    Neal, D.E.3    Robson, C.N.4
  • 15
    • 0037010122 scopus 로고    scopus 로고
    • E2F1 pathways to apoptosis
    • Ginsberg, D. (2002) E2F1 pathways to apoptosis FEBS Lett, 529, pp. 122-125.
    • (2002) FEBS Lett , vol.529 , pp. 122-125
    • Ginsberg, D.1
  • 16
    • 20144367578 scopus 로고    scopus 로고
    • Chalcones: An update on cytotoxic and chemoprotective properties
    • Go, ML and Wu, X and Liu, XL. (2005) Chalcones: An update on cytotoxic and chemoprotective properties Curr Med Chem, 12, pp. 481-499.
    • (2005) Curr Med Chem , vol.12 , pp. 481-499
    • Go, M.L.1    Wu, X.2    Liu, X.L.3
  • 17
    • 0035886865 scopus 로고    scopus 로고
    • Requirement for Mdm2 in the survival effects of Bcr-Abl and interleukin 3 in hematopoietic cells
    • Goetz, AW and van der Kuip, H and Maya, R and Oren, M and Aulitzky, WE. (2001) Requirement for Mdm2 in the survival effects of Bcr-Abl and interleukin 3 in hematopoietic cells Cancer Res, 61, pp. 7635-7641.
    • (2001) Cancer Res , vol.61 , pp. 7635-7641
    • Goetz, A.W.1    van der Kuip, H.2    Maya, R.3    Oren, M.4    Aulitzky, W.E.5
  • 18
    • 13944275218 scopus 로고    scopus 로고
    • Treatment of chronic myeloid leukemia cells with imatinib (STI571) impairs p53 accumulation in response to DNA damage
    • Goldberg, Z and Levav, Y and Krichevsky, S and Fibach, E and Haupt, Y. (2004) Treatment of chronic myeloid leukemia cells with imatinib (STI571) impairs p53 accumulation in response to DNA damage Cell Cycle, 3, pp. 1188-1195.
    • (2004) Cell Cycle , vol.3 , pp. 1188-1195
    • Goldberg, Z.1    Levav, Y.2    Krichevsky, S.3    Fibach, E.4    Haupt, Y.5
  • 19
    • 85047699328 scopus 로고    scopus 로고
    • Cross-talk between Akt, p53 and Mdm2: Possible implications for the regulation of apoptosis
    • Gottlieb, TM and Leal, JF and Seger, R and Taya, Y and Oren, M. (2002) Cross-talk between Akt, p53 and Mdm2: Possible implications for the regulation of apoptosis Oncogene, 21, pp. 1299-1303.
    • (2002) Oncogene , vol.21 , pp. 1299-1303
    • Gottlieb, T.M.1    Leal, J.F.2    Seger, R.3    Taya, Y.4    Oren, M.5
  • 20
    • 0037333264 scopus 로고    scopus 로고
    • The "Gab" in signal transduction
    • Gu, H and Neel, BG. (2003) The "Gab" in signal transduction Trends Cell Biol, 13, pp. 122-130.
    • (2003) Trends Cell Biol , vol.13 , pp. 122-130
    • Gu, H.1    Neel, B.G.2
  • 21
    • 0028946602 scopus 로고
    • Differential expression of multiple MDM2 messenger RNAs and proteins in normal and tumorigenic breast epithelial cells
    • Gudas, JM and Nguyen, H and Klein, RC and Katayose, D and Seth, P and Cowan, KH. (1995) Differential expression of multiple MDM2 messenger RNAs and proteins in normal and tumorigenic breast epithelial cells Clin Cancer Res, 1, pp. 71-80.
