Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer

Breast Cancer Research and Treatment

Volumn 71, Issue 1, 2002, Pages 77-84

  Hori, Masao ^a   Shimazaki, Jiro ^a   Inagawa, Satoshi ^a   Itabashi, Masayuki ^a   Hori, Mitsuo ^b  

^a IBARAKI PREFECTURAL CENTRAL HOSPITAL   (Japan)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Estrogen receptor alpha; Human breast cancer MDM2 oncoprotein; MDM2 oncogene; MDM2 splice variants

Indexed keywords

ESTROGEN RECEPTOR ALPHA; MESSENGER RNA; ONCOPROTEIN; PROTEIN MDM2;

ARTICLE; BREAST CANCER; CODON; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL NUCLEUS; CODON; CYTOPLASM; DISEASE PROGRESSION; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; NUCLEAR PROTEINS; POINT MUTATION; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECEPTORS, ESTROGEN; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0036159438     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013350419426     Document Type: Article

References (24)

1. Estrogen receptor mutations in tamoxifen-resistant breast cancer
2. Determination of estrogen receptor in primary breast cancer using two different monoclonal antibodies, and correlation with its mRNA expression
3. Hypermethylation of the estrogen receptor alpha gene is not related to lack of receptor protein in human breast cancer
4. Aberrant methylation of the estrogen receptor and E-cadherin 5′ CpG islands increases with malignant progression in human breast cancer
5. Nuclear receptor coactivators and corepressors
6. Purification and identification of p 68 RNA helicase acting as a transcriptional coactivator specific for the activation function l of human estrogen receptor α
7. The tumor suppressor p 53 is a negative regulator of estrogen receptor signaling pathways
8. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
9. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
10. Monitoring of interobserver agreement in nuclear atypia scoring of node-negative breast carcinomas judged at individual collaborating hospitals in the national surgical adjuvant study of breast cancer (NSAS-BC) protocol
11. Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer
12. Alternatively spliced MDM2 transcripts in human breast cancer in relation to tumor necrosis and lymph node involvement
13. Amplification of a gene encoding a p53-associated protein in human sarcomas
14. The MDM2 oncogene over-expression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin
15. Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumour cells
16. Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status
17. Abnormal expression of MDM-2 in breast carcinomas
18. MDM2 overexpression in benign and malignant lesions of the human breast: Association with ER expression
19. Mdm2 gene alterations and mdm2 protein expression in breast carcinomas
20. Estrogen receptor protects p53 from deactivation by human double minute-2
21. Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53
22. Absence of point mutations at codon 17 of the Mdm2 gene (serine 17) in human primary tumors
23. Mutations in human ARF exon2 disrupt its nuclear localization and impair its ability to block nuclear export of MDM2 and p53