    • (1995) Clin Cancer Res , vol.1 , pp. 71-80
    • Gudas, J.M.1    Nguyen, H.2    Klein, R.C.3    Katayose, D.4    Seth, P.5    Cowan, K.H.6
  • 22
    • 0141814666 scopus 로고    scopus 로고
    • Specificity in the activation and control of transcription factor E2F-dependent apoptosis
    • Hallstrom, TC and Nevins, JR. (2003) Specificity in the activation and control of transcription factor E2F-dependent apoptosis Proc Natl Acad Sci USA, 100, pp. 10848-10853.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10848-10853
    • Hallstrom, T.C.1    Nevins, J.R.2
  • 23
    • 14644397961 scopus 로고    scopus 로고
    • MDM2 splice variants and their therapeutic implications
    • Harris, L.C. (2005) MDM2 splice variants and their therapeutic implications Curr Cancer Drug Targets, 5, pp. 21-26.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 21-26
    • Harris, L.C.1
  • 24
    • 3042609978 scopus 로고    scopus 로고
    • Manipulation of the tumor suppressor p53 for potentiating cancer therapy
    • Haupt, S and Haupt, Y. (2004) Manipulation of the tumor suppressor p53 for potentiating cancer therapy Semin Cancer Biol, 14, pp. 244-252.
    • (2004) Semin Cancer Biol , vol.14 , pp. 244-252
    • Haupt, S.1    Haupt, Y.2
  • 25
    • 0031896910 scopus 로고    scopus 로고
    • Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction
    • Hazzalin, CA and Le Panse, R and Cano, E and Mahadevan, LC. (1998) Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction Mol Cell Biol, 18, pp. 1844-1854.
    • (1998) Mol Cell Biol , vol.18 , pp. 1844-1854
    • Hazzalin, C.A.1    Le Panse, R.2    Cano, E.3    Mahadevan, L.C.4
  • 26
    • 0036159438 scopus 로고    scopus 로고
    • Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer
    • Hori, M and Shimazaki, J and Inagawa, S and Itabashi, M and Hori, M. (2002) Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer Breast Cancer Res Treat, 71, pp. 77-83.
    • (2002) Breast Cancer Res Treat , vol.71 , pp. 77-83
    • Hori, M.1    Shimazaki, J.2    Inagawa, S.3    Itabashi, M.4    Hori, M.5
  • 27
    • 0033082231 scopus 로고    scopus 로고
    • RB regulates the stability and the apoptotic function of p53 via MDM2
    • Hsieh, JK and Chan, FS and O'Connor, DJ and Mittnacht, S and Zhong, S and Lu, X (1999) RB regulates the stability and the apoptotic function of p53 via MDM2 Mol Cell, 3, pp. 181-193.
    • (1999) Mol Cell , vol.3 , pp. 181-193
    • Hsieh, J.K.1    Chan, F.S.2    O'Connor, D.J.3    Mittnacht, S.4    Zhong, S.5    Lu, X.6
  • 28
    • 0028074536 scopus 로고
    • Alterations in the p53 and MDM-2 genes are infrequent in clinically localized, stage B prostate adenocarcinomas
    • Ittmann, M and Wieczorek, R and Heller, P and Dave, A and Provet, J and Krolewski, J. (1994) Alterations in the p53 and MDM-2 genes are infrequent in clinically localized, stage B prostate adenocarcinomas Am J Pathol, 145, pp. 287-293.
    • (1994) Am J Pathol , vol.145 , pp. 287-293
    • Ittmann, M.1    Wieczorek, R.2    Heller, P.3    Dave, A.4    Provet, J.5    Krolewski, J.6
  • 29
    • 0347716455 scopus 로고    scopus 로고
    • MDM2, an introduction
    • Iwakuma, T and Lozano, G. (2003) MDM2, an introduction Mol Cancer Res, 1, pp. 993-1000.
    • (2003) Mol Cancer Res , vol.1 , pp. 993-1000
    • Iwakuma, T.1    Lozano, G.2
  • 31
    • 0041630956 scopus 로고    scopus 로고
    • Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression
    • Kinyamu, HK and Archer, TK (2003) Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression Mol Cell Biol, 23, pp. 5867-5881.
    • (2003) Mol Cell Biol , vol.23 , pp. 5867-5881
    • Kinyamu, H.K.1    Archer, T.K.2
  • 32
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    • Kussie, PH and Gorina, S and Marechal, V and Elenbaas, B and Moreau, J and Levine, AJ and Pavletich, NP. (1996) Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain Science, 274, pp. 948-953.
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1    Gorina, S.2    Marechal, V.3    Elenbaas, B.4    Moreau, J.5    Levine, A.J.6    Pavletich, N.P.7
  • 33
    • 0027956208 scopus 로고
    • Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells
    • Landers, JE and Haines, DS and Strauss, JF, 3rd and George, DL. (1994) Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells Oncogene, 9, pp. 2745-2750.
    • (1994) Oncogene , vol.9 , pp. 2745-2750
    • Landers, J.E.1    Haines, D.S.2    Strauss III, J.F.3    George, D.L.4
  • 34
    • 0032912721 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis
    • Leri, A and Liu, Y and Claudio, PP and Kajstura, J and Wang, X and Wang, S and Kang, P and Malhotra, A and Anversa, P. (1999) Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis Am J Pathol, 154, pp. 567-580.
    • (1999) Am J Pathol , vol.154 , pp. 567-580
    • Leri, A.1    Liu, Y.2    Claudio, P.P.3    Kajstura, J.4    Wang, X.5    Wang, S.6    Kang, P.7    Malhotra, A.8    Anversa, P.9
  • 36
    • 1842378642 scopus 로고    scopus 로고
    • The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter
    • Leveillard, T and Wasylyk, B. (1997) The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter J Biol Chem, 272, pp. 30651-30661.
    • (1997) J Biol Chem , vol.272 , pp. 30651-30661
    • Leveillard, T.1    Wasylyk, B.2
  • 37
    • 0348134742 scopus 로고    scopus 로고
    • Mono-versus polyubiquitination: Differential control of p53 fate by Mdm2
    • Li, M and Brooks, CL and Wu-Baer, F and Chen, D and Baer, R and Gu, W. (2003) Mono-versus polyubiquitination: Differential control of p53 fate by Mdm2 Science, 302, pp. 1972-1975.
    • (2003) Science , vol.302 , pp. 1972-1975
    • Li, M.1    Brooks, C.L.2    Wu-Baer, F.3    Chen, D.4    Baer, R.5    Gu, W.6
  • 38
    • 0036683093 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
    • Lin, HK and Wang, L and Hu, YC and Altuwaijri, S and Chang, C. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase EMBO J, 21, pp. 4037-4048.
    • (2002) EMBO J , vol.21 , pp. 4037-4048
    • Lin, H.K.1    Wang, L.2    Hu, Y.C.3    Altuwaijri, S.4    Chang, C.5
  • 39
    • 0033595798 scopus 로고    scopus 로고
    • p53 down-regulates ER-responsive genes by interfering with the binding of ER to ERE
    • Liu, G and Schwartz, JA and Brooks, SC. (1999) p53 down-regulates ER-responsive genes by interfering with the binding of ER to ERE Biochem Biophys Res Commun, 264, pp. 359-364.
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 359-364
    • Liu, G.1    Schwartz, J.A.2    Brooks, S.C.3
  • 40
    • 0034127791 scopus 로고    scopus 로고
    • Estrogen receptor protects p53 from deactivation by human double minute-2
    • Liu, G and Schwartz, JA and Brooks, SC. (2000) Estrogen receptor protects p53 from deactivation by human double minute-2 Cancer Res, 60, pp. 1810-1814.
    • (2000) Cancer Res , vol.60 , pp. 1810-1814
    • Liu, G.1    Schwartz, J.A.2    Brooks, S.C.3
  • 41
    • 0033998439 scopus 로고    scopus 로고
    • Apoptotic and growth-promoting activity of E2F modulated by MDM2
    • Loughran, O and La Thangue, NB. (2000) Apoptotic and growth-promoting activity of E2F modulated by MDM2 Mol Cell Biol, 20, pp. 2186-2197.
    • (2000) Mol Cell Biol , vol.20 , pp. 2186-2197
    • Loughran, O.1    La Thangue, N.B.2
  • 42
    • 13144249170 scopus 로고    scopus 로고
    • Mdmx and Mdm2: Brothers in arms?
    • Marine, JC and Jochemsen, AG. (2004) Mdmx and Mdm2: Brothers in arms? Cell Cycle, 3, pp. 900-904.
    • (2004) Cell Cycle , vol.3 , pp. 900-904
    • Marine, J.C.1    Jochemsen, A.G.2
  • 44
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    • Mayo, LD and Donner, DB (2001) A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus Proc Natl Acad Sci USA, 98, pp. 11598-11603.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 45
    • 0036710512 scopus 로고    scopus 로고
    • The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
    • Mayo, LD and Donner, DB (2002) The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network Trends Biochem Sci, 27, pp. 462-467.
    • (2002) Trends Biochem Sci , vol.27 , pp. 462-467
    • Mayo, L.D.1    Donner, D.B.2
  • 46
    • 0029020147 scopus 로고
    • Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status
    • McCann, AH and Kirley, A and Carney, DN and Corbally, N and Magee, HM and Keating, G and Dervan, PA. (1995) Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status Br J Cancer, 71, pp. 981-985.
    • (1995) Br J Cancer , vol.71 , pp. 981-985
    • McCann, A.H.1    Kirley, A.2    Carney, D.N.3    Corbally, N.4    Magee, H.M.5    Keating, G.6    Dervan, P.A.7
  • 47
    • 0346455772 scopus 로고    scopus 로고
    • Posttranslational modification of MDM2
    • Meek, DW and Knippschild, U. (2003) Posttranslational modification of MDM2 Mol Cancer Res, 1, pp. 1017-1026.
    • (2003) Mol Cancer Res , vol.1 , pp. 1017-1026
    • Meek, D.W.1    Knippschild, U.2
  • 48
    • 20844451181 scopus 로고    scopus 로고
    • Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes
    • Metivier, R and Penot, G and Carmouche, RP and Hubner, MR and Reid, G and Denger, S and Manu, D and Brand, H and Kos, M and Benes, V and (2004) Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes EMBO J, 23, pp. 3653-3666.
    • (2004) EMBO J , vol.23 , pp. 3653-3666
    • Metivier, R.1    Penot, G.2    Carmouche, R.P.3    Hubner, M.R.4    Reid, G.5    Denger, S.6    Manu, D.7    Brand, H.8    Kos, M.9    Benes, V.10
  • 49
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • Michael, D and Oren, M. (2003) The p53-Mdm2 module and the ubiquitin system Semin Cancer Biol, 13, pp. 49-58.
    • (2003) Semin Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 50
  • 51
    • 8844232663 scopus 로고    scopus 로고
    • The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
    • Minsky, N and Oren, M. (2004) The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression Mol Cell, 16, pp. 631-639.
    • (2004) Mol Cell , vol.16 , pp. 631-639
    • Minsky, N.1    Oren, M.2
  • 53
    • 0033959744 scopus 로고    scopus 로고
    • MDM2 - Master regulator of the p53 tumor suppressor protein
    • Momand, J and Wu, HH and Dasgupta, G. (2000) MDM2 - master regulator of the p53 tumor suppressor protein Gene, 242, pp. 15-29.
    • (2000) Gene , vol.242 , pp. 15-29
    • Momand, J.1    Wu, H.H.2    Dasgupta, G.3
  • 54
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand, J and Zambetti, GP and Olson, DC and George, D and Levine, AJ. (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Cell, 69, pp. 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 56
    • 0029827632 scopus 로고    scopus 로고
    • p53-dependent association between cyclin G and the B′ subunit of protein phosphatase 2A
    • Okamoto, K and Kamibayashi, C and Serrano, M and Prives, C and Mumby, MC and Beach, D. (1996) p53-dependent association between cyclin G and the B′ subunit of protein phosphatase 2A Mol Cell Biol, 16, pp. 6593-6602.
    • (1996) Mol Cell Biol , vol.16 , pp. 6593-6602
    • Okamoto, K.1    Kamibayashi, C.2    Serrano, M.3    Prives, C.4    Mumby, M.C.5    Beach, D.6
  • 58
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner, JD and Kinzler, KW and Meltzer, PS and George, DL and Vogelstein, B. (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas Nature, 358, pp. 80-83.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 62
    • 0036248845 scopus 로고    scopus 로고
    • Antisense anti-MDM2 oligonucleotides as a novel approach to the treatment of glioblastoma multiforme
    • Prasad, G and Wang, H and Agrawal, S and Zhang, R. (2002) Antisense anti-MDM2 oligonucleotides as a novel approach to the treatment of glioblastoma multiforme Anticancer Res, 22, pp. 107-116.
    • (2002) Anticancer Res , vol.22 , pp. 107-116
    • Prasad, G.1    Wang, H.2    Agrawal, S.3    Zhang, R.4
  • 64
    • 0037351881 scopus 로고    scopus 로고
    • Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling
    • Reid, G and Hubner, MR and Metivier, R and Brand, H and Denger, S and Manu, D and Beaudouin, J and Ellenberg, J and Gannon, F. (2003) Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling Mol Cell, 11, pp. 695-707.
    • (2003) Mol Cell , vol.11 , pp. 695-707
    • Reid, G.1    Hubner, M.R.2    Metivier, R.3    Brand, H.4    Denger, S.5    Manu, D.6    Beaudouin, J.7    Ellenberg, J.8    Gannon, F.9
  • 65
    • 0037080483 scopus 로고    scopus 로고
    • E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
    • Ren, B and Cam, H and Takahashi, Y and Volkert, T and Terragni, J and Young, RA and Dynlacht, BD. (2002) E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints Genes Dev, 16, pp. 245-256.
    • (2002) Genes Dev , vol.16 , pp. 245-256
    • Ren, B.1    Cam, H.2    Takahashi, Y.3    Volkert, T.4    Terragni, J.5    Young, R.A.6    Dynlacht, B.D.7
  • 68
    • 0035883863 scopus 로고    scopus 로고
    • Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2
    • Sengupta, S and Wasylyk, B. (2001) Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2 Genes Dev, 15, pp. 2367-2380.
    • (2001) Genes Dev , vol.15 , pp. 2367-2380
    • Sengupta, S.1    Wasylyk, B.2
  • 69
    • 3042795223 scopus 로고    scopus 로고
    • Physiological and pathological consequences of the interactions of the p53 tumor suppressor with the glucocorticoid, androgen, and estrogen receptors
    • Sengupta, S and Wasylyk, B. (2004) Physiological and pathological consequences of the interactions of the p53 tumor suppressor with the glucocorticoid, androgen, and estrogen receptors Ann NY Acad Sci, 1024, pp. 54-71.
    • (2004) Ann NY Acad Sci , vol.1024 , pp. 54-71
    • Sengupta, S.1    Wasylyk, B.2
  • 71
    • 4544379668 scopus 로고    scopus 로고
    • Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates
    • Shiraishi, T and Nielsen, PE. (2004) Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates Nucleic Acids Res, 32, pp. 4893-4902.
    • (2004) Nucleic Acids Res , vol.32 , pp. 4893-4902
    • Shiraishi, T.1    Nielsen, P.E.2
  • 73
    • 0032545222 scopus 로고    scopus 로고
    • p53-independent role of MDM2 in TGF-beta1 resistance
    • Sun, P and Dong, P and Dai, K and Hannon, GJ and Beach, D. (1998) p53-independent role of MDM2 in TGF-beta1 resistance Science, 282, pp. 2270-2272.
    • (1998) Science , vol.282 , pp. 2270-2272
    • Sun, P.1    Dong, P.2    Dai, K.3    Hannon, G.J.4    Beach, D.5
  • 74
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • Thut, CJ and Goodrich, JA and Tjian, R. (1997) Repression of p53-mediated transcription by MDM2: A dual mechanism Genes Dev, 11, pp. 1974-1986.
    • (1997) Genes Dev , vol.11 , pp. 1974-1986
    • Thut, C.J.1    Goodrich, J.A.2    Tjian, R.3
  • 78
    • 0036467496 scopus 로고    scopus 로고
    • TGF-beta signaling: Positive and negative effects on tumorigenesis
    • Wakefield, LM and Roberts, AB. (2002) TGF-beta signaling: Positive and negative effects on tumorigenesis Curr Opin Genet Dev, 12, pp. 22-29.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 79
    • 0035186743 scopus 로고    scopus 로고
    • Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms
    • Wang, H and Nan, L and Yu, D and Agrawal, S and Zhang, R. (2001) Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms Clin Cancer Res, 7, pp. 3613-3624.
    • (2001) Clin Cancer Res , vol.7 , pp. 3613-3624
    • Wang, H.1    Nan, L.2    Yu, D.3    Agrawal, S.4    Zhang, R.5
  • 80
    • 0036042573 scopus 로고    scopus 로고
    • Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms
    • Wang, H and Nan, L and Yu, D and Lindsey, JR and Agrawal, S and Zhang, R. (2002) Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms Mol Med, 8, pp. 185-199.
    • (2002) Mol Med , vol.8 , pp. 185-199
    • Wang, H.1    Nan, L.2    Yu, D.3    Lindsey, J.R.4    Agrawal, S.5    Zhang, R.6
  • 81
    • 0037441417 scopus 로고    scopus 로고
    • Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: In vitro and in vivo activities and mechanisms
    • Wang, H and Yu, D and Agrawal, S and Zhang, R. (2003) Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: In vitro and in vivo activities and mechanisms Prostate, 54, pp. 194-205.
    • (2003) Prostate , vol.54 , pp. 194-205
    • Wang, H.1    Yu, D.2    Agrawal, S.3    Zhang, R.4
  • 82
    • 0028081261 scopus 로고
    • The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin
    • Watanabe, T and Hotta, T and Ichikawa, A and Kinoshita, T and Nagai, H and Uchida, T and Murate, T and Saito, H. (1994) The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin Blood, 84, pp. 3158-3165.
    • (1994) Blood , vol.84 , pp. 3158-3165
    • Watanabe, T.1    Hotta, T.2    Ichikawa, A.3    Kinoshita, T.4    Nagai, H.5    Uchida, T.6    Murate, T.7    Saito, H.8
  • 84
    • 4444240191 scopus 로고    scopus 로고
    • The functional interactions between the p53 and MAPK signaling pathways
    • Wu, G.S. (2004) The functional interactions between the p53 and MAPK signaling pathways Cancer Biol Ther, 3, pp. 156-161.
    • (2004) Cancer Biol Ther , vol.3 , pp. 156-161
    • Wu, G.S.1
  • 85
    • 0344995254 scopus 로고    scopus 로고
    • MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins
    • Yam, CH and Siu, WY and Arooz, T and Chiu, CH and Lau, A and Wang, XQ and Poon, RY. (1999) MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins Cancer Res, 59, pp. 5075-5078.
    • (1999) Cancer Res , vol.59 , pp. 5075-5078
    • Yam, C.H.1    Siu, W.Y.2    Arooz, T.3    Chiu, C.H.4    Lau, A.5    Wang, X.Q.6    Poon, R.Y.7
  • 86
    • 14644410433 scopus 로고    scopus 로고
    • Novel antisense anti-MDM2 mixed-backbone oligonucleotides: Proof of principle, in vitro and in vivo activities, and mechanisms
    • Zhang, R and Wang, H and Agrawal, S. (2005) Novel antisense anti-MDM2 mixed-backbone oligonucleotides: Proof of principle, in vitro and in vivo activities, and mechanisms Curr Cancer Drug Targets, 5, pp. 43-49.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 43-49
    • Zhang, R.1    Wang, H.2    Agrawal, S.3
  • 87
    • 1642377946 scopus 로고    scopus 로고
    • Radiosensitization by antisense anti-MDM2 mixed-backbone oligonucleotide in in vitro and in vivo human cancer models
    • Zhang, Z and Wang, H and Prasad, G and Li, M and Yu, D and Bonner, JA and Agrawal, S and Zhang, R. (2004) Radiosensitization by antisense anti-MDM2 mixed-backbone oligonucleotide in in vitro and in vivo human cancer models Clin Cancer Res, 10, pp. 1263-1273.
    • (2004) Clin Cancer Res , vol.10 , pp. 1263-1273
    • Zhang, Z.1    Wang, H.2    Prasad, G.3    Li, M.4    Yu, D.5    Bonner, J.A.6    Agrawal, S.7    Zhang, R.8
  • 88
    • 0037044103 scopus 로고    scopus 로고
    • The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure
    • Zhao, J and Wang, M and Chen, J and Luo, A and Wang, X and Wu, M and Yin, D and Liu, Z. (2002) The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure Cancer Lett, 183, pp. 69-77.
    • (2002) Cancer Lett , vol.183 , pp. 69-77
    • Zhao, J.1    Wang, M.2    Chen, J.3    Luo, A.4    Wang, X.5    Wu, M.6    Yin, D.7    Liu, Z.8
  • 89
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC. 2001. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 3:973-982
    • (2001) Nat Cell Biol , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.C.6


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